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hepatitis C virus core protein-induced miR-93-5p upregulation inhibits interferon signaling pathway by targeting IFNAR1

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World Journal of Gastroenterology 2018年第2期24卷 226-236页

作者： chang-long he Ming Liu Zhao-Xia Tan Ya-Jun Hu Qiao-Yue Zhang Xue-Mei Kuang Wei-long Kong Qing Mao Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400037China Chongqing Key Laboratory for Research of Infectious Diseases Chongqing 400037China

AIM To investigate the mechanism by which hepatitis C virus(HCV) core protein-induced mi R-93-5 p up-regulation regulates the interferon(IFN) signaling *** HCV-1 b core protein was exogenously expressed in Huh7 cells using pc DNA3.1(+) vector. The expression of mi R-93-5 p and interferon receptor 1(IFNAR1) was measured using quantitative reverse transcriptionpolymerase chain reaction and Western blot. The protein expression and phosphorylation level of STAT1 were evaluated by Western blot. The overexpression and silencing of mi R-93-5 p and IFNAR1 were performed using mi R-93-5 p agomir and antagomir, and pc DNA3.1-IFNAR1 and IFNAR1 si RNA, respectively. Luciferase assay was used to identify whether IFNAR1 is a target of mi R-93-5 p. Cellular experiments were also *** Serum mi R-93-5 p level was increased in patients with HCV-1 b infection and decreased to normal level after HCV-1 b clearance, but persistently increased in those with pegylated interferon-α resistance, compared with healthy subjects. Serum mi R-93-5 p expression had an AUC value of 0.8359 in distinguishing patients with pegylated interferon-α resistance from those with pegylated interferon-α sensitivity. HCV-1 b core protein increased mi R-93-5 p expression and induced inactivation of the IFN signaling pathway in Huh7 cells. Furthermore, IFNAR1 was identified as a direct target of mi R-93-5 p, and IFNAR1 restore could rescue mi R-93-5 p-reduced STAT1 phosphorylation, suggesting that the mi R-93-5 p-IFNAR1 axis regulates the IFN signaling *** HCV-1 b core protein-induced mi R-93-5 p up-regulation inhibits the IFN signaling pathway by directly targeting IFNAR1, and the mi R-93-5 p-IFNAR1 axis regulates STAT1 phosphorylation. This axis may be a potential therapeutic target for HCV-1 b infection.

关键词： hepatitis C virus miR-93-5p Interferon receptor 1 IFN signaling pathway

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Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1113-1115页

作者： chang-long he Lu-Yi Huang Kai Wang Chen-Jian Gu Jie Hu Gui-Ji Zhang Wei Xu You-Hua Xie Ni Tang Ai-long Huang Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqingChina Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Department of Medical Microbiology and ParasitologySchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghaiChina Children's Hospital Fudan UniversityShanghaiChina

Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a major public health *** spike(S)protein mutation D614G became dominant in SARS-CoV-2 during a global pandemic,which displayed increased infectivity.1 Entry of a virus into host cells is one of the most critical steps in the viral life *** blockade of the entry process is a promising therapeutic option for COVID-19,research attention has been focused on the discovery of viral entry *** SARS-CoV-2 entry inhibitor development is very attractive,no candidates have progressed into clinical trials yet.

关键词： acute respiratory attractive

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蛇形微通道气液两相流型的数值研究

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高校化学工程学报 2016年第5期30卷 1067-1073页

作者：周云龙常赫东北电力大学能源与动力工程学院吉林吉林132012

采用CLSVOF(coupled level set and volume of fluid)方法,以空气和水为介质对矩形截面蛇形微通道内气液两相流动进行模拟研究。验证模型的合理性后,系统地研究了表面张力,液相黏度,壁面接触角及通道截面形状对蛇形微通道内不同流型间... 详细信息

采用CLSVOF(coupled level set and volume of fluid)方法,以空气和水为介质对矩形截面蛇形微通道内气液两相流动进行模拟研究。验证模型的合理性后,系统地研究了表面张力,液相黏度,壁面接触角及通道截面形状对蛇形微通道内不同流型间转换界限的影响,并绘制了不同表面张力、液相黏度及接触角下的流型图。最后,将计算结果与相同当量直径不同截面微通道内两相流流型图进行对比,分析截面形状及高宽比对流型间转换界限的影响。这些基本规律为微通道的系统设计提供了一定依据。

关键词：蛇形微通道气液两相流数值模拟流型微流体学

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壁面性质对蛇形微通道流动特性的影响

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原子能科学技术 2017年第1期51卷 27-32页

作者：周云龙常赫东北电力大学能源与动力工程学院吉林省吉林市132012

采用CLSVOF方法,以空气和水为介质,对不同壁面性质的矩形截面蛇形微通道内气液两相流动进行模拟研究。验证模型的合理性后,改变粗糙度及雷诺数Re,讨论其对泊肃叶数Po和努塞尔数Nu的影响并分析其影响机制;改变壁面接触角及粗糙度,探讨其... 详细信息

采用CLSVOF方法,以空气和水为介质,对不同壁面性质的矩形截面蛇形微通道内气液两相流动进行模拟研究。验证模型的合理性后,改变粗糙度及雷诺数Re,讨论其对泊肃叶数Po和努塞尔数Nu的影响并分析其影响机制;改变壁面接触角及粗糙度,探讨其对微通道内流体流动的综合影响;由于蛇形微通道特有的回转弯道,针对几种具有不同壁面性质的通道组合情况对流体流动特性进行研究。计算结果表明,壁面粗糙度的增加对Po的影响高于Nu,且可强化传热;壁面粗糙度对亲水壁面与疏水壁面的影响效果相反;当直微通道为亲水性光滑壁面、回转弯道为疏水性粗糙壁面时,其传热效果更好。

关键词：蛇形微通道气液两相流数值模拟微流体学

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Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson’s disease

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Signal Transduction and Targeted Therapy 2021年第3期6卷 596-598页

作者： An-Guo Wu Rong Pan Betty Yuen-Kwan Law Wen-Qiao Qiu Jian-Ming Wu chang-long he Vincent Kam-Wai Wong Chong-Lin Yu Xiao-Gang Zhou Da-Lian Qin Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSchool of PharmacyDepartment of Human AnatomySchool of Preclinical MedicineEducation Ministry Key Laboratory of Medical ElectrophysiologySouthwest Medical UniversityLuzhou 646000China State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacaoChina

Dear Editor,PD is characterized by the loss of dopaminergic neurons in substantia nigra,and the loss of dopamine resulting in motor deficit.1 Its main pathological hallmarks include the genetic mutations of gene such as a-synudein.2 Increasing study showed that the dopaminergic neurons in midbrain are sensitive and damaged by the PD toxins.

关键词： nude dopamine therapeutic

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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong he Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei Lv Wei Qin Xin he Yuanhua he Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

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二级增压柴油机压缩比和喷油提前角优化研究

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兵工学报 2017年第1期38卷 20-26页

作者：商海昆董长龙何剑丰樊丰李萍黄绵敦谢亮河北华北柴油机有限责任公司河北石家庄050081 解放军驻国营第5460厂军事代表室河北石家庄050081 北京理工大学机械与车辆学院北京100081

为解决某V型柴油机由单级增压改为二级增压后,最高燃烧压力过高问题,通过GTPower软件建立柴油机仿真模型,利用试验数据进行校核,仿真研究了喷油提前角和压缩比对二级增压柴油机性能及最高燃烧压力的影响规律。以二级增压柴油机的试验最... 详细信息

为解决某V型柴油机由单级增压改为二级增压后,最高燃烧压力过高问题,通过GTPower软件建立柴油机仿真模型,利用试验数据进行校核,仿真研究了喷油提前角和压缩比对二级增压柴油机性能及最高燃烧压力的影响规律。以二级增压柴油机的试验最高燃烧压力作为限制条件,以转矩达到最大为目标,利用GT-POWER中的DOE工具对喷油提前角和压缩比进行联合优化。仿真结果表明:降低压缩比能够有效降低最大转矩点(1 300 r/min)和标定点(2 100 r/min)的最高燃烧压力,压缩比每降低1,最大转矩点最高燃烧压力降低0.8 MPa,标定点最高燃烧压力降低1.16 MPa;得出优化后的压缩比和喷油提前角相对变化值为14.9°CA和4.3°CA.根据试验机的结构条件,利用试验机在柴油机台架上验证了优化结果的可行性。

关键词：动力机械工程二级增压柴油机压缩比喷油提前角最高燃烧压力动力性

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塔北地区三叠系油藏原油中性含氮化合物和烷基苯酚的运移分馏作用

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沉积学报 2001年第1期19卷 150-155页

作者：张敏龙长河张俊张春明胡伯良江汉石油学院地球化学研究中心河北唐山063200 北田石油勘探开发有限公司湖北荆州434102

塔北地区三叠系油藏原油中性含氮化合物和烷基苯酚自南向北存在着运移分馏作用 ,表现为中性含氮化合物的绝对浓度由高变低 ,屏蔽型化合物相对富集而部分屏蔽型化合物和裸露型化合物相对贫瘠 ,1,8 DMCA/1,7 DM CA ,1,8 DMCA/2 ,7 DMCA ,1... 详细信息

塔北地区三叠系油藏原油中性含氮化合物和烷基苯酚自南向北存在着运移分馏作用 ,表现为中性含氮化合物的绝对浓度由高变低 ,屏蔽型化合物相对富集而部分屏蔽型化合物和裸露型化合物相对贫瘠 ,1,8 DMCA/1,7 DM CA ,1,8 DMCA/2 ,7 DMCA ,1,8 DMCA/部分屏蔽化合物 ,1,8 DMCA/裸露化合物的比值由小变大 ,而 [a]/[c]的比值则由大变小 ,烷基苯酚化合物 2 MPH/3 MPH和 2 ,6 DMPH/2 ,3 DMPH的比值亦由小变大。此外同一构造带中原油自西向东 ,从下而上中性含氮化合物同样存在着运移分馏效应。研究还表明塔北地区三叠系原油横向上自南向北 ,从吉拉克地区向桑塔木断垒和轮南断垒带方向运移 ,而侧向上原油从下而上。

关键词：中性含氮化合物烷基苯酚运移分馏作用原油塔北地区三叠系油藏

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song he Li Li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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