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Free Radical Pathway Cleavage of C-O Bonds for the Synthesis of Alkylboron Compounds

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Chinese Journal of Chemistry 2019年第1期37卷 11-18页

作者： Xi Lu Zhen-Qi Zhang Lu Yu Ben Zhang Bing Wang tian-Jun Gong chang-lin tian Bin Xiao Yao Fu Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Urban Pollutant ConversionAnhui Province Key Laboratory of Biomcass Clean EnergyiChEMUniversity of Science and Technology of ChinaHefeiAnhui 230026China High Magnetic Field Laboratory Chinese Academy of SciencesHefeiAnhui 230031China School of Life Sciences University of Science and Technology of ChinaHefeiAnhui 230027China

Sumrnary of main observation and conclusion We report a silver-catalyzed borylation of alkyl tosylates,which provides a new method for the synthesis of all 详细信息

Sumrnary of main observation and conclusion We report a silver-catalyzed borylation of alkyl tosylates,which provides a new method for the synthesis of all

关键词： Sumrnary report work

Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors

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Protein & Cell 2019年第3期10卷 211-216页

作者： Qing-Yan Guo Long-Hua Zhang Chao Zuo Dong-Liang Huang Zhipeng A.Wang Ji-Shen Zheng chang-lin tian School of Life Sciences University of Science and Technology of ChinaHefei 230027China

Dear Editor,It is known that most of lives on the earth compose of homochiral molecules of L-amino acids and D-ribose nucleic ***,little is known why and how the life's chirality in such a *** on an artificial mirror-image life could strengthen our understanding of the question about the origin of life on the Earth and even elsewhere in the *** studies on mirror-image life would also have a plenty of vast application prospects in materials,energy and pharmaceutical sciences(Bohannon,2010).

关键词： Editor chirality question

Visual test paper based on Au/δ-MnO_(2) hollow nanosphere oxidase-like activity regulation using hexavalent chromium as a smart switch

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Rare Metals 2024年第2期43卷 711-722页

作者： Wen-chang Zhuang Hai-Yue Zhang Zhen-Yang Chen Wen-Jing Cheng Wei-Dan Na Zhao Li lin tian School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou221018China School of Chemistry and Environmental Science Yili Normal UniversityYining835000China

Paper-based sensing platform is a point of need analytical toolkit for safety ***,the sensitivity,specificity,and simplicity are still ***,we report a novel strategy(Au/δ-MnO_(2) hollow nanosphere and 3,3′,5,5′-tetramethylbenzidine(TMB)induced test strips for signal-on detection)that can be utilized for hexavalent chromium(Cr^(6+))***,Cr^(6+)(CrO_(4)^(2−)) as a smart switch can remarkably enhance the oxidase-like activity of Au/δ-MnO_(2) hollow *** presence of Cr^(6+) can regulate the surface electronic redistribution of Au/δ-MnO_(2) and adjust the geometric configuration,which leads to the improvement in oxidase-like activity of Au/δ-MnO_(2).As a proof-of-concept application,a visual paper-based sensing platform of Cr^(6+) along with quantitative analysis by the test strips was successfully *** paper-based sensing platform exhibits a linear range with excellent selectivity for other interfering substances and lower limit of detection of 0.09μmol·L^(−1),providing a promising toolkit at-home Cr^(6+) measurement and environmental monitoring.

关键词： Point of need Colorimetric biosensing platform Au/δ-MnO_(2) hollow nanosphere Test strip Cr^(6+)

A toroidal SAW gyroscope with focused IDTs for sensitivity enhancement

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Microsystems & Nanoengineering 2024年第2期10卷 47-56页

作者： Lu tian Haitao Zhao Qiang Shen Honglong chang Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an710072China

A surface acoustic wave(SAW)gyroscope measures the rate of rotational angular velocity by exploiting a phenomenon known as the SAW gyroscope *** a gyroscope is a great candidate for application in harsh environments because of the simplification of the suspension vibration mechanism necessary for traditional microelectromechanical system(MEMS)***,for the first time,we propose a novel toroidal standing-wave-mode SAW gyroscope using focused interdigitated transducers(FIDTs).Unlike traditional SAW gyroscopes that use linear IDTs to generate surface acoustic waves,which cause beam deflection and result in energy dissipation,this study uses FIDTs to concentrate the SAW energy based on structural features,resulting in better focusing performance and increased SAW *** experimental results reveal that the sensitivity of the structure is 1.51µV/(°/s),and the bias instability is 0.77°/s,which are improved by an order of magnitude compared to those of a traditional SAW ***,the FIDT component can enhance the performance of the SAW gyroscope,demonstrating its superiority for angular velocity *** work provides new insights into improving the sensitivity and performance of SAW gyroscopes.

关键词： angular deflection gyroscope

Adversarial attacks and defenses for digital communication signals identification

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Digital Communications and Networks 2024年第3期10卷 756-764页

作者： Qiao tian Sicheng Zhang Shiwen Mao Yun lin College of Computer Science and Technology Harbin Engineering UniversityHarbin150001China College of Information and Communication Engineering Harbin Engineering UniversityHarbin150000China Department of Electrical and Computer Engineering Auburn UniversityAuburnAL36849USA

As modern communication technology advances apace,the digital communication signals identification plays an important role in cognitive radio networks,the communication monitoring and management *** has become a promising solution to this problem due to its powerful modeling capability,which has become a consensus in academia and ***,because of the data-dependence and inexplicability of AI models and the openness of electromagnetic space,the physical layer digital communication signals identification model is threatened by adversarial *** examples pose a common threat to AI models,where well-designed and slight perturbations added to input data can cause wrong ***,the security of AI models for the digital communication signals identification is the premise of its efficient and credible *** this paper,we first launch adversarial attacks on the end-to-end AI model for automatic modulation classifi-cation,and then we explain and present three defense mechanisms based on the adversarial *** we present more detailed adversarial indicators to evaluate attack and defense ***,a demonstration verification system is developed to show that the adversarial attack is a real threat to the digital communication signals identification model,which should be paid more attention in future research.

关键词： Digital communication signals identification AI model Adversarial attacks Adversarial defenses Adversarial indicators

DMF-scMT-seq linking methylome and transcriptome within single cells with digital microfluidics

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Science China Chemistry 2024年第6期67卷 2070-2078页

作者： Xing Xu Xi Zeng Xin lin Shiyan lin Shanshan Liang tian tian Rui Su Jia Song Chaoyong Yang Collaborative Innovation Center of Chemistry for Energy Materials The MOE Key Laboratory of Spectrochemical Analysis and InstrumentationState Key Laboratory of Physical Chemistry of Solid SurfacesDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringThe First Affiliated Hospital of Xiamen UniversityXiamen UniversityXiamen361005China Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai200127China Chemistry and Materials Science College Shanghai Normal UniversityShanghai200234China Chemistry and Biomedicine Innovation Center(ChemBIC) School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China

Single-cell joint analysis of methylome and transcriptome reveals how the methylation regulates the transcriptional ***,traditional bench-top protocols for single-cell DNA methylation and RNA transcription co-detection are laborintensive,cost-ineffective and ***,we establish the DMF-sc MT-seq,a highly-efficient and cost-effective method to simultaneously analyze single-cell DNA methylation and transcriptional activity based on digital *** MT-seq automates the workflow of single-cell isolation,cellular hypotonic lysis,nucleic acid separation and methylome/transcriptome library construction in a contactless and addressable *** system ensures high accuracy(R>0.85),high gene detection ability(14,697 genes per cell at 4 million sequencing depth),and high CpG coverage(677,198 CpG sites per cell at 1million sequencing depth).By using DMF-sc MT-seq,the relationship of DNA methylation and RNA transcription under different genomic contexts is *** further apply DMF-sc MT-seq to study the dynamics of transcription regulation with methylation-inhibiting anti-tumor Decitabine,and identify the methylated promoter/gene body driven genes in response to Decitabine ***-sc MT-seq facilitates the construction of the correlation of DNA methylation and transcriptional activity at the single-cell level in a flexible,sensitive and accurate way,which is anticipated to be a powerful tool in studying single-cell biological systems.

关键词： single-cell analysis digital microfluidics methylome sequencing transcriptome sequencing

Molecular crowding electrolytes for stabilizing Zn metal anode in rechargeable aqueous batteries

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Chinese Chemical Letters 2024年第7期35卷 445-451页

作者： Li lin Song-lin tian Zhen-Yu Hu Yu Zhang Li-Min chang Jia-Jun Wang Wan-Qiang Liu Qing-Shuang Wang Fang Wang School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China School of Life Science and Technology Changchun University of Science and TechnologyChangchun 130022China Key Laboratory of Preparation and Applications of Environmental Friendly Materials of the Ministry of Education Jilin Normal UniversityChangchun 130103China Zhongshan Institute of changchun University of Science and Technology Zhongshan 528437China

A solid electrolyte interphase(SEI)with a robust mechanical property and a high ionic conductivity is imperative for high-performance zinc metal ***,it is difficult to form such a SEI directly from an *** this work,a molecular crowding effect is based on the introduction of Zn(OTF)_(2)and Zn(ClO_(4))_(2)to 2 mol/L ZnSO_(4)*** and experiments indicate that the Zn(OTF)_(2)and Zn(ClO_(4))_(2)not only create a molecularly crowded electrolyte environment to promote the interaction of Zn^(2+)and OTF^(-),but also participate in the reduction to construct a robust and high ionic-conductive SEI,thus promoting metal zinc deposition to the(002)crystal *** this molecular crowding electrolyte,a high current density of 1 mA/cm^(2)can be obtained by assembling symmetric batteries with Zn as the anode for over 1000 *** in a temperature environment of-10℃,a current density of 1 mA/cm^(2)can be obtained by assembling symmetric batteries with Zn for over 200 ***//Bi_(2)S_(3)/VS4@C cells achieve a CE rate of up to 99.81%over 1000 ***,the utilization of a molecular crowding electrolyte is deemed a highly effective approach to fabricating a sophisticated SEI for a zinc anode.

关键词： Zinc ion batteries Anode Electrolyte Solid electrolyte interphase Molecular crowding effect

Epileptic brain network mechanisms and neuroimaging techniques for the brain network

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Neural Regeneration Research 2024年第12期19卷 2637-2648页

作者： Yi Guo Zhonghua lin Zhen Fan Xin tian Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Sichuan Provincial Center for Mental Health Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Geriatrics Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurology Chongqing Key Laboratory of NeurologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Epilepsy can be defined as a dysfunction of the brain network,and each type of epilepsy involves different brain-network changes that are implicated diffe rently in the control and propagation of interictal or ictal *** more detailed information on brain network alterations can help us to further understand the mechanisms of epilepsy and pave the way for brain network-based precise therapeutic approaches in clinical *** increasing number of advanced neuroimaging techniques and electrophysiological techniques such as diffusion tensor imaging-based fiber tra ctography,diffusion kurtosis imaging-based fiber tractography,fiber ball imagingbased tra ctography,electroencephalography,functional magnetic resonance imaging,magnetoencephalography,positron emission tomography,molecular imaging,and functional ultrasound imaging have been extensively used to delineate epileptic *** this review,we summarize the relevant neuroimaging and neuroelectrophysiological techniques for assessing structural and functional brain networks in patients with epilepsy,and extensively analyze the imaging mechanisms,advantages,limitations,and clinical application ranges of each technique.A greater focus on emerging advanced technologies,new data analysis software,a combination of multiple techniques,and the construction of personalized virtual epilepsy models can provide a theoretical basis to better understand the brain network mechanisms of epilepsy and make surgical decisions.

关键词： electrophysiological techniques epilepsy functional brain network functional magnetic resonance imaging functional near-infrared spectroscopy machine leaning molecular imaging neuroimaging techniques structural brain network virtual epileptic models

In situ autophagy regulation in synergy with phototherapy for breast cancer treatment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2317-2332页

作者： Huijuan Zhang Xiangyang Xuan Yaping Wang Zijun Qi Kexuan Cao Yingmei tian Chaoqun Wang Junbiao chang Zhenzhong Zhang lin Hou School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450001China Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou 450001China School of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China

Autophagy is an important factor in reducing the efficacy of tumor phototherapy(including PTT and PDT).Accurate regulation of autophagy in tumor cells is a new strategy to improve the anti-tumor efficiency of PTT/*** project intended to construct a tumor-activated autophagy regulator to efficiently block PTT/PDT-induced autophagy and realize synergistic sensitization to tumor *** achieve this goal,we first synthesized TRANSFERRIN(Tf)biomimetic mineralized nano-tellurium(Tf-Te)as photosensitizer and then used disulfide bond reconstruction technology to induce Tf-Te *** autophagy inhibitor hydroxychloroquine(HCQ)and iron ions carried by Tf were simultaneously loaded to prepare a tumor-responsive drug reservoir Tf-Te/*** entering breast cancer cells through the“self-guidance system”,Tf-Te/HCQ can generate hyperpyrexia and ROS under NIR laser irradiation,to efficiently induce PTT/PDT ***,the disulfide bond broke down in response to GSH,and the nanoparticles disintegrated to release Fe2+and HCQ at fixed *** simultaneously induce lysosomal alkalinization and increased osmotic pressure,effectively inhibit autophagy,and synergistically enhance the therapeutic effect of *** vivo anti-tumor results have proved that the tumor inhibition rate of Tf-Te/HCQ can be as high as 88.6%on 4T1 tumor-bearing *** multifunctional drug delivery system might provide a new alternative for more precise and effective tumor phototherapy.

关键词： Autophagy Tumor phototherapy Synergistic sensitization HCQ TRANSFERRIN Disulfide bond reconstruction GSH Biomimetic mineralized nano-tellurium