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老年高血压患者血清视黄醇结合蛋白水平与颈动脉病变的相关性分析

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中国社区医师 2022年第6期38卷 55-57页

作者：蒋琳莫江英陈频广西桂林市第二人民医院全科医疗科广西桂林541001 广西桂林市第二人民医院心血管内科广西桂林541001

目的:研究老年高血压患者血清视黄醇结合蛋白水平与颈动脉病变的相关性。方法:选取2016年1月-2020年12月广西桂林市第二人民医院全科医疗科及心血管内科老年高血压住院患者200例,年龄61~78岁,以颈动脉内膜中层厚度(IMT)为切点分为IMT正... 详细信息

目的:研究老年高血压患者血清视黄醇结合蛋白水平与颈动脉病变的相关性。方法:选取2016年1月-2020年12月广西桂林市第二人民医院全科医疗科及心血管内科老年高血压住院患者200例,年龄61~78岁,以颈动脉内膜中层厚度(IMT)为切点分为IMT正常组、IMT增厚组和IMT斑块组。分析血清视黄醇结合蛋白水平与颈动脉病变的关系。结果:IMT增厚组血清视黄醇结合蛋白水平高于IMT正常组,差异有统计学意义(P<0.05);IMT斑块组血清视黄醇结合蛋白高于IMT正常组及IMT增厚组,差异有统计学意义(P<0.05)。相关性分析表明,血清视黄醇结合蛋白和IMT为正相关。LogistiC回归分析结果显示,血清视黄醇蛋白水平是发生颈动脉硬化疾病的独立危险因素。结论:老年高血压患者血清视黄醇结合蛋白水平增高与颈动脉病变呈正相关。

关键词：老年高血压血清视黄醇结合蛋白颈动脉病变

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重要生态系统水土保持功能监测评价工作思考

中国水利 2023年第10期 28-30页

作者：莫沫水利部水土保持监测中心北京100055

我国水土流失主要发生在林地、草地和耕地上,科学准确评价森林、草原和农田生态系统水土保持功能,对于统筹推进山水林田湖草沙综合治理、系统治理、源头治理尤为重要。在系统阐述生态系统水土保持功能内涵的基础上,提出了森林、草原和... 详细信息

我国水土流失主要发生在林地、草地和耕地上,科学准确评价森林、草原和农田生态系统水土保持功能,对于统筹推进山水林田湖草沙综合治理、系统治理、源头治理尤为重要。在系统阐述生态系统水土保持功能内涵的基础上,提出了森林、草原和农田生态系统水土保持功能监测评价指标体系,明确了重点工作方向和需要解决的主要问题,为新阶段国家生态文明建设宏观决策提供科学依据。

关键词：生态系统水土保持功能监测评价

Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

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Signal Transduction and Targeted Therapy 2019年第1期4卷 63-101页

作者： Yuan Cheng Cai He Manni Wang Xuelei Ma Fei mo Shengyong Yang Junhong Han Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduChina

Epigenetic alternations concern heritable yet reversible changes in histone or DNA modifications that regulate gene activity beyond the underlying *** dysregulation is often linked to human disease,notably *** the development of various drugs targeting epigenetic regulators,epigenetic-targeted therapy has been applied in the treatment of hematological malignancies and has exhibited viable therapeutic potential for solid tumors in preclinical and clinical *** this review,we summarize the aberrant functions of enzymes in DNA methylation,histone acetylation and histone methylation during tumor progression and highlight the development of inhibitors of or drugs targeted at epigenetic enzymes.

关键词： epigenetic clinical drugs

OsNAC2d基因编辑水稻突变体的创建及其对干旱胁迫的响应

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作物学报 2023年第2期49卷 365-376页

作者：李兆伟莫祖意孙聪颖师宇尚平林伟伟范凯林文雄福建农林大学生命科学学院福建福州350002 福建农林大学/福建省农业生态过程与安全监控重点实验室福建福州350002 福建农林大学农学院福建福州350002

为探究转录因子OsNAC2d的生物学功能及其对水稻耐旱性的影响,本研究利用CRISPR/Cas9编辑技术对粳稻中花11中的OsNAC2d基因进行突变,并考察osnac2d突变体在田间种植下的农艺性状,以及突变体幼苗在干旱胁迫下的生长情况和OsNAC2d基因表达... 详细信息

为探究转录因子OsNAC2d的生物学功能及其对水稻耐旱性的影响,本研究利用CRISPR/Cas9编辑技术对粳稻中花11中的OsNAC2d基因进行突变,并考察osnac2d突变体在田间种植下的农艺性状,以及突变体幼苗在干旱胁迫下的生长情况和OsNAC2d基因表达水平。结果表明,OsNAC2d基因主要在水稻成熟籽粒、叶片和花药中表达,在根系和茎中的表达量较低,并且受干旱胁迫诱导,在10株阳性OsNAC2d基因突变株系的T2代植株中,筛选出6种纯合osnac2d突变体,田间试验调查表明,osnac2d突变体与野生型中花11相比,株高、有效穗、穗长、穗粒数、结实率、千粒重和单株产量等农艺性状无显著差异。在干旱胁迫时,osnac2d突变体幼苗的根系与植株生长、根系和地上部生物量的积累均受到抑制,且OsNAC2d在osnac2d突变体中的表达量维持在较低水平,而野生型水稻的OsNAC2d表达则受干旱胁迫诱导而增强,植株生长与生物量积累未受到显著抑制,表明转录因子OsNAC2d正调控水稻响应干旱胁迫。创建的osnac2d突变体材料为进一步揭示OsNAC2d的生物学功能及其响应干旱胁迫的精细调控机制提供了优质种质资源。

关键词：水稻干旱胁迫基因编辑 OsNAC2d基因

Variation and heritability of morphological and physiological traits among Leymus chinensis genotypes under different environmental conditions

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Journal of Arid Land 2019年第1期11卷 66-74页

作者： YANG Xue LI Junpeng ZHAO Tingting mo Lidong ZHANG Jianli REN Huiqin ZHAO Nianxi GAO Yubao Department of Plant Biology and Ecology College of Life Science Nankai University

Intraspecific trait variation and heritability in different environmental conditions not only suggest a potential for an evolutionary response but also have important ecological consequences at the population, community, and ecosystem levels. However, the contribution of quantitative trait variation within a grassland species to evolutionary responses or ecological consequences is seldom documented. Leymus chinensis is an important dominant species in semi-arid grasslands of China, which has seriously suffered from drought and high temperature stresses in recent decades. In the present study, we measured variation and heritability of 10 quantitative traits, namely the number of tillers, maximum shoot height, number of rhizomes, maximum rhizome length, rhizome mass, aboveground mass, root mass, maximum net photosynthetic rate(Pmax), specific leaf area(SLA), and leaf length to leaf width ratio(LL/LW), for 10 genotypes of L. chinensis under one non-stress(Ck) condition and three environmental stress conditions(i.e., drought(Dr), high temperature(Ht), and both drought and high temperature(DrHt)). Result indicated that(1) the interaction of genotype and environmental condition(G×E) was significant for 6 traits but not significant for the other 4 traits as shown by two-way analysis of variance(ANOVA), suggesting that different selection forces were placed for different traits on the factors dominating phenotypic responses to different environmental conditions. moreover, these significant G×E effects on traits indicated significantly different phenotypic adaptive responses among L. chinensis genotypes to different environmental conditions. Additionally, individuals could be grouped according to environmental condition rather than genotype as shown by canonical discriminant analysis, indicating that environmental condition played a more important role in affecting phenotypic variation than genotype;(2) by one-way ANOVA, significant differences among L. chinensis genotypes w

关键词： Leymus chinensis genotype quantitative trait variation heritability drought high temperature

Meridional movement of northern and southern equatorial ionization anomaly crests in the East-Asian sector during 2002-2003SSW

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Science China Earth Sciences 2017年第4期60卷 776-785页

作者： mo XiaoHua ZHANG DongHe Larisa GONCHARENKO ZHANG ShunRong HAO YongQiang XIAO Zuo PEI JiaZheng Akimasa YOSHIKAWA CHAU HaDuyen College of Science Guangxi University for Nationalities Department of Geophysics Peking University Haystack Observatory Massachusetts Institute of Technology School of Automation Wuhan University of Technology Earth and Planetary Sciences International Center for Space WeatherKyushu University Hanoi Institute of Geophysics Vietnamese Academy of Science and Technology

The present paper investigates the asymmetrical variability of the location of the north and the south equatorial ionization anomaly(EIA) crests in the East-Asian sector,along with their association with simultaneous observations of equatorial electrojet(EEJ) strength,geomagnetic activity index,and solar flux index during the 2002-2003 sudden stratospheric wanning(SSW) *** of these observations indicates the existence of a large-scale quasi 16-day periodic meridional movement in both EIA crests,and also reveals a strong correlation between the quasi 16-day oscillation in geomagnetic latitudes of the EIA crest and EEJ *** latitude of the northern/southern EIA crest and the EEJ strength indicate that obvious synchronous periodic oscillations were in-phase in the northern and southern hemisphere when the SSW *** addition,it is also found that both the EIA crest location and amplitude of the periodic movement of the EIA locations exhibit hemispheric *** amplitude of the periodic movement of the EIA location in the southern hemisphere is larger than that of the northern hemisphere,and the southern EIA crest is further off from the equator than the north *** these asymmetries requires a combination of mechanisms that involve at least trans-equator meridional winds and the position of a sub-solar point;however,potential disturbances in neutral winds associated with the SSW may additionally complicate the equatorial ionospheric dynamics.

关键词：赤道异常周期运动波峰东亚板块不对称性周期振荡环境影响评估

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大型-超大型矿床成矿地球动力学背景

地学前缘 2020年第2期27卷 13-19页

作者：莫宣学中国地质大学(北京) 北京100083

大型-超大型矿床是地球成矿元素超常富集的产物,发现新的大型-超大型矿床是满足国家对矿产需求的关键。实践证明,将成矿地球动力学背景和成矿过程研究与定量勘查评价"三位一体"有机结合,是卓有成效的。大型-超大型矿床的成矿地球动力学... 详细信息

大型-超大型矿床是地球成矿元素超常富集的产物,发现新的大型-超大型矿床是满足国家对矿产需求的关键。实践证明,将成矿地球动力学背景和成矿过程研究与定量勘查评价"三位一体"有机结合,是卓有成效的。大型-超大型矿床的成矿地球动力学条件从宏观层次影响和控制着成矿,主要包括大地构造环境、壳幔结构与深部过程、成矿的岩石系统、区域热-流体条件等4个基本方面。要从根本上探明我国矿产的分布格局与资源潜力,从深层次上揭示区域成矿规律和金属巨量堆积过程,开辟新的找矿空间和深度,预测找矿战略新区,尤其要深入揭示地球深部物质、结构和各圈层间物质-能量交换的地球动力学过程。

关键词：大型-超大型矿床地球动力学成矿过程壳慢深部过程战略性关键金属矿产

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岩浆作用与地球深部过程

地球科学 2019年第5期44卷 1487-1493页

作者：莫宣学中国地质大学北京100083

为纪念马杏垣院士诞辰一百周年而作.首先简述了地球系统科学的基本思想和指导意义.指出岩浆作用实质上是地球各层圈之间相互作用的结果,岩浆是地球各层圈之间物质和能量交换的重要载体.通过众多研究实例,重点讨论了岩浆作用的地球动力... 详细信息

为纪念马杏垣院士诞辰一百周年而作.首先简述了地球系统科学的基本思想和指导意义.指出岩浆作用实质上是地球各层圈之间相互作用的结果,岩浆是地球各层圈之间物质和能量交换的重要载体.通过众多研究实例,重点讨论了岩浆作用的地球动力学意义:一方面,火成岩及其所携带的深源岩石包体可以当作地球深部的"探针"和"窗口";另一方面,火成岩也是大地构造事件的记录,可以用以恢复古板块构造格局,追溯大地构造演化历史.

关键词：地球系统科学岩浆岩与岩浆作用岩石探针大地构造事件记录构造地质

X-ray Photoemission Spectroscopy Studies of the Semiconducting molybdenum Purple Bronze Bi_(0.2)moO_3

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Journal of Materials Science & Technology 2006年第4期22卷 487-490页

作者： Rui XIONG chang LUO Wufeng TANG Jing SHI Department of Physics Wuhan University Wuhan 430072 China International Center for Materials Physics Chinese Academy of Sciences Shenyang 110016 China

The electronic structure of the quasi-two-dimensional （2D） semiconducting molybdenum purple bronze Bio.2moO3 was presented by X-ray photoemission spectroscopy. The valence band of Bio.2moO3 is made up of Opπ nonbonding level, π and a bonding bands. The peak at 1.5 eV and the shoulder at 0.5 eV in the forbidden band may be formed from the non-bonding dxy orbitals of some mo atoms. The O1s core-level spectrum demonstrates the presence of two inequivalent bonds of oxygen ions in Bio.2moO3. Bi4f core-level spectrum shows two bonding characters of Bi atoms in bismuth molybdenum single crystal. mo3d core-level spectrum confirms two kinds of valence states of molybdenum （mo^＋5 and mo^＋6）. Ar^＋ ion irradiation induces more significant distortion of moO6 octahedra.

关键词： Bi0.2moO3 single crystal X-ray photoemission spectroscopy Core-electron spectrum