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Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

BIOCELL 2024年第6期48卷 923-934页

作者： BINGJIE LI WENBO CAO JINJING XIAO YIXIAO CHEN QIYING WEI MINGJIN YUE SAIJUN mo Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouChina Collaborative Innovation Center of Henan Province for Cancer Chemoprevention ZhengzhouChina State Key Laboratory of Esophageal Cancer Prevention and Treatment ZhengzhouChina Department of Research and Development Henan Tianxing Education and Media Company LimitedZhengzhouChina

Perineural invasion(PNI),a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread,has the capacity to extend well beyond the primary tumor site,inﬁltrating distant regions devoid of lymphatic or vascular *** often heralds a decrease in patient survival rates and is recognized as an indicator of an unfavorable prognosis across a variety of *** its clinical signiﬁcance,the underlying molecular mechanisms of PNI remain elusive,complicating the development of speciﬁc and efﬁcacious diagnostic and therapeutic *** the realm of cancer research,non-coding RNAs(ncRNAs)have attracted considerable attention due to their multifaceted roles and cancer-speciﬁc expression proﬁles,positioning them as promising candidates for applications in cancer diagnostics,prognostics,and *** the various types of ncRNAs,microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs)have emerged as inﬂuential players in *** involvement is increasingly recognized as a contributing factor to tumor progression and therapeutic *** study synthesizes and explores the diverse functions and mechanisms of ncRNAs in relation to PNI in *** comprehensive review aims to shed light on cutting-edge perspectives that could pave the way for innovative diagnostic and therapeutic approaches to address the challenges posed by PNI in oncology.

关键词： Perineural invasion Non-coding RNA Diagnose and treatment Cancer Biomarker

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低周反复荷载下T型双波纹钢板混凝土组合剪力墙受力性能试验研究

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工程力学 2024年第6期41卷 87-104页

作者：陈宗平莫琳琳许新颖唐际宇广西大学土木建筑工程学院广西南宁530004 南宁学院土木与建筑工程学院广西南宁530200 广西大学工程防灾与结构安全教育部重点实验室广西南宁530004

为研究低周反复荷载下T型双波纹钢板混凝土组合剪力墙的受力性能,对5个T型双波纹钢板混凝土组合剪力墙进行了低周反复加载试验。基于试验数据,分析了T型组合剪力墙的破坏模式、滞回曲线、变形能力及耗能能力,重点研究了边缘约束条件、... 详细信息

为研究低周反复荷载下T型双波纹钢板混凝土组合剪力墙的受力性能,对5个T型双波纹钢板混凝土组合剪力墙进行了低周反复加载试验。基于试验数据,分析了T型组合剪力墙的破坏模式、滞回曲线、变形能力及耗能能力,重点研究了边缘约束条件、波纹类型以及轴压比不同变化参数对T型组合剪力墙抗震性能指标的影响规律。研究结果表明:T型双波纹钢板混凝土组合剪力墙破坏模式主要有压屈破坏和压弯破坏两种;设置边缘约束构件是提高T型双波纹钢板混凝土组合剪力墙承载能力和变形能力的关键因素;纵向窄波纹钢板对内部混凝土的约束能力更强,在低周反复荷载下两者协同工作性更优,而横向窄波纹钢板试件强度退化最严重;采用全截面塑性设计方法进行T型双波纹钢板混凝土组合剪力墙正截面承载力计算,试验值与计算值吻合良好;T型双波纹钢板混凝土组合剪力墙具有较好的承载能力和变形能力,可适用于高层及超高层建筑结构中。

关键词： T型组合剪力墙双波纹钢板低周反复荷载钢板类型承载力计算

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Research progress in spasmodic torticollis rehabilitation treatment

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World Journal of Clinical Cases 2024年第7期12卷 1205-1214页

作者： Shuang Zhang Ni Zeng Shuang Wu Hui-Hui Wu mo-Wei Kong Department of Rehabilitation The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550018Guizhou ProvinceChina Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

Spasmodic torticollis(ST)is a focal dystonia that affects adults,causing limited muscle control and impacting daily activities and quality of *** etiology and curative methods for ST remain *** toxin is widely used as a firstline treatment,but long-term usage can result in reduced tolerance and adverse *** therapy,with its minimal side effects and low potential for harm,holds significant clinical *** article explores the effectiveness of adjunctive therapies,including exercise therapy,transcranial magnetic stimulation,shockwave therapy,neuromuscular electrical stimulation,vibration therapy,electromyographic biofeedback,and acupuncture,in the treatment of *** aim is to provide clinicians with additional treatment options and to discuss the efficacy of rehabilitation therapy for ST.

关键词： Spasmodic torticollis Rehabilitation therapy Botulinum toxin Exercise therapy Adjunctive therapy Effectiveness

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Role of glucose metabolism and signaling pathways at different stages of ovarian folliculogenesis

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Reproductive and Developmental Medicine 2024年第2期8卷 111-120页

作者： Dan mo Zhong-Hong Zeng Xin Sui Rong Li Yi-Hua Yang Guangxi Reproductive Medical Center the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases Nanning 530021China Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology/National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital)Beijing 100191China

The female ovaries are critical for follicle growth and development in the process known as"folliculogenesis".This complex process is regulated by various factors,among which the microenvironment around follicles appears to be *** to previous studies,folliculogenesis is an energy-demanding *** fact,well-balanced follicular energy metabolism is associated with ovarian function and female ***,glucose metabolism has been widely described as the main source of energy during ***,the follicular glucose metabolism profiles change dynamically during follicular *** abnormalities during folliculogenesis are associated with aging,primary ovarian insufficiency,and polycystic ovary syndrome,thereby leading to subfertility and infertility in *** signaling pathways in follicles appear to form a link between glucose metabolism and ***,a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental *** review aimed to describe variations in glucose metabolism at different stages of folliculogenesis,provide new insights into glucose metabolic disorder-related diseases,and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis:phosphatidylinositol 3-kinase,protein kinase B(PI3K-PKB/AKT),and AMP-activated protein kinase(AMPK)signaling pathways.

关键词： Folliculogenesis Glucose metabolism Glycolysis Oxidative phosphorylation Signaling pathway

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Covalency competition induced selective bond breakage and surface reconstruction in manganese cobaltite towards enhanced electrochemical charge storage

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Green Energy & Environment 2024年第5期9卷 909-918页

作者： Peng Gao Pei Tang Ying mo Peitao Xiao Wang Zhou Shi Chen Hongliang Dong Ziwei Li Chaohe Xu Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan Province Key Laboratory for Advanced Carbon Materials and Applied TechnologyHunan UniversityChangshaHunan410082China Department of Materials Science and Engineering National University of Defense TechnologyChangshaHunan410073China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeTaipaMacao999078China Center for High Pressure Science and Technology Advanced Research PudongShanghai201203China College of Aerospace Engineering Chongqing UniversityChongqing400044China

Manganese cobaltite(MnCo_(2)_(4))is a promising electrode material because of its attractive redox chemistry and excellent charge storage *** previous work demonstrated that the octahedrally-coordinated Mn are prone to react with the hydroxyl ions in alkaline electrolyte upon electrochemical cycling and separates on the surface of spinel to reconstruct into d-MnO_(2) nanosheets irreversibly,thus results in a change of the reaction mechanism with Kþion ***,the low capacity has greatly limited its practical ***,we found that the tetrahedrally-coordinated Co_(2) þions were leached when MnCo_(2)_(4) was equilibrated in 1 mol L^(-1) HCl solution,leading to the formation of layered CoOOH on MnCo_(2)_(4) surface which is originated from the covalency competition induced selective breakage of the CoT–O bond in CoT–O–CoO and subsequent rearrangement of free Co_(6) *** as-formed CoOOH is stable upon cycling in alkaline electrolyte,exhibits conversion reaction mechanism with facile proton diffusion and is free of massive structural evolution,thus enables utilization of the bulk electrode material and realizes enhanced speciﬁc capacity as well as facilitated charge transfer and ion *** general,our work not only offers a feasible approach to deliberate modiﬁcation of MnCo_(2)_(4)'s surface structure,but also provides an in-depth understanding of its charge storage mechanism,which enables rational design of the spinel oxides with promising charge storage properties.

关键词： Manganese cobaltite Tetrahedrally-coordinated Co^(2+)leaching Selective bond breakage Surface reconstruction Charge storage mechanisms

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Feasibility of low-intensity ultrasound treatment with hydroxylamine to accelerate the initiation of partial nitrification and allow operation under intermittent aeration

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Journal of Environmental Sciences 2024年第5期139卷 446-459页

作者： Jianxiong Jian Xiaojian Liao Zhihua mo Shoupeng Li Lei Li Shaojin Chen Zhenhua Huang Junhao Chen Wencan Dai Shuiyu Sun Guangzhou Key Laboratory Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk ControlSchool of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Guangdong Province Solid Waste Recycling and Heavy Metal Pollution Control Engineering Technology Research Center Guangdong Polytechnic of Environmental Protection EngineeringFoshan 528216China Analysis and Test Center Guangdong University of TechnologyGuangzhou 510006China

Partial nitrification is a key aspect of efficient nitrogen removal,although practically it suf-fers from long start-up cycles and unstable long-term operational *** address these drawbacks,this study investigated the effect of low intensity ultrasound treatment combined with hydroxylamine(NH2OH)on the performance of partial *** showthat compared with the control group,low-intensity ultrasound treatment(0.10W/mL,15 min)combined with NH2OH(5 mg/L)reduced the time required for partial nitrification initiation by 6 days,increasing the nitrite accumulation rate(NAR)and ammonia nitro-gen removal rate(NRR)by 20.4% and 6.7%,respectively,achieving 96.48% ***-tic analysis showed that NH2OH enhanced ammonia oxidation,inhibited nitrite-oxidizing bacteria(NOB)activity and shortened the time required for partial nitrification ***,ultrasonication combined with NH2OH dosing stimulated EPS(extracellular polymeric substances)secretion,increased carbonyl,hydroxyl and amine functional group abundances and enhanced mass *** addition,16S rRNA gene sequencing results showed that ultrasonication-sensitive Nitrospira disappeared from the ultrasound+NH_(2)OH system,while Nitrosomonas gradually became the dominant ***,the results of this study provide valuable insight into the enhancement of partial nitrification start-up during the process of wastewater nitrogen removal.

关键词： Partial nitrification Low-intensity ultrasound Hydroxylamine Ammonia oxidizing bacteria Nitrite oxidizing bacteria

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Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2716-2726页

作者： Cai-Jing mo Xiao-Yuan Deng Ru-Lan Ma Kun Zhu Lei Shi Kang Li Department of Surgical Oncology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND The role of Sm-like 5(LSM5)in colon cancer has not been *** this study,we investigated the role of LSM5 in progression of colon cancer and the potential underlying mechanism *** To determine the role of LSM5 in the progression of colon cancer and the potential underlying mechanism *** The Gene Expression Profiling Interactive Analysis database and the Human Protein Atlas website were used for LSM5 expression analysis and prognosis ***-time quantitative polymerase chain reaction and Western blotting were utilized to detect the expression of mRNAs and proteins.A lentivirus targeting LSM5 was constructed and transfected into colon cancer cells to silence LSM5 *** and apoptosis assays were also conducted to evaluate the growth of the colon cancer *** GeneChip assay and bioinformatics analysis were performed to identify the potential underlying mechanism of LSM5 in colon *** LSM5 was highly expressed in tumor tissue and colon cancer cells.A high expression level of LSM5 was related to poor prognosis in patients with colon *** of LSM5 suppressed proliferation and promoted apoptosis in colon cancer *** of LSM5 also facilitates the expression of p53,cyclin-dependent kinase inhibitor 1A(CDKN1A)and tumor necrosis factor receptor superfamily 10B(TNFRSF10B).The inhibitory effect of LSM5 knockdown on the growth of colon cancer cells was associated with the upregulation of p53,CDKN1A and *** LSM5 knockdown inhibited the proliferation and facilitated the apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B.

关键词： Sm-like 5 Colon cancer Proliferation Apoptosis Knockdown

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3D打印速度对铸造蜡成型翘曲变形的影响

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华南理工大学学报（自然科学版） 2024年第6期52卷 81-88页

作者：莫海军梁道明林晨彬刘翔华南理工大学机械与汽车工程学院广东广州510640

通过快速模具制造可打印熔模铸造用的蜡模,缩短生产周期,提高生产效率。但在实际成型过程中,由于制件不同位置的温度分布不均,会造成内应力差异,导致制件翘曲变形,进而对制件的成型质量产生较大的影响;而且,受3D打印速度和沉积层数等成... 详细信息

通过快速模具制造可打印熔模铸造用的蜡模,缩短生产周期,提高生产效率。但在实际成型过程中,由于制件不同位置的温度分布不均,会造成内应力差异,导致制件翘曲变形,进而对制件的成型质量产生较大的影响;而且,受3D打印速度和沉积层数等成型参数的制约,较难在降低制件翘曲变形程度的同时提高成型效率。有鉴于此,文中通过建立成型制件翘曲变形的数学模型,并结合实验设计与数学计算等方法,探究打印速度对铸造蜡直写成型翘曲变形程度与打印效率的影响机制。实验结果显示:在一定打印速度下,试样翘曲值随沉积层数的增加而减小,且随着打印速度的不断增加翘曲值逐渐变大;成型打印速度越高,不同试样的打印耗时越接近于某一稳定值,表明打印速度对成型效率的影响随打印速度的增加而降低。文中还通过对成型翘曲变形和打印效率分别赋予权重系数,建立了表面轮廓最佳打印速度连续函数模型,并验证了模型的有效性。研究结果表明,基于铸造蜡成型翘曲变形建立的最佳打印速度连续函数模型可在降低翘曲变形的同时提高打印效率。

关键词：熔模铸造翘曲变形 3D打印速度权重系数函数模型

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Distributed Region Tracking and Perimeter Surveillance for Second-Order Multi-Agent Systems in Star-Shaped Sets

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Journal of Systems Science & Complexity 2024年第5期37卷 1995-2020页

作者： SHANG Juan mo Lipo MI Rongxin CAO Xianbing School of Mathematics and Statistics Beijing Technology and Business University The Department of Foundation Shijiazhuang Institute of Railway Technology School of Computer and Artificial Intelligence Beijing Technology and Business University Research Centre for Agri-Product Quality Traceability Beijing Technology and Business University Coordination Center of China National Computer Network Emergency Response Technical Team

This paper investigates region tracking and perimeter surveillance of second-order multi-agent systems, where all agents move within a star-shaped set. First, by coordination transformations,the region tracking problem is converted from the star-shaped sets to a circular region. The authors employ communication and collaboration to complete region tracking and perimeter surveillance tasks,and then revert back to the star-shaped set by using inverse transformations. Second, the authors propose a distributed control strategy based on attractive and interaction potential functions, under which all agents can quickly track a given circular region and move around the perimeter. Finally,the authors validate the effectiveness and performance advantages of the proposed method through simulation experiments.

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Protective effects of oleic acid and polyphenols in extra virgin olive oil on cardiovascular diseases

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Food Science and Human Wellness 2024年第2期13卷 529-540页

作者： Yan Lu Jun Zhao Qiqi Xin Rong Yuan Yu Miao Manli Yang Hui mo Keji Chen Weihong Cong Laboratory of Cardiovascular Diseases Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China National Clinical Research Center for Chinese Medicine Cardiology Beijing 100091China Traditional Chinese Medicine Department The Aff iliated Hospital of Qingdao UniversityQingdao 266000China Nanjing University of Chinese Medicine Nanjing 210023China Health Bureau of the Government of the Macao Special Administrative Region Macao 999078China

The Mediterranean diet has long been recognized as one of the most effective ways to prevent and improve cardiovascular *** virgin olive oil(EVOO)is the typical sources of fat in the Mediterranean diet which have been shown to have noteworthy nutritional value and positive impact on human *** is worth noting that EVOO owes its superior nutritional value to its bioactive *** main component of EVOO is monounsaturated fatty acids(MUFAs)in the form of oleic *** acid accounts for up to 70%-80%of ***,EVOO contains approximately more than 30 phenolic compounds,of which HT is essential for the protection against cardiovascular *** this review,we focused on the potential mechanisms of oleic acid and polyphenols combat cardiovascular diseases risk in terms of oxidative stress,inflammation,blood pressure,endothelial function and *** review might provide a reference for the studies on cardiovascular protective effects of EVOO.

关键词： Cardiovascular diseases Extra virgin olive oil Oleic acid Polyphenols

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