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Protective Effects of Danmu Extract Syrup on Acute Lung Injury Induced by Lipopolysaccharide in Mice through Endothelial Barrier Repair

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Chinese Journal of Integrative Medicine 2024年第3期30卷 243-250页

作者： XU Han XU Si-cong LI Li-yan WU Yu-huang TAN Yin-feng CheN Long LIU Pei LIANG chang-fu he Xiao-ning LI Yong-hui hainan Provincial Key Lab of Research&Development on Tropic herbs Hainan Medical UniversityHaikou571199China Department of Stomatology the Second Affiliated Hospital of Hainan Medical UniversityHaikou571199China

Objective:To investigate the effects of Danmu Extract Syrup(DMS) on lipopolysaccharide(LPS)-induced acute lung injury(ALI) in mice and explore the ***:Seventy-two male Balb/C mice were randomly divided into 6 groups according to a random number table(n=12),including control(normal saline),LPS(5 mg/kg),LPS+DMS 2.5 mL/kg,LPS+DMS 5 mL/kg,LPS+DMS 10 mL/kg,and LPS+Dexamethasone(DXM,5 mg/kg) *** pretreatment with DMS and DXM,the ALI mice model was induced by LPS,and the bronchoalveolar lavage fluid(BALF) were collected to determine protein concentration,cell counts and inflammatory *** lung tissues of mice were stained with hematoxylin-eosin,and the wet/dry weight ratio(W/D) of lung tissue was *** levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-1βin BALF of mice were detected by enzyme linked immunosorbent *** expression levels of Claudin-5,vascular endothelial(VE)-cadherin,vascular endothelial growth factor(VEGF),phospho-protein kinase B(p-Akt) and Akt were detected by Western blot ***:DMS pre-treatment significantly ameliorated lung histopathological *** with the LPS group,the W/D ratio and protein contents in BALF were obviously reduced after DMS pretreatment(Phe number of cells in BALF and myeloperoxidase(MPO) activity decreased significantly after DMS pretreatment(Phe levels of TNF-α,IL-6 and IL-1β(Phe phosphoinositide 3-kinase/protein kinase B(PI3K/Akt) pathway and reversed the expressions of Claudin-5,VE-cadherin and VEGF(Phelial *** might be a potential therapeutic drug for LPS-induced lung injury.

关键词： Danmu Extract Syrup acute lung injury inflammatory factors vascular endothelial growth factor phosphoinositide 3-kinase/protein kinase B Chinese medicine Nauclea officinalis

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Greedy Lattice Paths with General Weights

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2213-2222页

作者： Yin Shan chang An Qi ZheNG College of Mathematics Sichuan UniversityChengdu 610065P.R.China

Let{X_(v):v∈Z^(d)}be *** *** S(π)=Σ_(v∈π)X_(v)be the weight of a self-avoiding lattice pathπ.Let M_(n)=max{S(π):πhas length n and starts from the origin}.We are interested in the asymptotics of Mn as n→∞.This model is closely related to the first passage percolation when the weights{X_(v):v∈Z^(d)}are non-positive and it is closely related to the last passage percolation when the weights{X_(v):v∈Z^(d)}are *** general weights,this model could be viewed as an interpolation between first passage models and last passage ***,this model is also closely related to a variant of the position of right-most particles of branching random *** the two assumptions that∃α>0,E(X_(0)^(+))^(d)(log^(+)X_(0)^(+))^(d+α)here exists a finite real number M such that Mn/n converges to a deterministic constant M in L^(1)as n tends to *** under the stronger assumptions that∃α>0,E(X_(0)^(+))^(d)(log^(+)X_(0)^(+))^(d+α)he same constant M almost surely as n tends to infinity.

关键词： Last passage percolation first passage percolation greedy lattice path

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Event-triggered H_(∞) consensus control for input-constrained multi-agent systems via reinforcement learning

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Control Theory and Technology 2024年第1期22卷 25-38页

作者： Jinxuan Zhang chang-E Ren College of Information Engineering Capital Normal UniversityBeijing100089China

This article presents an event-triggered H_(∞) consensus control scheme using reinforcement learning (RL) for nonlinear second-order multi-agent systems (MASs) with control constraints. First, considering control constraints, the constrained H_(∞) consensus problem is transformed into a multi-player zero-sum game with non-quadratic performance functions. Then, an event-triggered control method is presented to conserve communication resources and a new triggering condition is developed for each agent to make the triggering threshold independent of the disturbance attenuation level. To derive the optimal controller that can minimize the cost function in the case of worst disturbance, a constrained Hamilton–Jacobi–Bellman (HJB) equation is defined. Since it is difficult to solve analytically due to its strongly non-linearity, reinforcement learning (RL) is implemented to obtain the optimal controller. In specific, the optimal performance function and the worst-case disturbance are approximated by a time-triggered critic network;meanwhile, the optimal controller is approximated by event-triggered actor network. After that, Lyapunov analysis is utilized to prove the uniformly ultimately bounded (UUB) stability of the system and that the network weight errors are UUB. Finally, a simulation example is utilized to demonstrate the effectiveness of the control strategy provided.

关键词： H_(∞)optimal control Input constrains Multi-agent systems(MASs) Reinforcement learning(RL)

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Algorithm of automatic identification of diabetic retinopathy foci based on ultra-widefield scanning laser ophthalmoscopy

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 610-615页

作者： Jie Wang Su-Zhen Wang Xiao-Lin Qin Meng Chen heng-Ming Zhang Xin Liu Meng-Jun Xiang Jian-Bin Hu hai-Yu Huang chang-Jun Lan Aier Eye Hospital(East of Chengdu) Chengdu 610051Sichuan ProvinceChina Department of Ophthalmology Chengdu First People’s HospitalChengdu 610095Sichuan ProvinceChina School of Computer and Artificial Intelligence Southwest Jiaotong UniversityChengdu 610097Sichuan ProvinceChina Chengdu Aier Eye Hospital Chengdu 610041Sichuan ProvinceChina

AIM:To propose an algorithm for automatic detection of diabetic retinopathy(DR)lesions based on ultra-widefield scanning laser ophthalmoscopy(SLO).METHODS:The algorithm utilized the FasterRCNN(Faster Regions with CNN features)+ResNet50(Residua Network 50)+FPN(Feature Pyramid Networks)method for detecting hemorrhagic spots,cotton wool spots,exudates,and microaneurysms in DR ultra-widefield *** segmentation combined with a deeper residual network FasterRCNN+ResNet50 was employed for feature extraction to enhance intelligent learning *** fusion was carried out by the feature pyramid network FPN,which significantly improved lesion detection rates in SLO fundus ***:By analyzing 1076 ultra-widefield SLO images provided by our hospital,with a resolution of 2600×2048 dpi,the accuracy rates for hemorrhagic spots,cotton wool spots,exudates,and microaneurysms were found to be 87.23%,83.57%,86.75%,and 54.94%,***:The proposed algorithm demonstrates intelligent detection of DR lesions in ultra-widefield SLO,providing significant advantages over traditional fundus color imaging intelligent diagnosis algorithms.

关键词： diabetic retinopathy ultra-widefield scanning laser ophthalmoscopy intelligent diagnosis system

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Numerical analysis of a projecting wall type oscillating water column(PW-OWC)wave energy converter in regular waves

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Journal of Hydrodynamics 2024年第3期36卷 479-491页

作者： Lei Tan Ruiyuan chang Tomoki Ikoma Department of Oceanic Architecture and Engineering College of Science and TechnologyNihon UniversityChibaJapan

Oscillating water column(OWC)based wave energy absorption devices are classic which have been widely used for harnessing ocean wave *** paper presents a numerical study on a projecting wall(PW)type OWC wave energy converter in regular *** computational fluid dynamics(CFD)modelling of a stationary floating PW-OWC model in a three-dimensional wave flume is achieved by the software *** analyses are carried out based on CFD simulations and the linear potential flow solutions with modifications to account for turbine-induced *** present numerical solutions are validated against our previous experimental *** is found that both the CFD and modified linear potential flow predictions are in reasonably good agreements with the experimental data in the first order results of OWC and air pressure *** the nonlinear responses are included in the result,the modified linear potential flow solution is found to slightly under-estimate the wave energy conversion performance at long *** the airflows above and below the chamber orifice,the CFD results suggest that they are almost unidirectional,oscillating in not only the base frequency but also subharmonic and ultraharmonic *** evolution of the OWC responses during an entire period and the phase analysis based on CFD simulations are *** phase results provide the crucial evidence to the reasonability of the physics-based modification of the potential flow model in modelling of *** present results and analysis are expected to be beneficial to the understanding on the physical mechanism of OWCs and the design of phase control strategies.

关键词： Computational fluid dynamics(CFD)simulation hydrodynamic analysis oscillating water column(OWC)damping orifice airflow phase difference

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OAAFormer:Robust and Efficient Point Cloud Registration Through Overlapping-Aware Attention in Transformer

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Journal of Computer Science & Technology 2024年第4期39卷 755-770页

作者： Jun-Jie Gao Qiu-Jie Dong Rui-An Wang Shuang-Min Chen Shi-Qing Xin chang-he Tu Wenping Wang School of Computer Science and Technology Shandong UniversityQingdao 266237China School of Information and Technology Qingdao University of Science and TechnologyQingdao 266061China College of Engineering Texas A&M UniversityTexasTX 77843U.S.A.

In the domain of point cloud registration,the coarse-to-fine feature matching paradigm has received significant attention due to its impressive *** paradigm involves a two-step process:first,the extraction of multilevel features,and subsequently,the propagation of correspondences from coarse to fine ***,this approach faces two notable ***,the use of the Dual Softmax operation may promote one-to-one correspondences between superpoints,inadvertently excluding valuable ***,it is crucial to closely examine the overlapping areas between point clouds,as only correspondences within these regions decisively determine the actual *** these issues,we propose OAAFormer to enhance correspondence *** the one hand,we introduce a soft matching mechanism to facilitate the propagation of potentially valuable correspondences from coarse to fine *** the other hand,we integrate an overlapping region detection module to minimize mismatches to the greatest extent ***,we introduce a region-wise attention module with linear complexity during the fine-level matching phase,designed to enhance the discriminative capabilities of the extracted *** on the challenging 3DLoMatch benchmark demonstrate that our approach leads to a substantial increase of about 7%in the inlier ratio,as well as an enhancement of 2%-4%in registration ***,to accelerate the prediction process,we replace the Conventional Random Sample Consensus(RANSAC)algorithm with the selection of a limited yet representative set of high-confidence correspondences,resulting in a 100 times speedup while still maintaining comparable registration performance.

关键词： point cloud registration coarse-to-fine overlapping region feature matching Transformer

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An Experimental Study on Response and Control of a Flapping-Wing Aerial Robot Under Wind Gusts

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Journal of Bionic Engineering 2024年第1期21卷 209-223页

作者： Kazuki Shimura Hikaru Aono chang-kwon Kang Graduate School of Science and Technology Shinshu University3-15-1 TokidaUedaNagano 3868567Japan Department of Mechanical Engineering and Robotics 3-15-1 TokidaUedaNagano 3868567Japan Department of Mechanical and Aerospace Engineering University of Alabama in HuntsvilleTechnology Hall N266HuntsvilleAL35899USA

Bioinspired flapping-wing micro-air-vehicles(FWMAVs)have the potential to be useful aerial tools for gathering information in various *** recent advancements in manufacturing technologies and better understanding of aerodynamic mechanisms behind of the flapping flight,outdoor flights have become a ***,to fully realize the potential of FWMAVs,further improvements are necessary,particularly in terms of stability and robustness under gusty *** this study,the response and control of a tailless two-winged FWMAV under the wind gusts are *** experiments are conducted with a one-degree-of-freedom gimbal to focus on effects of wind gusts on the rotational motion of the ***-derivative and sliding-mode controls are adopted for the attitude *** present that the body angles changed in time and reached approximately 50°at the maximum due to the wing *** sliding-mode controller can more effectively control the rotational angle in the presence of disturbances and both the wing speed and changes in wind speed have an impact on the effectiveness of attitude *** results contribute to the development of of tailless two-winged,single-motor driven FWMAVs in terms of the design of attitude controller and testing apparatus.

关键词： Flapping-wing micro-air vehicles Sliding-mode control Pitch and roll angle-Wind gus

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Cell replacement with stem cell-derived retinal ganglion cells from different protocols

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Neural Regeneration Research 2024年第4期19卷 807-810页

作者： Ziming Luo Kun-Che chang Spencer Center for Vision Research Byers Eye InstituteStanford University School of Medicine Department of Ophthalmology Louis J.Fox Center for Vision RestorationUniversity of Pittsburgh School of Medicine Department of Neurobiology Center of NeuroscienceUniversity of Pittsburgh School of Medicine

Glaucoma,characterized by a degenerative loss of retinal ganglion cells,is the second leading cause of blindness *** is currently no cure for vision loss in glaucoma because retinal ganglion cells do not regenerate and are not replaced after *** stem cell-derived retinal ganglion cell transplant is a potential therapeutic strategy for retinal ganglion cell degenerative *** this review,we first discuss a 2D protocol for retinal ganglion cell differentiation from human stem cell culture,including a rapid protocol that can generate retinal ganglion cells in less than two weeks and focus on their transplantation ***,we discuss using 3D retinal organoids for retinal ganglion cell transplantation,comparing cell suspensions and *** review provides insight into current knowledge on human stem cell-derived retinal ganglion cell differentiation and transplantation,with an impact on the field of regenerative medicine and especially retinal ganglion cell degenerative diseases such as glaucoma and other optic neuropathies.

关键词： cell clumps cell suspension cell transplantation differentiation direct-induced protocol glaucoma optic neuropathy regenerative medicine retinal ganglion cell retinal organoids stem cells

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Confluence of asymmetric catalysis and electrosynthesis in sustainable chemical transformations

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Science China Chemistry 2024年第3期67卷 755-758页

作者： Qinglin Zhang Kang Liang chang Guo hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of ChinaHefei 230026China

Electrosynthesis has gained widespread recognition for its extraordinary ability to precisely control the redox *** outstanding capability enables the direct conversion of non-functionalized substrates into reactive intermediates by utilizing easily accessible starting materials, eliminating the need for preliminary functionalization procedures and allowing for unconventional bond activations.

关键词： Confluence of asymmetric catalysis and electrosynthesis in sustainable chemical transformations

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Does the transformation of energy structure promote green technological innovation?A quasi-natural experiment based on new energy demonstration city construction

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Geoscience Frontiers 2024年第3期15卷 373-388页

作者： Chuanming Liu chang Tang Yiding Liu School of Economics Shandong University of Finance and EconomicsJinan 250014China School of Economics&Management Changsha University of Science and TechnologyChangsha 410076China School of Economic and Management Southeast UniversityNanjing 211189China

New energy development is essential to achieving carbon peaks and neutrality and promoting green technological *** the causal relationship between new energy demonstration city construction and green technological innovation is crucial for the expansion and promotion of new energy demonstration *** this study,we take the construction of new energy demonstration cities as a quasi-natural experiment,study their impact on green technological innovation using difference-indifference(DID),and conduct a robustness test using DID after propensity score matching(PSM-DID).The research results indicate the following:First,energy structure optimization can significantly improve the level of urban green technological innovation(this result was shown to be valid using PSM-DID and other tests involving the effects of placebo and instrumental variables).Second,new energy demonstration city construction mainly improves the level of urban green technological innovation through technology research and development,the improvement of the industrial innovation environment,and the promotion of environmental ***,the impact of energy structure optimization on green technological innovation has regional,financial,and economic development ***,new energy demonstration city policy affects the flow of capital,labor,technology,and other production factors to pilot areas according to new energy demonstration city policy,forming a“siphon effect”.The carbon reduction effect of new energy demonstration city construction is greater than its pollution reduction *** the results of the study,policy recommendations to promote the expansion of new energy demonstration cities are proposed.

关键词： New energy demonstration city Green technological innovation Theoretical mechanism Difference-in-difference

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