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Computational Fluid Dynamics Analysis of Shroud Design on Hemodynamic Performance and Blood Damage in a Centrifugal Blood Pump

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Computer Modeling in Engineering & Sciences 2018年第8期116卷 199-213页

作者： Guangliang Pan Yu chang Mingrui fu School of Life Science and BioEngineering Beijing University of TechnologyBeijing100124China.

Patients with extracorporeal membrane oxygenation still suffer from high rates of complication that linked to the flow field within the blood *** it is essential to optimise the geometry of the *** specification of shroud design is arguably the necessary design parameter in the centrifugal ***,the hemodynamic performances of the different shroud designs have not been studied *** this study,ten different shroud designs were made and divided into two groups as the different covering locations(A:Covering the blade leading edge,B:Covering the blade trailing edge).In every group,six shroud designs with the covering proportions of 0,1/5,2/5,3/5,4/5,1 were *** computational fluid dynamics(CFD)analyses were performed to investigate their effects on hemodynamics and hydraulic performance at the constant flow condition(4000 rpm,5 L/min).The percentage volumes of the scalar shear stress in specific threshold(τ9 Pa:the destruction of von Willebrand factor,τ>50 Pa:Platelet activation,τ>150 Pa:Break of red blood)were used to compare the blood damage of the different shroud ***,the modified index of hemolysis(MIH)were calculated based on a Eulerian approach for different *** simulations predicted an increase in the pump head,hydraulic efficiency,a fraction of fluid volume with scalar shear stress values above a threshold(9 Pa,50 Pa,150 Pa)and MIH with increasing shroud covering proportions from 0 to 1 in the same covering ***,these above results were higher in group B than group *** means that the risks of the hemolysis,thrombosis and bleeding increased as the rise of the covering proportion and they were higher in the pump whose shroud covers the blade trailing edge.

关键词： Computational fluid dynamics(CFD) hemodynamics centrifugal blood pump shroud design blood damage thrombosis hemolysis

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Fractography and morphology of shear bands of a Zr-based bulk metallic glass

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Journal of Iron and Steel Research International 2017年第4期24卷 385-389页

作者： Jun Tan Jun-yan Gao Xue-mei qin Zheng-rong fu Dong Li Min Li Xiu-chang Wang Gang Wang School of Materials Science and Engineering Kunming University of Science and Technology Laboratory for Microstructures Shanghai University

Bulk metallic glasses（BMGs）have attracted considerable attention in the last few decades particularly triggered by their potential applications as novel structural and/or functional materials,owing to their superior strength,large elastic strain limit and relatively low Young′s modulus *** to their crystalline ***,a 3Dreconstruction application to the fractography and the morphology of shear bands was reported for a ductile Zr_（56）Co_（28）Al_（16）（at.%）BMG through a Phenom series desktop scanning electron *** results of the 3Dreconstruction and the following contour analysis indicate a typical shear fracture mode for the investigated *** is inferred that the fractography and the morphology of shear bands might be dependent on their composition,structure states,and loading conditions for BMGs.

关键词： Amorphous alloy Fractography Mechanical property Shear band

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Effects of Dietary Lysine on Growth Performance, Serum Concentrations of Insulin-Like Growth Factor-I (IGF-I) and IGF-I mRNA Expression in Growing Rabbits

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Agricultural Sciences in China 2010年第6期9卷 887-895页

作者： JING Wen-qian LI fu-chang College of Animal Science and Technology Shandong Agricultural University Tai＇an 271018 P.R.China College of Life Science Linyi Normal University Linyi 276005 P.R.China

The effects of dietary lysine on production performance,serum concentrations of metabolites,growth hormone （GH）,insulin-like growth factor-I （IGF-I） and IGF-I mRNA expression in growing rabbits were *** hundred weaned New Zealand rabbits were allocated to individual cages and randomly offered a diet containing 5.5 （L1）,6.5 （L2）,7.5 （L3）,8.5 （L4）,or 9.5 g （L5） lysine per kg *** results showed that the average daily gain （ADG） of the rabbits from L3,L4 or L5 was higher than those from L1 or L2 （P 〈 0.05）.The feed gain ratio （F/G） in the rabbits from L4 or L5 was lower than those from L1 or L2 （P 〈 0.05）.Dietary lysine did not affect serum concentrations of total protein （TP）,glucose,insulin （INS）,and growth hormone （GH）（P 〉 0.05）.The quadratic effects of lysine on the serum urea nitrogen （SUN） concentration was detected （P = 0.035）.Serum IGF-I concentrations had a trend to increase quadratically with the increasing dietary lysine （P = 0.07）.A significant correlation was found between serum IGF-I concentrations （x,ng mL-1） and ADG （y,g kg-1）： y = -0.017x2 ＋ 1.984x ＋ 20.87 （R2 = 0.8982,P = 0.003）.The relative abundance of hepatic and muscular IGF-I mRNA tended to increase with increasing dietary lysine levels （P = 0.053 and 0.082,respectively）.Providing the diets mainly consisted of corn,wheat bran and peanut vine,the most appropriate dietary lysine level for growing meat rabbits from weaning to 70 d old was found to be 8.5 g kg-1,and IGF-I may be an important factor controlling growth of weaned rabbits.

关键词： New Zealand rabbit lysine growth performance IGF-I mRNA expression

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Oblique and Herringbone Buckling Analysis of Steel Strip by Spline FEM

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Journal of Iron and Steel Research International 2011年第9期18卷 21-26页

作者： qin Jian ZHANG qing-dong HUANG Ke-fu College of Engineering Peking University Beijing 100871 China Mechanical Engineering School University of Science and Technology Beijing Beijing 100083 China

The tilted waves in steel strip during rolling and leveling of sheet metal can be classified into two different types of buckling, oblique and herringbone buckling, respectively. Numerical considerations of oblique and herringbone buckling phenomena are dealt with by the spline finite element method （FEM）. It is pointed out that the shear stress due to residual strains caused by the rolling process or applied non-uniform loading is the main reason of oblique and herringbone buckle. According to the analysis of stress distribution in plane, the appropriate initial strain patterns are adopted and the corresponding buckling modes are calculated by the spline FEM. The developed numerical model provides an estimation of buckling critical load and wave configuration.

关键词： steel strip spline FEM initial strain oblique buckling herringbone buckling

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Chemical conversion of human and mouse fibroblasts into motor neurons

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Science China(Life Sciences) 2018年第10期61卷 1151-1167页

作者： Hua qin ANDong Zhao Kui Ma Xiaobing fu Graduate School of Tianjin Medical University Tianjin 300070 China Cell Biology and Tissue Repair Laboratory Key Laboratory of Wound Repair and Regeneration of PLA First Affiliated Hospital of PLA General HospitalBeijing 100048 China College of Life Sciences PLA General Hospital PLA Medical College Beijing 100853 China

Transplantation of motor neurons can provide long-term functional benefits in animal models of neurodegenerative motor neuron diseases such as amyotrophic lateral sclerosis and traumatic spinal cord injury. Although embryonic stem cells can differentiate into motor neurons, alternative sources of motor neurons may be controllable for disease modeling and transplantation. Here, we show that human and mouse fibroblasts can be efficiently and directly converted into motor neurons by a cocktail of five small molecules, without the involvement of the neural progenitor stage. The chemically-induced motor neurons display the distinct neuronal morphology and express motor neuron markers. Interestingly, when the same chemical compounds were soaked in beads and implanted in the hypodermis of the back skins of mice, surrounding cells begin to express motor neuron markers,indicating in vivo motor neuron reprogramming. Taken together, we provide an efficient approach for chemically converting human and mouse fibroblasts into motor neurons suitable for cell replacement therapy and neurodegenerative disease modeling.

关键词： fibroblast motor neuron small molecule transdifferentiation reprogramming conversion regeneration neurodegenerative diseases

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Flood cascading on critical infrastructure with climate change:A spatial analysis of the extreme weather event in Xinxiang,China

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Advances in Climate change Research 2023年第3期14卷 458-468页

作者： Xiao-Ling qin Shi-fu WANG Meng MENGa Department of Urban Planning School of ArchitectureSouth China University of TechnologyGuangzhou510640China State Key Laboratory of Subtropical Building Science Guangzhou510640China

Floods caused by extreme weather events and climate change have increased in occurrence and severity all over the world,resulting in devastation and disruption of *** and policy practitioners have increasingly paid attention to the role of critical infrastructure(CI)in disaster risk reduction,flood resilience and climate change adaptation in terms of its backbone functions in maintaining societal services in hazard *** analysed city in this study,Xinxiang(Henan province,China),was affected by an extreme flood event that occurred on 17–23 July 2021,which caused great socio-economic ***,few studies have focused on medium-sized cities and the flood cascading effects on CI during this ***,this study explores the damages caused by this flooding event with links to CI,such as health services,energy supply stations,shelters and transport facilities(HEST infrastructure).To achieve this,the study first combines RGB(red,green blue)composition and supervised classification for flood detection to monitor and map flood inundation ***,it manages a multiscenario simulation and evaluates the cascading effects on HEST *** open-source data are employed,including Sentinel-1 synthetic aperture radar(SAR)data and Landsat-8 OIL data,point-of-interest(POI)and OpenStreetMap(OSM)*** study reveals that this extreme flood event has profoundly affected croplands and *** to the revisiting period of Sentinel-1 SAR data,four scenarios are simulated to portray the retreated but‘omitted’floodwater:Scenario 0 is the flood inundation area on 27 July,and Scenarios 1,2 and 3 are built based on this information with a buffer of 50,100 and 150 m outwards,*** the four scenarios,as the inundation areas expand,the affected HEST infrastructure becomes more clustered at the centre of the core study area,indicating that those located in the urban centre are more susceptible to ***,the affec

关键词： Flood cascading effects Critical infrastructure Extreme rainstorm event Flood scenarios

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Evolution of the Late Cretaceous Yongfeng-Chongren Basin in Jiangxi Province,southeast China: insights from sedimentary facies analysis and pebble counting

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Journal of Mountain Science 2016年第2期13卷 342-351页

作者： CHEN Liu-qin GUO fu-sheng TANG Chao State Key Laboratory Breeding Base of Nuclear Resources and Environment East China Institute of Technology College of Earth Sciences East China Institute of Technology

The Gan-Hang Belt in Southeast China is characterized by several igneous and siliciclastic basins associated with crustal extension during Late Mesozoic. The sedimentary evolution of the red basins is still poorly understood. In this study, sedimentary fades analysis and pebble counting were performed on outcrop sections of the Late Cretaceous Guifeng Group in the Yongfeng-Chongren Basin in central Jiangxi Province. Thirty-five conglomerate outcrops were chosen to measure pebble lithology, size, roundness, weathering degree and preferred orientation. Results show that gravels are mostly fine to coarse pebbles and comprise dominantly quartzites, metamorphic rocks, granitoids and sandstones. Rose diagrams based on imbricated pebbles indicate variable paleocurrent directions. Combining with typical sedimentary structures and vertical successions, we suggest that the Guifeng Group were deposited in alluvial fan, river and playa lake depositional systems. The proposed depositional model indicates that the Hekou Formation represents the start-up stage of the faulted basin, accompanied by sedimentation in alluvial fan and braided river environments. Then this basin turned into a stable expansion stage during the deposition of the Tangbian Formation. Except for minor coarse sediments at the basin margin, the other area is covered with fine-grained sediments of lake and river environments. The Lianhe Formation, however, is once again featured by conglomerates, suggesting a probable tectonic event. Therefore, the study region possibly suffered two tectonic events represented by the conglomerates of the Hekou and Lianhe formations in the context of the crustal extension in Southeast China.

关键词： Late Cretaceous redbeds Pebble counting Yongfeng-Chongren Basin Gan-Hang Belt Geological evolution

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Discovery potentials of double-charm tetraquarks

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Chinese Physics C 2021年第10期45卷 53-57页

作者： qin qin Yin-Fa Shen fu-Sheng Yu School of physics Huazhong University of Science and TechnologyWuhan 430074China School of Nuclear Science and Technology and Frontiers Science Center for Rare IsotopesLanzhou UniversityLanzhou 730000China Lanzhou Center for Theoretical Physics and Key Laboratory of Theoretical Physics of Gansu ProvinceLanzhou UniversityLanzhou 730000China Center for High Energy Physics Peking UniversityBeijing 100871China

In this study,we investigate the discovery potential of double-charm tetraquarks■.We find that their production cross sections at the LHCb with■TeV reach O(10^(4))pb,which indicates that the LHCb has collected O(10^(8))such *** the decay channels of■or■or■(if unstable),it is highly expected that they get discovered at the LHCb in the near *** also discuss the productions and decays of the double-charm tetraquarks at future Tera-Z factories.

关键词： tetraquark doubly heavy hadron LHCb

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Theory and experiment of observer based magnetostrictive self-sensing actuator

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 99-103页

作者： Zhi-feng TANG fu-zai LV Zhan-qin XIANG Modern Manufacture Engineering Institute Zhejiang University Hangzhou 310027 China

Giant magnetostrictive actuators (GMAs) often work in a close-loop feedback system. This system needs independent sensors which may be difficult to be fixed, besides, excessive sensors may cause more unpredicted problems in a large system. This paper aims to develop a self-sensing GMA. An observer based on piezomagnetic equations is constructed to estimate the stress and strain of the magnetostrictive material. The observer based self-sensing approach depends on the facts that the magnetic field is controllable and that the magnetic induction is measurable. Aiming at the nonlinear hysteresis in magnetization, a hys- teresis compensation observer based on Preisach model is developed. Experiment verified the availability of the observer approach, and the hysteresis compensation observer has higher tracking precision than linear observer for dynamic force sensing.

关键词： Magnetostrictive Self-sensing actuator Hysteresis Giant magnetostrictive actuators (GMAs)

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Degradation of phenol in industrial wastewater over the F–Fe/TiO_2 photocatalysts under visible light illumination

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Chinese Journal of Chemical Engineering 2016年第12期24卷 1712-1718页

作者： Yandong Liu Shijian Zhou fu Yang Hua qin Yan Kong State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemistry and Chemical Engineering Nanjing Tech University Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University

F–Fe/TiO_2 composite photocatalyst was synthesized by a facile one-step hydrothermal method and then characterized by XRD, XPS and UV–Vis DRS. The catalyst of F–Fe/TiO_2 exhibited the highest photodegradation rate for phenol as compared with pure TiO_2, F/TiO_2, Fe/TiO_2, F0.38–Fe0.13–TiO_2 and Fe(III)/F-TiO_2 under visible light irradiation. The simulated conditions of industrial phenolic wastewater including initial phenol concentration,visible light intensity, p H and different anions were investigated in the presence of F–Fe/TiO_2 photocatalyst. In addition, as expected, the F–Fe/TiO_2 photocatalyst displayed excellent stability, showing a potential industrial application for the treatment of phenolic wastewater.

关键词： Phenolic wastewater Visible light Photodegradation F–Fe/TiO_2

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