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Attempts to enhance the eradication rate of helicobacter pylori infection

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World Journal of Gastroenterology 2014年第18期20卷 5252-5262页

作者： chang seok bang Gwang Ho Baik Department of Internal Medicine Hallym University College of MedicineChuncheon 200-704South Korea

Increasing rates of antimicrobial resistance to clarithromycin and metronidazole present challenges in maintaining optimal eradication *** of local antibiotic resistance and consumption pattern is important in selecting a reliable *** addition,adverse effect profiles of therapeutic regimens are important and must be addressed to enhance compliance *** methods of enhancing the eradication rates of Helicobacter pylori(***)have been investigated,including changing combinations or durations of established drugs,adding adjuvant drugs,or development of new molecules or ***-containing quadruple,sequential,concomitant,and levofloxacin-based triple therapies are replacing the long-standing standard of the triple *** the encouraging results of these regimens,individualized approaches like treatment after antibiotics resistance test or CYP2C19genotyping would be the mainstream of future *** scientific,economic,and technical problems make these advance therapies unfit for widespread use,future development for *** therapy should be directed to overcome individualized antibiotic *** various novel regimens and additive agents have indicated favorable outcomes,more studies or validations are needed to become a mainstream *** therapy.

关键词： Helicobacter pylori Antimicrobial drug resistance Clarithromycin Metronidazole Microbial sensitivity tests

Evaluating the role of large language models in inflammatory bowel disease patient information

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World Journal of Gastroenterology 2024年第29期30卷 3538-3540页

作者： Eun Jeong Gong chang seok bang Department of Internal Medicine Hallym University College of MedicineChuncheon 24253Gangwon-doSouth Korea

This letter evaluates the article by Gravina et al on ChatGPT’s potential in providing medical information for inflammatory bowel disease *** promising,it highlights the need for advanced techniques like reasoning+action and retrieval-augmented generation to improve accuracy and *** that simple question and answer testing is insufficient,it calls for more nuanced evaluation methods to truly gauge large language models’capabilities in clinical applications.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Chat generative pre-trained transformer Large language model Artificial intelligence

Clinical characteristics of peptic ulcer perforation in Korea

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World Journal of Gastroenterology 2017年第14期23卷 2566-2574页

作者： Young Joo Yang chang seok bang Suk Pyo Shin Tae Young Park Ki Tae Suk Gwang Ho Baik Dong Joon Kim Department of Internal Medicine Hallym University College of Medicine Chuncheon Sacred Heart Hospital

AIM To elucidate the epidemiological characteristics and associated risk factors of perforated peptic ulcer(PPU).METHODS We retrospectively reviewed medical records of patients who were diagnosed with benign PPU from 2010 through 2015 at 6 Hallym university-affiliated *** A total of 396 patients were identified with postoperative complication rate of 9.1% and mortality rate of 0.8%. Among 174(43.9%) patients who were examined for Helicobacter pylori(H. pylori) infection, 78(44.8%) patients were positive for H. pylori infection, 21(12.1%) were on non-steroidal anti-inflammatory drugs(NSAIDs) therapy, and 80(46%) patients were neither infected of H. pylori nor treated by any kinds of NSAIDs. Multivariate analysis indicated that older age(OR = 1.09, 95%CI: 1.04-1.16) and comorbidity(OR = 4.11, 95%CI: 1.03-16.48) were risk factors for NSAID-associated PPU compared with non-H. pylori, non-NSAID associated PPU and older age(OR = 1.04, 95%CI: 1.02-1.07) and alcohol consumption(OR = 2.08, 95%CI: 1.05-4.13) were risk factors for non-H. pylori, non-NSAID associated PPU compared with solely H. pylori positive *** Elderly patients with comorbidities are associated with NSAIDs-associated PPU. Non-H. pylori, non-NSAID peptic ulcer is important etiology of PPU and alcohol consumption is associated risk factor.

关键词： Helicobacter pylori Non-steroidal anti-inflammatory drugs Peptic ulcer perforation Stomach ulcer Duodenal ulcer

Advancements and challenges in gastrointestinal imaging

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World Journal of Clinical Cases 2024年第33期12卷 6591-6594页

作者： Eun Jeong Gong chang seok bang Department of Internal Medicine Hallym University College of MedicineChun-cheon 24253Gangwon-doSouth Korea Department of Internal Medicine Hallym University College of MedicineChuncheon Sacred Heart HospitalChuncheon 24253Gangwon-doSouth Korea

A recent review by Gulinac et al,provides an in-depth analysis of current clinical issues and challenges in gastrointestinal *** editorial highlights the advancements in imaging techniques,including the integration of artificial intelligence and functional imaging modalities,and discusses the ongoing relevance of traditional nuclear medicine *** future of gastrointestinal imaging looks promising,with continuous improvements in resolution,enhanced ability to analyze color and texture beyond visual diagnosis,faster image processing,and the application of molecular imaging and nanoparticles expected to enhance diagnostic accuracy and clinical outcomes.

关键词： Imaging methods Gastrointestinal diseases Gastrointestinal tract Radiology Tumors of the gastrointestinal tract

changing trends and characteristics of peptic ulcer disease:A multicenter study from 2010 to 2019 in Korea

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World Journal of Gastroenterology 2023年第44期29卷 5882-5893页

作者： Yoon Jin Choi Tae Jun Kim chang seok bang Yong Kang Lee Moon Won Lee Su Youn Nam Woon Geon Shin Seung In Seo Department of Internal Medicine National Cancer CenterGoyang-si 13620South Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chuncheon Sacred Heart HospitalChuncheon 24253South Korea Department of Internal Medicine National Health Insurance Service Ilsan HospitalGoyang-si 10444South Korea Department of Internal Medicine Pusan National University School of MedicineBusan 50463South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKyungpook National University Chilgok HospitalDaegu 41404South Korea Department of Internal Medicine Kangdong Sacred Heart HospitalHallym University College of MedicineSeoul 05355South Korea Institute for Liver and Digestive Diseases Hallym UniversityChuncheon 24253South Korea Division of Gastroenterology Department of Internal MedicineKangdong Sacred Heart HospitalSeoul 05355South Korea

BACKGROUND The clinical trend and characteristics of peptic ulcer disease(PUD)have not fully been investigated in the past *** To evaluate the changing trends and characteristics of PUD according to age and METHODS We analyzed seven hospital databases converted into the Observational Medical Outcomes Partnership-Common Data Model between 2010 and *** classified patients with PUD who underwent rapid urease tests or Helicobacter pylori(***)serology into three groups:***-related,drug[nonsteroidal anti-inflammatory drugs(NSAIDs)or aspirin]-related,and idiopathic(***/NSAID/aspirin-negative)PUD and compared the yearly trends and characteristics among the three *** We included 26785 patients in 7 databases,and the proportion of old age(≥65 years)was 38.8%.The overall number of PUD exhibited no decrease,whereas PUD in old age revealed an increasing trend(P=0.01 for trend).Of the 19601 patients,41.8%had ***-related,36.1%had drug-related,and 22.1%had idiopathic *** PUD exhibited a decreasing trend after 2014(P=0.01),drug-related PUD demonstrated an increasing trend(P=0.04),and idiopathic PUD showed an increasing trend in the old-age group(P=0.01)during 10 *** with drug-related PUD had significantly more comorbidities and concomitant ulcerogenic *** idiopathic PUD group had a significantly higher number of patients with chronic liver *** With the aging population increase,the effects of concomitant ulcerogenic drugs and preventive strategies should be investigated in drug-induced *** studies are required to clarify the relationship between idiopathic PUD and chronic liver disease.

关键词： Peptic ulcer disease Drug Idiopathic Trend Characteristics

Osteoporosis and bone fractures in alcoholic liver disease:A meta-analysis

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World Journal of Gastroenterology 2015年第13期21卷 4038-4047页

作者： chang seok bang In Soo Shin Sung Wha Lee Jin Bong Kim Gwang Ho Baik Ki Tae Suk Jai Hoon Yoon Yeon Soo Kim Dong Joon Kim Department of Internal Medicine Hallym University College of MedicineChuncheon 200-704South Korea College of Education Jeonju UniversityJeonju 560-759South Korea

AIM: To evaluate the association between alcoholic liver disease(ALD) and bone fractures or osteoporosis. METHODS: Non-randomized studies were identified from databases(Pub Med, EMBASE, and the Cochrane Library). The search was conducted using Boolean operators and keywords, which included "alcoholic liver diseases", "osteoporosis", or "bone fractures". The prevalence of any fractures or osteoporosis, and bone mineral density(BMD) were extracted and analyzed using risk ratios and standardized mean difference(SMD). A random effects model was applied. RESULTS: In total, 15 studies were identified and analyzed. Overall, ALD demonstrated a RR of 1.944(95%CI: 1.354-2.791) for the development of bone fractures. However, ALD showed a RR of 0.849(95%CI: 0.523-1.380) for the development of osteoporosis. BMD was not significantly different between the ALD and control groups, although there was a trend toward lower BMD in patients with ALD(SMD in femur-BMD:-0.172, 95%CI:-0.453-0.110; SMD in spine-BMD:-0.169, 95%CI:-0.476-0.138). Sensitivity analyses showed consistent results. CONCLUSION: Current publications indicate significant associations between bone fractures and ALD, independent of BMD or the presence of osteoporosis.

关键词： Alcoholic liver diseases Bone fractures Osteoporos

Characteristics of nonvariceal upper gastrointestinal hemorrhage in patients with chronic kidney disease

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World Journal of Gastroenterology 2013年第43期19卷 7719-7725页

作者： chang seok bang Yong Seop Lee Yun Hyeong Lee Hotaik Sung Hong Jun Park Hyun Soo Kim Jin Bong Kim Gwang Ho Baik Yeon Soo Kim Jai Hoon Yoon Dong Joon Kim Ki Tae Suk Department of Internal Medicine Hallym University College of MedicineChuncheon 200-704South Korea Department of Biology Stanford UniversityStanfordCA 94305United States Department of Internal Medicine Yonsei University Wonju College of MedicineWonju 220-786South Korea

AIM:To evaluate the clinical characteristics of nonvariceal upper gastrointestinal hemorrhage(NGIH)in patients with chronic kidney disease(CKD).METHODS:From 2003 to 2010,a total of 72 CKD patients(male n=52,72.2%;female n=20,27.8%)who had undergone endoscopic treatments for NGIH were retrospectively *** findings,endoscopic features,prognosis,rebleeding risk factors,and mortality-related factors were *** characteristics of the patients and rebleeding-related data were recorded for the following variables:gender,age,alcohol use and smoking history,past hemorrhage history,endoscopic findings(the cause,location,and size of the hemorrhage and the hemorrhagic state),therapeutic options for endoscopy,endoscopist experience,clinical outcomes,and ***:The average size of the hemorrhagic site was 13.7±10.2 mm,and the most common hemorrhagic site in the stomach was the antrum(n=21,43.8%).The most frequent method of hemostasis was combination therapy(n=32,44.4%).The incidence of rebleeding was 37.5%(n=27),and 16.7%(n=12)of patients expired due to *** a multivariate analysis of the risk factors for rebleeding,alcoholism(OR=11.19,P=0.02),the experience of endoscopists(OR=0.56,P=0.03),and combination endoscopic therapy(OR=0.06,P=0.01)compared with monotherapy were significantly related to rebleeding after endoscopic *** a risk analysis of mortality after endoscopic therapy,only rebleeding was related to mortality(OR=7.1,P=0.02).CONCLUSION:Intensive combined endoscopic treatments by experienced endoscopists are necessary for the treatment of NGIH in patients with CKD,especially when a patient is an alcoholic.

关键词： Chronic kidney diseases Gastrointestinal hemorrhage Endoscopy Peptic ulcer Alcoholics

Endoscopic submucosal dissection for early gastric cancer with undifferentiated-type histology:A meta-analysis

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World Journal of Gastroenterology 2015年第19期21卷 6032-6043页

作者： chang seok bang Gwang Ho Baik In Soo Shin Jing Bong Kim Ki Tae Suk Jai Hoon Yoon Yeon Soo Kim Dong Joon Kim Woon Geon Shin Kyung Ho Kim Hak Yang Kim Hyun Lim Ho seok Kang Jong Hyeok Kim Jin Bae Kim Sung Won Jung Sea Hyub Kae Hyun Joo Jang Min Ho Choi Department of Internal Medicine Hallym University College of Medicine College of Education Jeonju University

AIM: To evaluate the efficacy and safety of endoscopicsubmucosal dissection(ESD) for early gastric cancer(EGC) with undifferentiated-type ***: A systematic literature review was conducted using the core databases. Complete resection,curative resection, en bloc resection, recurrence and adverse event rate were extracted and analyzed. A random effect model was applied. The methodological quality of the enrolled studies was assessed using the Newcastle-Ottawa Scale. Publication bias was evaluated using a funnel plot, the trim and fill method, Egger's test,and a rank correlation ***: Fourteen retrospective studies between2009 and 2014 were identified(972 EGC lesions with undifferentiated-type histology). The total en bloc and complete resection rates were estimated as92.1%(95%CI: 87.4%-95.2%) and 77.5%(95%CI:69.3%-84%), respectively. The total curative resection rate was 61.4%(95%CI: 44.5%-75.9%). The overall recurrence rate was 7.6%(95%CI: 3.4%-16%).Limited to histologically diagnosed expanded-criteria lesions, the en bloc and complete resection rates were91.2% and 85.6%, respectively. The curative resection rate was 79.8%.CONCLUSION: In this analysis, ESD is a technically feasible treatment modality for EGC with undifferentiatedtype histology. Long-term studies are needed to confirm these therapeutic outcomes.

关键词： Carcinoma Endoscopic submucosal dissection Endoscopy Gastric cancer Meta-analysis

Efficient and simple synthesis of B_(2)O_(3)-Al_(2)O_(3)nanocomposites assisted by deep eutectic solvent for production of 5-hydroxymethylfurfural from glucose

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Nano Research 2025年第1期18卷 236-248页

作者： Yuchen Wang Kai Rong Shanlei chang Youxing Fang Shaojun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry Jilin UniversityChangchun 130012China

The catalytic conversion of glucose to high valueadded platform chemical 5-hydroxymethylfurfural(HMF)is a promising biorefinery process,and alumina-boria catalysts are considered to be green and mild solid acid catalysts for this catalytic ***,compared to the common synthesis methods with complicated steps,we reported a simple and efficient strategy to prepare B_(2)O_(3)-Al_(2)O_(3)nanocomposites by calcining cost-effective glucose-urea deep eutectic solvent(DES)solution containing the *** prepared B_(2)O_(3)-Al_(2)O_(3)nanocomposites exhibited an open three-dimensional skeleton and two-dimensional porous lamellar substructure,endowing them with a high specific surface area(228.27 m2/g).The introduction of boron changed the ratios of different aluminum species(AlⅣ,AlⅤ,and AlⅥ)and borate species(BO3 and BO4),thus further affecting the acidity and the types of acid sites of the *** prepared B_(2)O_(3)-Al_(2)O_(3)bifunctional acid catalysts possessing abundant Lewis acid sites and adjustable Brønsted acid sites showed complete glucose conversion and 55.38%of HMF yield under the optimum *** study proposed a concise method to synthesize alumina-boria solid acid catalysts assisted by glucose-urea *** hope to extend the application and prospect of this efficient and simple synthesis strategy.

关键词： 5-hydroxymethylfurfural(HMF) deep eutectic solvent glucose alumina-boria acid catalyst