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World Journal of Clinical Cases 2019年第19期7卷 2976-2985页

作者： chang ho hwang Department of Physical Medicine and Rehabilitation Ulsan University Hospital University of Ulsan College of Medicine Department of Biomedical Engineering School of Electrical EngineeringUniversity of Ulsan

BACKGROUND De-afferentation or non-weight bearing induces rapid cortical and spinalα-motor neuron *** supposed that an end-effector type gait robot(EEGR)could provide patients with a training condition that was specific enough to activate rapid cortical/spinal neuroplasticity,leading to immediate muscle *** electromyographic and biomechanical comparisons were *** To compare the electromyographic activities of the thigh and shank muscles and isometric peak torque(PT)before and after walking training on a floor or in the end-effector gait *** Twelve outpatients without ambulatory dysfunction were *** of two interventions(5-min training on a floor at a comfortable pace or training in an EEGR with non-weight bearing on their feet and 100%guidance force at 2.1 km/h)were randomly *** PT,maximal ratio of torque development,amplitude of compound motor action potential(CMAP),and area under the curve(AUC)were evaluated before and 10 min after both *** The degree of PT improvement of the dominant knee flexors was larger in the EEGR than on the floor(9.6±22.4 Nm/BW,Phose who trained on the floor(4.5±28.1 Nm/BW,Phowever,all electromyographic activities of the thigh and shank muscles(peak CMAP,mean and peak AUC)were significantly lower for the use of the EEGR than walking on the *** Immediate strengthening of the knee flexors and extensors was induced after the 5-min EEGR training,despite reduced muscular use.

关键词： Robotics Rehabilitation Muscles Neuronal plasticity Gait Knee

Ataxic gait following total gastrectomy for gastric cancer

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World Journal of Gastroenterology 2016年第37期22卷 8435-8438页

作者： chang ho hwang Dong Jin Park Gyu Yeol Kim Department of Physical Medicine and Rehabilitation Medicine Ulsan University Hospital University of Ulsan College of Medicine Department of Surgery Ulsan University Hospital University of Ulsan College of Medicine

A 58-year-old woman, who had undergone total gastrectomy for early gastric cancer 9 years previously, visited the outpatient clinic complaining of progressive difficulty in walking for 15 d. Laboratory examinations showed macrocytic anemia and a decreased serum vitamin B12 concentration and increased serum concentrations of folate, vitamin E and copper. Magnetic resonance imaging showed multifocal high signal intensities along the posterior column of the cervical and thoracic spinal cord. Treatment consisted of intramuscular injections of vitamin B12 for 7 d, which increased her serum level of vitamin B12 to normal. This was followed by weekly intramuscular injections of vitamin B12 for another 2 wk and oral administration of vitamin B12 three times per day. After comprehensive rehabilitation for 4 wk, she showed sufficient improvements in strength and ataxic gait, enabling her to return to her normal daily activities.

关键词： Subacute combined degeneration Vitamin B12 deficiency Total gastrectomy Gastric cancer

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑chang Sung Gwang‑Hee Lee Byoungjoon hwang Sojung Seo Ji‑Hun Seo Dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo hwang Seunghwan Choi Soo-ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

台湾北部近岸海域春末浮游动物的组成及分布特征

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台湾海峡 2004年第1期23卷 62-68页

作者：陈禾张黄将修连光山台湾海洋大学海洋生物研究所台湾基隆20224 国家海洋局第三海洋研究所福建厦门361005

本研究于2003年5月5日至6日对台湾北部近岸海域,具有地区特征的5个测站进行浮游动物数量、组成等调查研究.结果共发现22大类浮游动物,桡足类为此次调查的主要优势大类,约占总浮游动物个体数量的42.57%,其次为桡足幼体(copep odids),占27... 详细信息

本研究于2003年5月5日至6日对台湾北部近岸海域,具有地区特征的5个测站进行浮游动物数量、组成等调查研究.结果共发现22大类浮游动物,桡足类为此次调查的主要优势大类,约占总浮游动物个体数量的42.57%,其次为桡足幼体(copep odids),占27.38%,两者在各测站的出现率皆高达100%.根据浮游动物丰度比较、群聚分析与水文状况,可将东北3个测站与西北2个测站分为两个不同的群落.其中,西北部测站可能因沿岸溪流大量有机物的注入,有利浮游动物增生,因此丰度较高,但5个测站的浮游动物多样性皆不高,与台湾其它沿岸海域研究结果相似.

关键词：浮游动物近岸海域桡足类群聚

Polygonal multi-polymorphed Li4Ti5Oi2@rutile TiO2 as anodes in lithium-ion batteries

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Nano Research 2019年第4期12卷 897-904页

作者： chang Hyun hwang Hee-eun Kim Inho Nam Jin ho Bang Department ofBionano Technology Hanyang University 55 Hanyangdaehak-ro Sangnok-gu Ansan Gyeonggi-do 15588 Republic of Korea School of Chemical Engineering & Materials Science Chung-Ang University 84 Heukseok-ro Dongjak-gu Seoul 06974 Republic of Korea Department of Chemical and Molecular Engineering Hanyang University 55 Hanyangdaehak-ro Sangnok-gu Ansan Gyeonggi-do 15588 Republic of Korea

Li4Ti50i2 (LTO) has attracted considerable attention in lithium-ion battery (LIB) applications because of its favorable characteristics as an anode material. Despite its promise, the widespread use of LTO is still limited primarily due to its intrinsically poor electric and ionic con ductivities and high surface reactivity. To address these issues, we desig ned polyg onal nano architectures composed of various Li-Ti oxide crystal polymorphs by a facile synthesis route. Depending on the pH condition, this synthesis approach yields multi-polymorphed Li-Ti oxides where the interior is dominantly composed of a Li-rich phase and the exterior is a Li-deficient (or Li-free) phase. As one of these variations, a polygonal LTO-rutile TiO2 structure is formed. The rutile TiO2 on the surface of this LTO composite significantly improves the kinetics of Li^+ insertion/extraction because the channel along the o-axis in TQ2 provides a Li^+ highway due to the significantly low energy barrier for Li^+ diffusion. Moreover, the presenee of rutile TiO2, which is less reactive with a carbonate-based electrolyte, ensures Iong-term stability by suppress)ng the undesirable interfacial reaction on LTO.

关键词： micro-polygon structure Li-Ti oxide multi-polymorphs Li4Ti5Oi2@ rutile TiO2 anode lithium-ion batteries

Minimally invasive vs open pancreatectomy for nonfunctioning pancreatic neuroendocrine tumors

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1133-1145页

作者： Juwan Kim ho Kyoung hwang Woo Jung Lee chang Moo Kang Department of Surgery Yonsei University College of MedicineSeoul 03722South Korea

BACKGROUND The mainstay of treating nonfunctioning-pancreatic neuroendocrine tumors(NFPNETs)is surgical ***,minimally invasive approaches to pancreatic resection for treating NF-PNETs are not widely accepted,and the longterm oncological outcomes of such approaches remain *** To determine the short-and long-term outcomes of minimally invasive pancreatic resection conducted in patients with *** Prospective databases from Severance hospital were searched for 110 patients who underwent curative resection for NF-PNETs between January 2003 and August *** The proportion of minimally invasive surgery(MIS)procedures performed for NF-PNET increased to more than 75%after *** was no significant difference in post-operative complications(P=0.654),including pancreatic fistula(P=0.890)and delayed gastric emptying(P=0.652),between MIS and open *** statistically significant difference was found in disease-free survival between the open approach group and the MIS group(median follow-up period,28.1 mo;P=0.428).In addition,the surgical approach(MIS vs open)was not found to be an independent prognostic factor in treating NF-PNET patients[Exp(β)=1.062;P=0.929].CONCLUSION Regardless of the type of surgery,a minimally invasive approach can be safe and feasible for select NF-PNET patients.

关键词： Nonfunctioning-pancreas neuroendocrine tumor Pancreatic neuroendocrine tumor Minimally invasive surgery Oncologic outcome Laparoscopic pancreaticoduodenectomy Laparoscopic distal pancreatectomy

Preoperative defining system for pancreatic head cancer considering surgical resection

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World Journal of Gastroenterology 2016年第26期22卷 6076-6082页

作者： Seok Jeong Yang ho Kyoung hwang chang Moo Kang Woo Jung Lee Department of Surgery Ulsan University Hospital University of Ulsan College of Medicine Department of Hepatobiliary and Pancreatic Surgery Yonsei University College of Medicine Pancreaticobiliary Cancer Clinic Yonsei Cancer Center Institute of Gastroenterology Yonsei Severance Hospital

AIM: To provide appropriate treatment, it is crucial to share the clinical status of pancreas head cancer among multidisciplinary treatment ***: A retrospective analysis of the medical records of 113 patients who underwent surgery for pancreas head cancer from January 2008 to December 2012 was performed. We developed preoperative defining system of pancreatic head cancer by describing “resectability - tumor location - vascular relationship - adjacent organ involvement - preoperative CA19-9 (initial bilirubin level) - vascular anomaly”. The oncologic correlations with this reporting system were ***: Among 113 patients, there were 75 patients (66.4%) with resectable, 34 patients (30.1%) with borderline resectable, and 4 patients (3.5%) with locally advanced pancreatic cancer. Mean disease-free survival was 24.8 mo (95%CI: 19.6-30.1) with a 5-year disease-free survival rate of 13.5%. Pretreatment tumor size ≥ 2.4 cm [Exp(B) = 3.608, 95%CI: 1.512-8.609, P = 0.044] and radiologic vascular invasion [Exp(B) = 5.553, 95%CI: 2.269-14.589, P = 0.002] were independent predictive factors for neoadjuvant treatment. Borderline resectability [Exp(B) = 0.222, P = 0.008], pancreatic head cancer involving the pancreatic neck [Exp(B) = 9.461, P = 0.001] and arterial invasion [Exp(B) = 6.208, P = 0.010], and adjusted CA19-9 ≥ 50 [Exp(B) = 1.972 P = 0.019] were identified as prognostic clinical factors to predict tumor ***: The suggested preoperative defining system can help with designing treatment plans and also predict oncologic outcomes.

关键词： Preoperative defining system Pancreas head cancer Borderline resectable Adjusted CA19-9 Neoadjuvant therapy

Geometric-phase intraocular lenses with multifocality

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Light(Science & Applications) 2022年第11期11卷 2805-2816页

作者： Seungmin Lee Gayeon Park Senho Kim Yeonghwa Ryu Jae Woong Yoon ho Sk hwang In Seok Song chang Sun Lee Seok ho Song Department of Physics Hanyang UniversitySeoul 04763Republic of Korea Department of Ophthalmology Catholic University of KoreaSeoul 07345Republic of Korea Seoul Ophthalmic Clinic Goyang 10463Republic of Korea Koryoeyetech In.Seoul 06093Republic of Korea Tigernics IncSeoul 04763Republic of Korea

We demonstrate a new type of multifocal and extended depth of focus(EDOF)intraocular lenses(IOLs)embeddingμm-thin geometric phase(GP)lens *** an emerging approach for lens phase design,the GP modulated IOLs outperform conventional diffractive IOLs in multifocality while completely avoiding the clinically undesirable demand for additional surface patterns to standard monofocal IOL *** number of foci and light splitting ratio of the GP IOLs are adjusted by changing the number of stacked GP layers and the thickness of each *** and trifocal GP IOLs are fabricated by radial alignment of anisotropic orientation in UV-curable liquid crystal *** characterizing the defocus image and modulation transfer function of the GP IOLs,it is expected that GP IOLs will alleviate the most common problems associated with multifocal and EDOF IOLs,blurred vision and photic phenomena caused by light scattering and posterior capsule opacification.

关键词： layer phase alignment

Numerical simulation of solidification morphologies of Cu-0.6Cr casting alloy using modified cellular automaton model

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Transactions of Nonferrous Metals Society of China 2010年第6期20卷 1072-1077页

作者： TSAI De-chang hwang Weng-sing Department of Materials Science and Engineering National Cheng Kung University

The purpose of this study is to predict the morphologies in the solidification process for Cu-0.6Cr(mass fraction,%)alloy by vacuum continuous casting(VCC)and verify its accuracy by the observed experimental *** numerical simulation aspect, finite difference(FD)method and modified cellular automaton(MCA)model were used to simulate the macro-temperature field, micro-concentration field,nucleation and grain growth of Cu-0.6Cr alloy using real data from actual casting *** the observed casting experiment,the preliminary grain morphologies are the directional columnar grains by the VCC *** solidification morphologies by MCAFD model are in agreement with the result of actual casting experiment well.

关键词： Cu-Cr alloy vacuum continuous casting solidification morphology simulation modified cellular automaton model finite difference method