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Intelligent gold nanocluster for effective treatment of malignant tumor via tumor-specific photothermal–chemodynamic therapy with AIE guidance

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National Science Review 2024年第5期11卷 326-342页

作者： Feng liu Tianfeng Yang Xiaowei chang Li Chen Cheng Cheng Xiuhong Peng Haihu liu Yanmin Zhang xin Chen School of Energy and Power Engineering Xi'an Jiaotong University Department of Chemical Engineering Shaanxi Key Laboratory of Energy Chemical Process IntensificationInstitute of Polymer Science in Chemical Engineering School of Chemical Engineering and Technology Xi'an Jiaotong University School of Pharmacy Health Science Center Xi'an Jiaotong University

Precise and efficient therapy of malignant tumors is always a challenge. Herein, gold nanoclusters co-modified by aggregation-induced-emission（AIE） molecules, copper ion chelator（acylthiourea） and tumor-targeting agent（folic acid） were fabricated to perform AIE-guided and tumor-specific synergistic therapy with great spatio-temporal controllability for the targeted elimination and metastasis inhibition of malignant tumors. During therapy, the functional gold nanoclusters（Au NTF） would rapidly accumulate in the tumor tissue due to the enhanced permeability and retention effect as well as folic acid-mediated tumor targeting, which was followed by endocytosis by tumor cells. After that, the overexpressed copper ions in the tumor cells would trigger the aggregation of these intracellular Au NTF via a chelation process that not only generated the photothermal agent in situ to perform the tumor-specific photothermal therapy damaging the primary tumor, but also led to the copper deficiency of tumor cells to inhibit its ***, the copper ions were reduced to cuprous ions along with the chelation, which further catalysed the excess H2O2in the tumor cells to produce cytotoxic reactive oxygen species, resulting in additional chemodynamic therapy for enhanced antitumor efficiency. The aggregation of Au NTF also activated the AIE molecules to present fluorescence, which not only imaged the therapeutic area for real-time monitoring of this tumor-specific synergistic therapy, but also allowed us to perform near-infrared radiation at the correct time point and location to achieve optimal photothermal therapy. Both in vitro and in vivo results revealed the strong tumor elimination, effective metastasis inhibition and high survival rate of tumor-bearing mice after treatment using the Au NTF nanoclusters, indicating that this AIE-guided and tumor-specific synergistic strategy could offer a promising approach for tumor therapy.

关键词： AIE-guided precise tumor treatment copper-dependent photothermal therapy copper-triggered chemodynamic therapy primary tumor elimination copper-plunder-induced metastasis inhibition

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负载抗原的DC及DC-CIK对小细胞肺癌杀伤作用的比较研究

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中国实验诊断学 2016年第10期20卷 1627-1629页

作者：赵鑫常颖刘玉侠赵晖卢卫平于鸿王启文吉林省肿瘤医院吉林长春130012 吉林省肿瘤防治研究所吉林长春130012

目的探讨负载抗原的树突状细胞(Dendritic cells,DC)以及DC联合CIK细胞(cytokine induced killer cells)对小细胞肺癌细胞株NCIH-446的杀伤作用,为DC、CIK应用于小细胞肺癌的治疗提供实验数据。方法体外培养DC、CIK细胞,并将NCIH-446提... 详细信息

目的探讨负载抗原的树突状细胞(Dendritic cells,DC)以及DC联合CIK细胞(cytokine induced killer cells)对小细胞肺癌细胞株NCIH-446的杀伤作用,为DC、CIK应用于小细胞肺癌的治疗提供实验数据。方法体外培养DC、CIK细胞,并将NCIH-446提取的抗原负载到DC,同时将DC与CIK联合培养,将负载抗原的DC(DC-Ag)及DC-CIK与NCI446按50∶1的比例进行杀伤活性实验,检测培养不同时间的两种细胞对NCIH-446的杀伤作用。结果 DC-Ag及DC-CIK在与NCIH-446CIK共同培养2个小时就监测到了两种细胞对NCIH-446的杀伤作用,而且随着时间的推移,杀伤作用逐渐增强,DC-Ag从2小时的57.63%提高到48小时的90.78%,而DC-CIK从62.95%提高到了91.57%,显示了两种细胞强大的杀伤作用,而且这种作用随着时间的延长效果越明显。结论负载抗原的DC及DC-CIK对小细胞肺癌细胞株NCIH-446有极强的杀伤活性,为临床小细胞肺癌的治疗提供了一种新的方法。

关键词：树突状细胞细胞因子活化杀伤细胞小细胞肺癌,杀伤活性

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Microstructure Evolution of Primary γ′ Phase in Ni3Al-Based Superalloy

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Acta Metallurgica Sinica(English Letters) 2020年第12期33卷 1709-1726页

作者： xin He Jianbo Zhang Yuanyi Peng Jingan Li Jian Ding chang liu xingchuan Xia Xueguang Chen Yongchang liu School of Material Science and Engineering Hebei University of TechnologyTianjin 300130China School of Material Science and Engineering Tianjin UniversityTianjin 300130China

In this work,water cooling,air cooling(AC)and furnace cooling(FC)were applied to investigate the effect of cooling rate on microstructure evolution of primaryγ′in a newly designed Ni3Al-based *** results showed that nucleation rate of primaryγ′increased with increasing cooling *** addition,higher cooling rate shortened growth period of primaryγ′,which made its morphology close to the initial precipitatedγ′.For AC and FC specimens,due to the lower cooling rate,primaryγ′possessed longer growth period and its morphology was mainly due to the evolution of lattice misfit betweenγand primaryγ′.Meanwhile,growth of primaryγ′depended on lattice misfit distribution between its corner and edge ***,primaryγ′morphologies of sphere,cube and concave cube with tip corners were illustrated by considering interaction between elemental diffusion and elastic strain energy.

关键词： Ni3Al-based alloy Primaryγ′ Cooling rate Nucleation rate Lattice misfit

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Research on the cutting force of a pick

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Mining Science and Technology 2009年第4期19卷 514-517页

作者： liu Song-yong DU chang-long CUI xin-xia School of Mechanical and Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Cutting tests were done using a test bed designed to measure pick cutting forces when cutting coal and *** test equipment has a drum with two starting helical *** forces on a pick were measured as a function of coal compressive strength,pick carbide tip diameter and the cutting depth per drum *** results show that the cutting force is linearly related to the compressive *** relationship between the cutting force and both the carbide tip diameter and the cutting depth are *** in the cutting force does not increase with coal compressive strength but it has a linear relationship to tip diameter.A plot of cutting force fluctuations versus the cutting depth follows a sigmoidal *** on the analysis of these test results a theoretical basis is supplied for design and effective use of shearer drums.

关键词： pick cutting force shearer cutting theory carbide tip diameter cutting depth

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The distribution of 10-year cardiovascular risk in Chinese adults： analysis of the China Health Examination Database （CHED） 2008

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Journal of Geriatric Cardiology 2010年第3期7卷 131-137页

作者： liu-xin Wu Qiang Zen Dong-chang Qiang Institute of Aviation Medicine Chinese PLA Air Force Beijing 100036 China Chinese PLA General Hospital Beijing 100853 China

Objective Global cardiovascular risk assessment has been incorporated into current Chinese guidelines for the management of hypertension and hypercholesterolemia. The aim of our study is to determine the distribution of 10-year risk for ischemic cardiovascular disease （ICVD） among middle-aged Chinese adults, and to evaluate the usefulness of global risk assessment tools in the primary prevention of ICVD in Chinese *** Simplified prediction tools derived from the USA-PRC Collaborative Study of Cardiovascular Epidemiology cohort were applied to the Chinese Health Examination Database （CHED） 2008. 10-year risk for ICVD was estimated in 461 157 ICVD-free subjects （264 432 male and 196 725 female） aged 35 to 59 years. Results Among the male subjects, 82.4% had a 10-year risk for ICVD of 〈5%, 14.4% of 5% to 12.1% and 3.4 of≥ 12.2%, and in female subjects, 86.7% had a 10-year risk for ICVD of 〈5%, 12.1% of 5% to 12.0% and 1.2% of ≥ 12.1%. All subjects with predicted high level ICVD risk （≥ 12.2% in male or ≥ 12.1% in female） had either remarkably elevated （≥ 160 mmHg） blood pressure, significantly increased （≥ 6.22 mml/L） total serum cholesterol or *** Using the currently recommended prediction tools, only very small proportions of middle-aged Chinese men and women who were free of ICVD would be classified into high level risk group. These prediction tools are unlikely to help for the medical intervention decision making in Chinese adult patients with hypertension and/or hypercholesterolemia

关键词： cardiovascular disease hypertension hypercholesterolemia prevention Chinese

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Synthesis and Properties of a Novel Polyimide with Side Chain Containing Biphenyl Unit

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Chemical Research in Chinese Universities 2012年第2期28卷 334-339页

作者： WANG Xu chang Tong-xin ZHANG Peng CHEN Yi liu Xiang-yang State Key Laboratory of Polymeric Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065P.R.China

A novel biphenyl side-chained diamine with alkyloxy spacer and alkyloxy tail,4＇-butoxy-4-（3,5-diaminobenzoyloxy）hexyloxybiphenyl（C6BBC4）,was synthesized and characterized by FTIR and 1 H NMR.A series of polyimide（PI） films with different side chain contents was synthesized from biphenyltetracarboxylicdianhydride（BPDA）,4,4＇-oxydianiline（ODA） and C6BBC4,and their thermal properties,optical transparency and liquid crystal alignment property,and so on,were investigated by thermogravimetric analysis（TGA）,differential scanning calorimetry（DSC）,crystal rotation method,polarizing microscopy and UV-Vis *** the content of side chained diamine increasing from 0 to 100%,the η inh of poly（amide acid）（PAA） decreased rapidly from 3.0 to 0.51,the glass transition temperature（T g） of polyimides（PIs） decreased from 274 ℃ to 203 ℃ and the Vis-light transmittance of alignment films substantially *** for the alignment properties,the pretilt angle of PI alignment films without rubbing could reach 90° when the content of C6BBC4 was 60% or *** the same time,the alignment stability could meet the industrial *** was considered that the alkoxy spacer,the biphenyl unit and the alkoxy tail may all play important roles in achieving a large pretilt angle even up to 90°,and the introduction of only the alkoxy spacer or alkoxy tail can also improve the pretilt angle,but not by much.

关键词： Polyimide Alignment film Liquid crystal Biphenyl side chain

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Diagnostic ion filtering strategy for chemical characterization of Guge Fengtong Tablet with high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry

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Chinese Journal of Natural Medicines 2015年第5期13卷 390-400页

作者： ZENG Su-Ling liu xin-Guang LAI chang-Jiang-Sheng liu E-Hu LI Ping State Key Laboratory of Natural Medicines China Pharmaceutical University

The present study was designed to characterize the chemical constituents of Guge Fengtong Tablet(GGFTT).Based on the chromatographic retention behavior,fragmentation pathways of chemical components and the published literatures,a diagnostic ion filtering strategy with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(HPLC-ESI-Q-TOF/MS) was established to identify the multiple bioactive constituents of *** rapid identification of forty-seven components,including 18 phenolic acids,8 saponins,14 gingerol-related compounds,and 7 diarylhepatonoids,was accomplished using this newly developed *** coupling of HPLC-ESI-Q-TOF/MS with the diagnostic ion filtering strategy was useful and efficient for the in-depth structural elucidation of chemical compounds of GGFTT.

关键词： Guge Fengtong Tablet HPLC-ESI-Q-TOF/MS Diagnostic ion filtering strategy

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Pore-filling Three-dimensionally Ordered Macroporous Polyimide Composite Proton Conducting Membranes

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Chemical Research in Chinese Universities 2011年第5期27卷 896-899页

作者： DAI xin GENG Lei liu Dan LU chang-li YANG Bai Institute of Chemistry Northeast Normal University Changehun 130024 P. R. China State Key Laboratory of Supramolecular Structure ＆ Materials College of Chemistry Jilin University Changehun 130012 P. R. China

The silica opal templates were prepared from three silica colloids of different diameters of 230 nm, 500 nm and 1.5 mm by a filtration route. The large-scale stable opal template membranes after sintering the deposited SiO2 opal template can be successfully obtained by optimizing the pH value and NaCl concentration in silica colloidal solutions. The three-dimensionally ordered macroporous（3DOM） polyimide membranes without crack were fabricated by reproducing the structure of silica opal template. We prepared the pore-filling composite proton exchange membranes by filling the 3DOM structure with proton conducting organosilane sol. The result indicates that the composite membranes exhibit higher water uptake than pure filling organosilane gel. The proton conductivity increased with the increasing of pore cell in composite membranes.

关键词： Three-dimensionally ordered macroporous(3DOM) Pore-filling Proton conducting membrane Polymercomposite material

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Livability assessment of 101,630 communities in China's major cities: A remote sensing perspective

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Science China Earth Sciences 2022年第6期65卷 1073-1087页

作者： xin HUANG Yue liu School of Remote Sensing and Information Engineering Wuhan UniversityWuhan 430079China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China

Some of China's major cities have entered the middle and late stages of urbanization, and the development focus of these cities has gradually shifted from outward expansion to inward renewal. The community, as the basic unit of a city, is undoubtedly the main object of urban renewal. In order to efficiently and effectively address the problems in current community construction, it is necessary to conduct a large-scale in-depth assessment of the community livability, which can directly imply the satisfaction of residents with their quality of life. This study achieved the first comprehensive livability assessment at the individual community scale for 42 major cities of China from the perspective of remotely sensed and crowd-sourced geographic information. Specifically, we produced abundant fine-grained datasets for 42 cities, including high-resolution land cover maps interpreted from Ziyuan-3 satellites(ZY-3, 2.1 m), building height, point-of-interest, and boundaries of 101,630 *** designed in our proposed framework, the community livability was evaluated by 5 level-1 indicators, 27 level-2 indicators and an integrated community livability index(CLI). A number of interesting findings were obtained from this assessment:(1)According to the expert questionnaires, living comfort was considered as the most important livability factor for residents with the highest weight, while the building environment was rated the least. The negative factors(e.g., the factories around the community) impacted more on livability than the positive ones.(2) Most communities in major Chinese cities were characterized by dense buildings and sparse green spaces.(3) In these cities, community security construction was severely insufficient,particularly in less developed regions.(4) Imbalanced community livability development was prevalent across cities, and simultaneously, the CLI distribution within cities also exhibited significant spatial aggregation and heterogeneity. This resear

关键词： Community Livability Living comfort Building environment Security Remote sensing

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The manipulation of light pulse from subluminal to superluminal propagation in a degenerate two-level Cs atomic system

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Science China(Physics,Mechanics & Astronomy) 2014年第12期57卷 2246-2250页

作者： ZHANG Jun Xiang JIANG Qi chang liu Chao ZHANG xin Sheng liu Jin Hong The State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-Electronics Shanxi University

We experimentally demonstrate the propagation of light pulse from subluminal to superluminal light based on quantum coher- ence in a degenerate two-level atomic system in a Cs vapor cell. It is shown that the group velocity of light pulse can be switched from subluminal to superluminal propagation via changing the coupling field from a traveling wave to a standing wave, while can also be continuously manipulated by varying the intensity of two waves superposed to form a standing wave. The observed maximum delay and advance times are about 0.45 and 0.54 μs, corresponding to the group velocity of v8 = 168 km/s and ve =-138 krrt/s, respectively. This investigation may have the practical applications of devices for optical tunable delay lines, optical switching and optical buffering.

关键词： group velocity subluminal superluminal quantum coherence standing wave

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