检索结果-南通市图书馆

Tremella polysaccharide mitigates high fat diet-induced anxiety-like behavior through the microbiota-gut-brain axis

Food Science and Human Wellness 2024年

作者： Haicui Wu Shuyu Chen Wenxiu Zhang Yuqing Lu Jiayi Zheng Jinhui chang Jiachi Chiou Research Institute for Future Food， The Hong Kong Polytechnic University Shenzhen Key Lab for Food Biological Safety Control， The Hong Kong Polytechnic University Shenzhen Research Institute Bo InnoHealth Biotechnology Company Limited， Hong Kong Science park Department of Food Science and Nutrition， The Hong Kong Polytechnic University Department of Neurology， The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

High-fat diet (HFD) consumption induces gut microbiota dysbiosis and neuropsychiatric disorders， including anxiety. Previous research found that Tremella polysaccharide (TP) exhibited neuroprotective effects in vitro and in vivo. This study aimed to investigate the beneficial effects of TP on HFD-induced anxiety-like behaviors and elucidate the underlying mechanisms from the point view of the microbiota-gut-brain axis. Two groups of HFD-induced obese mice were orally gavaged with low dose (TPL， 40 mg/kg) and high dose (TPH， 400 mg/kg) of TP. A 12-week administration of TPH could significantly improve anxiety-like behaviors in HFD mice. In the hippocampus， microglia activation， the expression of blood-brain barrier (BBB) markers， and the levels of two neurotransmitters (serotonin and norepinephrine) were countered by TPH in mice consuming HFD. Furthermore， TPH improved the intestinal permeability and immune response of the enterocytes in HFD-fed mice. The gut microbiota dysbiosis induced by HFD was also rebalanced by TP treatments， especially in Proteobacteria and its lower taxa. The correlational analysis also suggested that shifts of some microbial genera were closely associated with body weight and the parameters of behavioral tests. Interestingly， fecal microbiota transplantation (FMT) results indicated that fecal microbiota from TPH-treated obese mice could prevent HFD-induced anxiety-like behaviors， suppressing microglia activation and intestinal permeability. In conclusion， the present study indicated that TP intake is a promising dietary intervention strategy to prevent HFD-induced anxiety via the microbiota-gut-brain axis.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Environmental friendly synthesis of hierarchical mesoporous platinum nanoparticles templated by fucoidan biopolymer for enhanced hydrogen evolution reaction

引用

Journal of Materials Science & Technology 2020年第11期42卷 185-190页

作者： Seung man Lim Kyunglee Kang Hongje Jang Jung Tae park Department of Chemical Engineering Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Republic of Korea Department of Chemistry Kwangwoon University20 Cwangwoon-roNowon-guSeoul 01897Republic of Korea

Researching novel hydrogen evolution reaction(HER)catalysts with enhanced electrocatalytic activity,excellent stability,and cost-efficiency is of great significance for the large-scale hydrogen production from industrial electrolysis *** report the preparation of hierarchical mesoporous-Pt nanoparticles(HM-Pt NPs)with coral-like rough surface morphologies using environmental friendly and biocompatible fucoidan(Fu)biopolymer as a surface engineering compound and its application to electrocatalysts for *** designed HM-Pt NPs yields better mass activity of electrocatalysts compared to a commercial Pt/***-Pt NPs showed an overpotential of 33 mV at 10 mA cm-2 for the HER in 0.5 MH2SO4,which was highly comparable to that of the commercial Pt/C catalysts(29 mV).However,the amount of HM-Pt NPs loaded in glassy carbon electrode(0.033 mg mL-1)was approximately 20 times lower than that of the commercial Pt/C(0.64 mg *** HM-Pt NPs also maintained high catalytic stability with a consistent HER current density after 1000 continuous *** excellent HER performance is attributed to the improved electrochemical surface area,highly porous structure,and good surface wettability of the HM-Pt NPs,which results in enhanced electrocatalytic activity,decreased resistance at the electrode/electrolyte interface,and facile penetration of the electrolytes inside the electrode.

关键词： Mesoporous Fucoidan Biopolymer Low Pt content Hydrogen evolution reaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

超微针刀联合高低频重复经颅磁刺激治疗脑卒中后上肢痉挛的临床观察

引用

广州中医药大学学报 2024年第9期41卷 2259-2265页

作者：胡万春张畅畅赵曼曼张俊杰刘星广州中医药大学第五临床医学院广东广州510095 广州中医药大学第四临床医学院广东广州518033 广东省第二中医院广东广州510095

【目的】观察超微针刀联合高低频重复经颅磁刺激(rTMS)治疗脑卒中后上肢痉挛的临床疗效。【方法】将106例脑卒中后上肢痉挛患者随机分为观察组和对照组,每组各53例,2组患者均给予常规药物与运动疗法治疗,对照组给予高低频rTMS治疗,观察... 详细信息

【目的】观察超微针刀联合高低频重复经颅磁刺激(rTMS)治疗脑卒中后上肢痉挛的临床疗效。【方法】将106例脑卒中后上肢痉挛患者随机分为观察组和对照组,每组各53例,2组患者均给予常规药物与运动疗法治疗,对照组给予高低频rTMS治疗,观察组在对照组治疗的基础上,给予超微针刀治疗。2组均治疗4周。治疗2、4周后,分别评价2组临床疗效,观察2组患者治疗前后改良Ashworth量表(MAS)评分的变化情况,以及上肢Fugl-Meyer量表评分的情况。比较2组患者治疗前后Berg平衡量表(BBS)评分与改良Barthel指数(BI)评分的变化情况。并评价2组的安全性及不良反应的发生情况。【结果】(1)治疗2周后,观察组总有效率为81.13%(43/53),对照组为62.26%(33/53)。观察组疗效优于对照组,差异有统计学意义(P0.05)。【结论】超微针刀联合高低频重复经颅磁刺激治疗脑卒中后上肢痉挛,能明显改善患者的临床症状,改善患者上肢的肌力状态,提高上肢运动与平衡能力,提高患者日常生活能力,疗效显著。

关键词：超微针刀高低频重复经颅磁刺激脑卒中上肢痉挛运动功能临床观察

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Formation control and collision avoidance for multi-UAV systems based on Voronoi partition

引用

Science China(Technological Sciences) 2020年第1期63卷 65-72页

作者： HU JinWen WANG man ZHAO ChunHui PAN Quan DU chang School of Automation Northwestern Polytechnical University

This paper deals with the formation control problem of multiple unmanned aerial vehicles(UAVs) with collision avoidance. A distributed formation control and collision avoidance method is proposed based on Voronoi partition and conventional artificial potential field. The collision avoidance is achieved by partitioning the whole space into non-overlapping regions based on Voronoi partition theory, which is taken as the task region to confine the movement of each UAV. The general motion control law is designed based on the conventional artificial potential field. As this often leads to local optimum when two UAVs are going to collide with each other and they may stay still where the repulsive force is adversely equivalent to the attractive force. To address this problem,the destination switch scheme is further proposed to let UAVs switch destinations when they reach the local equilibrium. Finally,the effectiveness of proposed formation control algorithm is validated by simulations and experiments.

关键词： unmanned aerial vehicles formation control Voronoi partition artificial potential field

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vacuum states on compressible Navier-Stokes equations with general density-dependent viscosity and general pressure law

引用

Science China Mathematics 2007年第8期50卷 1173-1185页

作者： Mei-man SUN chang-jiang ZHU Laboratory of Nonlinear Analysis Department of MathematicsCentral China Normal UniversityWuhan 430079China

In this paper,we study the one-dimensional motion of viscous gas with a general pres- sure law and a general density-dependent viscosity coefficient when the initial density connects to the vacuum state with a *** prove the global existence and the uniqueness of weak solutions to the compressible Navier-Stokes equations by using the line *** this,some new a priori estimates are obtained to take care of the general viscosity coefficientμ(ρ)instead ofρ~θ.

关键词： Navier-Stokes equations density-dependent viscosity vacuum global existence 35Q30 76D05 35B45

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Probiotic Bio-Three induces Th1 and anti-inflammatory effects in PBMC and dendritic cells

引用

World Journal of Gastroenterology 2010年第28期16卷 3529-3540页

作者： man-Chin Hua Tzou-Yien Lin Chien-chang Chen Ming-Wei Lai man-Shan Kong Hung-Ju chang Department of Pediatrics chang Gung Memorial Hospital Keelung 204 Taiwan China Graduate Institute of Clinical Medical Sciences College of Medicine chang Gung University Taoyuan 333 Division of Infectious Disease Division of Gastroenterology Department of Pediatrics Chang Gung Memorial HospitalTaoyuan 333TaiwanChina

AIM:To investigate the immune response of peripheral blood mononuclear cells(PBMCs)and dendritic cells (DCs)that were stimulated by probiotic preparations. METHODS:PBMCs were isolated,cultured,and stimulated with Bio-Three(a mixture of Bacillus mesentericus, Clostridium butyricum and Enterococcus faecalis;105, 10 6 and 10 7 CFU/mL for 24 h).Cytokine production of (1)circulating PBMCs;(2)PBMCs stimulated by probiotic preparation;(3)monocyte-derived DCs;and(4)DC andT cell co-culture was determined by enzyme-linked immunosorbent *** analysis of circulating PBMCs was also investigated by flow *** was obtained from individuals who consumed Bio-Three (10 9 CFU/d ***,*** and ***) for 2 wk,or those who did not take probiotics orally. RESULTS:In culture supernatants,interferon-γ(IFN-γ) and interleukin(IL)-10 production increased,but IL-4 and tumor necrosis factor-α(TNF-α)production by PBMCs decreased after 1 and 2 wk of probiotic *** cytometry was also performed on day 14 and detected enhanced expression of CD11b,HLA-DR, CD4,CD45RA,CD25,CD44 and CD69 in response to ***,IL-10 and IL-12 were upregulated in supernatants of monocyte-derived DCs,and IFN-γand IL-10 were enhanced in supernatants of CD4 + T cells co-cultured with DCs. CONCLUSION:Bio-Three appeared to stimulate the Th1 immune response,downregulate pro-inflammatory cytokines(TNF-α)and upregulate anti-inflammatory cytokine(IL-10).Probiotics could be effective in activation of PBMCs and DCs.

关键词： Probiotics Bio-Three Peripheral blood mono- nuclear cells Dendritic cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

聚丙烯电缆及模塑接头绝缘层性能对比分析

引用

南方电网技术 2024年第6期18卷 20-28页

作者：展云鹏刘唱徐曼侯帅惠宝军朱闻博傅明利西安交通大学电气工程学院西安710049 南方电网科学研究院广州510663

聚丙烯(polypropylene,PP)具有工作温度高、绝缘性能优良和可回收再利用的优点,已成为热塑性电缆绝缘材料研发的热点。模塑接头采用与电缆本体相同的材料作为接头绝缘,不仅可以解决预制式接头可活动界面的问题,还有助于实现整个PP电缆... 详细信息

聚丙烯(polypropylene,PP)具有工作温度高、绝缘性能优良和可回收再利用的优点,已成为热塑性电缆绝缘材料研发的热点。模塑接头采用与电缆本体相同的材料作为接头绝缘,不仅可以解决预制式接头可活动界面的问题,还有助于实现整个PP电缆线路体系的绿色可回收性。首先完成了10kVPP电缆模塑接头的制作,并对PP电缆及模塑接头绝缘切片的晶体结构、电气性能和力学性能进行了研究。结果表明:与电缆绝缘切片试样相比,PP模塑接头绝缘切片试样的结晶度较高、微晶尺寸较大、熔融温度较高;电气性能上,其体积电阻率较高、介质损耗角正切值较小、工频击穿场强较高;力学性能上,其断裂伸长率较小、弹性模量较大。这可能是由于电缆与模塑接头工艺不同所致,电缆采用水冷方式进行冷却,PP在快速降温过程中形成小尺寸球晶,而模塑接头在室温下自然冷却,PP分子链充分折叠排列形成大尺寸晶体。晶体结构的不同导致了电缆绝缘与模塑接头绝缘电气性能和力学性能的差异,但二者之间仍具有较好的一致性,验证了模塑接头应用于PP电缆的可行性,并为高压PP电缆和模塑接头的进一步研发提供参考。

关键词：聚丙烯电缆模塑接头晶体结构电气性能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

2-D eddy resolving simulations of flow past a circular array of cylindrical plant stems

引用

Journal of Hydrodynamics 2018年第2期30卷 317-335页

作者： Kyoungsik chang George Constantinescu Sanghyun park School of Mechanical Engineering Ulsan University Ulsan Korea Civil and Environmental Engineering Department IIHR-Hydroscience and Engineering Stanley Hydraulics Laboratory The University of Iowa Iowa City USA Korea Aerospace Research Institute Daejeon Korea

In the present study, 2-D large eddy simulations（LES） are conducted for flow past a porous circular array with a solid volume fraction（SVF） of 8.8%, 15.4% and 21.5%. Such simulations are relevant to understanding flow in natural streams and channels containing patches of emerged vegetation. In the simulations discussed in the paper, the porous cylinder of diameter D contains a variable number of identical solid circular cylinders（rigid plant stems） of diameter d= 0.048 D. Most of the simulations are conducted at a Reynolds number of 2 100 based on the diameter D and the velocity of the steady uniform incoming flow. Though in all cases wake billows are shed in the regions where the separated shear layers（SSLs） forming on the sides of the porous cylinder interact, the effect of these wake billows on the mean drag is different. While in the high SVF case（21.5%）, the total drag force oscillates quasi-regularly in time, similar to the canonical case of a large solid cylinder, in the cases with a lower SVF the shedding of the wake billows takes place sufficiently far from the cylinder such that the unsteady component of the total drag force is negligible. The mean amplitude of the oscillations of the drag force on the individual cylinders is the largest in a streamwise band centered around the center of the porous cylinder, where the wake to wake interactions are the strongest. In all cases the maximum drag force on the individual cylinders is the largest for the cylinders directly exposed to the flow, but this force is always smaller than the one induced on a small isolated cylinder and the average magnitude of the force on the cylinders directly exposed to the flow decreases monotonically with the increase in the SVF. Predictions of the global drag coefficients, Strouhal numbers associated with the wake vortex shedding and individual forces on the cylinders in the array from the present LES are in very good agreement with those of 2-D direct numerical simulations conduc

关键词： Vegetation eddy resolving simulation solid volume fraction porous cylinder bleeding flow

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于自适应多保真度Co-Kriging代理模型的地下水污染源反演识别

引用

中国环境科学 2024年第3期44卷 1376-1385页

作者：安永凯张岩祥闫雪嫚长安大学水利与环境学院陕西西安710054 长安大学旱区地下水文与生态效应教育部重点实验室陕西西安710054 中国电建集团西北勘测设计研究院有限公司陕西西安710065 西北大学城市与环境学院陕西西安710127

为高效率高精度地进行地下水污染源反演识别,综合运用高保真度和低保真度地下水溶质运移数值模拟模型,研究应用集成差分进化算法的Co-Kriging方法建立模拟模型的多保真度代理模型;在此基础上,探索应用马尔科夫链蒙特卡洛(MCMC)-DREAM_((... 详细信息

为高效率高精度地进行地下水污染源反演识别,综合运用高保真度和低保真度地下水溶质运移数值模拟模型,研究应用集成差分进化算法的Co-Kriging方法建立模拟模型的多保真度代理模型;在此基础上,探索应用马尔科夫链蒙特卡洛(MCMC)-DREAM_((D))算法,并采用自适应更新多保真度代理模型策略进行地下水污染源反演识别.为验证上述方法的有效性和可行性,开展了数值算例研究.结果表明:相比仅基于高保真度模型输入-输出样本构建的Kriging代理模型,联合运用高保真度和低保真度模型输入-输出样本构建的Co-Kriging代理模型对模拟模型的逼近精度更高;耦合多保真度Co-Kriging代理模型和MCMC-DREAM_((D))算法能够得到较高精度的污染源反演结果,且能够大幅度减小计算负荷;同时,采用自适应更新多保真度代理模型策略能够进一步提高污染源反演识别精度.

关键词：地下水污染源多保真度代理模型 Co-Kriging方法 DREAM((D))算法自适应

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transient interactions between bubbles and a high-speed cylinder in underwater launches: An experimental and numerical study

引用

Journal of Hydrodynamics 2023年第1期35卷 36-45页

作者： Sai Zhang Qi-Hang Chen chang Liu A-man Zhang Shuai Li College of Shipbuilding Engineering Harbin Engineering UniversityHarbin150001China

The underwater launch of high-speed vehicles involves complex bubble-structure interactions,which are not currently well *** this study,two small-scale experiments are carried out involving transient bubble-cylinder *** adopt the underwater electric discharge method to generate a high-pressure bubble that drives a cylinder to a maximum velocity of∼25 m/s within 1 ms.A tail bubble forms as the cylinder is ejected from the launch ***,we observe a shoulder cavity around the head of the cylinder due to the pressure reduction in the *** better understand the complex interaction between bubbles and the high-speed cylinder,we use the boundary element method to establish a bubble—structure interaction *** numerical model reproduces the experimental observations quite well,including the cylinder motion and the transient evolution of the ***,a systematic study is carried out to reveal the dependence of the bubble-cylinder interactions on the initial pressure of the tail bubble *** obtain a scaling law for the maximum velocity of the cylinder v_(m) with respect to p_(0),namely,v_(m) ∝ p_(0)^(0.45).The findings from this study may provide a reference for subsequent research into underwater launches.

关键词： Bubble dynamics underwater launch cavitation boundary element method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：