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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2024年

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase SpeF and P450 monooxygenase SpeG, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, SpeF/SpeG metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-mA with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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能量经济性也是绿色化学的重要理念

化学教育（中英文） 2024年第15期45卷 1-6页

作者：张诗曼李存璞郑长龙四川外国语大学附属外国语学校重庆400039 重庆大学化学化工学院重庆400044 东北师范大学化学教育研究所吉林长春130024

从化学反应热力学与动力学角度出发,基于化学学科的能量思维提出“能量经济性”原则,建立绿色化学的统一认知。该原则沟通“化学平衡思想”与“反应路径优化思想”等学科思想,应用“宏观辨识与微观探析”学科思维,联络绿色化学12原则,... 详细信息

从化学反应热力学与动力学角度出发,基于化学学科的能量思维提出“能量经济性”原则,建立绿色化学的统一认知。该原则沟通“化学平衡思想”与“反应路径优化思想”等学科思想,应用“宏观辨识与微观探析”学科思维,联络绿色化学12原则,与“原子经济性”原则一起构成绿色化学新认知。通过“能量经济性”原则,可将绿色化学思想潜移默化地传递给学生,对学生深入认识化学学科与现代社会发展的关系及可持续发展策略具有重要价值。

关键词：绿色化学化学平衡反应路径优化化学反应能量学科本原

Three-dimensional reconstruction of Late Miocene Trapa from eastern Zhejiang Province,China:Insights into its phytogeography and evolution

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Journal of Palaeogeography 2024年第4期13卷 954-970页

作者： Liang Xiao man Yuan De-Shuang Ji Li-Yan Guo Xiang-Chuan Li Xing Wang Jia-Nan Wang Jia-Qi Liang Mei-Ting Wang School of Earth Science and Resources and Key Laboratory of Western Mineral Resources and Geological Engineering of the Ministry of EducationChang'an University State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of Sciences Shaanxi Key Laboratory of Early Life and Environments Northwest University State Key Laboratory of Continental Dynamics Northwest University

Abundant plant fossils were found in the Upper Miocene Shengxian Formation,eastern Zhejiang Province,China,among which Trapa belongs to a dominant *** fossil fruits of Trapa were well preserved with abundant ***,due to compaction during fossilization,Trapa fruits were often flattened,leading to the loss of some characteristic ***,a bias in taxonomic and phylogenetic studies would occur when such studies were based on these fruit *** this study,we present the first quantitative three-dimensional reconstruction of compressed Trapa fruit fossils to restore their original morphology prior to *** approach provides a novel perspective for the identification and classification of compressed fruit *** three-dimensional reconstruction of Trapa fruit fossils enabled accurate comparisons with extant *** subsequently identified it as a new species,named Trapa radiatiformis *** ***.,revealing differences from previously known taxa of ***,our comparison suggests that the long lower horns and residual stalk may represent inherent characteristics of early Trapa ***,these traits gradually degenerated during fruit evolution,resulting in morphological simplification during geological *** with primitive features exhibits good resemblance to Trapa natans fruit characteristics,which means it may be an ancestor of *** summarize the palaeogeographic distribution of fossil Trapa using previously published literature and demonstrate that the genus was mostprosperous in the Miocene and exhibited the same distribution as that at ***,through detailed morphological comparisons between Trapa and Hemitrapa fruits,along with phylogenetic analysis within the Primotrapa genus itself,we propose a homology between Trapa and Hemitrapa,suggesting that they could have a common ancestor.

关键词： Trapa Late Miocene Shengxian Formation Three-dimensional reconstruction Phytogeographic history Evolutionary history

Targeting proprotein convertase subtilisin/kexin type 9(PCSK9):from bench to bedside

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Signal Transduction and Targeted Therapy 2024年第2期9卷 509-557页

作者： Xuhui Bao Yongjun Liang Hanman chang Tianji Cai Baijie Feng Konstantin Gordon Yuekun Zhu Hailian Shi Yundong He Liyi Xie Institute of Therapeutic Cancer Vaccines Fudan University Pudong Medical CenterShanghaiChina Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghaiChina Department of Oncology Fudan University Pudong Medical CenterShanghaiChina Center for Clinical Research Fudan University Pudong Medical CenterShanghaiChina Clinical Research Center for Cell-based Immunotherapy Fudan UniversityShanghaiChina Department of Pathology Duke University Medical CenterDurhamNCUSA Center for Medical Research and Innovation Fudan University Pudong Medical CenterShanghaiChina Institute for Food Safety and Health Illinois Institute of TechnologyChicagoILUSA Department of Sociology University of MacaoTaipaMacaoChina Medical Institute Peoples’Friendship University of RussiaMoscowRussia A.Tsyb Medical Radiological Research Center ObninskRussia Department of Colorectal Surgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Shanghai Key Laboratory of Compound Chinese Medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineZhangjiang Hi-tech ParkShanghaiChina Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina

Proprotein convertase subtilisin/kexin type 9(PCSK9)has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its related cardiovascular diseases(CVD).This comprehensive review delineates the intricate roles and wide-ranging implications of PCSK9,extending beyond CVD to emphasize its significance in diverse physiological and pathological states,including liver diseases,infectious diseases,autoimmune disorders,and notably,*** exploration offers insights into the interaction between PCSK9 and low-density lipoprotein receptors(LDLRs),elucidating its substantial impact on cholesterol homeostasis and cardiovascular *** also details the evolution of PCSK9-targeted therapies,translating foundational bench discoveries into bedside applications for optimized patient *** advent and clinical approval of innovative PCSK9 inhibitory therapies(PCSK9-iTs),including three monoclonal antibodies(Evolocumab,Alirocumab,and Tafolecimab)and one small interfering RNA(siRNA,Inclisiran),have marked a significant breakthrough in cardiovascular *** therapies have demonstrated unparalleled efficacy in mitigating hypercholesterolemia,reducing cardiovascular risks,and have showcased profound value in clinical applications,offering novel therapeutic avenues and a promising future in personalized medicine for cardiovascular ***,emerging research,inclusive of our findings,unveils PCSK9’s potential role as a pivotal indicator for cancer prognosis and its prospective application as a transformative target for cancer *** review also highlights PCSK9’s aberrant expression in various cancer forms,its association with cancer prognosis,and its crucial roles in carcinogenesis and cancer *** conclusion,this synthesized review integrates existing knowledge and novel insights on PCSK9,providing a holistic perspective on its transformative impact in reshaping therapeutic paradigms acr

关键词： PCSK9 metabolism convert

Transcriptome and metabolome analysis of preharvest internal browning in Nane plum fruit caused by high temperature

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Horticultural Plant Journal 2024年第5期10卷 1099-1111页

作者： Cheng Peng Linping Deng Hejun Tan Wancong Meng Jianliang Luo Zengwen Zhang Huiqiong Chen Jishui Qiu Xiaoxiao chang Yusheng Lu Institute of Fruit Tree Research Guangdong Academy of Agricultural SciencesKey Laboratory of South Subtropical Fruit Biology and Genetic Resource UtilizationMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Tropical and Subtropical Fruit Tree ResearchGuangzhouGuangdong 510640China Lechang Lingnan Institute of Deciduous Fruit Tree Research ShaoguanGuangdong 512200China

The preharvest internal browning of Nane plum fruit,with no visible effects on the appearance of the fruit,has become a serious problem in recent years in its production area in Guangdong Province,*** study investigated the effects of environmental factors,including temperature,on Nane plum internal *** orchards at different elevations with different incidences of internal browning were *** fruits with different internal browning incidence levels,the internal browning mechanism was analyzed with transcriptome and metabolome *** results revealed decreased internal browning at high *** treatment significantly reduced internal browning,whereas bagging and insect-proof net-covering treatments significantly increased internal *** bagging and net coverings increase the local ambient temperature,the findings suggest that high temperature is an important factor influencing the internal browning of Nane *** metabolome experiments showed that with increased internal browning,the levels of phenolic hydroxyls such as catechol increased,with simultaneous increases in hydrogen peroxide content and oxidase *** can be speculated that the oxidation of phenolic hydroxyl substances is the main cause of the preharvest browning of Nane *** analysis revealed the increased expression of calcium signaling-related and downstream effector genes and indicated an important role of calcium in internal browning,possibly due to its increased content in the ***,with increasingly serious internal browning,genes related to photosynthesis were down-regulated,while genes related to senescence were up-regulated,thus suggesting the up-regulation of the process of cell senescence during internal *** conclusion,heat stress should be eliminated to reduce preharvest internal browning in Nane plum.

关键词： Nane plum Fruit internal browning High temperature Calcium

错位与归位:“平衡论”视角下环评告知承诺制审批改革

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黑龙江生态工程职业学院学报 2024年第5期37卷 56-62页

作者：苏阳吴满昌昆明理工大学法学院云南昆明650500

随着“放管服”改革的推进,环评审批在行政基础理论指导下呈现由“管理”到“控权”的转变,其中环评告知承诺制审批改革就是“控权”下的产物。但在改革过程中由于跨度较大,出现了“揠苗助长”的现象。主要表现在地方政府将效率价值置... 详细信息

随着“放管服”改革的推进,环评审批在行政基础理论指导下呈现由“管理”到“控权”的转变,其中环评告知承诺制审批改革就是“控权”下的产物。但在改革过程中由于跨度较大,出现了“揠苗助长”的现象。主要表现在地方政府将效率价值置于环境价值之上,使变革行为与环评制度的设计初衷发生了错位,打破了“管”与“控”间的平衡,突破了环评制度预防功能的底线。作为一项行政审批,环评告知承诺制审批改革既要把控“管理”的边界,同时也要把控“控权”的边界,遵循“平衡论”。实施“折衷审查”能够维持“管”与“控”间的平衡,避免环评审批改革从一个极端走向另一个极端。

关键词：环评告知承诺制平衡论折衷审查

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张量学习诱导的多视图谱聚类

计算机学报 2024年第1期47卷 52-68页

作者：陈曼笙蔡晓莎林家祺王昌栋黄栋赖剑煌中山大学计算机学院广州510006 中山大学数学学院(珠海) 广东珠海519000 广东省知识产权大数据重点实验室广州510006 华南农业大学数学与信息学院广州510642

现有的方法将通过张量奇异值分解(t-SVD)正则化的低秩表示应用到多视图子空间聚类中,取得了令人印象深刻的聚类性能.然而,它们都具有以下两个共同的缺点:(1)他们专注于探索样本之间的关系以构建表征,然后将其堆叠为张量,其计算复杂度至... 详细信息

现有的方法将通过张量奇异值分解(t-SVD)正则化的低秩表示应用到多视图子空间聚类中,取得了令人印象深刻的聚类性能.然而,它们都具有以下两个共同的缺点:(1)他们专注于探索样本之间的关系以构建表征,然后将其堆叠为张量,其计算复杂度至少为O(n2logn);(2)他们总是直接在整合的表征上运行标准的谱聚类算法,而忽略了不同表征对最终聚类结果的先验知识.为了解决这些问题,本文提出了一种新颖的张量学习诱导的多视图谱聚类(TLIMSC)方法,其中同时探索了空间聚类结构和互补信息.具体来说,该方法将关联样本和簇关系的多视图谱嵌入表示堆叠成张量,计算复杂度最终变为O(n logn).然后,将学习到的带有不同自适应置信度的表征与最终的一致聚类结果联系起来.在五个数据集上的广泛实验证明了TLIMSC所具有的有效性和高效性.

关键词：多视图聚类加权张量核范数谱嵌入表征自适应置信度

地域文化建设融入黔东农文旅融合发展的技术路径——以玉屏县老寨村建设特色田园乡村示范为例

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城市建筑 2024年第21期21卷 137-141页

作者：唐漫常镪铜仁职业技术学院雅和人居工程学院

农文旅融合已经成为实现乡村振兴、构建现代乡村产业体系、提升乡村经济价值、拓展乡村产业链条、促进城乡联动的必要手段和必然趋势。为解决实施农文旅过程中出现的各类问题、更好地指导基层工作,文章旨在通过政策研究、样本收集、案... 详细信息

农文旅融合已经成为实现乡村振兴、构建现代乡村产业体系、提升乡村经济价值、拓展乡村产业链条、促进城乡联动的必要手段和必然趋势。为解决实施农文旅过程中出现的各类问题、更好地指导基层工作,文章旨在通过政策研究、样本收集、案例研究、案例实践的方法,从理论和实践操作层面,较为系统、全面地探讨以地域文化促进乡村农文旅融合的实施技术路径,即以地域文化为内核,构建产业产品体系丰富产业生态,并以地域文化贯穿规划、设计、建设、运营全过程,为行业和政府基层更好地落实乡村振兴工作提供一定的参考价值。

关键词：地域文化农文旅融合农业旅游化产业产品体系

Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits

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Plant Communications 2024年第6期5卷 173-192页

作者： Xue-Mei Lu Xiao-Fen Yu Guo-Qiang Li Ming-Hao Qu Huan Wang Chuang Liu Yu-Ping man Xiao-Han Jiang Mu-Zi Li Jian Wang Qi-Qi Chen Rui Lei Cheng-Cheng Zhao Yun-Qiu Zhou Zheng-Wang Jiang Zuo-Zhou Li Shang Zheng chang Dong Bai-Lin Wang Yan-Xiang Sun Hui-Qin Zhang Jie-Wei Li Quan-Hui Mo Ying Zhang Xin Lou Hai-Xu Peng Ya-Ting Yi He-Xin Wang Xiu-Jun Zhang Yi-Bo Wang Dan Wang Li Li Qiong Zhang Wen-Xia Wang Yongbo Liu Lei Gao Jin-Hu Wu Yan-chang Wang CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubeiChina Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansuChina College of Life Sciences University of Chinese Academy of SciencesBeijingChina Wuhan Frasergen Bioinformatics Co. LtdWuhanHubeiChina Institute of Soil and Fertilizer Anhui Academy of Agricultural SciencesHefeiChina College of Agricultural Sciences Xichang UniversityXichangSichuanChina Department of Horticulture Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiangChina College of Life Sciences Langfang Normal UniversityLangfangHebeiChina Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiangChina Guangxi Institute of Botany Chinese Academy of SciencesGuilinGuangxiChina Xi’an Botanical Garden of Shaanxi Province Institute of Botany of Shaanxi ProvinceXi’anShaanxiChina Institute of Modern Agricultural Research Dalian UniversityDalianLiaoningChina Bioinformatics Center College of Plant Science and TechnologyBeijing University of AgricultureBeijingChina College of Agriculture Eastern Liaoning UniversityDandongLiaoningChina Dalian Institute of Chemical Physics Chinese Academy of SciencesDalianLiaoningChina State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijingChina Hubei Hongshan Laboratory WuhanHubeiChina The New Zealand Institute for Plant and Food Research Limited AucklandNew Zealand

Actinidia arguta,the most widely distributed Actinidia species and the second cultivated species in the genus,can be distinguished from the currently cultivated Actinidia chinensis on the basis of its small and smooth fruit,rapid softening,and excellent cold *** evolution of tetraploid Actinidia species and the genetic basis of their important agronomic traits are still ***,we generated a chromosome-scale genome assembly of an autotetraploid male *** *** genome assembly was 2.77 Gb in length with a contig N50 of 9.97 Mb and was anchored onto 116 *** and clustering of 101 geographically representative accessions showed that they could be divided into two geographic groups,Southern and Northern,which first diverged 12.9 million years *** underwent two prominent expansions and one demographic bottleneck from the midPleistocene climate transition to the late *** genomics studies using paleoclimate data enabled us to discern the evolution of the species’adaptation to different historical *** genes(AaCEL1,AaPME1,and AaDOF1)related to flesh softening were identified by multi-omics analysis,and their ability to accelerate flesh softening was verified through transient expression assays.A set of genes that characteristically regulate sexual dimorphism located on the sex chromosome(Chr3)or autosomal chromosomes showed biased expression during stamen or carpel *** chromosome-level assembly of the autotetraploid *** genome and the genes related to important agronomic traits will facilitate future functional genomics research and improvement of ***.

关键词： kiwiberry dioecism adaptive evolution paleoclimate GEA rapid softening