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Polycrystalline diamond mini-cubes for sawing applications

金刚石与磨料磨具工程 2008年第S1期28卷 83-87页

作者： Sung James C. chang kuen-liang Tso Pei-lum Hsu Kai-hung Sung Michael KINIK Company 64Chung-San Rd.Ying-Kuo National Taiwan University National Taipei University of Technology PME Dept.National Tsing Hua University Advanced Diamond Solutions Inc.351 King Street Suite 813San FranciscoCA 94158U.S.A.

Diamond grits are indispensable for sawing granite or *** year about 1 000 tons of diamond grits are consumed for such *** all cases,mono crystalline diamond is ***, polycrystalline grits(polygrits) are generally better performed than mono grits as *** example,poly grits of cubic boron nitride(***(?) CBN-550 of Diamond Innovations) can cut faster and they last longer than mono grits(***(?) CBN-500). Polygrits of alumina(***(?) of 3M) also out perform by far glassy grits(*** alumina).For diamond superabrasives,micron polygrits formed by shock waves may polish as fast as mono grits of the same size,but without causing as much scratches due to the presence of smaller sintered *** improved performance of poly grits is attributed to their ability to micro chipping that renews the sharp cutting corners from time to *** contrast,mono grits tend to round off at low cutting force or macro fracture at high cutting force,so they may lose the cutting ability rapidly. For sawing granite with mesh sizes 40/50 or coarser,poly grits of diamond have not been available until *** this research,we have made polygrits in mini cube with sizes of 18/20,20/25,and 30/*** grinders and wire saws were made by brazing both mono grits and polygrits on steel *** performance on granite demonstrated that grinding speed was faster with turbo grinder,and the surface finish was smoother with wire saw for poly grits than mono ones. Polygrits and mono grits of diamond were mixed for comparison(upper left).Polygrits of mini cubes were brazed on the pearl of a wire saw(upper right).Mono diamond grits were brazed on a turbo grinder(bottom diagrams ).

关键词： granite sawing diamond grits polygrits turbo grinder wire saw

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Ultrahigh pressure sintering of polycrystalline diamond cubes

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金刚石与磨料磨具工程 2008年第S1期28卷 70-76,79页

作者： Hu Shao-Chung chang kuen-liang Sung James C. Tso Pei-Lum Hsu Kai-Hung Sung Michael KINIK Company 64Chung-San Rd.Ying-Kuo National Taipei University of Technology National Taiwan University PME Dept.National Tsing Hua University Advanced Diamond Solutions Inc.351 King Street Suite 813San FranciscoCA 94158U.S.A.

Polycrystalline grits(polygrits) have been used widely in industry as *** to their higher impact strength and the friable nature,polygrits are more endurable and more efficient than monocrystal grits (monogrits) in material removal *** example,polygrits of alumina may last longer and cut faster than ***,polygrits of cubic boron nitride is a superior superabrasive than monogrits of the same. Although diamond superabrasives have been indispensable for constructional sawing applications and industrial grinding applications,there has no polygrits of diamond that are commercially *** this research,we used a novel technology to sinter micron diamond fines to form polygrits of *** characterization demonstrated that polygrits of diamond can be tough to withstand *** due to the presence of micro grains,the grit can sharpen itself without dulling by shedding the worn *** paper revealed many examples of using diamond polygrits.

关键词： PCD superabrasives diamond grits CMP pad conditioners

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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Efficient and simple synthesis of B_(2)O_(3)-Al_(2)O_(3)nanocomposites assisted by deep eutectic solvent for production of 5-hydroxymethylfurfural from glucose

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Nano Research 2025年第1期18卷 236-248页

作者： Yuchen Wang Kai Rong Shanlei chang Youxing Fang Shaojun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry Jilin UniversityChangchun 130012China

The catalytic conversion of glucose to high valueadded platform chemical 5-hydroxymethylfurfural(HMF)is a promising biorefinery process,and alumina-boria catalysts are considered to be green and mild solid acid catalysts for this catalytic ***,compared to the common synthesis methods with complicated steps,we reported a simple and efficient strategy to prepare B_(2)O_(3)-Al_(2)O_(3)nanocomposites by calcining cost-effective glucose-urea deep eutectic solvent(DES)solution containing the *** prepared B_(2)O_(3)-Al_(2)O_(3)nanocomposites exhibited an open three-dimensional skeleton and two-dimensional porous lamellar substructure,endowing them with a high specific surface area(228.27 m2/g).The introduction of boron changed the ratios of different aluminum species(AlⅣ,AlⅤ,and AlⅥ)and borate species(BO3 and BO4),thus further affecting the acidity and the types of acid sites of the *** prepared B_(2)O_(3)-Al_(2)O_(3)bifunctional acid catalysts possessing abundant Lewis acid sites and adjustable Brønsted acid sites showed complete glucose conversion and 55.38%of HMF yield under the optimum *** study proposed a concise method to synthesize alumina-boria solid acid catalysts assisted by glucose-urea *** hope to extend the application and prospect of this efficient and simple synthesis strategy.

关键词： 5-hydroxymethylfurfural(HMF) deep eutectic solvent glucose alumina-boria acid catalyst

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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A Vanishing Result for Donaldson Thomas Invariants of P^1 Scroll

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Acta Mathematica Sinica,English Series 2014年第12期30卷 2079-2084页

作者： Huai liang chang Department of Mathematics Hong Kong University of Science and Technology

Let S be a smooth algebraic surface and let L be a line bundle on *** there is a holomorphic two form over S with zero loci to be a curve *** show that the DonaldsonThomas invariant of the P^1 scroll X = P（L＋Бs） vanishes unless the curves being enumerated lie in D = P（L︱C＋БC）.Our method is cosection localization of Y.-*** and ***.

关键词： Cosection DT invariants two form

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Community detection with attributed random walk via seed replacement

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Frontiers of Computer Science 2022年第5期16卷 45-56页

作者： Yang chang Huifang MA liang chang Zhixin LI College of Computer Science and Engineering Northwest Normal UniversityLanzhou 730070China Guangxi Key Lab of Multi-source Information Mining and Security Guangxi Normal UniversityGuilin 541004China Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin 541004China

Community detection methods based on random walks are widely adopted in various network analysis *** could capture structures and attributed information while alleviating the issues of *** random walks on plain networks have been studied before,in real-world networks,nodes are often not pure vertices,but own different characteristics,described by the rich set of data associated with *** node attributes contain plentiful information that often complements the network,and bring opportunities to the random-walk-based ***,node attributes make the node interactions more complicated and are heterogeneous with respect to topological ***,attributed community detection based on random walk is challenging as it requires joint modelling of graph structures and node *** bridge this gap,we propose a Community detection with Attributed random walk via Seed replacement(CAS).Our model is able to conquer the limitation of directly utilize the original network topology and ignore the attribute *** particular,the algorithm consists of four stages to better identify communities.(1)Select initial seed nodes in the network;(2)Capture the better-quality seed replacement path set;(3)Generate the structure-attribute interaction transition matrix and perform the colored random walk;(4)Utilize the parallel conductance to expand the *** on synthetic and real-world networks demonstrate the effectiveness of CAS.

关键词： community detection seeds colored random walk parallel conductance

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Calpain mediated cisplatin-induced ototoxicity in mice

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Neural Regeneration Research 2013年第21期8卷 1995-2002页

作者： liang chang Aimei Wang Party and Government Affairs Office Jinzhou Central Hospital Department of Physiology Liaoning Medical University

Ototoxic drug-induced apoptosis of inner ear cells has been shown to be associated with calpain expression. Cisplatin has severe ototoxicity, and can induce cochlear cell apoptosis. This study assumed that cisplatin activated calpain expression in apoptotic cochlear cells. A mouse model of cisplatin-induced ototoxicity was established by intraperitoneal injection with cisplatin （2.5, 3.5, 4.5, 5.5 mg/kg）. Immunofluorescence staining, image analysis and western blotting were used to detect the expression of calpain 1 and calpain 2 in the mouse cochlea. At the same time, the auditory brainstem response was measured to observe the change in hearing. Results revealed that after intraperitoneal injection with cisplatin for 5 days, the auditory brainstem response threshold shifts increased in mice. Calpain 1 and calpain 2 expression significantly increased in outer hair cells, the spiral ganglion and stria vascularis. Calpain 2 protein expression markedly increased with an increased dose of cisplatin. Results suggested that calpain 1 and calpain 2 mediated cisplatin-induced ototoxicity in BALB/c mice. During this process, calpain 2 plays a leading role.

关键词： neural regeneration biological factor cisplatin mice cochlea apoptosis calpain auditory brainstem response ototoxicity immunofluorescence staining image analysis technique western blotting grants-supported paper neuroregeneration

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Preparation of TiO_2-MoO_3 nano-composite photo-catalyst by supercritical fluid dry method

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Journal of Environmental Sciences 2005年第2期17卷 350-352页

作者： ZHANGJing-chang LIQing CAOWei-liang

A series of TiO 2-MoO 3 nano-composite photocatalysts were prepared by supercritical fluid dry method(SCFD) and an impregnation technique with TiCl 4 and (NH 4) 6Mo 7O 24 ·4H 2O as the starting materials. The catalysts were characterized by the means of XRD, TEM and UV-Vis. Methyl orange was used as model compound for the evaluation of their catalytic activities. The results indicated that the photo-catalyst prepared by SCFD had the advantages of small size(12.84 nm), narrow distribution and good dispersivity. The presence of small amount of Mo in composite catalyst gives rise to the red shift of its absorbance wavelength, decrease of its energy gap and increase of the utility of visible light. Furthermore, higher surface acidity of the photo-catalyst was obtained as the result of the addition of MoO 3. Compared with pure TiO 2, the catalytic activity of the TiO 2-MoO 3 nano-composite photo-catalyst was improved significantly. As the doping concentration of the composite catalysts was controlled at 0.6%(molar percentage), 100% degradation of methyl orange was achieved with in 1.2 h irradiation time.

关键词： TiO 2 MoO 3 photocatalytic supercritical fluid dry method

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