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Behavioral consequences of children with sleep-disordered breathing after adenotonsillectomy

World Journal of Pediatrics 2018年第1期14卷 57-65页

作者： Ji Yoon Kim chang ho Lee Hyoung-Mi Kim Otorhinolaryngology Department CHA UniversitySeongnamKorea Otorhinolaryngology Department CHA Bundang MedicalCenterCHA University351Yatap-dongBundang-guSeongnam-siGyeonggi-do463-712Korea

Background Adenotonsillectomy (AT) has been an effective treatment for sleep-disordered breathing (SDB) in children, and several studies described the risk of postoperative weight gain and obesity in children treated with AT. The present study aimed to evaluate behavioral improvements in children with SDB one year after adenotonsillectomy and to investigate an influence of postoperative weight gain on behaviors. Methods The study included 170 children aged 5–11 years who underwent adenotonsillectomy for SDB and 150 controls. Body mass index percentile was obtained for age and gender, and parental sleep-related breathing disorder (SRBD) question-naire was used to assess the severity of SDB. Psychological assessment was performed pre- and post-adenotonsillectomy using standardized questionnaires including strength and difficulties questionnaire, children's depression inventory and screen for child anxiety-related emotional disorder. Results The mean age of 170 patients was 7.7 ± 1.5 years with 73 (42.9%) girls and 97 (57.1%) boys. The mean follow-up period were 15.4 ± 2.7 months. The patients had shown significant improvements in SDB scores as well as in questionnaire-based behavioral problems after adenotonsillectomy. The odds of a child being overweight were significantly increased after adenotonsillectomy. Less improvements in hyperactivity and conduct problems were observed in the patients with older ages, higher SRBD scores, and overweight/obesity at 1-year follow-up after adenotonsillectomy. Conclusion These data suggest that abnormal behavioral outcomes should be evaluated postoperatively, which potentially could be reduced with the early adenotonsillectomy and adequate postoperative weight control.

关键词： Obesity Obstructive sleep apnea Pediatric Snoring Tonsillectomy

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Prospects for nucleic acid-based therapeutics against hepatitis C virus

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World Journal of Gastroenterology 2013年第47期19卷 8949-8962页

作者： chang ho Lee Ji Hyun Kim Seong-Wook Lee Department of Molecular Biology Institute of Nanosensor and BiotechnologyDankook UniversityYongin 448-701South Korea

In this review,we discuss recent advances in nucleic acid-based therapeutic technologies that target hepatitis C virus(HCV)*** the HCV genome is present exclusively in RNA form during replication,various nucleic acid-based therapeutic approaches targeting the HCV genome,such as ribozymes,aptamers,siRNAs,and antisense oligonucleotides,have been suggested as potential tools against *** acids are potentially immunogenic and typically require a delivery tool to be utilized as *** limitations have hampered the clinical development of nucleic acid-based ***,despite these limitations,nucleic acid-based therapeutics has clinical value due to their great specificity,easy and large-scale synthesis with chemical methods,and pharmaceutical ***,nucleic acid therapeutics are expected to broaden the range of targetable molecules essential for the HCV replication cycle,and therefore they may prove to be more effective than existing therapeutics,such as interferon-αand ribavirin combination *** review focuses on the current status and future prospects of ribozymes,aptamers,siRNAs,and antisense oligonucleotides as therapeutic reagents against HCV.

关键词： Hepatitis C virus Nucleic acid-based therapeutics Ribozyme Aptamer siRNA Antisense oligonucleotide

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PREPARATION AND PROPERTIES OF MMA/1-PROPYLMETHACRYLATE-POSS COPOLYMER WITH ATOM TRANSFER RADICAL POLYMERIZATION

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Chinese Journal of Polymer Science 2008年第5期26卷 533-537页

作者： He-xin Zhang ho-young Lee Young-jun shin Dong-ho Lee Seok Kyun Noh Department of Polymer Science and Engineering Kyungpook National UniversityDaegu 702-701Korea School of Display and Chemical Engineering Yeungnam UniversityGyeongsan 712-749Korea

The methyl methacrylate(MMA)/1-propylmethacrylate-polyhedral oligomeric silsesquioxane(PM-POSS) copolymers were synthesized via atom transfer radical polymerization with CuBr as *** unreacted PM-POSS monomer could be removed completely by washing the copolymerization product with *** copolymers were characterized with ~1H-NMR,X-ray diffraction,differential scanning calorimetry,thermogravimetric analysis and gel permeation *** increasing PM-POSS feed ratio,the total conversi...

关键词： Methyl methacrylate(MMA) Polyhedral oligomeric silsesquioxane(POSS) Copolymer ATRP

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Retrieval of Outgoing Longwave Radiation from COMS Narrowband Infrared Imagery

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Advances in Atmospheric Sciences 2015年第3期32卷 375-388页

作者： Myung-Sook PARK chang-hoi ho Heeje Cho Yong-Sang ChoI School of Earth and Environmental Sciences Seoul National UniversitySeoul Korea School of Urban and Environmental Engineering Ulsan National Institute of Science & TechnologyUlsan Korea Computational Science and Technology Seoul National UniversitySeoul Korea Computational Science and Technology Seoul National UniversitySeoul Korea Department of Environmental Science and Engineering Ewha Womans UniversitySeoul Korea

hourly outgoing longwave radiation （OLR） from the geostationary satellite Communication Oceanography Meteorological Satellite （COMS） has been retrieved since June *** COMS OLR retrieval algorithms are based on regression analyses of radiative transfer simulations for spectral functions of COMS infrared *** study documents the accuracies of OLRs for future climate applications by making an intercomparison of four OLRs from one single-channel algorithm （OLR12.0 using the 12.0 μm channel） and three multiple-channel algorithms （OLR10.8＋12.0 using the 10.8 and 12.0 pm channels; OLR6.7＋10.8 using the 6.7 and 10.8 μm channels; and OLRAll using the 6.7,10.8,and 12.0 μm channels）.The COMS OLRs from these algorithms were validated with direct measurements of OLR from a broadband radiometer of the Clouds and Earth＇s Radiant Energy System （CERES） over the full COMS field of view [roughly （50°S-50°N,70°-170°E）] during April *** results show that the root-mean-square errors of COMS OLRs are 5-7 W m-2,which indicates good agreement with CERES OLR over the vast ***6.7＋10.8 and OLRAll have much smaller errors （～ 6 W m-2） than OLR12.0 and OLR10.8＋12.0 （～ 8 W m-2）.Moreover,the small errors of OLR6.7＋10.8 and OLRAll are systematic and can be readily reduced through additional mean bias correction and/or radiance *** results indicate a noteworthy role of the 6.7 μm water vapor absorption channel in improving the accuracy of the *** dependence of the accuracy of COMS OLRs on various surface,atmospheric,and observational conditions is also discussed.

关键词： outgoing longwave radiation Communication Oceanography and Meteorological Satellite Cloud and Earth's Radiant Energy System

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Optical diffraction gratings embedded in BK-7 glass by low-density plasma formation using femtosecond laser

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 165-169页

作者： Jung-Kyu PARK Sung-Hak Cho Kwang-ho KIM Myung-chang KANG Nano Machining Laboratory Korea Institute of Machinery and Material Daejeon 305-343 Korea National Core Research Center for Hybrid Materials Solution Pusan National University

The optical embedded diffraction gratings with the internal refractive index modification in BK-7 glass plates were demonstrated using low-density plasma formation excited by a high-intensity femtosecond （130 fs） Ti： sapphire laser （λp=790 rim）. The refractive index modifications with diameters ranging from 400 nm to 4 gm were photoinduced after plasma formation occurred upon irradiation with peak intensities of more than 1 ×10^13 W/cm2. The graded refractive index profile was fabricated to be a symmetric around the center of the point at which low-density plasma occurred. The maximum refractive index change （An） was estimated to be 1.5x10 2. Several optical embedded gratings in BK-7 glass plate were demonstrated with refractive index modification induced by the scanning of low-density plasma formation.

关键词： BK-7 glass plate diffraction grating refractive index modification plasma formation femtosecond laser

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Spatial distribution and comparative evaluation of phosphorus release rate in benthic sediments of an estuary dam

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International Journal of Sediment Research 2022年第3期37卷 355-369页

作者： Yongsik Song Yong-hoon Jeong chang-Min shin Dong-Heui Kwak Geosystem Research Corporation Department of Civil Engineering Jeonbuk National University Department of Bio-Convergence Science Jeonbuk National University Water Quality Assessment Research Division National Institute of Environmental Research Department of Bioactive Materials Science Jeonbuk National University

A series of experiments and simulations were performed to ascertain the rate at which phosphorus is released using a water quality model in Saemangeum Lake, an artificially constructed lake located in an estuary. The general inflow of seawater once a day contributed to the formation of a halocline in the lake water, which caused variation in the vertical concentration of dissolved oxygen. The halocline was mainly observed in the deep downstream regions of Saemangeum Lake that are close to the open sea. In contrast, the shallower regions upstream, which are under the influence of pollutant-loading from upstream rivers, exhibited high concentrations of chemical oxygen demand, total phosphorus, and Chl-a,resulting in lower water quality than the downstream regions. Laboratory experiments investigating the release of phosphorus at five representative locations showed that the upstream release flux, where the halocline was weaker, was higher than that downstream, where the initial level of phosphorus sedimentation was high. In particular, a need for an accurate evaluation method for the release of phosphorus at each site was suggested as slight differences were obtained depending on the estimation method used at each representative location. The results of the phosphorus release experiments led to the use of time-weighted integration(TWI), terminated time evaluation, and statistical mean value; the Environmental Fluid Dynamics Code-National Institute of Environment Research model, a widely used water quality model for studying retention watersheds, was applied to the simulation of hydraulic and water quality characteristics for the Saemangeum Lake and its surrounding waters. The result of the water quality simulation indicated the highest reproducibility for release-time TWI so that TWI values were more useful in predicting phosphorus concentrations and the subsequent management of water quality.

关键词： Eutrophication Phosphorus release Salinity Sediments Water quality simulation Environmental Fluid Dynamics Code–National Institute of Environment Research model (EFDC-NIER)

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Controlled mutual quantum entity authentication using entanglement swapping

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Chinese Physics B 2015年第9期24卷 116-124页

作者： Min-Sung Kang chang-ho hong Jino Heo Jong-In Lim Hyung-Jin Yang Center for Information Security Technologies (CIST) Korea University Graduate School of Information Security Korea University Department of Physics Korea University

In this paper, we suggest a controlled mutual quantum entity authentication protocol by which two users mutually certify each other on a quantum network using a sequence of Greenberger–horne–Zeilinger（GHZ）-like states. Unlike existing unidirectional quantum entity authentication, our protocol enables mutual quantum entity authentication utilizing entanglement swapping; moreover, it allows the managing trusted center（TC） or trusted third party（TTP） to effectively control the certification of two users using the nature of the GHZ-like state. We will also analyze the security of the protocol and quantum channel.

关键词： quantum authentication quantum cryptography quantum communication GHZ-like state

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Memristive Devices Based on Two-Dimensional Transition Metal Chalcogenides for Neuromorphic Computing

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Nano-Micro Letters 2022年第4期14卷 29-58页

作者： Ki chang Kwon Ji Hyun Baek Kootak hong Soo Young Kim ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and Science(KRISS)Daejeon 34133Republic of Korea Department of Materials Science and Engineering Institute of Green Manufacturing TechnologyKorea UniversitySeoul 02841Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

Two-dimensional(2D)transition metal chalcogenides(TMC)and their heterostructures are appealing as building blocks in a wide range of electronic and optoelectronic devices,particularly futuristic memristive and synaptic devices for brain-inspired neuromorphic computing *** distinct properties such as high durability,electrical and optical tunability,clean surface,flexibility,and LEGO-staking capability enable simple fabrication with high integration density,energy-efficient operation,and high *** review provides a thorough examination of high-performance memristors based on 2D TMCs for neuromorphic computing applications,including the promise of 2D TMC materials and heterostructures,as well as the state-of-the-art demonstration of memristive *** challenges and future prospects for the development of these emerging materials and devices are also *** purpose of this review is to provide an outlook on the fabrication and characterization of neuromorphic memristors based on 2D TMCs.

关键词： Two-dimensional materials Memristors Neuromorphic computing Artificial synapses Transition metal chalcogenides

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Comparative study on discharge conditions in micro-hole electrical discharge machining of tungsten carbide (WC-Co) material

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中国有色金属学会会刊：英文版 2009年第B9期19卷 114-118页

作者： Hyun-Seok TAK chang-Seung HA Dong-Hyun KIM ho-Jun LEE Hae-June LEE Myung-chang KANG National Core Research Center for Hybrid Materials Solution Pusan National University Department of Electrical Engineering Pusan National University

WC-Co is used widely in die and mold industries due to its unique combination of hardness, strength and wear-resistance. For machining difficult-to-cut materials, such as tungsten carbide, micro-electrical discharge machining(EDM) is one of the most effective methods for making holes because the hardness is not a dominant parameter in EDM. This paper describes the characteristics of the discharge conditions for micro-hole EDM of tungsten carbide with a WC grain size of 0.5 μm and Co content of 12%. The EDM process was conducted by varying the condenser and resistance values. A R-C discharge EDM device using arc erosion for micro-hole machining was suggested. Furthermore, the characteristics of the developed micro-EDM were analyzed in terms of the electro-optical observation using an oscilloscope and field emission scanning electron microscope.

关键词：电火花加工碳化钨钴难切削材料硬质合金放电扫描电子显微镜微孔模具行业

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Characteristic evaluation of Al_2O_3/CNTs hybrid materials for micro-electrical discharge machining

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 28-32页

作者： Hyun-Seok TAK chang-Seung HA ho-Jun LEE Hyung-Woo LEE Young-Keun JEONG Myung-chang KANG National Core Research Center for Hybrid Materials Solution Pusan National University Department of Electrical Engineering Pusan National University

The characteristic evaluation of aluminum oxide （A1203）/carbon nanotubes （CNTs） hybrid composites for micro-electrical discharge machining （EDM） was described. Alumina matrix composites reinforced with CNTs were fabricated by a catalytic chemical vapor deposition method. A1203 composites with different CNT concentrations were synthesized. The electrical characteristic of A1203/CNTs composites was examined. These composites were machined by the EDM process according to the various EDM parameters, and the characteristics of machining were analyzed using field emission scanning electron microscope （FESEM）. The electrical conductivity has a increasing tendency as the CNTs content is increased and has a critical point at 5% A1203 （volume fraction）. In the machining accuracy, many tangles of CNT in A1203/CNTs composites cause violent spark. Thus, it causes the poor dimensional accuracy and circularity. The results show that conductivity of the materials and homogeneous distribution of CNTs in the matrix are important factors for micro-EDM of A1203/CNTs hybrid composites.

关键词： A1203/CNTs hybrid materials micro-electrical discharge machining micro-hole electrical conductivity

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