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Metachronous squamous cell carcinoma of pancreas and stomach in an elderly female patient:A case report

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World Journal of Clinical Cases 2021年第31期9卷 9680-9685页

作者： Ji Hyun Kim chang don kang Kyungyul Lee Kyu-Hyoung Lim Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24341Kangwon DoSouth Korea Department of Pathology Kangwon National University School of MedicineChuncheon 24341Kangwon DoSouth Korea

BACKGROUND Squamous cell carcinoma(SCC)in pancreas and stomach is a rare histologic subtype with aggressive behavior,poor prognosis,and no standardized *** SCC or gastric SCC has been previously ***,case of SCC occurring in both the pancreas and the stomach has not been reported *** SUMMARY A 75-year-old female with prior history of hypertension and diabetes mellitus visited our hospital with complaint of abdominal pain that started three months *** tomography(CT)scan of the abdomen showed 3.3 cm mass at the distal *** received surgical resection which was histologically found to be SCC of the pancreas with clear resection *** she was discharged,she no longer visited the *** years later,she was referred to our hospital after showing abnormal findings on a gastroscopy performed at another *** revealed a single,2cm sized,ill-defined irregular flat and hyperemic mass at high *** finding of the mass was *** scan and positive emission tomography CT showed metastatic lesions to the liver and the *** received combination chemotherapy with capecitabine and ***,she passed away 6 mo after diagnosis of gastric *** To the best of our knowledge,this is the first case of metachronous SCC of stomach occurring after diagnosis of pancreatic SCC.

关键词： Squamous cell carcinoma Pancreas Stomach Metachronous Pancreatectomy Case report

Cholecystoduodenal fistula presenting with upper gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2021年第2期9卷 410-415页

作者： Jin Myung Park chang don kang Ji Hyun Kim Sang Hoon Lee Seung-Joo Nam Sung Chul Park Sung JoonLee Seungkoo Lee Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289Kangwon DoSouth Korea Department of Gastroenterology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea Anatomy and Pathology Kangwon National University School of MedicineChuncheon 200947Kangwon DoSouth Korea Department of Pathology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea

BACKGROUND Cholecystoduodenal fistula is a rare complication of *** are usually non-specific and often indistinguishable from those of etiologic diseases,but it rarely presents as severe gastrointestinal *** associated with cholecystoduodenal fistula usually requires surgery because significant bleeding from the cystic artery is unlikely to be resolved by conservative management or endoscopic *** SUMMARY We report a case of cholecystoduodenal fistula that presented with hematemesis which was diagnosed by endoscopy and computed *** hemostasis could not be achieved,but surgical treatment was ***,we have presented a literature *** Cholecystoduodenal fistula should be considered as differential diagnosis when a patient with history of gallstone disease presents with gastrointestinal bleeding.

关键词： Biliary fistula Hematemesis Cholecystitis Gallstones Cholecystectomy Case report

Occult gastric cancer with distant metastasis proven by random gastric biopsy

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World Journal of Gastroenterology 2016年第16期22卷 4270-4274页

作者： Sang Hyuk Lee Kyu-Hyoung Lim Seo-Young Song Hui-Young Lee Sung Chul Park chang don kang Sung Joon Lee dong Wook Choi Sung Bae Park Young-Joon Ryu Department of Internal Medicine Kangwon National University School of Medicine Department of General Surgery Kangwon National University School of Medicine Department of Pathology Kangwon National University School of Medicine

Krukenberg tumor, a rare metastatic ovarian tumor arising from gastrointestinal adenocarcinoma mainly, tends to occur in premenopausal females. Finding the origin of a Krukenberg tumor is crucial for determining prognosis. In Eastern countries, the most common origin of Krukenberg tumor is stomach cancer, which is generally diagnosed via endoscopic biopsy to investigate an abnormal mucosal lesion. Here, we describe a case of huge adnexal mass in a 33-year-old woman who presented with abdominal distension. Two independent endoscopic examinations performed by experts in two tertiary university hospitals revealed no abnormal mucosal lesion. The patient was diagnosed with a Krukenberg tumor according to findings from random endoscopic biopsies taken from normal-looking gastric mucosa in our hospital. It is very rare to be diagnosed via a random biopsy in cases where three well-trained endoscopists had not found any mucosal lesion previously. Thus, in this case, random biopsy was helpful in finding the origin of a Krukenberg tumor.

关键词： Gastric cancer Krukenberg tumor Biopsy Endoscopy Diagnosis

Nonalcoholic fatty liver disease is associated with coronary artery disease in Koreans

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World Journal of Gastroenterology 2013年第38期19卷 6453-6457页

作者： Dae Hee Choi Sung Joon Lee chang don kang Myoung Ok Park dong Wook Choi Tae Suk Kim Wonho Lee Byung Ryul Cho Yong Hoon Kim Bong-ki Lee dong Ryeol Ryu Ji Won Lee Department of Internal Medicine Kangwon National University School of Medicine Department of Radiology Kangwon National University School of Medicine

AIM:To investigate whether nonalcoholic fatty liver disease(NAFLD)affects coronary artery disease(CAD)and identify candidate ***:Patients who underwent coronary angiography were consecutively *** patients were classified into four groups by coronary artery stenosis:A,insignificant;B,one-vessel disease;C,two-vessel disease;and D,three-vessel *** ultrasonography was performed to determine the presence of a fatty liver and categorize by grade:0,no evidence;1,mild;2,moderate;and 3,*** measured not only known CAD risk factors,but also serum insulin,HOMA-index,adiponectin,interleukin-6,tumor necrosis factor-αand high-sensitivity C-reactive protein ***:Of the 134 patients who met the inclusion criteria,82(61.2%)had ultrasonographically diagnosed *** the 46 patients with CAD,37(80.4%)had evidence of a fatty *** two groups(A vs B-D)were significantly different in terms of age,total cholesterol,triglycerides,low-density lipoprotein levels and fatty *** artery stenosis was strongly associated with fatty liver in a grade-dependent manner(P=0.025).In binary logistic regression,NAFLD was a significant independent predictor of CAD(P=0.03,OR=1.685;95%CI:1.051-2.702).Among the candidate mediators,the serum adiponectin level showed a trend toward lowering based on CAD progression(P=0.071).CONCLUSION:NAFLD is an independent risk factor for CAD in a grade-dependent ***,adiponectin might be related to the pathogenesis of NAFLD.

关键词： Nonalcoholic fatty liver disease Coronary artery disease Coronary angiography Adiponectin Insulin resistance

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-kang Chen Ming-Ming Cao Yao-Wen chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-chang Zeng Jun-Hong Wu Dan-Dan Xu kang He chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Theory of phonon-modulated electron spin relaxation time based on the projection reduction method

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Chinese Physics B 2014年第8期23卷 436-443页

作者： Nam Lyong kang Sang don Choi Department of Applied Nanoscience Pusan National University Department of Physics Kyungpook National University

This paper introduces a new method for a formula for electron spin relaxation time of a system of electrons interacting with phonons through phonon-modulated spin-orbit coupling using the projection-reduction method. The phonon absorption and emission processes as well as the photon absorption and emission processes in all electron transition processes can be explained in an organized manner, and the result can be represented in a diagram that can provide intuition for the quantum dynamics of electrons in a solid. The temperature （T） dependence of electron spin relaxation times （T1） in silicon is T1 ∝ T-1.07 at low temperatures and T1 ∝ T-3.3 at high temperatures for acoustic deformation constant Pad = 1.4 × 10^7 eV and optical deformation constant Pod = 4.0 × 10^17 eV/m. This means that electrons are scattered by the acoustic deformation phonons at low temperatures and optical deformation phonons at high temperatures, respectively. The magnetic field （B） dependence of the relaxation times is T1 ∝ B-2.7 at 100 K and T1 ∝ B-2.3 at 150 K, which nearly agree with the result of Yafet, T1 ∝ B-3.0- B -2.5.

关键词： electron spin resonance spin-orbit coupling projection-reduction method phonon scattering

Gravity-triggered rotational connecting method for automated segmental bridge construction

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Frontiers of Structural and Civil Engineering 2024年第10期18卷 1595-1609页

作者： Yaoyu YANG Shihchung kang Chiaming chang Department of Civil Engineering Taiwan UniversityTaipei 10617China

Automated construction has become urgently needed because the construction industry faces labor safety and cost ***,these developments require investments in new equipment to facilitate automation in construction,resulting in even higher capital ***,the research proposes a gravity-triggered rotational connecting(GTRC)method for automating segmental bridge *** this automated construction method,a segment-to-segment connector is developed to exploit an eccentric moment introduced by gravity and achieve segmental *** implementation,a specific rigging method is presented for a conventional telescopic crane to maintain a particular ***,crane path planning is also proposed to guide one segment toward the other segment.A combined computational and experimental verification program is established and employs a simply supported bridge as an example for the proposed *** the designed connector and rigging assembly,the proposed method is computationally and experimentally verified to automate segmental bridge construction.

关键词： automated construction crane path planning segment-to-segment connector rigging design rotational connection

Integration of uniform design and quantum-behaved particle swarm optimization to the robust design for a railway vehicle suspension system under different wheel conicities and wheel rolling radii

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Acta Mechanica Sinica 2017年第5期33卷 963-980页

作者： Yung-chang Cheng Cheng-kang Lee Department of Mechanical and Automation Engineering Kaohsiung First University of Science and Technology Department of Industrial Engineering and Management Cheng Shiu University

This paper proposes a systematic method, integrating the uniform design (UD) of experiments and quantum-behaved particle swarm optimization (QPSO), to solve the problem of a robust design for a railway vehicle suspension system. Based on the new nonlinear creep model derived from combining Hertz contact theory, Kalker's linear theory and a heuristic nonlinear creep model, the modeling and dynamic analysis of a 24 degree-of-freedom railway vehicle system were investigated. The Lyapunov indirect method was used to examine the effects of suspension parameters, wheel conicities and wheel rolling radii on critical hunting speeds. Generally, the critical hunting speeds of a vehicle system resulting from worn wheels with different wheel rolling radii are lower than those of a vehicle system having original wheels without different wheel rolling radii. Because of worn wheels, the critical hunting speed of a running railway vehicle substantially declines over the long term. For safety reasons, it is necessary to design the suspension system parameters to increase the robustness of the system and decrease the sensitive of wheel noises. By applying UD and QPSO, the nominal-the-best signal-to-noise ratio of the system was increased from -48.17 to -34.05 dB. The rate of improvement was 29.31%. This study has demonstrated that the integration of UD and QPSO can successfully reveal the optimal solution of suspension parameters for solving the robust design problem of a railway vehicle suspension system.

关键词： Speed-dependent nonlinear creep model Quantum-behaved particle swarm optimization Uniform design Wheel rolling radius Hunting stability