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China CDC weekly 2021年第15期3卷 316-319页

作者： Zhilong Dong Xiaohong Pan chang cai Qianqian Qin George F.Gao Fan Lyu National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouZhejiangChina National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina.

Summary What is already known about this topic?Significant changes in human immunodeficiency virus(HIV)transmission modes have occurred in China,and the proportion of heterosexual transmission increased in recent *** is added by this report?The proportions of diverse transmission routes and subgroups of heterosexual transmission were analyzed by provincial-level administrative divisions(PLADs).

关键词： HIV/AIDS Spatial immunodeficiency

Arsenic trioxide alleviates airway hyperresponsiveness and eosinophilia in a murine model of asthma

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Cellular & Molecular Immunology 2010年第5期7卷 375-380页

作者： Kuan-Hua Chu Chen-Chen Lee Shao-Chi Hsin Bao-chang cai Jin-Hong Wang Bor-Luen Chiang Graduate Institute of Immunology National Taiwan UniversityTaipeiTaiwan School of Medicine China Medical UniversityTaichungTaiwan Nanjing University of Traditional Chinese Medicine NanjingChina Department of Pediatrics National Taiwan University HospitalTaipeiTaiwan

Asthma is one of the most common chronic airway inflammatory *** clinical hallmarks of asthma include elevated serum levels of immunoglobulin E(IgE),eosinophilic inflammation and airway hyper-responsiveness(AHR).Arsenic trioxide(As2O3)is considered a carcinogen;however,it has also been used to treat diseases,such as syphilis,in traditional Chinese and Western ***,As2O3 is used as one of the standard therapies for acute promyelocytic leukemia(APL).Previous studies have indicated that As2O3 can induce apoptosis in ***,the effect of As2O3 on asthma has not been *** used ovalbumin(OVA)-immunized mice as a model for asthma and treated mice with As2O3 at doses of 2.5 and 5 mg/*** mice were then monitored for OVA-specific IgE production,airway inflammatory cell infiltration and *** found that administration of As2O3 in OVA-immunized mice abrogated airway eosinophil recruitment by downregulating eotaxin expression but did not alter serum IgE or IL-5 levels in bronchoalveolar lavage fluid(BALF).Furthermore,the development of AHR and cellular infiltration into the airway were reduced by treating mice with *** vitro data suggested that low concentrations of As2O3 could induce only a small degree of apoptosis in primary pulmonary cells but could significantly inhibit the secretion of eotaxin by these *** results indicate that the administration of As2O3 to OVA-immunized mice can suppress lung allergic inflammatory ***2O3 might therefore have therapeutic potential in treating allergic airway inflammatory diseases.

关键词： arsenic trioxide asthma eosinophils

Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells

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World Journal of Gastroenterology 2012年第31期18卷 4199-4206页

作者： Ning-Li Chai Qiang Fu Hui Shi chang-Hao cai Jun Wan Shi-Ping Xu Ben-Yan Wu Department of Gastroenterology South Build-ing of Chinese People's Liberation Army General Hospital Bei-jing 100853 China Department of Gastroenterology Xi'an Children'sHospital Xi'an 710002 Shaanxi Province China

AIM： To investigate the potential mechanism of Arg- Gly-Asp （RGD） peptide-labeled liposome loading oxy- matrine （OM） therapy in CCI4-induced hepatic fibrosis in rats. METHODS： We constructed a rat model of CCh- induced hepatic fibrosis and treated the rats with dif- ferent formulations of OM. To evaluate the antifibrotic effect of OM, we detected levels of alkaline phospha- tase, hepatic histopathology （hematoxylin and eosin stain and Masson staining） and fibrosis-related gene expression of matrix metallopeptidase （MMP）-2, tis- sue inhibitor of metalloproteinase （TIMP）-I as well as type I procollagen via quantitative real-time poly- merase chain reaction. To detect cell viability and apop- tosis of hepatic stellate cells （HSCs）, we performed 3-（4,5）-dimethylthiahiazo（-z-yl）-3,5-diphenytetrazoli- umromide assay and flow cytometry. To reinforce the combination of oxymatrine with HSCs, we constructed fluorescein-isothiocyanate-conjugated Arg-Gly-Asp peptide-labeled liposomes loading OM, and its targeting of HSCs was examined by fluorescent microscopy. RESULTS： OM attenuated CCh-induced hepatic fibro- sis, as defined by reducing serum alkaline phosphatase （344.47± 27.52 U/L vs 550.69 ± 43.78 U/L, P 〈 0.05）, attenuating liver injury and improving collagen deposits （2.36% ± 0.09% vs 7.70% ±0.60%, P 〈 0.05） and downregulating fibrosis-related gene expression, that is, MMP-2, TIMP-1 and type I procollagen （P 〈 0.05）. OM inhibited cell viability and induced apoptosis of HSCs in vitro. RGD promoted OM targeting of HSCs and en- hanced the therapeutic effect of OM in terms of serum alkaline phosphatase （272.51 ± 19.55 U/L vs 344.47 ± 27.52 U/L, P 〈 0.05）, liver injury, collagen deposits （0.26%± 0.09% vs 2.36% ± 0.09%, P 〈 0.05） and downregulating fibrosis-related gene expression, that is, MMP-2, TIMP-1 and type I procollagen （P 〈 0.05）. Moreover, in vitro assay demonstrated that RGD en- hanced the effect of OM on HSC viability and apoptosis. CONCLUSION： OM attenuated hepatic fi

关键词： Oxymatrine Arg-Gly-Asp peptide Hepaticstellate cell Hepatic fibrosis Target therapy

HYDRAULIC CHARACTERISTICS OF WATER-WINGS FOR THE MIDDLE-PIER OF A DISCHARGE TUNNEL

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Journal of Hydrodynamics 2006年第5期18卷 567-571页

作者： WU Jian-hua cai chang-guang JI Wei RUAN Shi-ping College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China China Hydropower Mid-South Design and Research Institute Changsha 410014 China

Water-wings, induced by the middle-pier placed in the inlet of a discharge tunnel, have harmful effects on the operation of the discharge tunnel. Based on dimensional analysis and physical model tests, the hydraulic characteristics of water-wings were investigated and their causes were analyzed in this study. The results show that the height and length of the water-wings increased with the increase of three factors, i.e., the Froude number Frd of the outlet of the pressure section, the depth Hc of the water surface concave at the end of the middle-pier, and the impact length Li of the two flows after this end.

关键词： water-wing dimensional analysis discharge tunnel middle-pier

Modeling and Simulation of the Tracked Pipe Duct Cleaning Robot Based on the Pro/Engingeer and RecurDyn

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International Journal of Plant Engineering and Management 2014年第3期19卷 180-185页

作者： cai chang-liang School of Mechanical Engineering Inner Mongolia University of Technology

In order to solve the problem of the pipeline inspection and cleaning, combining the 3D modeling software Pro/Eningeer （Pro/E） and the dynamics analysis software RecurDyn, the main model, the track system model of the tracked pipe duct cleaning robot and the road model are built, and the entity assembly in RecurDyn is applied and the simulation model is obtained. The paper RecurDyn. The speed, the torque of driving wheel and the carries out the dynamic simulation with the software vibration-acceleration of gravity of the whole robot in the vertical direction are obtained and analyzed. Finally, the simulation and the calculation results are compared, the two results are basically the same, it has guiding significance for the further study and the potential applications of the tracked pipe duct cleaning robot

关键词： tracked pipe duct cleaning robot RecurDyn dynamics simulation model

Review on Research about Wake Effects of Offshore Wind Turbines

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Energy Engineering 2022年第4期119卷 1341-1360页

作者： Yehong Dong Guangyin Tang Yan Jia Zekun Wang Xiaomin Rong chang cai Qingan Li Yingjian Yang Southern Marine Science and Engineering Guangdong Laboratory(Zhanjiang) Zhanjiang524013China CSIS(Chongqing)HaizhuangWind Power Equipment Co. Ltd.Chongqing401122China Offshore Technology Center of CCS Tianjin300457China School of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot010051China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China

In recent years,the construction of offshore wind farms is developing *** the wake effect of the upstream wind turbines seriously affect the performance of the downstream wind turbines,the wake effect of offshore wind turbines has become one of the research ***,this article reviews the research methods of wake effects,including CFD numerical simulation method,wind turbine wake model based on roughness and engineering wake ***,there is no general model that can be used *** it puts forward some factors that affect the wake of offshore wind *** turbulence intensity in offshore wind fields is lower than that in onshore wind *** makes the wake recovery length of offshore wind turbines longer than that of onshore wind *** offshore wind turbines are simultaneously disturbed by wind loads and wave *** movement of the platform caused by wave *** affects the development and changes of the wake of wind *** this regard,the focus of research on the wake effects of offshore wind farms will be the proposal of accurate prediction models for the wake effects of sea wind farms.

关键词： Wind energy offshore wind turbines wake effects offshore wind farms

Heat treatment and granule medium internal highpressure forming of AA6061 tube

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Journal of Central South University 2017年第5期24卷 1040-1049页

作者： BI Jiang ZHAO chang-cai BI Meng-meng DU Bing CHEN Xiao-hua DONG Guo-jiang Key Laboratory of Advanced Forging&Stamping Technology and Science of Ministry of Education of China Yanshan UniversityQinhuangdao 066004China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China College of Vehicles and Energy Yanshan UniversityQinhuangdao 066004China

The new forming process of AA6061 alloy tube, including solution treatment, granule medium internal high-pressure forming and aging treatment, was developed. The AA6061 alloy tube via heat treatment satisfied the forming requirement, and the granule medium internal high pressure forming method for AA6061 alloy tube was also realized by using convenient implementation with low requirement of equipment and flexible design of product. At a solution temperature of 560℃ and time of 120 min, the elongation of the AA6061 extruded tube increases by 300% and the strength and the hardness dramatically decrease too. Therefore, the AA6061 alloy tube meets the requirement of internal high-pressure forming because of the improvement of formability. The experiments shows that the strength and hardness of AA6061 alloy workpiece recover to that of the as-received alloy at an aging temperature of 180℃ and time of 360 min, and the strength of AA6061 alloy workpiece is equal to the base alloy. The typical parts of convex ring tube, stepped shaft tube and hexagonal tube were successfully produced in lab by using the present forming method. The forming tests show that the maximum expansion ratio(MER) of the AA6061 extruded tube increases by 25.5% and the material properties of formed AA6061 alloy tube reached the performance of as-received alloy.

关键词： aluminum alloy tube solution treatment aging treatment granule medium internal high pressure forming

Evolution of HIV Epidemic and Emerging Challenges—China,1989–2023

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China CDC weekly 2024年第48期6卷 1251-1256页

作者： chang cai Houlin Tang Dongmin Li Qianqian Qin Fangfang Chen Yichen Jin Fan Lyu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:This study aimed to provide a comprehensive analysis of the human immunodeficiency virus(HIV)epidemiological landscape in China through a historical review and current ***:Data were extracted from China’s HIV/AIDS Comprehensive Response Information Management System(CRIMS).Transmission patterns across different phases were visualized using stacked area *** correlations between transmission routes were analyzed using scatter plots and Pearson correlation *** extent and trends of HIV spread among the general population were evaluated using Venn diagrams and Cochran-Armitage ***:The HIV epidemic in China evolved through four distinct phases:injecting drug user(IDU)dominated(1989–1994),former plasma donor(FPD)outbreak(1995–2005),sexual transmission dominance(2006–2014),and general population spread(2015–present).A strong correlation was observed between provinces reporting high numbers of IDU cases and those with elevated heterosexual transmission(r=0.88,P<0.001).Between 2015 and 2023,393,926 cases were identified among the general population through non-marital and non-commercial heterosexual contact(NMNCHC).The proportion of general population cases among heterosexual transmissions increased significantly from 46.2%to 55.7%(Z=42.7,P<0.001).Conclusion:The significant spread of HIV into the general population necessitates the development of targeted prevention strategies for both high-risk and general populations to address emerging epidemiological challenges.

关键词： prevention elevated IDU

Mammography and ^(99m)Tc-MIBI scintimammography inbreast cancer diagnosis

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Nuclear Science and Techniques 2000年第4期11卷 213-217页

作者： ZHU Hui-Qing, LIN Xiang-Tong, LIU Yong-chang, REN chang-cai, HE Wan-Ting, GONG Hai-Xia (Huashan Hospital, Medical Center of Fundan University, Shanghai 200040) 复旦大学上海 200040

The aim of this work has been to evaluate whether a diagnostic protocol based on the joint use of mammography and 99mTc-MIBI scintimammography can help to distinguish the lesions and to reduce the number of biopsies required in patients with suspected breast cancer. A total of 58 women were evaluated by palpation, mammography, scintimammography. Twenty-four patients were scintimammographed with 99mTc-MIBI at 10min after injection. Thirty-four patients were taken doublephase scintimammography with 99mTc-MIBI 10min and 60-90min after injection. Based on mammography, the supicion degrees of malignancy were rated, and 30 results of malignancy were confirmed by histopathology. Based on mammography, 18 lesions were considered to be most probably benign (of which 3 were histopathologi-cally breast cancer), 19 as indeterminate (of which 9 were histopathologically breast cancer), and 21 as malignant (of which 18 were histopathologically breast cancer). The results of early and delayed phases 99mTc-MIBI scintimammography were the same. The sensitivity, specificity and accuracy of scintimammography were 74.29%, 86.96% and 79.31%, respectively. Scintimammography gave 16 correct diagnosis in 19 mammogram indeterminate (84.2%) and demonstrated 5 out of 8 cases axillary lymph nodes metastasis (62.5%). These studies show that 99mTc-MIBI scintimammography used as a complementary testing technique to mammography is useful in the examination of patients with suspected breast cancer. The adoption of a joint mammography-scintimammography diagnostic protocol conld considerably reduce the number of biopsies performed in patients with lesions of indeterminate mammographic suspicion of malignancy.

关键词： ^99mTc-MIBI 锝99 放射性核素标记放射性治疗药物乳腺癌乳房X线照片

Research on Optical Properties and Micro-processing Characteristics of Collodion Thin Film

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Defence Technology（防务技术） 2013年第3期9卷 167-170页

作者： chang-long cai Xiong HAN Xiao-ling NIU Wei-guo LIU Micro-Optoelectrical System Laboratory Xi'an Technological University

Colorless and transparent thin films of collodion are prepared on silicon wafers and K9 optical glass substrates by using spin-coating *** visible light transmittance,IR absorption spectra and optical constants of collodion thin film are measured by UV-3501Spectrophotometer,Fourier transform infrared spectrometer(FTIR)and spectroscopic *** measured results show that its average visible light transmittance is 91.9%,and its average infrared absorptivity is better than 0.69/*** the visible light region,the refractive index of collodion thin film changes in the range of 1.5—1.53,which accords with normal *** collodion films are etched using oxygen gas *** surface morphology and thickness of etched thin film are measured by the polarizing microscope and MP-100S thickness measurement system,*** results show that the collodion thin film is etched out in the oxygen gas plasma.

关键词：光学性能火棉胶薄膜加工特性傅里叶变换红外光谱仪可见光透射率厚度测量系统红外吸收光谱