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Analysis of risk factors for bile leakage after laparoscopic exploration and primary suture of common bile duct

World Journal of Gastrointestinal Surgery 2025年第3期17卷 278-287页

作者： Qing-Song Yang Meng Zhang chang-Song Ma Da Teng Ao Li Ji-Dong Dong Xi-Fei Wang Fu-bao Liu Department of Hepatopancreatobiliary Surgery Affiliated Chuzhou Hospital of Anhui Medical University(The First People’s Hospital of Chuzhou)Chuzhou 239001Anhui ProvinceChina Department of Hepatobiliary and Pancreatic Surgery General SurgeryThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina

BACKGROUND Bile leakage is a common complication following laparoscopic common bile duct exploration(LCBDE)with primary duct closure(PDC).Identifying and analyzing the risk factors associated with bile leakage is crucial for improving surgical *** To explore the value analysis of common risk factors for bile leakage after LCBDE and PDC,with a focus on strict adherence to *** Clinical data of 106 cases undergoing LCBDE+PDC in the Hepatobiliary and Pancreatic Surgery Department(Division 1)of Chuzhou First People’s Hospital from April 2019 to March 2024 were *** and multiple factor regression analysis were conducted on common risk factors for bile *** change in surgical time was analyzed using the cumulative summation(CUSUM)method,and the minimum number of cases required to complete the learning curve for PDC was obtained based on the proposed fitting curve by identifying the CUSUM maximum *** Multifactor logistic regression analysis showed that fibrinous inflammation and direct bilirubin/indirect bilirubin were significant independent high-risk factors for postoperative bile leakage(Phan in cases with bile leakage(P<0.05),with statistical *** CUSUM method indicated that a minimum of 51 cases were required for the surgeon to complete the learning curve(P=0.023).CONCLUSION With a good assessment of duodenal papilla sphincter function,unobstructed bile-pancreatic duct convergence,exact stone clearance,and sufficient surgical experience to complete the learning curve,PDC remains the preferred method for bile duct closure and is worthy of clinical promotion.

关键词： Laparoscopic common bile duct exploration Primary duct closure Bile leakage Risk factor analysis Cumulative summation

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热塑性聚氨酯基杂化纳米复合材料的导电和拉伸应变传感性能

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高分子学报 2025年第1期56卷 124-134页

作者：闫茂昌黄汉雄华南理工大学广东省高分子先进制造技术及装备重点实验室微/纳成型与流变学研究室广州510640

采用湿法刻蚀MAX相的方法,制备了少层二维过渡金属碳化物(MXene)纳米片;采用溶液混合和模压成型制备不同碳纳米管(CNT)、MXene和杂化CNT/MXene含量的热塑性聚氨酯(TPU)基纳米复合材料.结果表明,杂化CNT/MXene有效提高了纳米复合材料的... 详细信息

采用湿法刻蚀MAX相的方法,制备了少层二维过渡金属碳化物(MXene)纳米片;采用溶液混合和模压成型制备不同碳纳米管(CNT)、MXene和杂化CNT/MXene含量的热塑性聚氨酯(TPU)基纳米复合材料.结果表明,杂化CNT/MXene有效提高了纳米复合材料的导电性能,MXene含量从0.2 wt%增加至0.4 wt%使TPU/CNT(0.8 wt%)纳米复合材料的电导率提高5个数量级.扫描电镜观测和流变性能测试结果表明,这归因于TPU内杂化CNT/MXene形成了良好的导电网络.对具有较高导电率的4种TPU/CNT/MXene纳米复合材料(即CNT含量固定为0.8 wt%、MXene含量为0.4 wt%~1.0 wt%)的拉伸应变传感性能进行对比研究.有意义的是,发现MXene含量为0.8 wt%的纳米复合材料呈现更高的应变传感性能,其应变因子最高为7.5.该纳米复合材料在不同的循环拉伸/释放测试中表现良好的响应和恢复性能、较高的循环响应稳定性和重复性,且能准确检测手指弯曲、手腕弯曲和低头这些人体运动产生的电阻信号.研究表明,采用杂化CNT/MXene并选择合适的含量,在聚合物基体内形成良好的导电网络,可明显提高纳米复合材料的导电和拉伸应变传感性能.

关键词：热塑性聚氨酯基纳米复合材料二维过渡金属碳化物导电性能拉伸应变传感流变行为

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen chang Cheng Yu-han Wang Wen-Chao Cheng De-Zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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基于车辆轨迹预测与宏微观指标聚合的临近交叉口路段交通运行风险综合评估

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东南大学学报(自然科学版) 2025年第1期55卷 230-238页

作者：鲍琼吴臻陈建明沈永俊韩天园东南大学交通学院南京211189 苏州万集车联网技术有限公司苏州215000

针对城市道路临近交叉口路段的复杂交通流运行特点,提出了一种基于车辆轨迹预测与宏微观指标聚合的实时交通运行风险综合评估方法。首先,构建了基于长短时记忆网络的驾驶人意图识别模型,以实现车辆轨迹的准确预测。然后,基于预测的轨迹... 详细信息

针对城市道路临近交叉口路段的复杂交通流运行特点,提出了一种基于车辆轨迹预测与宏微观指标聚合的实时交通运行风险综合评估方法。首先,构建了基于长短时记忆网络的驾驶人意图识别模型,以实现车辆轨迹的准确预测。然后,基于预测的轨迹数据,提取交通流宏观运行指标和车辆微观行驶风险指标,采用数据包络分析方法构建了临近交叉口路段交通运行风险综合评价模型。最后,对比基于实际数据和预测数据的风险评价结果,以验证模型的有效性。结果表明,该方法在高风险等级的召回率为0.955,评价结果差异较小,能够有效预测交通流运行风险,为临近交叉口路段的交通安全主动管控提供了有力的决策依据。

关键词：临近交叉口路段运行风险评价指标风险预测

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Implementation of Rapid Code Transformation Process Using Deep Learning Approaches

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Computer Modeling in Engineering & Sciences 2023年第7期136卷 107-134页

作者： bao Rong chang Hsiu-Fen Tsai han-Lin Chou Department of Computer Science and Information Engineering National University of KaohsiungKaohsiung811Taiwan Department of Fragrance and Cosmetic Science Kaohsiung Medical UniversityKaohsiung811Taiwan

Our previous work has introduced the newly generated program using the code transformation model GPT-2,verifying the generated programming codes through simhash(SH)and longest common subsequence(LCS)***,the entire code transformation process has encountered a time-consuming ***,the objective of this study is to speed up the code transformation process signi􀀀*** paper has proposed deep learning approaches for modifying SH using a variational simhash(VSH)algorithm and replacing LCS with a piecewise longest common subsequence(PLCS)algorithm to faster the veri􀀀cation process in the test *** the code transformation model GPT-2,this study has also introduced MicrosoMASS and Facebook BART for a comparative analysis of their ***,the explainable AI technique using local interpretable model-agnostic explanations(LIME)can also interpret the decision-making *** experimental results show that VSH can reduce the number of quali􀀀ed programs by 22.11%,and PLCS can reduce the execution time of selected pocket programs by 32.39%.As a result,the proposed approaches can signi􀀀cantly speed up the entire code transformation process by 1.38 times on average compared with our previous work.

关键词： Code transformation model variational simhash piecewise longest common subsequence explainable AI LIME

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扭振分析在轴功测量技术中的应用

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内燃机 2006年第5期22卷 35-37页

作者：程付安常汉宝刘伯运邵利民海军工程大学湖北武汉430033

在柴油机轴系扭振理论的基础上对通过轴应变来测功的测量信号量进行分析,并通过实例证明了这种分析在对测量信号量进行数学处理中的重要意义。

关键词：扭振轴功测量数据处理

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基于注意力机制的联邦无线流量预测模型

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软件学报 2025年第2期36卷 715-731页

作者：柴宝宝董安明王桂娟韩玉冰李浩禹继国山东科技大学计算机科学与工程学院山东青岛266590 齐鲁工业大学(山东省科学院) 山东济南250353 中国石油大学(华东)计算机科学与技术学院山东青岛266580

移动数据每天都在不断增长,如何精准预测无线流量对高效、合理的配置通信和网络资源至关重要.现有的流量预测方法多采用集中式训练架构,涉及大规模的流量数据传输,会导致用户隐私泄露等安全问题.联邦学习可以在数据本地存储的前提下训... 详细信息

移动数据每天都在不断增长,如何精准预测无线流量对高效、合理的配置通信和网络资源至关重要.现有的流量预测方法多采用集中式训练架构,涉及大规模的流量数据传输,会导致用户隐私泄露等安全问题.联邦学习可以在数据本地存储的前提下训练一个全局模型,保护用户隐私,有效减轻数据频繁传输负担.但是在无线流量预测中,单个基站数据量有限,且不同基站流量数据模式异构,流量模式难以捕捉,导致训练得到的全局模型泛化能力较差.此外,传统联邦学习方法在进行模型聚合时采用简单平均,忽略了客体贡献差异,进一步导致全局模型性能下降.针对上述问题,提出一种基于注意力的“类内平均,类间注意力”联邦无线流量预测模型,该模型根据基站的流量数据进行聚类,更好地捕捉具有相似流量模式基站的流量变化特性;同时,设计一个预热模型,利用少量基站数据缓解数据异构,提高全局模型的泛化能力;在模型聚合阶段引入注意力机制,量化不同客体对全局模型的贡献,并在模型迭代过程中融入预热模型,大幅提升模型的预测精度.在两个真实数据集(Milano和Trento)上进行大量实验,结果表明该方法优于所有基线方法.并且与目前最先进的方法相比,在两个数据集上的平均绝对误差性能增益最高分别达到10.1%和9.6%.

关键词：无线流量预测联邦学习聚类注意力机制

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电站柴油机可修系统可靠性综合评估方法研究

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陕西电力 2011年第1期39卷 6-10页

作者：王承禹常汉宝刘伯运王志新海军工程大学船舶与动力学院湖北武汉430033 上海交通大学电气工程系．上海200240

针对可修系统难以准确评定其运行过程中的可靠性状态,把可修系统的可靠性评估分为运行可靠性和性能参数可靠性。对于不同维修阶段的运行可靠性,用故障统计的方法评价其可靠性;对于性能参数可靠性,通过构建可测参数的可靠性退化模型进行... 详细信息

针对可修系统难以准确评定其运行过程中的可靠性状态,把可修系统的可靠性评估分为运行可靠性和性能参数可靠性。对于不同维修阶段的运行可靠性,用故障统计的方法评价其可靠性;对于性能参数可靠性,通过构建可测参数的可靠性退化模型进行评价。以柴油机喷油系统可靠性综合评估为实验研究对象,结果表明,文中所提供的方法很好地表达出可修系统任意时刻的可靠性状态,而且为类似可修系统的可靠性评估提供参考。

关键词：电站柴油机可靠性性能退化状态评估

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Elafibranor:A promising therapeutic approach for liver fibrosis and gut barrier dysfunction in alcohol-associated liver disease

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World Journal of Gastroenterology 2025年第3期31卷 123-126页

作者： Chun-han Cheng Wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328TaiwanChina

This article discusses the recent study written by Koizumi et ***-associated liver disease(ALD)is a major cause of liver-related morbidity and mortality,which is driven by complex mechanisms,including lipid accumulation,apoptosis,and inflammatory responses exacerbated by gut barrier *** study explored the therapeutic potential of elafibranor,a dual peroxisome proliferatoractivated receptor alpha/delta *** clinical trials,elafibranor has shown promise for the treatment of other liver conditions;however,its effects on ALD remain *** authors’findings indicate that elafibranor significantly reduced liver fibrosis and enhanced gut barrier integrity in patients with *** positive effects of elafibranor are mediated through multiple *** promotes lipid metabolism,reduces oxidative stress,and inhibits inflammatory responses by restoring gut barrier ***,it improves hepatocyte function by enhancing autophagic and antioxidant capacity,and it mitigates inflammation by suppressing the lipopolysaccharide/toll-like receptor 4/nuclear factor kappa B signaling *** findings indicate that elafibranor has promising clinical *** addition,the study highlights elafibranor’s potential as a therapeutic agent for liver diseases,particularly *** article underscores the importance of understanding the mechanistic pathways underlying ALD and suggests directions for future research aimed at elucidating the benefits and limitations of elafibranor.

关键词： Elafibranor Liver fibrosis Gut barrier function Alcohol-associated liver disease Peroxisome proliferatoractivated receptor agonists

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