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Genome-wide analysis of differential DNA methylation in Silver-Russell syndrome

Science China(Life Sciences) 2017年第7期60卷 692-699页

作者： Di Wu Chunxiu Gong chang su Department of Endocrinology Genetics and Metabolism Beijing Children's Hospital Capital Medical University National Center for Children's Health MOE Key Laboratory of Major Diseases in Children Beijing 100045 China

Silver-Russell Syndrome(SRS) is clinically heterogeneous disorder characterized by low birth weight, postnatal growth restriction, and variable dysmorphic features. Current evidence strongly implicates imprinted genes as an important etiology of SRS. Although almost half of the patients showed DNA hypomethylation at the H19/IGF2 imprinted domain, and approximately7%–10% of SRS patients have maternal uniparental disomy of chromosome 7(UPD(7) mat); the rest of the SRS patients shows unknown etiology. In this study, we investigate whether there are further DNA methylation defects in SRS patients. We measured DNA methylation in seven SRS patients and five controls at more than 485,000 CpG sites using DNA methylation microarrays. We analyzed methylation changes genome-wide and identified the differentially methylated regions(DMRs) using bisulfite sequencing and digital PCR. Our analysis identifies epimutations at the previously characterized domains of H19/IGF2,providing proof of principle that our methodology can detect the changes in DNA methylation at imprinted loci. In addition,our results showed a novel SRS associated imprinted gene OSBPL5 located on chromosome 11p14 with the probe cg25963939,which is hypomethylated in 4/7 patients(P=0.023, β=.0.243). We also report DMRs in other genes including TGFβ3, HSF1,GAP43, NOTCH4 and MYH14. These DMRs were found to be associated with SRS using GO pathway analysis. In this study,we identified the probe cg25963939, located at the 5′UTR of imprinted gene OSBPL5, as a novel DMR that is associated with SRS. This finding provides new insights into the mechanism of SRS etiology and aid the further stratification of SRS patients by molecular phenotypes.

关键词： Silver-Russell syndrome methylation differences imprinted gene

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Achieving Excellent Electromagnetic Interference Shielding Effectiveness in High Rare Earth Mg-12Gd-3Y alloy via Nd Addition Combined with Hot Rolling and Aging

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Acta Metallurgica Sinica(English Letters) 2023年第10期36卷 1665-1679页

作者： Wenlong Xu chang su Yuan Yuan Jingying Bai Xianhua Chen College of Materials Science&Engineering Chongqing UniversityChongqing400045China National Engineering Research Center for Mg Alloys Chongqing UniversityChongqing400045China Beijing Spacecrafts China Academy of Space TechnologyBeijing100194China

Achieving excellent electromagnetic interference(EMI)shielding effectiveness(SE)in high rare earth(RE)-content Mg alloys is currently a significant technical *** work systematically investigated the effects of different Nd elements on the electrical conductivity and EMI SE of Mg-12Gd-3Y-xNd alloy by adding Nd elements to the high RE content Mg-12Gd-3Y alloy,followed by a combined process of hot rolling and aging(R-A).The results indicate that the addition of Nd elements leads to reduced solid solubility of Gd and Y,resulting in a large amount of *** Mg-12Gd-3Y-2.0Nd alloy has the optimum EMI SE after 63%R-A treatment,reaching 88-118 dB at 30-1500 *** Mg-12Gd-3Y-xNd alloy has acicular and granular forms of the Mg5(Gd,Y,Nd)(abbreviated as Mg5RE)phase after R-A *** granular Mg5RE phase gradually breaks up and refines into more minor scales with increasing rolling reduction and is diffusely distributed in the *** acicular Mg5RE phase is densely arranged,with cross-distribution in some *** cross-distributed acicular Mg5RE phase,the delicate granular Mg5RE phase,and the denseβ′phase provide more interfaces for reflecting electromagnetic waves and increase the multiple reflection loss of incident electromagnetic *** addition,the Mg-12Gd-3Y-xNd alloy deflects most of the c-axis of the grains parallel to the normal direction(ND)as the rolling reduction increases,making the impedance difference between the plate surface and air *** increased impedance makes the material reflect more loss to incident electromagnetic *** combined use of these two leads to an excellent EMI SE of Mg-12Gd-3Y-xNd with high RE content after R-A treatment.

关键词： Mg-Gd-Y-Nd alloy Acicular phase Granular phase Electrical conductivity Electromagnetic interference shielding effectiveness

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Optimum Metallic-Bond Scheme: A Quantitative Analysis of Mass Spectra of Sodium Clusters

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Chinese Physics Letters 2001年第12期18卷 1575-1577页

作者： su chang-Rong LI Jia-Ming Department of Physics Center for Atomic and Molecular NanosciencesTsinghua UniversityBeijing 100084 Institute of Physics Chinese Academy of SciencesBeijing 100080

Based on the results of the optimum metallic-bond scheme for sodium clusters, we present a quantitative analysis of the detailed features of the mass spectra of sodium clusters. We find that, in the generation of sodium clusters with various abundances, the quasi-steady processes through adding or losing a sodium atom dominate. The quasi-steady processes through adding or losing a sodium dimer are also important to understand the detailed features of mass spectra for small clusters.

关键词： adding quasi spectra

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A Combined Experimental and Numerical Study of Shotcrete Jets and Related Wet Spray Nozzles

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Fluid Dynamics & Materials Processing 2020年第5期16卷 947-960页

作者： chang su Qiangqiang Zheng Wukun Zhao State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Huainan232001China School of Mechanical Engineering Anhui University of Science and TechnologyHuainan232001China School of Civil Engineering and Architecture Anhui University of Science and TechnologyHuainan232001China State Key Laboratory of Safety and Health for Metal Mines Maanshan243000China

In this research,the dynamics of wet spray nozzles with different geometries,used to accelerate shotcrete,are investigated on the basis of a suitable three-dimensional mathematical model and related numerical *** have been conducted in the frame of the SIMPLEC *** k-εturbulence model has been used to account for turbulent *** study shows that when the angle of the convergent section is less than 3°,it has a scarce effect on the dynamics of the jet of shotcrete;with the increase of the convergence angle,the shotcrete jet velocity decreases and the nozzle wear increases;when this angle is greater than 6°,the concrete outlet jet velocity is very small and the nozzle can easily be *** results are in good agreement with the outcomes of the numerical simulations,which indicates that the used approach is reliable.

关键词： Shotcrete wet spraying nozzle turbulence flow convergence angle numerical simulation

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Cascade failure modeling and resilience analysis of mine cyber physical systems under deliberate attacks

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Journal of Safety Science and Resilience 2024年第3期5卷 266-280页

作者： Xinping Wang Jialin Zhu chang su Xinyue Zhen School of Management Xi'an University of Science and Technology Xi'an710054China School of Safety Science and Engineering Xan University of Science and TechnologyXi'an0054China

Guided by the intelligent construction of coal mines and integrating the concept of the Cyber-Physical System(CPS),a novel approach to a coal mine information-physical fusion system is *** concept emerges from the advancement of intelligent mines and the growing need for enhanced safety in coal mine *** a system safety perspective,this approach aims to effectively evaluate security issues by better integrating the informational and physical layers of intelligent ***,research in areas such as power grids and water networks has widely adopted concepts of cascade failures and *** is suggested that the CPS framework be adapted to the mining *** the critical role of coal mines in China's energy security and their vulnerability to cyber attacks,a mine-specific CPS system is *** system incorporates a model of mine information-physical fusion,including networks for mine operations,management,and control,tailored to the unique conditions of mine shafts and underground *** Markov process theory,the paper delves into the theoretical study of the cascade failure process under deliberate attack *** analysis is essential to effectively assess the safety issues within the information-physical system,providing vital support for fault prediction and safety *** model of cascading failures in the mine information-physical system is developed,and based on an analysis of resilience and robustness,the study identifies key factors influencing the security of mine information-physical *** factors affecting the reliability of these systems include the number of system nodes,node coupling,edge count,and the interconnection methods of the dual-layer dependency *** paper concludes by discussing the challenges in analyzing the security of information-physical systems and suggesting directions for future research.

关键词： Minecyber physical system Cascading failure Resilience Robustness

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Acoustic radiation force on a rigid cylinder near rigid corner boundaries exerted by a Gaussian beam field

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Chinese Physics B 2022年第4期31卷 373-380页

作者： Qin chang Yuchen Zang Weijun Lin chang su Pengfei Wu Institute of Acoustics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Deep Sea Drilling Measurement Engineering Technology Research Center Beijing 100190China

Acoustic manipulation is one of the well-known technologies of particle control and a top research in acoustic *** of acoustic radiation force on a particle nearby boundaries is one of the critical tasks,as it approximates realistic ***,it is quite difficult to solve the problem by theoretical method when the boundary conditions are *** this study,we present a finite element method numerical model for the acoustic radiation force exerting on a rigid cylindrical particle immersed in fluid near a rigid *** effects of the boundaries on acoustic radiation force of a rigid cylinder are analyzed with particular emphasis on the non-dimensional frequency and the distance from the center of cylinder to each *** results reveal that these parameters play important roles in acoustic manipulation for particle-nearby complicated rigid *** study verifies the feasibility of numerical analysis on the issue of acoustic radiation force calculation close to complex boundaries,which may provide a new idea on analyzing the acoustic particle manipulation in confined space.

关键词： acoustic radiation force finite element method Gaussian beam field acoustic manipulation

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Synthesis of hierarchical nanohybrid CNT@Ni-PS and its applications in enhancing the tribological,curing and thermal properties of epoxy nanocomposites

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Frontiers of Chemical Science and Engineering 2021年第5期15卷 1281-1295页

作者： Jinian Yang Yuxuan Xu chang su Shibin Nie Zhenyu Li School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan232001China School of Energy Resources and Safety Anhui University of Science and TechnologyHuainan232001China School of Mechanical Engineering Anhui University of Science and TechnologyHuainan232001China

Poor interfacial adhesion and dispersity severely obstruct the continued development of carbon nanotube(CNT)-reinforced epoxy(EP)for potential ***,hierarchical CNT nanohybrids using nickel phyllosilicate(Ni-PS)as surface decorations(CNT@Ni-PS)were synthesized,and the nanocomposites derived from varied mass fractions of EP and CNT@Ni-PS were *** morphological structures,tribological performances,curing behaviors and thermal properties of EP/CNT@Ni-PS nanocomposites were carefully *** show that hierarchical CNT nanohybrids with homogeneous dispersion and well-bonded interfacial adhesion in the matrix are successfully obtained,presenting significantly improved thermal and tribological ***,analysis on cure kinetics proves the excellent promotion of CNT@Ni-PS on the non-isothermal curing process,lowering the curing energy barrier steadily.

关键词： nickel phyllosilicate surface decoration tribological property curing kinetics thermal performance

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Basic fibroblast growth factor improves learning and memory functions in chronic stress mice

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Neural Regeneration Research 2011年第19期6卷 1473-1477页

作者： Xian Qu Chunying Li Hongchang Liu chang su Basic Medical College of Beihua University Jilin 132013 Jilin Province China Jilin Provincial Qian Wei Hospital Changchun 130000 Jilin Province China

Four weeks of uncertain stress was used to establish an animal model of chronic stress. Basic fibroblast growth factor was injected daily for 15 days following stress induction. Cell morphology in the hippocampal CA3 region of chronic stress mice revealed cell damage. Nitric oxide content and calcium concentration were significantly increased in the hippocampus, and learning and memory functions were significantly decreased. After basic fibroblast growth factor intervention, Ca2~ overload was decreased and neuronal damage was relieved in hippocampal neurons, which improved learning and memory functions in chronic stress mice. Latency was prolonged and the number of errors was decreased in a passive avoidance test.

关键词： basic fibroblast growth factor chronic stress step-down test passive avoidance test learning and memory nitric oxide neural regeneration

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Reply to “Comment on ‘A numerical investigation of the acoustic mode waves in a deviated borehole penetrating a transversely isotropic formation' ”

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Science China(Physics,Mechanics & Astronomy) 2016年第8期59卷 91-92页

作者： chang su XiuMei Zhang WeiJun Lin HaiLan Zhang XiuMing Wang State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

We appreciate the comment from Horne,Miller and Wang on the paper‘A numerical investigation of the acoustic mode waves in a deviated borehole penetrating a transversely isotropic formation’by Liu et al.（2015）[1],for the opportunity to consider and clarify the group and phase velocity issue in sonic logging with a deviated borehole penetrating a VTI *** re-read the paper by Liu et al.[1]and did some numerical tests and analyses.

关键词： penetrating Comment on Reply to isotropic borehole sonic opportunity logging comment appreciate

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Pressure calibration and sound velocity measurement to 12 GPa in multi-anvil apparatus

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Acta Geochimica 2021年第4期40卷 525-531页

作者： Wei Song Shuangming Shan Qizhe Tang chang su Yonggang Liu Key Laboratory of High-Temperature and High-Pressure Study of the Earth’s Interior Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China School of Information Engineering Huzhou UniversityHuzhou 313000China Institute of Disaster Prevention Sanhe 065201China

We performed the pressure calibration to 12 GPa for 14/6 type(octahedron edge length/WC truncated edge length,in mm) cell assembly in DS 6 × 1400 multi-anvil apparatus by using the phase transitions in Bi(Ⅰ-Ⅱ2.55 GPa,Ⅲ-Ⅴ 7.67 GPa) and ZnTe(LPP-HPP Ⅰ 9.6 GPa,HPP Ⅰ-Ⅱ 12.0 GPa).As verification and application,sound velocity measurements on poly crystalline Al_(2)O_(3) to 12 GPa at room temperature were conducted and the ultrasonic result is in good agreement with previous *** demonstrates the feasibility of performing sound velocity measurements close to the mantle transition zone pressure condition in our laboratory.

关键词： Pressure calibration Sound velocity Multi-anvil apparatus Polycrystalline alumina

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