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Humoral Immune Response of Inactivated Bivalent <i>Leptospira</i>Vaccine among Dogs in Tiruchirappalli, Tamilnadu, India

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World Journal of Vaccines 2012年第2期2卷 85-90页

作者： Kalimuthusamy Natarajaseenivasan chandramohan lakshmi priya Shanmugam Vanithamani Santhanam Shanmughapriya Subbiah Anandhagiri Government Veterinary Clinic Department of Animal Husbandry Tiruchirappalli India Medical Microbiology Laboratory Department of Microbiology School of Life Sciences Bharathidasan University Tiruchirappalli India

Leptospirosis has been recognized as the disease of the dogs. The prevention of canine leptospirosis can block the transmission of the etiological agent to humans. Commercial vaccines prevent not only clinical leptospirosis but also the renal carrier state in dogs. Thus in this present investigation, the humoral immune response of the vaccinated dogs with the multivalent vaccine (Megavac-6) was analyzed. Enzyme linked immunosorbent assay (ELISA) with preparations of 2 whole cell lysate, 2 leptospiral LPS, 4 purified recombinant proteins were used to test sera from 30 dogs vaccinated with MEGAVAC-6, a commercial vaccine practiced by the animal husbandary Departments in Tamilnadu. All 30 sera were positive by ELISA with whole cell lysate of Canicola and Icterohaemorrhagiae, and ELISA with Canicola LPS, Icterohaemorrhagiae LPS;antibody titres ranged from 20 to ≥10,240. Although there was less frequent reactivity of sera with recombinant antigens, antibodies to LipL32 and LigA were detected in 25 (83.3%) serum samples. Less frequent reactivity was noted when recombinant GroEl, LK73.5 antigens were included separately in ELISAs. The highest MAT titre was observed against the serovar Canicola and Icterohaemorrhagiae. The more reactivity against LPS may be due to the dominance of serovar specific leptospiral LPS, which may be the dominant immunogenic antigen in inactivated bivalent leptospiral vaccines. Eventhough LPS is the dominant antigen. It is serovars specific and hence recommends the incorporation of the locally circulating serovars in vaccine for its efficient use. The efficiency at this point can be increased by the use of subunit vaccines rather than recombinant proteins as such. The present study has proposed certain epitopes with increased antigenic potency.

关键词： Recombinant Proteins LPS Humoral Response Canine Vaccine

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Synthesis and characterization of Nd^(3+)-doped Ce_(0.6)Zr_(0.4)O_(2) and its doping significance on oxygen storage capacity

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Rare Metals 2021年第1期40卷 231-236页

作者： Natesan Shanmuga priya chandramohan Somayaji S.Kanagaraj Siddaganga Institute of Technology TumkurKarnataka 572103India Indian institute of Technology Guwahati 781039India

Cerium and cerium-based oxides are found to be an important element in three-way catalytic converter(TWC).The effective utilization of TWC is found to be reduced due to thermal loading which results in structural deformation of ceria,Doping Zr^(4+)into the rare earth element can increase the oxygen storage capacity and thermal ***,an attempt was made to study the oxygen storage capacity and thermal stability of ceria by doping Zr^(4+)and Nd^(3+).Cerium-based nanocrystallite in the composition of Ce_(0.6)Zr_(0.4-x)Nd_(1.3)xO_(2)(0≤x≤0.4)was prepared by sol-gel synthesize technique with citric acid as a gel-forming agent.X-ray diffraction(XRD)result shows that doping Nd^(3+)into ceria lattice forms homogenous solid solution of cubic fluorite structure up to 25%of substitute *** higher amount of Nd^(3+)into ceria lattice leads to the formation of Nd_(2)O_(3).Raman spectrum study confirms that oxygen storage capacity band is present in Ce_(0.6)Zr_(0.4)O2 and Ce_(0.6)Zr_(0.3)Nd_(0.13)O_(2).The oxygen storage capacity was calculated through weight loss of the sample during the second heating cycle with cyclic heating from30 to 800℃in thermogravimetric analysis(TGA).The TGA study reveals that the oxygen storage capacity of Ce_(0.6)Zr_(0.4)O2 decreases after the substitution of Nd^(3+),which is due to the larger ionic radius of Nd^(3+)compared with that of Zr4+and CeO2.

关键词： Cerium oxide Sol-gel technique Thermogravimetric analysis Ionic radius Homogeneous solid solution Oxygen storage capacity

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