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Circuits and Systems 2011年第3期2卷 249-259页

作者： Nihal Kularatna chandani jindasa 不详

A series connected power semiconductor array, with digital control capability could be used for developing single phase AC regulators or other applications such as AC electronic loads. This technique together with an ordinary gapless transformer could be used to develop a low cost AC voltage regulator (AVR) to provide better or comparable specifications with bulky ferro-resonant AVR types. One primary advantage of the technique is that digital control can be used to minimize harmonics. Commencing with a review of AC voltage regulator techniques for single phase power conditioning systems, an analysis and design aspects of this technique is presented with experimental results for AVRs. Guidelines on how to utilize the technique in a generalized basis is also summarized together with a summary of a technique for achieving harmonic control.

关键词： Power Conditioners AC Voltage Regulators (AVR) Power Semiconductors Digital Control Electronic AC Loads

An updated inventory of marine opisthobranch(Mollusca,Gastropoda)from the territorial waters of the Republic of Mauritius

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Journal of Oceanology and Limnology 2024年第1期42卷 226-243页

作者： Lisa AH SHEE TEE chandani APPADOO Daneshwar PUCHOOA Vishwakalyan BHOYROO Department of Agricultural&Food Science Faculty of AgricultureUniversity of MauritiusRéduit 80837Mauritius Department of Biosciences&Ocean Studies Pole of Research Excellence Sustainable Marine BiodiversityFaculty of ScienceUniversity of MauritiusRéduit 80837Mauritius

Island ecosystems support diverse aquatic invertebrate communities comprising endemic *** of existing species is important for *** this study,a checklist of marine opisthobranch from the Republic of Mauritius is presented.A combination of benthic surveys(50 m×5 m in triplicates),rover diving techniques and photo documentation were used over two years(2018–2020)within 35 sheltered and unsheltered *** and molecular analysis were used for *** composition within sheltered and unsheltered areas in Mauritius was estimated using the Bray-Curtis *** checklist featured 117 species belonging to 61 genera and 28families,of which 13 are new *** findings increased the knowledge of opisthobranch diversity from the Mauritius by 15.4%.Among the listed species,the distribution range of Cyerce nigra,Actinocyclus papillatus,and Phyllidia picta extended from the Western Pacific to the South Western Indian *** analysis of the undescribed Gymnodoris *** it resembled Gymnodoris *** Hawaii and were different by a genetic distance value of 10.6%.The species richness and evenness were higher within the sheltered regions of Mauritius which harboured the food resource of *** areas as compared to unsheltered regions were heavily populated,suggesting the probable influence of wave actions on opisthobranch diversity and *** order Nudibranchia was reported as most speciose,with 86 *** Sacoglossa and Nudibranchia were observed only on macroalgae and sponges *** abundance was also recorded on shipwrecks which are the most common form of artificial *** the inclusion of observations from previous studies,201species belonging to 94 genera and 36 families are now known from the Mauritius.

关键词： marine opisthobranch inventory new record occurrence Republic of Mauritius Indian Ocean

Low testing rates and high BRCA prevalence: Poly (ADP-ribose) polymerase inhibitor use in Middle East BRCA/homologous recombination deficiency-positive cancer patients

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World Journal of Clinical Oncology 2024年第7期15卷 848-858页

作者： Naveed Syed Ashish Vittalrao Chintakuntlawar Deepti Vilasini Aisha Mohamed Al Salami Riad Al Hasan Imrana Afrooz Kanishka Uttam chandani Ashok Uttam chandani Aref Chehal Department of Hematology and Oncology Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Oncology Mayo ClinicRochesterNY 790339United States Department of Oncology Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Clinical Research Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Internal Medicine Landmark Medical CenterRhode IslandRI 02895United States

BACKGROUND Poly(ADP-ribose)polymerase inhibitors(PARPis)are approved as first-line therapies for breast cancer gene(BRCA)-positive,human epidermal growth factor receptor 2-negative locally advanced or metastatic breast *** are also effective for new and recurrent ovarian cancers that are BRCA-or homologous recombination deficiency(HRD)-***,data on these mutations and PARPi use in the Middle East are *** To assess BRCA/HRD prevalence and PARPi use in patients in the Middle East with breast/ovarian *** This was a single-center retrospective study of 57 of 472 breast cancer patients tested for BRCA mutations,and 25 of 65 ovarian cancer patients tested for *** adult patients participated in at least four visits to the oncology service at our center between August 2021 and May *** were summarized using descriptive statistics and compared using counts and *** to treatment was assessed using Response Evaluation Criteria in Solid Tumors *** Among the 472 breast cancer patients,12.1%underwent BRCA testing,and 38.5%of 65 ovarian cancer patients received HRD *** mutations were found in 25.6%of the tested patients:26.3%breast cancers had germline BRCA(gBRCA)mutations and 24.0%ovarian cancers showed ***,40.0%of gBRCA-positive breast cancers and 66.0%of HRD-positive ovarian cancers were Middle Eastern and Asian patients,*** treatment was used in 5(33.3%)gBRCA-positive breast cancer patients as first-line therapy(n=1;7-months progression-free),for maintenance(n=2;>15-months progression-free),or at later stages due to compliance issues(n=2).Four patients(66.6%)with HRD-positive ovarian cancer received PARPi and all remained *** Lower testing rates but higher BRCA mutations in breast cancer were *** reflected United Arab Emirates demographics,with breast cancer in Middle Eastern and ovarian cancer in Asian patients.

关键词： Homologous recombination repair BRCA1 BRCA2 Homologous recombination deficiency Ovarian cancer Breast cancer Poly(ADP-ribose)polymerase inhibitors Olaparib DNA double-strand breaks

Assessing intersectional gender analysis in Nepal’s health management information system: a case study on tuberculosis for inclusive health systems

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贫困所致传染病(英文) 2024年第2期13卷 1-11页

作者： Parajuli Ayuska Kakchapati Sampurna Arjyal Abriti Joshi Deepak Kharel chandani del Barrio Mariam Otmani Baral Sushil C HERD International Saibu Awas Cr-Marga Bhaisepati Lalitpur Nepal UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) World Health Organization Geneva Switzerland

Background Tuberculosis (TB) remains a major public health problem in Nepal, high in settings marked by prevalent gender and social inequities. Various social stratifiers intersect, either privileging or oppressing individuals based on their characteristics and contexts, thereby increasing risks, vulnerabilities and marganilisation associated with TB. This study aimed to assess the inclusiveness of gender and other social stratifiers in key health related national policies and the Health Management Information System (HMIS) of National Tuberculosis Programme (NTP) by conducting an intersectional analysis of TB cases recorded via *** A desk review of key policies and the NTP’s HMIS was conducted. Retrospective intersectional analysis utilized two secondary data sources: annual NTP report (2017–2021) and records of 628 TB cases via HMIS 6.5 from two TB centres (2017/18–2018/19). Chi-square test and multi-variate analysis was used to assess the association between social stratifers and types of TB, registration category and treatment *** Gender, social inclusion and concept of intersectionality are incorporated into various health policies and strategies but lack effective implementation. NTP has initiated the collection of age, sex, ethnicity and location data since 2014/15 through the HMIS. However, only age and sex disaggregated data are routinely reported, leaving recorded social stratifiers of TB patients static without analysis and dissemination. Furthermore, findings from the intersectional analysis using TB secondary data, showed that male more than 25 years exhibited higher odds [adjusted odds ratio (aOR) = 4.95, 95% confidence interval (CI): 1.60–19.06,P = 0.01)] of successful outcome compared to male TB patients less than 25 years. Similarly, sex was significantly associated with types of TB (P < 0.05) whereas both age (P < 0.05) and sex (P < 0.05) were significantly associated with patient registration category (old/new cases).Conclusio

关键词： Tuberculosis Intersectional gender analysis Gender and social inequities Social determinant Health Management Information System National Tuberculosis Programme Social inclusion Gender

Prediction of chemical composition for callus production in Gyrinops walla Gaetner through machine learning

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Information Processing in Agriculture 2020年第4期7卷 511-522页

作者： Sachithri P.Munasinghe Seneviratnege Somaratne Shyama R.Weerakoon chandani Ranasinghe Department of Botany The Open University of Sri LankaP.O.Box 21NawalaNugegoda 10250Sri Lanka Department of Chemistry The Open University of Sri LankaP.O.Box 21NawalaNugegoda 10250Sri Lanka

Developing new tissue culture protocols and optimization of plant media composition for particular plant species are precluded by the higher labor,time and *** usage of machine learning becomes rewarding tools for efficient,cost-effective method of optimization of growth media composition for desires growth *** are often encountered in determination of media composition for raising calli from explants of woody Gyrinops *** paper provides the finding of the study performed on modeling and optimization of chemical composition of culture media for raising callus from explants of *** of experiments were conducted to raise calli from sterilized leaf and node explants with varying concentrations of 1-Naphthaleneacetic acid(NAA),6-Benzylaminopurine(BAP)and coconut water in Murashige and Skoog medium(MSM)and Woody plant medium(WPM)were *** Neural Networks(ANNs)were developed to predict the best media composition on callus weight(CW),callus induction percentage(CIP)and days taken to initiate callus(DC).Callus formation was observed in all the experiments except for *** ANN models were developed to predict the best media composition for CW,CIP and *** results of ANN models predict optimum media composition during the training,validation and testing with satisfactory levels of *** R2 values of the best ANN models;CWnet,CIPnet and DCnet were 0.95,0.95 and 0.88 *** mean sums of square errors(RMSRs)of CWnet,CIPnet and DCnet were 0.1410,0.1391 and 0.1961 and mean residual(MRs)were 0.0199,0.0194 and *** corrected Akaike information criterion(AICc)of the models was331.431,254.926 and210.777,and Schwarz Bayesian information criterion(SBC)were490.495,454.229 and*** predicted best media consisting MSM+3.0 mg/l NAA+0.5 mg/l BAP and MSM+1.5 mg/l NAA+0.5 mg/l BAP were the optimum combination for leaves and nodal explants *** AICc and SBC of CWnet indicated

关键词： Gyrinops walla Gaetner Tissue culture Coconut water Woody plant Artificial neural network

On-chip multiplexed single-cell patterning and controllable intracellular delivery

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Microsystems & Nanoengineering 2020年第1期6卷 1222-1232页

作者： Zaizai Dong Yanli Jiao Bingteng Xie Yongcun Hao Pan Wang Yuanyuan Liu Junfeng Shi chandani Chitrakar Stephen Black Yu-Chieh Wang LJames Lee Mo Li Yubo Fan Lingqian Chang School of Biological Science and Medical Engineering Beihang University100083 BeijingChina Institute of Nanotechnology for Single Cell Analysis(INSCA) Beijing Advanced Innovation Center for Biomedical EngineeringBeihang University100083 BeijingChina College of Agricultural and Life Sciences University of FloridaGainesvilleFL 32611USA Center for Reproductive Medicine Peking University Third Hospital100191 BeijingChina Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace Northwestern Polytechnical University710072 Xi’anChina Chemical and Biomolecular Engineering Department Ohio State UniversityColumbusOH 43209USA Department of Biomedical Engineering University of North TexasDentonTX 76207USA Department of Pharmaceutical Sciences University of North Texas Health Science CenterFort WorthTX 76107USA

Conventional electroporation approaches show limitations in the delivery of macromolecules in vitro and in *** limitations include low efficiency,noticeable cell damage and nonuniform delivery of ***,we present a simple 3D electroporation platform that enables massively parallel single-cell manipulation and the intracellular delivery of macromolecules and small molecules.A pyramid pit micropore array chip was fabricated based on a silicon wet-etching method.A controllable vacuum system was adopted to trap a single cell on each *** this chip,safe single-cell electroporation was performed at low *** of various sizes ranging from oligonucleotides(molecular beacons,22 bp)to plasmid DNA(CRISPR-Cas9 expression vectors,>9 kb)were delivered into targeted cells with a significantly higher transfection efficiency than that of multiple benchmark methods(e.g.,commercial electroporation devices and Lipofectamine).The delivered dose of the chemotherapeutic drug could be controlled by adjusting the applied *** using CRISPR-Cas9 transfection with this system,the p62 gene and CXCR7 gene were knocked out in tumor cells,which effectively inhibited their cellular ***,this vacuum-assisted micropore array platform provides a simple,efficient,high-throughput intracellular delivery method that may facilitate on-chip cell manipulation,intracellular investigation and cancer therapy.

关键词： inhibited vacuum limitations

Understanding gender and its intersection with social stratifiers on prevention and care seeking behavior of lymphatic filariasis in Nepal

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Infectious Diseases of Poverty 2023年第4期12卷 104-104页

作者： Abriti Arjyal Ayuska Parajuli chandani Kharel Mariam Otmani Del Barrio Sushil Chandra Baral HERD International Kathmandu Nepal UNICEF UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) World Health Organization Geneva Switzerland

BackgroundLymphatic filariasis (LF) is a debilitating and painful neglected tropical disease and is one of the leading causes of permanent disability. In many countries, the intersection of gender with various social stratifiers has influenced exposure to LF and ultimately impacting the disease burden and its elimination. This study aimed to explore the influence of gender and its intersection with other social stratifiers for the prevention and care seeking behavior of LF in *** study employed qualitative research methods: in-depth interviews (IDIs) and focus group discussions (FGDs) for data collection in Bardiya, Nepal. A total of 22 IDIs (11 male, 11 female) and 2 FGDs (1 male and 1 female) were conducted with the community people between January and March 2020. The participants were purposively selected to represent different social stratifiers including age, sex, ethnicity, occupation. The data collected were analyzed using a thematic framework approach with use of intersectional gender analysis *** study findings revealed that men spend more time outside their household compared to women while fulfilling their roles and responsibilities, largely determined by societal expectations and gender norms. This resulted in limited access to preventive health services for men, as they often missed annual mass drug administration programme in their community and limited access to preventive methods. Further traditional occupation, specific to particular ethnicity, influenced the vulnerability to LF for certain ethnic groups. The ability to prevent exposure varied among individuals. Although women made decisions regarding the use of protective methods, it was influenced by patriarchal and gender norms. They often felt a responsibility to take care and priorities males and other family members when resources are limited. The intersectionality of gender with other social stratifiers such as marital status, ethnicity, and geographical areas infl

关键词： Gender Intersectionality Lymphatic filariasis Social stratifer Intersectional gender analysis Gender norm Disease vulnerability

A Note on the Status of Dairy Farming in Galle District, Sri Lanka

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Journal of Physical Science and Application 2015年第3期5卷 173-178页

作者： Palapa Gamage Mihiri Kalpani Kodithuwakku Arachchige Mangala Sudarshanie Hemantha chandani Edirisinghage Wegiriya Department of Zoology University of Ruhuna Matara 8100 Sri Lanka

Present investigation was carried out to study the factors which affect milk production of dairy cattle in Labuduwa, Rathgama and Yakkalamulla veterinary ranges in Galle district, Sri Lanka. Breed type of cattle, insemination method, sex of the calves, milk production of mother cows, rearing methods and ectoparasitic tick infestations were studied. The studied cattle were belonged to cross breeds of Jersey, Friesian, Sahiwal and AFS （Australian friesian sahiwal）and Jersey was the most common breed. Sahiwal and AFS breeds tend to produce more male calves under artificial insemination. The milk production of mother cows reared under semi intensive management system was high （p 〈 0.05）. In addition, results revealed that the milk production of artificially inseminated mother cows was higher than that of the naturally bred mother cows （p 〉 0.05）. Boophillus decolaratus was the only tick species present on studied calves with low percentage abundance （14.54%） of male ticks compared to that of female ticks （85.45%）. Tick abundance was high in calves reared under free range management system. The tick abundance was high in Labuduwa range than Rathgama range （p 〉 0.05）. According to the findings of the present study, the effect of the cattle management system has considerable impacts on milk production and tick infestations of dairy cattle in studied veterinary ranges in Galle district.

关键词： Milk production cattle management systems Boophillus decolaratus.