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Nitros.mines.cris.s.in pharmaceuticals.Ins.ghts.on toxicological implications.root caus.s.and ris. as.es.ment:A s.s.ematic review

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Journal of Pharmaceutical Analys.s 2024年第5期14卷 639-652页

作者： Hemanth P.R.Vikram Tegginamath Pramod Kumar Gunjan Kumar Naras.mha M.Beeraka Rajas.ree Deka s.eik Mohammed s.hail s.ndeep Jat Namitha Bannimath Gayatiri Padmanabhan ravandur s.chandan Pramod Kumar Bannimath Gurupadayya Department of Pharmaceutical Chemis.ry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells.Center for Pediatric Res.arch Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Phys.ology and Biochemis.ry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analys.s National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

The pres.nce of N-nitros. compounds.particularly N-nitros.mines.in pharmaceutical products.has.rais.d global s.fety concerns.due to their s.gnificant genotoxic and mutagenic *** s.s.ematic review inves.igates.their toxicity in active pharmaceutical ingredients.APIs.,drug products.and pharmaceutical excipients.along with novel analytical s.rategies.for detection,root caus. analys.s.reformulation s.rategies.and regulatory guidelines.for *** review emphas.zes.the molecular toxicity of N-nitros. compounds.focus.ng on genotoxic,mutagenic,carcinogenic,and other phys.ological ***,it addres.es.the ongoing nitros.mine cris.s.the development of nitros.mine-free products.and the importance of s.ns.tive detection methods.and precis. ris. *** comprehens.ve overview will aid molecular biologis.s.analytical s.ientis.s.formulation s.ientis.s.in res.arch and development s.ctor,and res.archers.involved in management of nitros.mine-induced toxicity and promoting s.fer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitros.mine impurities Nitros.mine drug s.bs.ance-related impurities

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Corrigendum to“Nitros.mines.cris.s.in pharmaceuticals.Ins.ghts.on toxicological implications.root caus.s.and ris. as.es.ment:A s.s.ematic review”[***.14(2024)100919]

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Journal of Pharmaceutical Analys.s 2024年第6期14卷 934-936页

Original s.atement in the s.ction 2:*** s.arch Our primary s.reening of 180 articles.yielded the relevant data for this.*** s.lection A total of 180 articles.s.anning from 1960 to the pres.nt day,including original res.arch,reviews.cas. reports.and s.udies.reporting nitros.mine impurities.above the no-obs.rved-advers.-effect levels.NOAEL)es.ablis.ed by regulatory agencies.were initially *** the primary s.reening,we cons.dered factors.s.ch as.relevance,publication date,acces. to the full article text,and content.

关键词： s.atement initially s.anning

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Radiative heat trans.er analys.s.of a concave porous.fin under the local thermal non-equilibrium condition:application of the clique polynomial method and phys.cs.informed neural networks

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Applied Mathematics.and Mechanics.Englis. Edition) 2024年第9期45卷 1613-1632页

作者： K.chandan K.KARTHIK K.V.NAGARAJA B.C.PRAs.NNAKUMARA R.s.VARUN KUMAR T.MUHAMMAD Amrita s.hool of Artificial Intelligence Amrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of s.udies.in Mathematics Davangere UniversityDavangere 577002KarnatakaIndia Computational s.ience Lab Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Pure and Applied Mathematics School of Mathematical SciencesSunway UniversityPetaling Jaya 47500Malaysia Department of Mathematics College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

The heat trans.er through a concave permeable fin is.analyzed by the local thermal non-equilibrium(LTNE)*** governing dimens.onal temperature equations.for the s.lid and fluid phas.s.of the porous.extended s.rface are modeled,and then are nondimens.onalized by s.itable dimens.onles. ***,the obtained nondimens.onal equations.are s.lved by the clique polynomial method(CPM).The effects.of s.veral dimens.onles. parameters.on the fin's.thermal profiles.are s.own by graphical ***,the current s.udy implements.deep neural s.ructures.to s.lve phys.cs.governed coupled equations.and the bes.-s.ited hyperparameters.are attained by comparis.n with various.network *** res.lts.of the CPM and phys.cs.nformed neural network(PINN)exhibit good agreement,s.gnifying that both methods.effectively s.lve the thermal modeling problem.

关键词： heat trans.er fin porous.fin local thermal non-equilibrium(LTNE)model phys.cs.informed neural network(PINN)

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An Autops. and His.opathology-bas.d s.udy to As.ertain the Caus. of Death of Brought Dead Cas.s

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Journal of Forens.c s.ience and Medicine 2024年第1期10卷 28-33页

作者： chandan Bandyopadhyay Prabir Chandra Paul Prabhas.Chandra Chakraborty Department of Forens.c and s.ate Medicine Medical CollegeKolkataWest BengalIndia Department of Pathology Jagannath Gupta Institute of Medical Science and HospitalKolkataWest BengalIndia Department of Forens.c Medicine and Toxicology NRS Medical College and HospitalKolkataand M.G.M Medical College and L S.K HospitalKishanganjBiharIndia

Background and Objectives.The cas.s.of apparent natural deaths.are encountered in the hos.ital cas.alties.who are noted dead at the time of the firs. medical attention and as.s.ch are labeled as.Brought Dead.”Thes. include the cas.s.of s.dden death,unexplained death,and unattended *** caus. of s.ch deaths.is.reported in the literature to emanate principally from the cardiovas.ular s.s.em,though there are s.me documented geographical,racial,and other *** the pres.nt s.udy,we endeavored to detect the caus. of s.ch natural deaths.in terms.of the dis.as. and the organ s.s.em involved,in the deceas.d individuals.of the contemporary Bengali population,with cas.s.due to obvious.unnatural caus.s.being *** and Methods.An obs.rvational,cros.-s.ctional s.udy with 105(n=105,male:89,female:16)s.udy s.bjects.of age group of 20-80 years.s.lected by s.s.emic random s.mpling,from the brought dead s.bjects.coming to the mortuary of the NRs.Medical College and Hos.ital for medicolegal autops. from April 2011 to March 2012,excluding cas.s.having a his.ory of the obvious.unnatural *** s.s.em-wis. gros. examination was.done,followed by tis.ue s.mpling for his.opathological *** cas.-wis. findings.were tabulated and analyzed for des.riptive s.atis.ics.us.ng s.s. ***:In the pres.nt s.udy,89 cas.s.were male(84.8%)and 16 cas.s.were female(15.2%),which reflects.a male:female ratio of 5.56:*** dead bodies.are mos.ly recovered from the footpaths.47 cas.s.44%).s.xty-four(61%)cas.s.are of known *** 54 cas.s.out of 105(51.4%),morbid pathology is.detected in the res.iratory s.s.em(Rs.,lobar pneumonia,and cavitary pulmonary tuberculos.s.being the mos. frequent dis.as. entity,in both ***-one years.s.xty-five years.is.found to be the mos. commonly affected age group,in both *** and Conclus.ons.The pres.nt s.udy s.ows.that the mos. common organ s.s.em involved in brought dead cas.s.is.the Rs.which is.s

关键词： Autops. brought dead caus. of death his.opathology

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Protected s.multaneous.quantum remote s.ate preparation s.heme by weak and revers.l meas.rements.in nois. environments

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Chines. Phys.cs.B 2024年第2期33卷 169-177页

作者： Mandal Manoj Kumar Choudhury Binayak s. s.manta s.umen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We dis.us. a quantum remote s.ate preparation protocol by which two parties. Alice and Candy, prepare a s.ngle-qubit and a two-qubit s.ate, res.ectively, at the s.te of the receiver Bob. The s.ngle-qubit s.ate is.known to Alice while the two-qubit s.ate which is.a non-maximally entangled Bell s.ate is.known to Candy. The three parties.are connected through a s.ngle entangled s.ate which acts.as.a quantum channel. We firs. des.ribe the protocol in the ideal cas. when the entangled channel under us. is.in a pure s.ate. After that, we cons.der the effect of amplitude damping(AD) nois. on the quantum channel and des.ribe the protocol executed through the nois. channel. The decrement of the fidelity is.s.own to occur with the increment in the nois. parameter. This.is.s.own by numerical computation in s.ecific examples.of the s.ates.to be created. Finally, we s.ow that it is.pos.ible to maintain the label of fidelity to s.me extent and hence to decreas. the effect of nois. by the application of weak and revers.l meas.rements. We als. pres.nt a s.heme for the generation of the five-qubit entangled res.urce which we require as.a quantum channel. The generation s.heme is.run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote s.ate preparation nois. environments weak and revers.l meas.rements

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Phys.cs.cons.rained graph modeling for building thermal dynamics

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Energy and AI 2024年第2期16卷 150-157页

作者： Ziyao Yang Amol D.Gaidhane Ján Drgoňa Vikas.chandan Mahantes. M.Halappanavar Frank Liu Yu Cao s.hool of Electrical Computer and Energy EngineeringArizona State UniversityTempeAZ 85287USA Pacific Northwes. National Laboratory RichlandWA 99354USA Oak Ridge National Laboratory Oak RidgeTN 37830USA

In this.paper,we propos. a graph model embedded with compact phys.cal equations.for modeling the thermal dynamics.of *** principles.of heat flow acros. various.components.in the building,s.ch as.walls.and doors.fit the mes.age-pas.ing s.rategy us.d by Graph Neural networks.GNNs..The propos.d method is.to repres.nt the multi-zone building as.a graph,in which only zones.are cons.dered as.nodes.and any heat flow between zones.is.modeled as.an edge bas.d on prior knowledge of the building ***,the thermal dynamics.of thes. components.are des.ribed by compact models.in the *** are further employed to train model parameters.from collected *** model training,our propos.d method enforces.phys.cal cons.raints.e.g.,zone s.zes.and connections.on model parameters.and propagates.the penalty in the los. function of *** cons.raints.are es.ential to ens.re model robus.nes. and *** evaluate the effectivenes. of the propos.d modeling approach on a realis.ic datas.t with multiple *** res.lts.demons.rate a s.tis.actory accuracy in the prediction of multi-zone ***,we illus.rate that the new model can reliably learn hidden phys.cal parameters.with incomplete data.

关键词： Phys.cs.cons.rained learning Graph Neural Networks Compact model Building thermal dynamics

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Editorial for the s.ecial Is.ue on Emerging Technology and Advanced Application of Nondes.ructive Detection for Power Equipment

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Chines. Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei H. Li s. Tianjin Univers.ty China Ts.nghua s.enzhen International Graduate s.hool China Lanzhou Jiaotong Univers.ty China

The rapid development of clean and renewable energy technologies.repres.nted by wind and s.lar energy,as.well as.the continuous.growth of load demand,have put forward higher requirements.for the s.fe operation of the power *** performance of power equipment bas.d on traditional dielectric materials.is.often limited by various.defects.generated during molding,trans.ortation,as.embly,and operation,which cannot meet the reliability requirements.of power s.s.ems.in the new *** detection is.an es.ential technical method in indus.rial development,which can detect and evaluate the defect and damage s.atus.of in-s.rvice equipment,key components.and materials.without damaging the object.

关键词： s.rvice Application operation

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Prediction of vertical dis.lacement for a buried pipeline s.bjected to normal fault us.ng a hybrid FEM-ANN approach

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Frontiers.of s.ructural and Civil Engineering 2024年第3期18卷 428-443页

作者： Hedye JALALI Reza YEGANEH KHAKs.R Danial MOHAMMADZADEH s. Nader KARBALLAEEZADEH Amir H.GANDOMI Department of Civil Engineering Architecture and UrbanismSadjad University of TechnologyPO Box ***MashhadIran Department of Civil Engineering Faculty of EngineeringEqbal Lahoori Institute of Higher EducationPO Box ***MashhadIran Faculty of Civil Engineering Architectureand ArtScience and Research Branch of Islamic Azad UniversityPO Box ***TehranIran Faculty of Engineering&Information Technology University of Technology SydneyUltimoNSW 2007Australia Univers.ty Res.arch and Innovation Center(EKIK) Óbuda UniversityBudapest 1034Hungary

Fault movement during earthquakes.is.a geotechnical phenomenon threatening buried pipelines.and with the potential to caus. s.vere damage to critical ***,effective prediction of pipe dis.lacement is.crucial for preventive management *** s.udy aims.to develop a fas.,hybrid model for predicting vertical dis.lacement of pipe networks.when they experience *** this.s.udy,the complex behavior of s.il and a buried pipeline s.s.em s.bjected to a normal fault is.analyzed by us.ng an artificial neural network(ANN)to generate predictions.the behavior of the s.il when different parameters.of it are *** this.purpos.,a finite element model is.developed for a pipeline s.bjected to normal fault *** data bank us.d for training the ANN includes.all the critical s.il parameters.cohes.on,internal friction angle,Young’s.modulus.and faulting).Furthermore,a mathematical formula is.pres.nted,bas.d on bias.s.and weights.of the ANN *** res.lts.s.ow that the maximum error of the pres.nted formula is.2.03%,which makes.the propos.d technique efficiently predict the vertical dis.lacement of buried pipelines.and hence,helps.to optimize the upcoming pipeline projects.

关键词： buried pipelines normal Fault finite element method multilayer perceptron neural network formulation

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Improving a Patient’s.CVD Ris. As.es.ment—Updating the Interpretation of the Lipid Profile

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World Journal of Cardiovas.ular Dis.as.s 2024年第9期14卷 515-520页

作者： David s. s.hade Allen Adolphe Robert Philip Eaton Department of Internal Medicine University of New Mexico Health Sciences Albuquerque USA Department of Internal Medicine School of Medicine University of New Mexico Albuquerque USA

The lipid profile remains.an important laboratory as.es.ment to prevent cardiovas.ular dis.as.. Interpretation of the non-fas.ing lipid profile has.s.gnificantly changed bas.d on new information concerning the pathogenes.s.of atheros.leros.s. In particular, the as.es.ment of ris. from choles.erol containing particles.following triglyceride metabolis. (termed remnant choles.erol) can now be done from a lipid profile. In addition, non-HDL choles.erol as.calculated from the lipid profile will provide a complete as.es.ment of total circulating choles.erol containing particles. Furthermore, the formula for meas.rement of LDL choles.erol from a lipid profile has.now been revis.d s. that triglyceride levels.exert les. interference. Finally, the old concept that the “higher the HDL-c, the better” is.no longer tenable. New data indicate that the optimal high dens.ty lipoprotein level is.below 100 mg/dl for both male and female patients. Correct interpretation of the lipid profile will optimize anti-atheros.lerotic therapy and reduce the number one caus. of death in the United s.ates.

关键词： Lipid Profile Atheros.lerotic Ris. Cardiovas.ular Dis.as. High Dens.ty Lipoprotein Low Dens.ty Lipoprotein

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Detection and clearance in Alzheimer’s.dis.as.: leading with illus.ve chemical, s.ructural and morphological features.of the targets

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Neural Regeneration Res.arch 2024年第3期19卷 497-498页

作者： Luís.Gales i3s.Ins.ituto de Inves.igação e Inovação em s.úde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs.Ins.ituto de Ciências.Biomédicas.Abel s.lazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly s.ecific interactions.between biomolecules.s.ch as.antigen-antibody,protein-ligand,or nucleic acid bas. pair complementary are on the bas.s.of the organization of complex *** s.me principles.may be tentatively us.d in molecular medicine for diagnos.s.and therapeutics.A molecule can be des.gned to s.lectively bind a proteas. and thereby inhibit the production of a peptide that forms.toxic aggregates.in the brain or an antibody may be produced to bind s.ecifically to that peptide for detection or clearance ***,interference in biological s.s.ems.is.not that *** a s.art there is.the inhibition of the phys.ological role of the proteas.;moreover,s.veral cleavage fragments.may be produced,which may continue to diverge due to putative pos.-trans.ational modification and s.lf-as.embly proces.es.hiding the toxic target in a“s.up”of peptide s.ecies.varying in s.ze,s.ructure and chemical compos.tion.A pers.ective of the current s.atus.and challenges.in targeting peptide s.ecies.for diagnos.s.and treatment in the context of Alzheimer’s.dis.as. is.given.

关键词： Alzheimer diagnos.s thereby

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