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On the reality of broad iron L lines from the narrow line Seyfert 1 galaxies 1H0707–495 and IRAS 13224–3809

Research in Astronomy and Astrophysics 2016年第11期16卷 37-42页

作者： Pramod Karbhari Pawar Gulab chand Dewangan Madhav Khushalrao patil Ranjeev Misra Sharada Keshav Jogadand S. R. T. M. University Nanded- 431 606 India Inter-University Center for Astronomy and Astrophysics Pune - 411 007 India

We performed time resolved spectroscopy of 1H0707-495 and IRAS 13224-3809 using long XMM-Newton observations. These are strongly variable narrow line Seyfert 1 galaxies and show broad features around 1 keV that have been interpreted as relativistically broad Fe Lc~ lines. Such features are not clearly observed in other active galactic nuclei despite sometimes having high iron abundance required by the best fitted blurred reflection models. Given the importance of these lines, we explore whether the rapid variability of spectral parameters may introduce broad bumps/dips artificially in the time averaged spectrum, which may then be mistaken as broadened lines. We tested this hypothesis by performing time resolved spectroscopy using long （〉 100 ks） XMM-Newton observations and by dividing them into segments with typical exposures of a few ks. We extracted spectra from each such segment and modeled them using a two component phenomenological model consisting of a power law to represent the hard component and a black body to represent the soft emission. As expected, both the sources showed variations in the spectral parameters. Using these variation trends, we simulated model spectra for each segment and then co-added to get a combined simulated spectrum. In the simulated spectra, we found no broad features below 1 keV and in particular no deviation near 0.9 keV as seen in the real averaged spectra. This implies that the broad Fe Lα line that is seen in the spectra of these sources is not an artifact of the variation of spectral components and, hence, provides evidence that the line is indeed genuine.

关键词： galaxies: general -- galaxies: active -- galaxies: individual (1H0707-495 IRAS 13224-3809)

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Anthraquinone Derivatives as an Immune Booster and their Therapeutic Option Against COVID-19

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Natural Products and Bioprospecting 2020年第5期10卷 325-335页

作者： Pukar Khanal B.M.patil Jagdish chand Yasmin Naaz Department of Pharmacology and Toxicology KLE College of PharmacyBelagaviKLE Academy of Higher Education and Research(KAHER)Belagavi 590010India Department of Pharmaceutical Chemistry KLE College of PharmacyBelagaviKLE Academy of Higher Education and Research(KAHER)Belagavi 590010India

Anthraquinone derivatives are identified for their immune-boosting,anti-inflammatory,and anti-viral ***,the pre-sent study aimed to investigate the reported anthraquinone derivatives as immune booster molecules in COVID-19 infection and evaluate their binding affinity with three reported targets of novel coronavirus i.e.3C-like protease,papain-like protease,and spike *** reported anthraquinone derivatives were retrieved from an open-source database and filtered based on a positive druglikeness *** with positive druglikeness scores were predicted for their targets using DIGEP-Pred and the interaction among modulated proteins was evaluated using ***,the associated pathways were recorded concerning the Kyoto Encyclopedia of Genes and Genomes pathway ***,the docking was performed using autodock4 to identify the binding efficacy of anthraquinone derivatives with 3C-like protease,papain-like protease,and spike *** docking the pose of ligand scoring minimum binding energy was chosen to visualize the ligand-protein *** 101 bioactives,36 scored positive druglikeness score and regulated multiple pathways concerned with immune modulation and(non-)infectious ***,docking study revealed torososide B to possess the highest binding affinity with papain-like protease and 3C-like protease and 1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6′-O-acetyl)-β-d-xylopyranosyl-(1→2)-β-d-glucopyranoside with spike protein.

关键词： 3CLpro Anthroquine derivatives Coronavirus COVID-19 Immune boost

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Integration of network and experimental pharmacology to decipher the antidiabetic action of Duranta repens L.

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Journal of Integrative Medicine 2021年第1期19卷 66-77页

作者： Pukar Khanal Basanagouda M.patil Department of Pharmacology and Toxicology KLE College of Pharmacy BelagaviKLE Academy of Higher Education and ResearchBelagavi 590010India

Objective:Duranta repens is reported to contain a wide array of secondary metabolites,including aamylase and a-glucosidase inhibitors,and-has potent antioxidant *** present study evaluated the network pharmacology of ***(whole plant)with targets related to diabetes mellitus and assessed its outcome by evaluating the effects of the hydroalcoholic extract of *** in streptozotocin-nicotinamide-induced diabetes mellitus in ***:Phytoconstituents of *** were retrieved from an open-source database and published literature,and their targets were predicted for diabetes mellitus using Binding DB and the therapeutic target ***-protein interaction was predicted using STRING,and pathways involved in diabetes mellitus were identified using the Kyoto Encyclopedia of Genes and Genomes pathway ***,ADMET profile(absorption,distribution,metabolism,excretion and toxicity)and cytotoxicity of compounds modulating proteins involved in diabetes were predicted using Mol Soft,admet SAR2.0 and CLC-Pred,*** interaction network among phytoconstituents,proteins and pathways was constructed using Cytoscape,and the docking study was performed using Auto *** hydroalcoholic extract of *** was evaluated using streptozotocin-nicotinamide-induced diabetes mellitus animal model for 28 d,followed by an oral glucose tolerance *** the end of the study,biochemical parameters like glycogen content,hepatic enzymes,antioxidant biomarkers and lipid profiles were ***,the liver and pancreas were collected for a histopathology ***:Thirty-six different secondary metabolites from *** were identified to regulate thirty-one targets involved in diabetes mellitus,in which protein-tyrosine phosphatase 1 B(PTP1 B)was primarily *** analysis of modulated proteins identified 12 different pathways in diabetic pathogenesis in which the phosphatidylinositol 3-kinase-protein kinase B(PI3 K-ak

关键词： Diabetes mellitus Duranta repens DurantaninⅠ Network pharmacology Phosphatidylinositol 3-kinase-protein kinase B signaling pathway Protein-tyrosine phosphatase 1B

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Low-salinity-based enhanced oil recovery literature review and associated screening criteria

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Petroleum Science 2019年第6期16卷 1344-1360页

作者： Mukul Chavan Abhijit Dandekar Shirish patil Santanu Khataniar Department of Petroleum Engineering University of Alaska FairbanksFairbanksAKUSA

A thorough literature review is conducted that pertains to low-salinity-based enhanced oil recovery(EOR).This is meant to be a comprehensive review of all the refereed published papers,conference papers,master’s theses and other reports in this *** review is specifically focused on establishing various relations/characteristics or"screening criteria"such as:(1)classification/grouping of clays that have shown or are amenable to low-salinity benefits;(2)clay types *** of residual oil saturations;(3)API gravity and down hole oil viscosity range that is amenable for low salinity;(4)salinity range for EOR benefits;(5)pore sizes,porosity,absolute permeability and wettability range for low-salinity EOR;(6)continuous low-salinity injection ***-wise injection;(7)grouping of possible low-salinity mechanisms;(8)contradictions or similarities between laboratory experiments and field evidence;and(9)compositional variations in tested low-salinity waters.A proposed screening criterion for low-salinity waterflooding is *** can be concluded that either one or more of these mechanisms,or a combination thereof,may be the case-specific mechanism,i.e.,depending on the particular oil–brine–rock(OBR)system rather than something that is"universal"or universally ***,every OBR system that is unique or specific ought to be individually investigated to determine the benefits(if any)of low-salinity water injection;however,the proposed screening criteria may help in narrowing down some of the dominant responsible *** this review primarily focuses on sandstones,given the prominence of carbonates containing^60%of the world’s oil reserves,a summary of possible mechanisms and screening criteria,pertaining to low-salinity waterflooding,for carbonates is also ***,the enhancement of polymer flooding by using low-salinity water as a makeup water to further decrease the residual oil saturation is also discussed.

关键词： Low salinity Waterflooding EOR Clays Screening criteria Mechanism

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卵磷脂对甲烷水合物形成的影响

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化工学报 2007年第11期58卷 2895-2900页

作者：陈卫东 patil S.L. Kamath V.A. Chukwu G.A. 中海油田服务股份有限公司 University of Alaska-Fairbanks FairbanksAK 99775USA Oil and Gas Division Reliance Industries LimitedNavi MumbaiIndia

建立了用于测定卵磷脂(lecithin)对钻井液中水合物形成影响的实验装置及方法,以理解化学添加剂卵磷脂对北极Cascade地区钻井过程中水合物层的稳定作用。本研究旨在理解卵磷脂对纯水中甲烷水合物形成热力学和动力学的影响。结果表明,卵... 详细信息

建立了用于测定卵磷脂(lecithin)对钻井液中水合物形成影响的实验装置及方法,以理解化学添加剂卵磷脂对北极Cascade地区钻井过程中水合物层的稳定作用。本研究旨在理解卵磷脂对纯水中甲烷水合物形成热力学和动力学的影响。结果表明,卵磷脂基本上不影响甲烷水合物生成的热力学条件,但当卵磷脂在水中的浓度超过0.003g.g-1时,它会影响甲烷水合物的生成速度和数量,是很好的水合物生成动力学促进剂。

关键词：甲烷水合物热力学动力学卵磷脂纯水促进剂

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