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Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： chanchal sharma Sehwan Kim Hyemi Eo Sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

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Oxidative stress:culprit or consequence in Alzheimer's amyloidopathy

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Neural Regeneration Research 2023年第9期18卷 1948-1949页

作者： chanchal sharma Sang Ryong Kim School of Life Sciences Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National UniversityDaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

Oxidative stress in Alzheimer’s disease:Oxidative stress refers to an imbalance between the prooxidative and anti-oxidative states that are part of normal cell metabolism that results in the elevated production of reactive oxygen species(ROS) and free *** products oxidize lipids,proteins,and DNA,significantly threatening the integrity of neurons(Pratico,2008;Padurariu et al.,2013).

关键词： metabolism Alzheimer elevated

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Phytochemical screening and traditional medicinal potential of Albizia lebbeck(L.)Benth:An update

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TMR Modern Herbal Medicine 2022年第4期5卷 28-36页

作者： Tanya sharma chanchal Rani Davinder Kumar Harish Kumar Aakash Deep DeshRaj College of Pharmacy Sisar Khas Meham-Rohtak 124112 HaryanaIndia Gurugram Global College of Pharmacy-Haily Mandi Rd Farukh NagarHaryana 122506India College of Pharmacy PGIMSUniversity of Health SciencesRohtak 124001-HaryanaIndia Department of Pharmaceutical Sciences Dr.Har Gobind Khorana Block3rd FloorPrem Nagar CampusCh.Bansi Lal UniversityBhiwani-127021India

Albizia lebbeck Benth,commonly referred to as Indian Siris,is a therapeutically potential plant drug and a financially significant plant with mechanical,therapeutic *** leaves of the plant are a rich source of protein and are said to have significant efficacy against cancer *** plant contains a variety of secondary metabolites such as alkaloids,flavonoids,saponins,anthraquinones,phenols and essential *** reports of the extract of *** show the diverse pharmacological effects such as anti-inflammatory,antibacterial,anti-fertility,antifungal,anthelmintic,antiulcer *** present review paper contains the literature on the scientific reports on the pharmacological and phytochemical importance of ***,which could be a good source of information for researchers,scientists and industry for future reference.

关键词： Albizia lebbeck Anticancer Antimicrobial Anti-inflammatory Albizia saponins Albizia extract Fabaceae

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