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Oxidative stress:culprit or consequence in Alzheimer's amyloidopathy

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Neural Regeneration Research 2023年第9期18卷 1948-1949页

作者： chanchal Sharma Sang Ryong Kim School of Life Sciences Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National UniversityDaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

Oxidative stress in Alzheimer’s disease:Oxidative stress refers to an imbalance between the prooxidative and anti-oxidative states that are part of normal cell metabolism that results in the elevated production of reactive oxygen species(ROS) and free *** products oxidize lipids,proteins,and DNA,significantly threatening the integrity of neurons(Pratico,2008;Padurariu et al.,2013).

关键词： metabolism Alzheimer elevated

Euler-Euler CFD modeling of fluidized bed:Influence of specularity coefficient on hydrodynamic behavior

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Particuology 2013年第6期11卷 673-680页

作者： chanchal Loha Himadri Chattopadhyay Pradip K.Chatterjee Thermal Engineering Group CSIR-Central Mechanical Engineering Research Institute Department of Mechanical Engineering Jadavpur University

Euler-Euler two-fluid model is used to simulate the hydrodynamics of gas-solid flow in a bubbling flu- idized bed with Geldert B particles where the solid property is calculated by applying the kinetic theory of granular flow （KTGF）. Johnson and Jackson wall boundary condition is used for the particle phase, and different amount of slip between particle and wall is given by varying the specularity coefficient （φ） from 0 to 1. The simulated particle velocity, granular temperature and particle volume fraction are compared to investigate the effect of different wall boundary conditions on the hydrodynamic behavior, Some of the results are also compared with the available experimental data from the literature. It was found that the model predictions are sensitive to the specularity coefficient. The hydrodynamic behavior deviated sig- nificantly for φ = 0 and φ = 0.01 with maximum deviation found at φ = 0 i.e. free-slip condition. However, the overall bed height predicted by all the conditions is similar.

关键词： Fluidized bed Hydrodynamics Specularity coefficient CFD

Effect of coefficient of restitution in Euler-Euler CFD simulation of fluidized-bed hydrodynamics

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Particuology 2014年第4期12卷 170-177页

作者： chanchal Loha Himadri Chattopadhyay Pradip K.Chatterjee Thermal Engineering Division CSIR-Central Mechanical Engineering Research InstituteDurgapur 713209India Department of Mechanical Engineering Jadavpur UniversityKolkata 700032India

Collision between particles plays an important role in determining the hydrodynamic characteristics of gas-solid flow in a fluidized bed. In the present work, earlier work （Loha, Chattopadhyay, ＆ Chatterjee, 2013） was extended to study the effect of the elasticity of particle collision on the hydrodynamic behavior of a bubbling fluidized bed filled with 530-~m particles. The Eulerian-Eulerian two-fluid model was used to simulate the hydrodynamics of the bubbling fluidized bed, where the solid-phase properties were calculated by applying the kinetic theory of granular flow. To investigate the effect of the elasticity of particle collision, different values of the coefficient of restitution were applied in the simulation and their effects were studied in detail. Simulations were performed for two different solid-phase wall boundary conditions. No bubble formation was observed for perfectly elastic collision. The bubble formation started as soon as the coefficient of restitution was set below 1.0, and the space occupied by bubbles in the bed increased with a decrease in the coefficient of restitution. Simulation results were also compared with experimental data available in the literature, and good agreement was found for coefficients of restitution of 0.95 and 0.99.

关键词： Coefficient of restitution Fluidization Hydrodynamics Computational fluid dynamics Euler-Euler approach

An Elegant Coupled Model

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Advances in Atmospheric Sciences 1993年第2期10卷 257-260页

作者： chanchal Guha-Roy Dilip Kumar Sinha Center for Atmospheric Sciences University of Calcutta 92 Acharya Prafulla Chandra RoadCalcutta-700009 IndiaCenter for Atmospheric Sciences University of Calcutta 92 Acharya Prafulla Chandra RoadCalcutta-700009 India

This paper deals with a new family of coupled wave equations which are basically nonlinear in nature. An analytical study enables us to show that these equations exhibit solitary wave profiles. Finally some remarks ar... 详细信息

关键词： An Elegant Coupled Model

Comparative Analysis of Splice Site Regions by Information Content

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Genomics, Proteomics & Bioinformatics 2006年第4期4卷 230-237页

作者： T.Shashi Rekha chanchal K.Mitra Department of Biochemistry University of HyderabadHyderabad 500046India.

We have applied concepts from information theory for a comparative analysis of donor （gt） and acceptor （ag） splice site regions in the genes of five different organisms by calculating their mutual information content （relative entropy） over a selected block of nucleotides. A similar pattern that the information content decreases as the block size increases was observed for both regions in all the organisms studied. This result suggests that the information required for splicing might be contained in the consensus of -6-8 nt at both regions. We assume from our study that even though the nucleotides are showing some degrees of conservation in the flanking regions of the splice sites, certain level of variability is still tolerated, which leads the splicing process to occur normally even if the extent of base pairing is not fully satisfied. We also suggest that this variability can be compensated by recognizing different splice sites with different spliceosomal factors.

关键词： splice site substitution matrix mutual information content relative entropy

Comparative Analysis of Transcription Start Sites Using Mutual Information

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Genomics, Proteomics & Bioinformatics 2006年第3期4卷 189-195页

作者： D. Ashok Reddy chanchal K. Mitra Department of Biochemistry University of Hyderabad Hyderabad 500046 India.

The transcription start site （TSS） region shows greater variability compared with other promoter elements. We are interested to search for its variability by using information content as a measure. We note in this study that the variability is significant in the block of 5 nucleotides （nt） surrounding the TSS region compared with the block of 15 nt. This suggests that the actual region that may be involved is in the range of 5-10 nt in size. For Escherichia coli, we note that the information content from dinucleotide substitution matrices clearly shows a better discrimination, suggesting the presence of some correlations. However, for human this effect is much less, and for mouse it is practically absent. We can conclude that the presence of short-range correlations within the TSS region is species-dependent and is not universal. We further observe that there are other variable regions in the mitochondrial control element apart from TSS. It is also noted that effective comparisons can only be made on blocks, while single nucleotide comparisons do not give us any detectable signals.

关键词： transcription start site (TSS) substitution matrices information content

An overview of biomass solid fuels:Biomass sources,processing methods,and morphological and microstructural properties

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Journal of Bioresources and Bioproducts 2023年第4期8卷 333-360页

作者： Segun E.Ibitoye Rasheedat M.Mahamood Tien-Chien Jen chanchal Loha Esther T.Akinlabi Department of Mechanical Engineering Science Faculty of Engineering and the Built EnvironmentUniversity of JohannesburgAuckland Park2006524South Africa Department of Mechanical Engineering Faculty of Engineering and TechnologyUniversity of IlorinIlorin P.M.B.1515Nigeria Energy Research and Technology Group CSIR-Central Mechanical Engineering Research InstituteWest BengalDurgapur-713209India Department of Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle NE18STUnited Kingdom

Biomass solid fuel(BSF)has emerged as a promising renewable energy source,but its morphological and microstructural properties are crucial in determining their physical,mechanical,and chemical *** paper provides an overview of recent research on *** focus is on biomass sources,BSF processing methods,and morphological and microstructural properties,with a special emphasis on energy-related *** inclusion and exclusion criteria were established for the study to ensure *** inclusion criteria encompassed studies about BSFs and studies investigating the influence of biomass sources and processing methods on the morphological and microstructural properties of solid fuels within the past five *** technologies for converting biomass into usable energy were discussed,including gasification,torrefaction,carbonization,hydrothermal carbonization(HTC),and *** has advantages and disadvantages in energy performance,techno-economics,and climate *** is efficient but requires high *** produces bio-oil,char,and gases based on feedstock *** generates low-cost biochar for solid fuels and carbon sequestration *** increases energy density for co-firing with *** processes wet biomass efficiently with lower energy *** treatment affects BSF durability and strength,often leading to less durability due to voids and gaps between *** carbonization alters surface morphology,creating cavities,pores,and distinctive *** pyrolysis generates biochar with better morphological properties,while fast pyrolysis yields biochar with lower porosity and surface *** constitutes 67%of the biomass sources utilized for bioenergy generation,followed by wood residues(5%),agro-residues(4%),municipal solid wastes(3%),energy crops(3%),livestock wastes(3%),and forest residues(1%).Each source has advantages and drawbacks,such as avail

关键词： Biomass feedstock Microstructural property Morphological property Renewable energy Thermal treatment

Clone-World:A visual analytic system for large scale software clones

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Visual Informatics 2019年第1期3卷 18-26页

作者： Debajyoti Mondal Manishankar Mondal chanchal K.Roy Kevin A.Schneider Yukun Li Shisong Wang Department of Computer Science University of SaskatchewanSaskatoonSKCanada

With the era of big data approaching,the number of software systems,their dependencies,as well as the complexity of the individual system is becoming larger and more *** these evolving software systems is thus a primary challenge for cost-effective software management and *** this paper we perform a case study with evolving code *** programmers often need to manually analyze the co-evolution of clone fragments to decide about refactoring,tracking,and bug ***,manual analysis is time consuming,and nearly infeasible for a large number of clones,e.g.,with millions of similarity pairs,where clones are evolving over hundreds of software *** propose an interactive visual analytics system,Clone-World,which leverages big data visualization approach to manage code clones in large software ***-World,gives an intuitive yet powerful solution to the clone analytic ***-World combines multiple informationlinked zoomable views,where users can explore and analyze clones through interactive exploration in real *** studies and experts’reviews suggest that Clone-World may assist developers in many real-life software development and maintenance *** believe that Clone-World will ease the management and maintenance of clones,and inspire future innovation to adapt visual analytics to manage big software systems.

关键词： Visual analytics Software clones Multivariate networks

Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs

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World Journal of Stem Cells 2020年第9期12卷 938-951页

作者： Nazmul Haque Ismail M Fareez Liew Fong Fong chanchal Mandal Noor Hayaty Abu Kasim Kranthi RajaKacharaju Pratiwi Soesilawati Department of Oral Biology and Biomedical Sciences Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia Biotechnology and Genetic Engineering Discipline Life ScienceKhulna UniversityKhulna 9208Bangladesh Faculty of Dentistry University Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty of Dental Medicine Universitas AirlanggaSurabaya 411007Indonesia Department of Conservative Dentistry Faculty of Dentistry MAHSA UniversitySelangor 42610Malaysia Department of Oral Biology Faculty of Dental MedicineUniversitas AirlanggaSurabaya 60115Indonesia

In recent years,several studies have reported positive outcomes of cell-based therapies despite insufficient engraftment of transplanted *** findings have created a huge interest in the regenerative potential of paracrine factors released from transplanted stem or progenitor ***,this notion has also led scientists to question the role of proteins in the secretome produced by cells,tissues or organisms under certain conditions or at a particular time of regenerative *** studies have revealed that the secretomes derived from different cell types contain paracrine factors that could help to prevent apoptosis and induce proliferation of cells residing within the tissues of affected *** could also facilitate the migration of immune,progenitor and stem cells within the body to the site of *** these different paracrine factors present within the secretome,researchers have given proper consideration to stromal cell-derived factor-1(SDF1)that plays a vital role in tissue-specific migration of the cells needed for *** researchers recognized that SDF1 could facilitate site-specific migration of cells by regulating SDF1-CXCR4 and/or HMGB1-SDF1-CXCR4 pathways which is vital for tissue *** in this study,we have attempted to describe the role of different types of cells within the body in facilitating regeneration while emphasizing the HMGB1-SDF1-CXCR4 pathway that orchestrates the migration of cells to the site where regeneration is needed.

关键词： C-X-C motif chemokine 12 Mesenchymal stem cells Monocytes Neutrophils Peripheral blood mononuclear cells Receptor for advanced glycation end products