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Chinese Journal of Integrative Medicine 2017年第12期23卷 916-922页

作者： ZAN Jun-feng SHEN chan-juan ZHANG Li-ping liu Yan-wen Provincial and the Ministry of Education Key Laboratory of Resource Science and Chinese Herbal Compound in Chinese Medicine Hubei University of Chinese MedicineWuhan(430065)China Pharmacy Faculty Hubei University of Chinese MedicineWuhan(430065)China

Objective: To evaluate the effect of Poria cocos(Schw.) Wolf hydroethanolic extract(PHE) against nephrotic syndrome(NS) in rats and to identify the potential active components from PHE. Methods: The high content compounds were isolated and purified by using column chromatography followed by preparative highperformance liquid chromatography(p-HPLC). Forty male Wistar rats with adriamycin(ADR)-induced NS were randomly divided into 5 groups, 8 in each group: model control group, positive control group(with prednisone treatment), PHE low-dose group, PHE middle-dose group and PHE high-dose group. Another 8 rats were recruited as vehicle control group. All rats received the intragastric administration of corresponding drugs or saline for 30 days. During the experimental period, rats’ behavior and appearance were observed and recorded daily, and their body weights were recorded weekly. After treatment, 24-h urine samples were collected to evaluate the urine protein and urine creatinine(Ucr); then the rats were sacrificed to collect carotid blood and to determine the levels of serum total protein(TP), albumin(Alb), globulin(Glo), total cholesterol(TC) and cytokine interlukin-4(IL-4). Results: Six acidic components were isolated and identified from the PHE section: pachymic acid, 15α-hydroxydehydrotumulosic acid, trametenolic acid, dehydropachymic acid, 3β-hydroxy-lanosta-7,9(11), 24-trien-21-oic-acid and dehydroeburicoic acid. Compared with the model control group, the urine protein content were significantly decreased in the PHE treatment groups and positive control group(P<0.05), especially PHE middle-dose group(P<0.01). The Ucr values and serum levels of TP, Glo, TC and IL-4 in PHE low-and middle-dose groups were also presented obvious recover tendency as compared with the model control group(P<0.05 or P<0.01). However, positive control group and all PHE groups indicated no significant therapeutic effect on raising Alb value, although PHE low-and middle-dose treatment gr

关键词： Poria cocos hydroethanolic extract nephrotic syndrome Chinese medicine

Effects of Neutral Detergent Soluble Fiber and Sucrose Supplementation on Ruminal Fermentation, Microbial Synthesis, and Populations of Ruminal Cellulolytic Bacteria Using the Rumen Simulation Technique (RUSITEC)

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Journal of Integrative Agriculture 2013年第8期12卷 1471-1480页

作者： ZHAO Xiang-hui liu chan-juan LI Chao-yun YAO Jun-hu College of Animal Science and Technology Northwest A&F University

We evaluated the effects of neutral detergent soluble fiber （NDSF） and sucrose supplementation on ruminal fermentation, microbial synthesis, and populations of ruminal cellulolytic bacteria using the rumen simulation technique （RUSITEC）. The experiment had a 2x2 factorial design with two dosages of sucrose, low （ca. 0.26 g d-1, low-sucrose） and high （ca. 1.01 g d-1, high-sucrose）, and two dosages of supplied NDSF, low （1.95 g d-1, Iow-NDSF） and high （2.70 g d-1, high-NDSF）. Interactions between NDSF and sucrose were detected for xylanase activity from solid fraction and apparent disappearance of neutral detergent fiber （NDF） and hemicellulose, with the lowest values observed for high-NDSF and high-sucrose treatment. Supplemental NDSF appeared to increase the molar proportion of acetate and reduce that of butyrate; however, the effects of supplemental sucrose on VFA profiles depended upon NDSF amount. There was a NDSFxsucrose interaction for the production of methane. High-NDSF fermenters had lower ammonia-N production, greater daily N flow of solid- associated microbial pellets and total microorganisms, and greater microbial synthesis efficiency compared with low- NDSF fermenters. Supplementation with NDSF resulted in an increase in 16S rDNA copies of Ruminococcusflavefaciens and a reduction in copies of Ruminococcus albus. Supplementation with sucrose tended to increase the 16S rDNA copies ofR. albus from liquid fraction, but did not affect daily total microbial N flow and cellulolytic bacterium populations from solid fraction. These data indicate that the effects of the interaction between NDSF and sugars on ruminal fermentation and fiber digestion should be taken into account in diet formulation. Ruminal fermentation and metabolism of sugars warrant further investigation.

关键词： neutral detergent soluble fiber sucrose ruminal fermentation Rusitec

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内冲击激发式安全雷管的研制与适配性测试

火工品 2025年第1期 1-6页

作者：邓小娟代鹏举董金龙刘晓娟王爱上海鲲程电子科技有限公司上海201100 广东宏大民爆集团有限公司广东广州510000 湖南湘科控股集团有限公司湖南长沙410000 江西新余国泰特种化工有限责任公司江西新余338000 湖南神斧集团湘南爆破器材有限责任公司湖南永州425000

针对工业雷管在使用过程中因起爆药感度高而引发的安全事故和环境污染问题,研制了一种新型内冲击激发式安全雷管(简称“IID雷管”),并开展其与不同点火药的适配性测试。通过采用猛炸药作为主要装药,以及设计激发组件,实现了高效有序的... 详细信息

针对工业雷管在使用过程中因起爆药感度高而引发的安全事故和环境污染问题,研制了一种新型内冲击激发式安全雷管(简称“IID雷管”),并开展其与不同点火药的适配性测试。通过采用猛炸药作为主要装药,以及设计激发组件,实现了高效有序的起爆和传爆过程;通过与不同点火药的适配测试,以及对起爆能力、延期精度等关键功能的全面评估,验证了IID雷管在与LTNR和K-K等药剂适配时,各项性能均满足行业标准。此外,IID雷管结构工艺简单、安全环保,具有广泛的应用前景。

关键词：安全雷管数码电子雷管内冲击激发无起爆药雷管激发组件

Antioxidant activity and hepatoprotective effect of 10 medicinal herbs on CCl4-induced liver injury in mice

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World Journal of Gastroenterology 2020年第37期26卷 5629-5645页

作者： Xiao Meng Guo-Yi Tang Pin-He liu chan-juan Zhao Qing liu Hua-Bin Li Department of Nutrition School of Public HealthSun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Bio-statistics School of Public HealthHainan Medical UniversityHaikou 571199Hainan ProvinceChina

BACKGROUND Many natural products confer health benefits against diverse diseases through their antioxidant *** tetrachloride(CCl4)is often used in animal experiments to study the effects of substances on liver injury and the related mechanisms of action,among which oxidative stress is a major pathogenic *** To compare antioxidant and hepatoprotective activities of ten herbs and identify and quantify phytochemicals for the one with strongest *** The antioxidant activity of ten medicinal herbs was determined by both ferricreducing antioxidant power and Trolox equivalent antioxidant capacity *** total phenolic and flavonoid contents were determined by Folin–Ciocalteu method and aluminum chloride colorimetry,*** effects on CCl4-induced oxidative liver injury were evaluated and compared in a mouse model by administrating each water extract(0.15 g/mL,10 mL/kg)once per day for seven consecutive days and a dose of CCl4 solution in olive oil(8%,v/v,10 mL/kg).The herb with the strongest hepatoprotective performance was analyzed for the detailed bioactive components by using high-performance liquid chromatography-electrospray ionization source-ion trap tandem mass *** The results revealed that all tested herbs attenuated CCl4-induced oxidative liver injury;each resulted in significant decreases in levels of serum alanine transaminase,aspartate transaminase,alkaline phosphatase,and *** addition,most herbs restored hepatic superoxide dismutase and catalase activities,glutathione levels,and reduced malondialdehyde *** officinalis(***)L.,Coptis chinensis Franch.,and Pueraria lobata(Willd.)Ohwi root were the three most effective herbs,and *** *** the strongest hepatoprotective *** active components were identified in *** *** acid and(+)-catechin were quantified(7.86±0.45 mg/g and 8.19±0.57 mg/g dried weight,respectively).

关键词： Antioxidant activity CCl4-induced liver injury Medicinal herbs Hepatoprotection Sanguisorba officinalis L. Coptis chinensis Franch

A Facile Strategy to Enhance the Formation of Stereocomplex Crystallites in Poly(L-lactic acid)/Poly(D-lactic acid) Blend with High Molecular Weights

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Chinese Journal of Polymer Science 2023年第7期41卷 1115-1122页

作者： chan-Na Zhong Ya-Dong liu juan Tang Wei-Shuo Chen Shuang-Cheng Li Jun Shao Hao-Qing Hou College of Chemistry&Chemical Engineering and Nanofiber Engineering Center of Jiangxi Province Jiangxi Normal UniversityNanchang330022China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal UniversityNanchang330022China

Blending of poly(levorotatory-lactic acid) (PLLA) and poly(dextrorotatory-lactic acid) (PDLA) produces the stereocomplex crystallites (PLA SC), which present higher melting temperature and mechanical properties than that of neat PLLA or PDLA. However, in the PLLA/PDLA blends with higher molecular weights, the phase separation occurs and the SC exhibits weak memory after melting, which lead to a small amount of SC together with a large amount of homochiral crystallites (HC) develop during crystallization from the melt. In this study, a small content of graphite oxide was blended with PLLA and PDLA to form ternary blends, and it was exciting to find that the formation of SC was enhanced gradually with the content of graphite oxide. The SC exclusively developed when 2 wt% graphite oxide was incorporated into the PLLA/PDLA, and the crystallinity with ∼50% was received even during fast cooling from the melt (−50 ℃/min). The acceleration formation of SC was speculated due to the interaction between PLA molecular chains and the hydroxyl groups on the surface of graphite oxide and the obstruction of proliferation of graphite oxide.

关键词： Poly(lactic acid)stereocomplex Graphite oxide Crystallization behavior Melt memory

Altered small-world,functional brain networks in patients with lower back pain

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Science China(Life Sciences) 2018年第11期61卷 1420-1424页

作者： Jing liu Feng zhang Xiufen liu Zhizheng Zhuo juan Wei Minyi Du Queenie chan Xiaoying Wang Dongxin Wang Department of Radiology Peking University First HospitalBeijing 100034China Department of Anesthesiology Peking University First HospitalBeijing 100034China Philips Healthcare Beijing 100600China Philips Research China Shanghai 200040China Philips Healthcare Hong KongChina

In this study, we aimed to investigate the functional network changes that occur in patients with lower back pain(LBP). We also investigated the link between LBP and the small-world properties of functional networks within the brain. Functional MRI(fMRI) was performed on 20 individuals with LBP and 17 age and gender-matched normal controls during the resting state. The severity of the pain in the individuals with LBP ranged from 5 to 8 on a 0–10 scale, with 0 indicating no pain. Network-based statistics were performed to investigate the differences between the brain networks of individuals with LBP and those of normal controls. Several small-world parameters of brain networks were calculated, including the clustering coefficient, characteristic path length, local efficiency, and global efficiency. These criteria reflect the overall network efficiency. The brain networks in the individuals with LBP due to herniation of a lumbar disc demonstrated a significantly longer characteristic path length as well as a lower clustering coefficient, global efficiency, and local efficiency compared to those in control subjects. We found that LBP patients tended to have unstable and inefficient brain networks when compared with healthy controls. In addition, LBP individuals showed significantly decreased functional connectivity in the anterior cingulate cortex, middle cingulate cortex, post cingulate cortex, inferior frontal gyrus, middle temporal gyrus, occipital gyrus, postcentral gyrus, precentral gyrus, supplementary motor area, thalamus, fusiform, caudate, and cerebellum. We believe that these regions may be involved in the pathophysiology of lower back pain.

关键词： small-world network brain functional networks resting-state fMRI low back pain

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基于能值法对区域系统的数据采集与应用研究

天津理工大学学报 2025年第1期41卷 145-152页

作者：郝如毅刘娟天津理工大学环境科学与安全工程学院

呼包鄂榆城市群是我国西北地区重要的城市群中心。基于能值理论的分析方法，对2020年呼包鄂榆城市群发展的各项数据进行采集、整理、计算后进行综合分析。结果显示：2020年呼包鄂榆城市群总能值中可更新资源能值的占比为0.24%、不可更... 详细信息

呼包鄂榆城市群是我国西北地区重要的城市群中心。基于能值理论的分析方法，对2020年呼包鄂榆城市群发展的各项数据进行采集、整理、计算后进行综合分析。结果显示：2020年呼包鄂榆城市群总能值中可更新资源能值的占比为0.24%、不可更新资源能值的占比较高，达95.67%;能值自给率为96%;区域环境负载率较高；能值产出率为24.46%;城市群能值密度和人均能值量超全国平均水平。可持续指标显示城市群为高度发达的“消费者”导向型经济体；健康能值指数表明呼包鄂榆城市群在城市健康评分分级标准中判定为“很健康”。最后根据数据结论，对呼包鄂榆城市群健康发展提出针对性对策和建议。

关键词：呼包鄂榆城市群能值理论可持续发展健康指数

Review of computer-generated hologram algorithms for color dynamic holographic three-dimensional display

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Light(Science & Applications) 2022年第9期11卷 1962-1978页

作者： Dapu Pi juan liu Yongtian Wang Beijing Engineering Research Center for Mixed Reality and Advanced Display School of Optics and PhotonicsBeijing Institute of TechnologyBeijing 100081China

Holographic three-dimensional display is an important display technique because it can provide all depth information of a real or virtual scene without any special *** recent years,with the development of computer and optoelectronic technology,computer-generated holograms have attracted extensive attention and developed as the most promising method to realize holographic ***,some bottlenecks still restrict the development of computer-generated holograms,such as heavy computation burden,low image quality,and the complicated system of color holographic *** overcome these problems,numerous algorithms have been investigated with the aim of color dynamic holographic three-dimensional *** this review,we will explain the essence of various computer-generated hologram algorithms and provide some insights for future research.

关键词： holographic dynamic overcome

Direct solution for fixed source location using well-posed TDOA and FDOA measurements

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Journal of Systems Engineering and Electronics 2020年第4期31卷 666-673页

作者： liu Congfeng YUN Jinwei SU juan Research Institute of Electronic Countermeasure Xidian UniversityXi’an 710071China

Based on the time differences of arrival(TDOA) and frequency differences of arrival(FDOA) measurements of the given planar stationary radiation source, the joint TDOA/FDOA location algorithm which solves the location of the target directly is proposed. Compared with weighted least squares(WLS) methods,the proposed algorithm is also suitable for well-posed conditions,and gets rid of the dependence on the constraints of Earth's surface. First of all, the solution formulas are expressed by the radial range. Then substitute it into the equation of the radial range to figure out the radial range between the target and the reference station. Finally use the solution expression of the target location to estimate the location of the target accurately. The proposed algorithm solves the problem that WLS methods have a large positioning error when the number of observation stations is not over-determined. Simulation results show the effectiveness of the proposed algorithm, including effectively increasing the positioning accuracy and reducing the number of observatories.

关键词： passive location joint time differences of arrival/frequency differences of arrival(TDOA/FDOA)location direct solution stationary emitter well-posed equations