检索结果-南通市图书馆

未行淋巴清扫的早期卵巢癌81例生存率的回顾性分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肿瘤 2008年第12期28卷 1059-1063页

作者：陈金虹 Karen kl chan Kar Fai TAM Hextan YS NGAN 上海交通大学医学院附属国际和平妇幼保健院上海200030 香港大学玛丽医院妇产科

目的:探讨对于因各种原因而未行淋巴清扫的早期卵巢癌患者,若不行二次分期手术,而是给予辅助化疗,其生存率是否会受影响。方法:收集1992年1月—2002年12月所有在香港玛丽医院妇产科就治的、因各种原因未接受淋巴清扫的、肉眼直视观察肿... 详细信息

目的:探讨对于因各种原因而未行淋巴清扫的早期卵巢癌患者,若不行二次分期手术,而是给予辅助化疗,其生存率是否会受影响。方法:收集1992年1月—2002年12月所有在香港玛丽医院妇产科就治的、因各种原因未接受淋巴清扫的、肉眼直视观察肿瘤局限于卵巢的Ⅰ期卵巢癌病例进行回顾性分析。结果:有81例患者被纳为研究对象,其中ⅠA期23例,ⅠB期1例,ⅠC期57例。年龄范围21～81岁,平均年龄47岁。随访时间50～179个月,平均随访时间为110个月。其中有64例(79.0%)患者接受了辅助化疗。总的5年生存率和4年无瘤生存率分别为91.4%和85.2%,与文献报道的行淋巴清扫后的结果相近。结论:对于未行淋巴清扫而病变局限于卵巢的Ⅰ期卵巢癌患者,若辅以适当的化疗,可以使她们获得与行淋巴清扫患者同样的生存率。

关键词：淋巴结切除术卵巢肿瘤生存率

马拉松赛对中老年人心脏结构、功能和血清酶的影响

在线全文

学校读者我要写书评

暂无评论

中国运动医学杂志 1990年第2期9卷 76-79页

作者：张宝慧 Pipe AL chan kl 北京医科大学运动医学研究所加拿大渥太华大学心脏研究所

为了了解中老年人马拉松赛后心脏结构、功能和血清磷酸肌酸激酶及同功酶变化的特点,对参加加拿大国家马拉松赛的10名50—73岁的马拉松运动员进行观察并与10名50岁以下的马拉松运动员作了比较,发现50岁以上有训练的马拉松运动员有较好的... 详细信息

为了了解中老年人马拉松赛后心脏结构、功能和血清磷酸肌酸激酶及同功酶变化的特点,对参加加拿大国家马拉松赛的10名50—73岁的马拉松运动员进行观察并与10名50岁以下的马拉松运动员作了比较,发现50岁以上有训练的马拉松运动员有较好的血管调节功能和良好的心脏代偿能力。血清磷酸肌酸激酶同功酶的变化,反映了马拉松跑对老年人心脏的影响。

关键词：马拉松赛心脏功能血清酶结构

Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第31期11卷 4865-4868页

作者： Wai K Leung Francis kl chan Sara SL Fung Mei-Yin Wong Joseph JY Sung Digestive Diseases Center

AIM： To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy. METHODS： Consecutive patients who underwent capsule endoscopy during the 16-mo study period were either given 250 mg oral erythromycin, 1 h prior to swallowing the capsule endoscope or nothing. The gastric and small bowel transit time, and the small bowel image quality were compared. RESULTS： Twenty-four patients received oral erythromycin whereas 14 patients were not given any prokinetic agent. Patients who received erythromycin had a significantly lower gastric transit time than control （16 min vs70 min, P= 0.005）, whereas the small bowel transit time was comparable between the two groups （227 rain vs 183 min, P= 0.18）. Incomplete small bowel examination was found in three patients of the control group and in one patient of the erythromycin group. There was no significant difference in the overall quality of small bowel images between the two groups. A marked reduction in gastric transit time was noted in two patients who had repeat capsule endoscopy after oral erythromycin. CONCLUSION： Use of oral erythromycin significantly reduces the gastric transit time of capsule endoscopy.

关键词： Capsule endoscopy Erythromycin Prokinetic

Anti-rods/rings autoantibody generation in hepatitis Cpatients during interferon-α/ribavirin therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第6期22卷 1966-1974页

作者： Gerson Dierley Keppeke S John Calise Edward kl chan Luis Eduardo C Andrade Rheumatology Division Escola Paulista de MedicinaUniversidade Federal de São PauloSP 04023-062Brazil Department of Oral Biology University of FloridaGainesvilleFL 32610-0424United States 3 Immunology DivisionFleury Medicine and Health Laboratories São PauloSP 04102-050Brazil

Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon α(IFN-α) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies(ANA). Between 20% to 40% of HCV patients treated with IFN-α and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings(RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings(antiRR) autoantibody production by HCV patients after IFN-α/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i.e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5'-monophosphate dehydrogenase 2(IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin is a direct IMPDH2 inhibitor and is able to induce the formation of RR structures in vitro and in vivo. In conclusion, these observations led to the hypothesis that anti-RR autoantibody production is a human model of immunologic tolerance breakdown that allows us to explore the humoral autoimmune response from the beginning of the putative triggering event: exposure to ribavirin and interferon.

关键词： Rods and rings autoantibodies Hepatitis C ribavirin Interferon-α

Arthroscopic treatment options for irreparable rotator cuff tears of the shoulder

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2014年第5期5卷 557-565页

作者： Cameron M Anley Samuel kl chan Martyn Snow Arthros-copy Division The Royal Orthopaedic Hospital

The management of patients with irreparable rotator cuff tears remains a challenge for orthopaedic surgeons with the final treatment option in many algorithms being either a reverse shoulder arthroplasty or a tendon transfer. The long term results of these procedures are however still widely debated, especially in younger patients. A variety of arthroscopic treatment options have been proposed for patients with an irreparable rotator cuff tear without the presence of arthritis of the glenohumeral joint. These include a simple debridement with or without a biceps tenotomy, partial rotator cuff repair with or without an interval slide, tuberplasty, graft interposition of the rotator cuff, suprascapular nerve ablation, superior capsule reconstruction and insertion of a biodegradable spacer(Inspace) to depress the humeral head. These options should be considered as part of the treatment algorithm in patients with an irreparable rotator cuff and could be used as either as an interim procedure, delaying the need for more invasive surgery in the physiologically young and active, or as potential definitive procedures in the medically *** aim of this review is to highlight and summarise arthroscopic procedures and the results thereof currently utilised in the management of these challenging patients.

关键词： Irreparable Arthroscopy Rotator cuff Repair Massive

白塞病相关自身抗原Kinectin的表达型cDNA文库筛选与鉴定

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华风湿病学杂志 2005年第10期9卷 577-581页

作者：陆瑜叶萍陈顺乐顾越英 Eng M.Tan Edward kl chan 上海第二医科大学附属仁济医院风湿科上海市风湿病研究所 200001 Scripps研究所自身免疫病中心

目的研究白塞病患者血循环中的自身抗体及其针对的细胞内靶抗原。方法应用免疫印迹-化学发光法对39例白塞病患者血清进行初步研究,以含有高滴度抗体的患者血清作为“探针”免疫筛选表达型!ZAP噬菌体cDNA文库并鉴定候选克隆,通过真核转... 详细信息

目的研究白塞病患者血循环中的自身抗体及其针对的细胞内靶抗原。方法应用免疫印迹-化学发光法对39例白塞病患者血清进行初步研究,以含有高滴度抗体的患者血清作为“探针”免疫筛选表达型!ZAP噬菌体cDNA文库并鉴定候选克隆,通过真核转录、翻译以及免疫沉淀实验分析阳性克隆表达产物的抗原性。结果文库筛选获得6个独立候选克隆,均为人Kinectin部分全长cDNA,以其中最大克隆的基因表达产物为抗原基质的免疫沉淀研究显示,23.1%(9/39)的白塞病患者血清呈阳性反应,正常人以及系统性红斑狼疮、干燥综合征患者对照阴性。结论Kinectin是白塞病相关自身靶抗原;抗Kinectin抗体与白塞病免疫发病机制的关系值得深入探索,抗体可能对疾病具有潜在血清学诊断价值。

关键词：自身抗原基因文库免疫沉淀法 Kinectin 白塞病 cDNA文库筛选自身抗原白塞病抗Kinectin抗体鉴定基因表达产物系统性红斑狼疮候选克隆全长cDNA

在线全文

学校读者我要写书评

暂无评论

氧化磷脂、脂蛋白a和钙化性主动脉瓣狭窄

中华高血压杂志 2015年第8期23卷 783-783页

作者：刘莉叶鹏 Capoulade R chan kl Yeang C Mathieu P Bossé Y Dumesnil JG Tam JW Teo KK Mahmut A Yang X Witztum JL Arsenault BJ Després JP Pibarot P Tsimikas S

升高的脂蛋白a与主动脉狭窄（aortic stenosis,AS）相关。氧化磷脂是瓣膜细胞内钙化的关键调节物质,由脂蛋白a运载。该研究旨在确定氧化磷脂、脂蛋白a与AS的血流动力学进展和AS相关事件的关联。方法：氧化磷脂载脂蛋白B（oxidized phosp... 详细信息

升高的脂蛋白a与主动脉狭窄（aortic stenosis,AS）相关。氧化磷脂是瓣膜细胞内钙化的关键调节物质,由脂蛋白a运载。该研究旨在确定氧化磷脂、脂蛋白a与AS的血流动力学进展和AS相关事件的关联。方法：氧化磷脂载脂蛋白B（oxidized phospholipids on apolipoprotein B,OxPL-apoB）-100可反映脂蛋白a的生物活性，在220例轻中度AS患者中检测OxPL-apoB水平和脂蛋白a水平。

关键词：钙化性主动脉瓣狭窄脂蛋白a 氧化磷脂 apoB水平主动脉狭窄血流动力学相关事件载脂蛋白

在线全文

学校读者我要写书评

暂无评论

亚太地区胃食管反流病的处理共识:更新版

胃肠病学 2008年第7期13卷 421-436页

作者： Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis kl chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 changi General Hospital Mayo Clinic College of Medicine Rochester University of Arizona Health Sciences Center University of Malaya University of Sydney McMaster University Medical Center Tohoku University Hospital Royal Adelaide Hospital Monash University The Third Hospital Peking University Queen Mary Hospital Prince of Wales Hospital University of Indonesia Korea University College of Medicine University of Santo Tomas National University Hospital Siriraj Hospital

背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,... 详细信息

背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。

关键词：共识糜烂性食管炎非糜烂性反流病

Risk stratification in providing inter-facility transport： Experience from a specialized transport team

在线全文

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2010年第1期1卷 49-52页

作者： LLY Lee WYL Lo kl Yeung E Kalinowski SYH Tang JTS chan Emergency Department Alice Ho Miu Ling Nethersole Hospital Departmentof Emergency Medical Services Kapiolani Community College University of Hawaii Honolulu Hawaii Emergency Department Pok Oi Hospital

The role of Inter-facility transport （IFT） of patients is an emerging specialty requiring service reorganization, diversion of major trauma to trauma center. This study aimed to determine the patients who are more prone to en route adverse event during the period of 22：00 to 07：00, based on critical in-patient needs provided by the Emergency Department （ED） nursing staff at Alice Ho Miu Ling Nethersole Hospital （AHNH）. This study included all 22：00 to 07：00 IFTs accompanied by ED nurses at AHNH for a period of 28 months from August 2006 until December 2008. The transports were reviewed for：（1） age, （2） gender, （3） transport configuration, （4） clinical category, and （5） physiological instability before transport. A total of 79 patients were transported during the 22：00 to 07：00 timeframe within the study period. The types of patients were mainly neurosurgical emergencies （n=32; 40.5%）, surgical emergencies （n=28; 35.4%）, and upper gastrointestinal bleeding （UGIB）（n=11; 13.9%）. En route adverse events were encountered by the accompanying nurses in 16 transports （20.3%） with a higher incidence of adverse events during transport of surgical emergencies, UGIB and patients who were physiological unstable before transport （P〈 0.05）. A specialized transport team from the ED can assist other clinical departments by providing expert care during IFT. In spite of the high quality of care, adverse events do commonly occur.

关键词： Inter-facility transport Specialized transport team Hong Kong