检索结果-南通市图书馆

Quality of survival in patients treated for malignant biliary obstruction caused by unresectable pancreatic head cancer: surgical versus non-surgical palliation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2008年第6期7卷 643-648页

作者： hyung Ook kim Sang Il Hwang Hungdai kim Jun Ho Shin Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

BACKGROUND:Appropriate palliation for unresectable pancreatic head cancer is most *** study was undertaken to compare the survival of patients with biliary obstruction caused by unresectable pancreatic head cancer after surgical and non-surgical palliation. METHODS:We retrospectively reviewed 69 patients who underwent palliative treatment for unresectable pancreatic head ***-two patients with locally advanced disease (local vascular invasion)and 17 with distant metastatic disease were *** patients were divided into two groups,surgical and non-surgical palliation. RESULTS:Thirty-eight patients underwent biliary bypass surgery and 31 had percutaneous transhepatic biliary drainage(PTBD).There was no significant difference in the early complications,successful biliary drainage, recurrent jaundice,and 30-day mortality between surgical palliation and ***,in 52 patients whose tumor was unresectable secondary to local vascular invasion,the rate of recurrent jaundice after successful surgical biliary palliation was lower than that in patients who had non- surgical palliation(P<0.05).The patients who underwent surgical palliation had a longer hospital-free survival rate(P<0.001),although they had a longer postoperative hospital stay(P=0.004)during the first admission ***:In patients with preoperative evaluations showing potentially resectable tumors and/or no metastatic lesions,surgical exploration should be ***,in patients who have unresectable cancer or limited metastatic disease on exploration,surgical palliation should be performed for longer survival and better quality of survival.

关键词： pancreatic cancer obstructive jaundice palliation

Smad3 and its phosphoisoforms are prognostic predictors of hepatocellular carcinoma after curative hepatectomy

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 51-59页

作者： Seok-hyung kim Soomin Ahn Cheol-Keun Park Department of Pathology Samsung Medical CenterSungkyunkwan University School of Medicine

BACKGROUND:Progression of hepatocellular carcinoma (HCC) often leads to vascular invasion and intrahepatic metastasis,which correlate with recurrence after surgical treatment and poor *** may be an unusual cancer affected by continuous inflammation that can lead to consistent upregulation of transforming growth factor-β (TGF-β).Chronic inflammation shifts hepatocytic TGF-β signaling from the tumor-suppressive pSmad3C pathway to the oncogenic pSmad3L *** this study,we investigated the functional roles of Smad3 and its phosphoisoforms in the progression of ***:Tumor tissue microarrays of samples from 272 HCC patients who underwent curative surgical resection were used to detect the expression of Smad3,Smad4,pSmad3C (S423/425),pSmad3L (T179),pSmad3L (S204),and pSmad3L (S213).Disease-specific death was defined as 1) tumor occupying more than 80% of the liver,2) portal venous tumor thrombus (PVTT) proximal to the second bifurcation,3) obstructive jaundice due to tumor,4) distant metastases,or 5) variceal hemorrhage with PVTT proximal to the first *** the time of analysis,tumor recurrence was detected in 184 (67.6%) patients,and 96 (35.3%) had died of ***:Nuclear and cytoplasmic localization of Smad3,and nuclear localization of Smad4 were observed in 18.0%,9.9%,and 9.2% of HCCs,*** rates of Smad3 phosphoisoform-immunoreactive HCC varied according to the location of phosphorylation:pSmad3C (S423/425) 8.1%,pSmad3L (T179) 2.6%,pSmad3L (S204) 2.2%,and pSmad3L (S213) 10.3%.Multivariate analyses revealed that pSmad3C (S423/425) (P=0.022) was an independent predictor of longer recurrence-free ***3L (S213) (P=0.006),intrahepatic metastasis,multicentric occurrence,and liver cirrhosis were independent predictors of shorter recurrence- free *** Smad3 (P=0.006),larger tumor size,and intrahepatic metastasis were independent predictors of shorter disease-specific *** pSmad3L (S213) did not sh

关键词： Smad3 pSmad3C (S423/425) pSmad3L (S213) hepatocellular carcinoma hepatectomy survival

Distribution of electric field for carbon nanotube assembly: Simulation (I)

在线全文

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 117-120页

作者： Soon-Geun KWON Soo-Hyun kim Kwang-Ho kim Myung-chang KANG hyung-Woo LEE Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Korea National Core Research Center for Hybrid Materials Solution Pusan National University

The distribution of electric field for the alignment and attachment of carbon nanotubes (CNTs) was simulated. To be attached at the desired place, the aligned and attracted CNTs should be stayed in the desired area called the stable region or the quasi-stable region for an instant where the change of electric field is minimized. Since the conical electrode has the very narrow sized quasi-stable region, few CNTs can be attached. The rectangular electrodes have a wide stable region, so lots of CNTs can be attached. The results indicate that the round electrode which has a proper sized quasi-stable region is more effective for aligning and attaching a single CNT than the conical or rectangular shaped electrodes.

关键词： carbon nanotubes (CNTs) dielectrophoresis (DEP) round shaped electrode simulation

Dynamic modeling and analysis of vortex filament motion using a novel curve-fitting method

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2016年第1期29卷 53-65页

作者： chang-Joo kim Soo hyung Park Sang Kyung Sung Sung-Nam Jung Department of Aerospace Information Engineering Konkuk UniversitySeoul 05029Republic of Korea

Applications of a novel curve-fitting technique are presented to efficiently predict the motion of the vortex filament, which is trailed from a rigid body such as wings and rotors. The gov- erning equations of the motion, when a Lagrangian approach with the present curve-fitting method is applied, can be transformed into an easily solvable form of the system of nonlinear ordinary dif- ferential equations. The applicability of Bezier curves, B-spline, and Lagrange interpolating polyno- mials is investigated. Local Lagrange interpolating polynomials with a shift operator are proposed as the best selection for applications, since it provides superior system characteristics with minimum computing time, compared to other methods. In addition, the Gauss quadrature formula with local refinement strategy has been developed for an accurate prediction of the induced velocity computed with the line integration of the Biot-Savart law. Rotary-wing problems including a vortex ring problem are analyzed to show the efficiency, accuracy, and flexibility in the applications of the pro- posed method.

关键词： Aerodynamics Biot-Savart law Curve-fitting method Free-vortex wake Rotary wing Vortex filament

Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第29期14卷 4705-4708页

作者： Bum-Soo kim Sun-hyung Joo Kwang-Ro Joo Department of Surgery East-West Neo Medical Center University of KyungHee College of Medicine149 Sangil-dong Gangdong-gu Seoul 134-727 Korea Department of Internal Medicine East-West Neo Medical Center University of KyungHee College of Medicine149 Sangil-dong Gangdong-gu Seoul 134-727 Korea

Tubulovillous adenomas are common in the colon and rectum, but are rare in the common bile duct. Biliary adenomas may produce obstructive jaundice, which can be easily confused with a malignant neoplasm or stone. We report a case of a carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct causing obstructive jaundice. A 55-year-old male presented with a 10-d history of pruritus and progressive jaundice. Abdominal sonography and computed tomography showed a mass in the distal common bile duct. Endoscopic retrograde cholangiopancreatography showed luminal narrowing of the bile duct due to a polypoid mass. Positron emission tomography demonstrated no abnormal uptake. It was thought that this mass was a malignant tumor, thus a pylorus-preserving panceaticoduodenectomy was performed. The final pathology showed a tubulovillous adenoma with carcinoma in situ of the distal common bile duct. At follow-up 8 mo later, endoscopy showed multiple polyps in the rectum, colon and stomach. The polyps were removed by endoscopic mucosal resection and shown to be tubular adenomas with high grade dysplasia. Biliary adenomas require careful follow-up for early detection of recurrence and malignant transformation.

关键词： Common bile duct Adenoma Carcinomain situ

Nitrogen mass balance in a constructed wetland treating piggery wastewater effluent

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2014年第6期26卷 1260-1266页

作者： Soyoung Lee Marla C.Maniquiz-Redillas Jiyeon Choi Lee-hyung kim Water Environment Research Dept. National Institute of Environmental Research Hwangyeong-ro 42 Seo-gu Incheon 404-708 Korea Department of Civil and Environmental Engineering Kongju National University 275 Budaedong Seobukgu Cheonan Chungnamdo 331-717Korea

The nitrogen changes and the nitrogen mass balance in a free water surface flow constructed wetland （CW） using the four-year monitoring data from 2008 to 2012 were estimated. The CW was composed of six cells in series that include the first settling basin （Cell 1）, aeration pond （Cell 2）, deep marsh （Cell 3）, shallow marsh （Cell 4）, deep marsh （Cell 5） and final settling basin （Cell 6）. Analysis revealed that the NH4＋-N concentration decreased because of ammonification which was then followed by nitrification. The NO4＋-N and NO4＋-N were also further reduced by means of microbial activities and plant uptake during photosynthesis. The average nitrogen concentration at the influent was 37,819 kg/year and approximately 45% of that amount exited the CW in the effluent. The denitrification amounted to 34% of the net nitrogen input, whereas the accretion of sediment was only 7%. The biomass uptake of plants was able to retain only 1% of total nitrogen load. In order to improve the nutrient removal by plant uptake, plant coverage in four cells （i.e., Cells 1, 3, 4 and 5） could be increased.

关键词： constructed wetland livestock wastewater nitrogen mass balance plant uptake sediment

S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis

在线全文

学校读者我要写书评

暂无评论

Bone Research 2019年第4期7卷 424-436页

作者： Haemin kim Bongjun kim Sang Il kim hyung Joon kim Brian YRyu Junho Chung Zang Hee Lee Hong-Hee kim Department of Cell and Developmental Biology BK21 Program and DRISeoul National UniversitySeoulKorea Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea Cancer Research Institute Seoul National University College of MedicineSeoulKorea Department of Cancer Biology Seoul National University College of MedicineSeoulKorea Department of Oral Physiology BK21 PLUS Projectand Dental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanKorea Interdisciplinary Program in Bioinformatics Seoul National University College of Natural SciencesSeoulKorea Department of Biomedical Sciences Seoul National University Graduate SchoolSeoulKorea

Bone destruction induced by breast cancer metastasis causes severe complications,including death,in breast cancer *** between cancer cells and skeletal cells in metastatic bone microenvironments is a principal element that drives tumor progression and ***-derived factors play fundamental roles in this form of *** identify soluble factors released from cancer cells in bone metastasis,we established a highly bone-metastatic subline of MDA-MB-231 breast cancer *** subline(mtMDA)showed a markedly elevated ability to secrete S100A4 protein,which directly stimulated osteoclast formation via surface receptor *** S100A4 stimulated osteoclastogenesis in vitro and bone loss in *** medium from mtMDA cells in which S100A4 was knocked down had a reduced ability to stimulate ***,the S100A4 knockdown cells elicited less bone destruction in mice than the control knockdown *** addition,administration of an anti-S100A4 monoclonal antibody(mAb)that we developed attenuated the stimulation of osteoclastogenesis and bone loss by mtMDA in *** together,our results suggest that S100A4 released from breast cancer cells is an important player in the osteolysis caused by breast cancer bone metastasis.

关键词： S100A4 breast metastatic

Gene expression profiling:Canonical molecular changes and clinicopathological features in sporadic colorectal cancers

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第43期14卷 6662-6672页

作者： Jin Cheon kim Seon Young kim Seon Ae Roh Dong-hyung Cho Dae Dong kim Jeong Hyun kim Yong Sung kim Department of Surgery University of Ulsan College of Medicine and Asan Medical Centerand Laboratory of Cancer Biology & GeneticsAsan Institute for Life SciencesSeoul 138-736South Korea Medical Genomics Research Center Korea Research Institute of Bioscience & BiotechnologyDaejeon 305-806South Korea

AIM： To investigate alternative or subordinate pathways involved in colorectal tumorigenesis and tumor growth, possibly determining at-risk populations and predicting responses to treatment. METHODS： Using microarray gene-expression analysis, we analyzed patterns of gene expression relative to canonical molecular changes and clinicopathological features in 84 sporadic colorectal cancer patients, standardized by tumor location. Subsets of differentially expressed genes were confirmed by real-time reverse-transcript polymerase chain reaction （RT-PCR）. RESULTS： The largest number of genes identified as being differentially expressed was by tumor location, and the next largest number by lymphovascular or neural invasion of tumor cells and by mismatch repair （NMR） defects. Amongst biological processes, the immune response was significantly implicated in entire molecular changes observed during colorectal tumorigenesis （P 〈 0.001）. Amongst 47 differentially expressed genes, seven （PISD, NIBP, BAI2, STOML1, MRPL21, MRPL16, and MKKS） were newly found to correlate with tumorigenesis and tumor growth. Most location-associated molecular changes had distinct effects on gene expression, but the effects of the latter were sometimes contradictory. CONCLUSION： We show that several differentially expressed genes were associated with canonical molecular changes in sporadic colorectal cancers, possibly constituting alternative or subordinate pathways of tumorigenesis. As tumor location was the dominant factor influencing differential gene expression, location-specific analysis may identify location-associated pathways and enhance the accuracy of class prediction.

关键词： Colorectal adenocarcinomas Sporadic Gene expression Profiling Tumorigenesis

Double layered self-expanding metal stents for malignant esophageal obstruction, especially across the gastroesophageal junction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第28期18卷 3732-3737页

作者： Min Dae kim Su Bum Park Dae Hwan Kang Jae hyung Lee Cheol Woong Choi hyung Wook kim Chung Uk Chung Young Il Jeong Department of Internal Medicine Bongseng Memorial Hospital Busan 601-723 South Korea Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan 626-770 South Korea

AIM: To evaluate the clinical outcomes of double-layered self-expanding metal stents (SEMS) for treatment of malignant esophageal obstruction according to whether SEMS crosses the gastroesophageal junction (GEJ). METHODS: Forty eight patients who underwent the SEMS insertion for malignant esophageal obstruction were enrolled. Patients were classified as GEJ group (SEMS across GEJ, 18 patients) and non-GEJ group (SEMS above GEJ, 30 patients) according to SEMS position. Double layered (outer uncovered and inner covered stent) esophageal stents were placed. RESULTS: The SEMS insertion and the clinical improvement were achieved in all patients in both groups. Stent malfunction occurred in seven patients in the GEJ group and nine patients in the non-GEJ group. Tumor overgrowth occurred in five and eight patients, respectively, food impaction occurred in one patient in each group, and stent migration occurred in one and no patient, respectively. There were no significant differences between the two groups. Reflux esophagitis occurred more frequently in the GEJ group (eight vs five patients, P = 0.036) and was controlled by proton pump inhibitor. Aspiration pneumonia occurred in zero and five patients, respectively, and tracheoesophageal fistula occurred in zero and two patients, respectively. CONCLUSION: Double-layered SEMS are a feasible and effective treatment when placed across the GEJ for malignant esophageal obstruction. Double-layered SEMS provide acceptable complications, especially migration, although reflux esophagitis is more common in the GEJ group.

关键词： Metal stent Gastroesophageal junction Malignant esophageal obstruction