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Does the antibody production ability affect the serum anti-Helicobacter pylori Ig G titer?

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World Journal of Gastrointestinal Pathophysiology 2016年第3期7卷 288-295页

作者： Hyun Ah Chung Sun-Young Lee Hee Won Moon Jeong Hwan kim In-Kyung Sung hyung Seok Park chan Sup Shim Hye Seung Han Department of Internal Medicine Konkuk University School of Medicine Department of Laboratory Medicine Konkuk University School of Medicine Department of Pathology Konkuk University School of Medicine

AIM: To investigate the relationship between serum titers of anti-Helicobacter pylori(***) immunoglobulin G(IgG) and hepatitis B virus surface antibody(HBsA b).METHODS: Korean adults were included whose samples had positive Giemsa staining on endoscopic biopsy and were studied in the hepatitis B virus surface antigen(HBsA g)/HBsA b serologic assay,pepsinogen(PG) assay,and *** serologic test on the same *** were excluded if they were positive for HBs Ag,had a recent history of medication,or had other medical condition(s).We analyzed the effects of the following factors on serum titers of HBsA b and the *** IgG : Age,density of *** infiltration in biopsy samples,serum concentrations of PG Ⅰ and PG Ⅱ,PG Ⅰ/Ⅱ ratio,and white blood cell ***: Of 111 included subjects,74(66.7%) exhibited a positive HBsA b *** serum *** IgG titer did not correlate with the serum HBsA b titer(P = 0.185); however,it correlated with the degree of *** infiltration on gastric biopsy(P < 0.001) and serum PG Ⅱ concentration(P = 0.042).According to the density of *** infiltration on gastric biopsy,subjects could be subdivided into those with a marked(median: 3.95,range 0.82-4.00)(P = 0.458),moderate(median: 3.37,range 1.86-4.00),and mild *** infiltrations(median: 2.39,range 0.36-4.00)(P < 0.001).Subjects with a marked *** infiltration on gastric biopsy had the highest serological titer,whereas in subjects with moderate and mild *** infiltrations titers were correspondingly lower(P < 0.001).After the successful eradication,significant decreases of the degree of *** infiltration(P < 0.001),serum *** IgG titer(P < 0.001),and serum concentrations of PG I(P = 0.028) and PG Ⅱ(P = 0.028) were ***: The *** IgG assay can be used to estimate the burden of bacteria in immunocompetent hosts with *** infection,regardless of the HBsA b titer after HBV vaccination.

关键词： Antibody Helicobacter pylori Hepatitis B Immunoglobulin G Pepsinogen

ASSOCIATION BETWEEN ACUPUNCTURE NEEDLING SENSATION(DE-QI) AND LOCAL SKIN BLOOD FLOW IN HEALTHY SUBJECTS:A SINGLE-BLIND, RANDOMIZED CONTROLLED TRIAL

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Journal of Integrative Medicine 2014年第3期 256-256页

作者： Kun hyung kim Seung Hee Noh Yu Ri kim Gi Young Yang Jae Kyu kim Division of Clinical Medicine School of Korean MedicinePusan National University Korean Medicine Hospital Pusan National University

Objective: De-qi refers to sensations generated by needle insertion into an acupuncture ***-qi sensation is believed to be associated with treatment effects of acupuncture with the increase of local blood flow, although some patients may feel these sensations *** study aimed to assess the association between the strength of de-qi sensation and local skin blood flow in healthy ***: Forty-five healthy subjects were randomized into real acupuncture(RA) group(n=15), Park-sham acupuncture(SA) group(n=15) and non-needling control(CO) group(n=15).A single acupuncture session was conducted on the right LI4 point with manual stimulation and 10-minute needle ***-qi sensation was assessed immediately after the removal of needling by the Southampton needle sensation *** skin blood flow recording within 2 cm in diameter of ipsilateral LI4 area was performed intermittently from just before the intervention to the end of the trial by the laser Doppler blood perfusion *** between the change of skin blood flow and strength of De-qi was ***: Median change of local skin blood flow from baseline to post-treatment was 48.85, 48.20 and 0.59 arbitrary unit(AU) in RA, SA and CO groups, *** total sensation score was 10, 3 and 0 of 51 points, *** significant correl ation between total sensation score and change of skin blood flow in the RA and SA groups was observed(0.105 9 of Spearman’s rho, P=0.57).Conclusion: The data suggest that there is no association between De-qi sensation and local skin blood flow after acupuncture in healthy *** role of De-qi sensation for physiological changes and clinical outcomes should be further investigated in future acupuncture trials.

关键词： SA AND LOCAL SKIN BLOOD FLOW IN HEALTHY SUBJECTS ASSOCIATION BETWEEN ACUPUNCTURE NEEDLING SENSATION DE-QI RANDOMIZED CONTROLLED TRIAL

Erratum to: Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots

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Nano Research 2021年第3期14卷 895-895页

作者： Xuan-Hung Pham Eunil Hahm Tae Han kim hyung-Mo kim Sang Hun Lee SangChul Lee Homan Kang Ho-Young Lee Dae Hong Jeong Hak Soo Choi Bong-Hyun Jun Department of Bioscience and Biotechnology Konkuk UniversitySeoul143-701Republic of Korea Department of Urology Seoul National University Bundang HospitalSeongnam13620Republic of Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital and Harvard Medical SchoolBostonMA02114USA Department of Chemistry Education Seoul National UniversitySeoul151-742Republic of Korea

Erratum to Nano Research 2020,13(12):3338-3346 htts://***/00.1007/s12274-020-3014-3 One author name and corresponding affiliation of the original version of this article were unfortunately mislabeled.

关键词： SERS bimetallic

Second-look endoscopy and factors associated with delayedbleeding after endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2016年第3期8卷 173-179页

作者： Su-Jin kim Cheol-Woong Choi Dae-Hwan Kang hyung-Wook kim Su-Bum Park Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan 626-770South Korea

Endoscopic submucosal dissection(ESD) is a widely used procedure as curative treatment for superficial gastric neoplasms, including early gastric cancer without lymph node metastasis. However, ESD requires advanced endoscopic skill and there is a major concern regarding complications from bleeding. So far, extensive efforts have been made to develop strategies to reduce post-ESD bleeding. Use of proton pump inhibitors and coagulating exposed vessels on the ulcer floor after ESD are strategies known to reduce the risk of delayed bleeding. Second-look endoscopy(SLE) is also carried out to reduce delayed bleeding following ESD in many institutions. However, the incidence of bleeding still remains around 5%, and further measures are needed to reduce delayed bleeding after gastric ESD. Recently, three randomized studies indicated that routine SLE was unnecessary. Although routine SLE may not be recommended for all patients after gastric ESD, SLE might be an important tool for the prevention of the delayed bleeding in selected high-risk patients. Thus, the identification of the risk factors, such as large size of resected specimen and treatment with multiple antiplatelet medications, may help to further guide clinicians in deciding whether to perform SLE. Studies carried out on larger cohorts are necessary to clarify the efficacy of SLE after ESD in the prevention of post-ESD bleeding in potentially high-risk patients.

关键词： Endoscopic submucosal dissection Secondlookendoscopy Early gastric cancer

物流信息系统对供应链合作效应分析——以韩国报关企业为例

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物流技术 2011年第6期30卷 207-210页

作者：金亨根洪承麟韩国仁荷大学静石物流通商研究院韩国仁川402751 韩国中源大学韩国槐山367805

分析了物流信息系统对供应链合作绩效的影响,发现物流信息系统对供应链内部合作和供应链间合作的服务以及费用绩效都有较大影响,指出供应链合作是提升供应链绩效水平的充要条件。

关键词：物流信息系统供应链管理合作韩国物流企业

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蕨菜超临界萃取物化学成分及其抑制3T3-L1前脂肪细胞分化作用研究

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中国药理学通报 2019年第11期35卷 1590-1595页

作者：吴永祥张瑶卢玮玮胡晓倩權泰亨金泰完黄山学院生命与环境科学学院安徽黄山245041 安东国立大学食品科学与生物技术学院韩国安东760749

目的分析蕨菜超临界CO 2萃取物(SFE-PA)的化学成分,并探究萃取物对3T3-L1前脂肪细胞分化的抑制作用及机制。方法采用GC-MS分析SFE-PA主要化学成分。体外培养3T3-L1前脂肪细胞,构建脂肪细胞分化的细胞模型,MTT法测定细胞毒性,采用油红... 详细信息

目的分析蕨菜超临界CO 2萃取物(SFE-PA)的化学成分,并探究萃取物对3T3-L1前脂肪细胞分化的抑制作用及机制。方法采用GC-MS分析SFE-PA主要化学成分。体外培养3T3-L1前脂肪细胞,构建脂肪细胞分化的细胞模型,MTT法测定细胞毒性,采用油红O染色法分析SFE-PA对脂肪细胞分化的抑制作用,利用qRT-PCR检测脂肪细胞分化中相关基因的mRNA表达水平。结果从SFE-PA中共鉴定出10种化合物,主要成分有4,4,5,7,8-五甲基-二氢香豆素(36.07%)、β-谷甾醇(25.66%)、4-氨基-7-二乙氨基-香豆素(8.26%)、棕榈酸(5.05%)等。SFE-PA浓度依赖性地抑制3T3-L1前脂肪细胞分化,并减少细胞中脂质的沉积。同时,SFE-PA明显下调PPARγ、CEBPα、SREBP-1c、FAS、ACC的mRNA表达水平。结论 SFE-PA具有明显抑制3T3-L1前脂肪细胞分化的作用,这一作用与其调控脂肪细胞分化转录调控因子和脂质合成相关基因等密切相关,而高含量的酚类、醇类化合物可能是其发挥作用的物质基础。

关键词：蕨菜超临界CO 2萃取化学成分 3T3-L1细胞脂肪细胞分化分子机制

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ASSESSMENT OF THE QUALITY OF REPORTING FOR TREATMENT COMPONENTS IN COCHRANE REVIEWS OF ACUPUNCTURE

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Journal of Integrative Medicine 2014年第3期 300-300页

作者： Kun hyung kim Jung Won Kang Myeong Soo Lee Jae Dong Lee Division of Clinical Medicine School of Korean MedicinePusan National University Department of Acupuncture & Moxibustion College of Oriental MedicineKyung Hee University Medical Research Division Korea Institute of Oriental Medicine

Objective: High-quality reporting of treatment details can aid replication of study results in real-world clinical *** Standards for Reporting Interventions in Clinical Trials of Acupuncture(STRICTA) is a reporting guideline for key elements of acupuncture interventions in clinical *** study used STRICTA to investigate whether Cochrane reviews of acupuncture adequately report important treatment ***: Systematic review methods: Cochrane reviews of acupuncture were identified from The Cochrane Library(Issue 7, 2012).Randomized controlled trials(RCTs) included in the reviews and published after 2005 were *** STRICTA, we extracted acupuncture-related information from both the Cochrane reviews and the *** characteristics of included studies table were the major source of intervention information from Cochrane *** quality of acupuncture interventions in Cochrane reviews was assessed and compared to the respective ***: Twenty-five Cochrane reviews of acupuncture and 92 RCTs met the selection *** reviews were 16% less likely to report the acupuncture-related items of STRICTA than RCTs(risk ratio 0.84, 95% confidence interval 0.79 to 0.88, I2=8%).Information was significantly better reported for 10 of the 15 treatment-group items of STRICTA in RCTs than in Cochrane reviews(P<0.05), while four items did so without *** item related to practitioner background was significantly better reported in Cochrane ***: Reporting quality of treatment details in Cochrane reviews of acupuncture was insufficient with regard to STRICTA, even though such information was readily reported in *** overall quality of reporting of the RCTs, while better than the reviews, was also often *** of STRICTA guideline during the review process is recommended to adequately report the key treatment components in Cochrane reviews of *** potential impact of STRICTA

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Formation of ZSM-5 on Silicon Carbide Fibers for Catalytic Support

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材料科学与工程（中英文B版） 2016年第5期6卷 211-217页

作者： Yoon-joo Lee Dong-geun Shin Younghee kim Woo-teck Kwon Soo-ryong kim Doh-hyung Riu Energy Materials Center Korea Institute of Ceramic Engineering and Technology 101 Soho-ro Jinju-si Gyeongsangnam-do52851 Korea Ceramic Fiber & Composite Center Korea Institute of Ceramic Engineering and Technology 101 Soho-ro Jinju-sLGyeongsangnam-do 52851 Korea Department of Materials Science and Engineering Seoul National University of Science and Technology 172 Gongreung 2-dongNowon-gu Seoul 139-743 Korea

Acupuncture for treating uremic pruritus in patients with end stage renal disease:a systematic review

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World Journal of Acupuncture-Moxibustion 2010年第4期20卷 42-42页

作者： Kun hyung kim Tae-Hun kim Jung Won Kang Myeong Soo Lee Sun Mi Choi Edzard Ernst Acupuncture Moxibustion & Meridian Research Center Korea Institute of Oriental Medicine Daejeon Republic of Korea Peninsula Medical School Universities of Exeter & Plymouth

Objective This review aimed to systematically summarize and critically evaluate the clinical evidence for or against the effectiveness of acupuncture as a symptomatic therapy for uremic pruritus (UP) in end-stage renal disease (ESRD) patients. Materials and method: We searched 16 electronic databases from their inceptions to November 2009. All prospective clinical studies of needle acupuncture for uremic pruritus in hemodialysis patients with end-stage renal disease were included regardless of their design. Risk of bias of the included studies were assessed using the Cochrane criteria. Results Of 464 initially located articles, 458 studies were excluded. Three randomized controlled trials (RCTs), one non-randomized controlled trial (CCT) and two uncontrolled observational studies were included. In three RCTs, acupuncture was compared to sham-acupuncture (n=1), oral antihistamine plus topical ointment (n=1) and oral calcitriol (n=1). In one CCT, electroacupuncture (EA) was compared to superfi cial electrical stimulation. In two observational studies, EA (n=1) or manual acupuncture (n=1) were employed. Four of 6 included studies mentioned mild or no occurrence of adverse events. All of included trials reported benef icial effects of acupuncture. However, most of the studies showed high risk of bias, which leave their reports unconvincing. Conclusion The current evidence is insuffi cient to show that acupuncture is an effective treatment for uremic pruritus in patients with end-stage renal disease due to suboptimal quality and lack of methodological rigor of included studies. Future trials should overcome the limitations of the currently available evidence.

关键词：中医学针灸学针法灸法

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