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Glutathione depletion based Pt(Ⅳ) hybrid mesoporous organosilica delivery system to conquer cisplatin chemoresistance: A “one stone three birds” strategy

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Chinese Chemical Letters 2024年第10期35卷 278-285页

作者： Linjie Ju Zhongxi Huang Qian Shen chan fu Shuanghe Li Wenjie Duan Chenfeng Xu Weizhen An Zhiqiang Zhai Jifu Wei changmin Yu Guoren Zhou Department of Pharmacy Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Institute of Cancer ResearchNanjing210009China Key Laboratory of Flexible Electronics(KLOFE) School of Flexible Electronics(Future Technologies)&Institute of Advanced Materials(IAM)Nanjing Tech University(NanjingTech)Nanjing211816China Department of Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Institute of Cancer ResearchNanjing 210009China Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization College of Resources and Environmental SciencesNanjing AgriculturalUniversityNanjing210095China

The occurrence of acquired resistance to cisplatin(DDP)that induces the toxic drug effects has always been a huge challenge and urgently needs to be resolved in the cancer *** combination of anticancer drugs with different mechanisms can remarkably improve the chemotherapeutic *** that glutathione(GSH)plays as the driving factors in the resistance of DDP,here we have firstly proposed a“three birds,one stone”based nanoplatform to achieve triple synergetic effects simultaneously addressing DDP resistance in non-small cell lung cancer(NSCLC).Specifically,we initially designed and synthesized a DDP prodrug[Pt(Ⅳ)]bridged silsesquioxane precursor(Pt-Si).Then Pt-Si and bis[3-(triethoxysilyl)propyl]diselenide(BTESe PD)were integrated into the framework of mesoporous organosilica nanoparticles(MONs)to obtain a nanocarrier MONPt/*** loading with norcantharidin(NCTD)and modifying with the aptamer AS1411 based G-quadruplex(Apt),the Apt@NCTD@MONPt/Seexhibit impressive tumor homing *** being endocytosed,(Ⅰ)the diselenide and-O-Pt(Ⅳ)-O-rich scaffold can be reduced by the excessive GSH,followed by(Ⅱ)breaking the redox homeostasis via GSH depletion and precise release of the ***,the encapsulated NCTD is also released along with the degradation of the nanocarriers thereby(Ⅲ)achieving the GSH depletion and synergistic anti-tumor effect of NCTD and *** together,we believe this“one stone,three birds”strategy may be a promising paradigm to conquer drug resistance for clinical care.

关键词： MON_(ptse) NSCLC Glutathione depletion Responsive biodegradation Traditional Chinese medicines Synergistictherapy

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一种模拟堆石料的二维多边形离散单元法及程序

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岩土力学 2017年第3期38卷 883-892页

作者：罗滔 OOI E T chan A H C 傅少君武汉大学土木建筑工程学院湖北武汉430072 澳大利亚联邦大学工程与计算机信息学院塔斯马尼亚大学工程信息与计算机技术学院

在考虑堆石料真实颗粒形状的基础上,将每个颗粒用一个多边形离散单元表示,基于一种线性搜索算法对多边形-多边形之间的接触详情进行检索计算,引入基于势能原理的法向多边形-多边形接触模型及切向库仑摩擦模型,形成了一种多边形离散元计... 详细信息

在考虑堆石料真实颗粒形状的基础上,将每个颗粒用一个多边形离散单元表示,基于一种线性搜索算法对多边形-多边形之间的接触详情进行检索计算,引入基于势能原理的法向多边形-多边形接触模型及切向库仑摩擦模型,形成了一种多边形离散元计算方法,并开发了相应的PDEM程序。可以从颗粒尺度层面展示颗粒之间的相互作用以及每个颗粒的位移和转动,帮助进一步揭示颗粒的细观特性(形状、大小、材料特性等)对堆石料的宏观强度和变形的影响。最后采用PDEM程序对某粗粒料的二维模型试验进行了数值模拟,得到了与室内试验一致的应力变形规律,展现了其方法和程序用于研究堆石料的有效性。

关键词：堆石料离散单元法接触检索接触模型 PDEM 双轴试验

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Regeneration characteristics of gaps and their effect on Abies fargesii forests in the Shennongjia National Nature Reserve,China

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Forestry Studies in China 2010年第4期12卷 206-212页

作者： fu chan-juan LIU Yan-hong XIONG Wen-juan Key Laboratory for Silviculture and Conservation of the Ministry of Education Beijing Forestry University Beijing 100083 P. R.China

Abiesfargesii is an evergreen tree species of the Pinaceae family, one of the most important cultivated timber species, endemic to China. It is of great importance for the maintenance of vegetation landscape and the preservation of endangered animal species. Community regeneration of forest gaps and their effect on A. fargesii forests in the Shennongjia National Nature Reserve were studied based on two-year field survey data. The results show that 1） forest gap regeneration is an important approach for the regeneration of A. fargesii communities; regeneration characteristics in the gaps of the broad-leaved species Betula albo-sinensis Burk. and the shade-tolerant species A. fargesii differed from those of understory species. 2） A. fargesii is most predominant in early gap regeneration but, over time, is gradually replaced by other species. Seedlings less than three years old accounted for 45.7% of all seedlings and only 6.3% of saplings older than seven years. 3） In terms of height and basal diameter in different sized gaps, size of seedlings showed the following trend： medium 〉 small 〉 large 〉 understory; the relative growth rate appeared in the same order. 4） The size of seedlings did not appear different between within-gap positions in medium and small gaps, but the tallest seedlings grew in the south of the large gaps and declined towards the center and north edges. 5） Principal component analysis suggests that the most important factors for the growth and distribution ofA. fargesii seedlings decreased in order of gap size, slope direction, gap microenvironment and tree-shrub-grass cover.

关键词： Abiesfargesii regeneration gap relative growth rate

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The intragraft vascularized bone marrow component plays a critical role in tolerance induction after reconstructive transplantation

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Cellular & Molecular Immunology 2021年第2期18卷 363-373页

作者： Cheng-Hung Lin Madonna R.Anggelia Hui-Yun Cheng Aline Yen Ling Wang Wen-Yu Chuang Chih-Hung Lin W.P.Andrew Lee fu-chan Wei Gerald Brandacher Center for Vascularized Composite Allotransplantation Department of Plastic and Reconstructive SurgeryChang Gung Memorial HospitalChang Gung Medical College and Chang Gung UniversityTaoyuanTaiwanChina Graduate Institute of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuanTaiwanChina Department of Pathology Chang Gung Memorial HospitalChang Gung Medical College and Chang Gung UniversityTaoyuanTaiwanChina Department of Plastic and Reconstructive Surgery Chiayi Chang Gung Memorial HospitalChiayi CountyTaiwanChina Department of Plastic and Reconstructive Surgery Vascularized Composite Allotransplantation(VCA)LaboratoryJohns Hopkins University School of MedicineBaltimoreMDUnited States

The role of the vascularized bone marrow component as a continuous source of donor-derived hematopoietic stem cells that facilitate tolerance induction of vascularized composite allografts is not completely *** this study,vascularized composite tissue allograft transplantation outcomes between recipients receiving either conventional bone marrow transplantation(CBMT)or vascularized bone marrow(VBM)transplantation from Balb/c(H2d)to C57BL/6(H2b)mice were *** high-or low-dose CBMT(1.5×10^(8)or 3×10^(7)bone marrow cells,respectively)was *** addition,recipients were treated with costimulation blockade(1 mg anti-CD154 and 0.5 mg CTLA4Ig on postoperative days 0 and 2,respectively)and short-term rapamycin(3 mg/kg/day for the first posttransplant week and then every other day for another 3 weeks).Similar to high-dose conventional bone marrow transplantation,5/6 animals in the vascularized bone marrow group demonstrated long-term allograft survival(>120 days).In contrast,significantly shorter median survival was noted in the low-dose CBMT group(~64 days).Consistently high chimerism levels were observed in the VBM transplantation ***,low levels of circulating CD4^(+)and CD8^(+)T cells and a higher ratio of Treg to Teff cells were maintained in VBM transplantation and high-dose CBMT recipients(>30 days)but not in low-dose VBM transplant ***-specific hyporesponsiveness was shown in tolerant recipients in *** of the vascularized bone marrow component after secondary donor-specific skin transplantation did not affect either primary allograft or secondary skin graft survival.

关键词： Vascularized composite allotransplantation Costimulation blockade Donor-specific tolerance Vascularized bone marrow transplantation Chimerism

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mproved Intermittent-clamped Drainage in Lower Lumbar Internal Fixation： A Randomized Prospective Study

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Chinese Medical Journal 2016年第23期129卷 2804-2809页

作者： Qing-Ying Hao Chu-Yin Liu chan-Juan fu Xiao-Hua Zhang Ming-Sheng Tan Department of Spinal Surgery China-Japan Friendship Hospital Beijing 100029 China Graduate School Beijing-University Of Chinese Medicine Beijing 100029 China

Background： Continuous negative pressure drainage （CNPD） is widely used after lower lumbar internal fixation; however, it may cause tremendous blood loss and lead to postoperative hernorrhagic anemia. The present study explored the efficacy and safety of improved intermittent-clamped drainage （ICD） for lower lumbar internal fixation. Methods： This was a prospective study that included 156 patients with decompression of the spinal canal and internal fixation for the first time from January 2012 to December 2014. The patients were randomly divided into ICD group and CNPD group, and each group had 78 cases. A drainage tube was placed under the deep fascia in all patients within 10 min after the commencement of wound closure. The postoperative drainage amount at different time points, the hemoglobin level, and postoperative complications were recorded and compared between the two groups. Shapiro-Wilk test, independent samples t-test, and Mann-Whitney U-test were used in this study. Results： The drainage amount was significantly reduced in the ICD group, as compared with the CNPD group （Z = 10.74, P 〈 0.01 ）. The mean total drainage amount （in rot） of the single-segment and two-segment procedures was significantly greater in the CNPD group than the ICD group （Z =10.63 and 10.75, respectively; P 〈 0.01 ）. For the adverse events, there was no significant difference in postoperative temperature, wound problem, and complications between the two groups. Conclusions： The present study showed a statistically significant reduction in postoperative drainage amount between ICD and CNPD groups, and ICD is an effective, convenient, and safe method for routine use in lower lumbar surgery. It is essential to focus on the effect of clamping drainage with long-segment surgical procedure and complex lumbar disease in the thrther investigation, as well as the effect of clamping on long-term functional outcomes.

关键词： Blood Loss Complications Drainage Lumbar Surgery

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一本哥特式文学评论——评莱斯利·费德勒《美国小说中的爱与死》

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湖南科技大学学报（社会科学版） 2016年第2期19卷 124-128页

作者：傅婵妮湖南科技大学外国语学院湖南湘潭411201

文学评论《美国小说中的爱与死》是美国当代文化批评先驱莱斯利·费德勒的代表作。凭借此书中对美国经典文学作品大胆而独特的评论,费德勒荣登美国当代最重要的文化批评家之列。该书在主题上以"爱与死"为主题,内容观点上颠覆了对美国经... 详细信息

文学评论《美国小说中的爱与死》是美国当代文化批评先驱莱斯利·费德勒的代表作。凭借此书中对美国经典文学作品大胆而独特的评论,费德勒荣登美国当代最重要的文化批评家之列。该书在主题上以"爱与死"为主题,内容观点上颠覆了对美国经典作品的传统评价,形式上僭越了传统文学评论的形式,是部哥特式的文学评论。

关键词：莱斯利·费德勒《美国小说中的爱与死》哥特小说文学评论

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Using free style proximal radial forearm free flaps for head and neck reconstructions

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中国口腔颌面外科杂志 2008年第B5期6卷 187-188页

作者： Jeng-Yee Lin Wei-Chao Huang Ming-Huei Cheng David CC Chuang fu-chan Wei Department of Plastic and Reconstructive Surgery Chang GungMemorial Hospital Taoyuan Taiwan China Xiamen ChangGung Memorial Hospital China

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A fast stereoscopic video coding algorithm based on JMVM

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Science China(Information Sciences) 2011年第6期54卷 1218-1226页

作者： DENG ZhiPin 1,2 , JIA KeBin 1 , chan YuiLam 2 , fu changHong 2 & SIU WanChi 2 1 Department of Electronic Information & Control Engineering, Beijing University of Technology, Beijing 100124, China 2 Department of Electronic Information Engineering, Hong Kong Polytechnic University, Hong Kong, China 1. Department of Electronic Information & Control Engineering Beijing University of Technology Beijing 100124 China2. Department of Electronic Information Engineering Hong Kong Polytechnic University Hong Kong China

In order to exploit the intra-view and inter-view dependencies in stereo video coding, a fast joint motion and disparity estimation algorithm is proposed in this paper. An efficient search strategy based on the motion-disparity constraint is developed, in which both the motion and disparity vectors can be obtained simultaneously with low complexity. Moreover, a credible initial predictive vector set is designed with the aid of the temporal and spatial neighboring blocks so that the coding efficiency can be further enhanced. The experimental results demonstrate that the proposed algorithm can reduce more than 96% coding time compared with the JMVM full search with a negligible quality drop.

关键词： H.264 stereoscopic video coding disparity estimation motion estimation

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Microsurgical Head and Neck Reconstruction

Microsurgical Head and Neck Reconstruction

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海峡两岸2008口腔癌诊治与修复重建新进展研讨会

作者： fu-chan Wei MD FACS Professor Dean Department of Plastic Surgery Medical College chang Gung University chang Gung Memorial Hospital

Development of microsurgical free flap surgery has revolutionized reconstruction approach to various tissue defects resulted from trauma,or cancer *** quality of reconstruction of head and neck defects are greatly enh...

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剩余污泥碱解上清液作为反硝化碳源的回用量实验研究

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土木建筑与环境工程 2010年第1期32卷 125-130页

作者：曹艳晓龙腾锐傅婵媛龚正重庆大学城市建设与环境工程学院重庆400045

考察剩余污泥碱解上清液作为反硝化碳源的反应速率,并据此初步确定上清液的回用量。对剩余污泥进行碱解发酵,选取SRT=9 d的上清液,采用不同的VFA/N比值进行批式试验,考察其反硝化速率,选择出试验条件下的较优比值,并应用于实际生活污水... 详细信息

考察剩余污泥碱解上清液作为反硝化碳源的反应速率,并据此初步确定上清液的回用量。对剩余污泥进行碱解发酵,选取SRT=9 d的上清液,采用不同的VFA/N比值进行批式试验,考察其反硝化速率,选择出试验条件下的较优比值,并应用于实际生活污水中,与单纯生活污水脱氮对照,考察回用的可行性以及回用量的确定,提出利用阶段反硝化率粗略估计污泥碱解上清液回用量的思路。结果显示,所有比值的反硝化速率曲线均可分为4段,且随着VFA/N比值的增加,反硝化速率明显增加,pH值的变化趋势也与之对应;以VFA/N=2.47为分界点,比值继续增加,反硝化速率的增长并不大;将上清液以一定比例投入生活污水,反硝化速率明显提高,平行组6 h反硝化量分别达到47.0 mg/L和33.9 mg/L。

关键词：剩余污泥碱解反硝化回用量

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