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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew chan Robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

QUASI-INTERPOLATING OPERATORS AND THEIR APPLICATIONS IN HYPERSINGULAR INTEGRALS

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Journal of Computational Mathematics 1998年第4期16卷 337-344页

作者： Wong, rh Lu, Y Dalian Univ Technol Inst Math Sci Dalian 116024 Peoples R China

The purpose of this paper is to propose and study a class of quasi-interpolating operators in multivariate spline space S-1/2(Delta(mn)(2*)) on non-uniform type-2 triangulation. Based on the operators, we construct cubature formula for two-dimensional hypersingular integrals. Some computing work have been done and the results are quite satisfactory.

关键词： hypersingular integral finite-part integral quasi-interpolating operator non-uniform type-2 triangulation

A SPLINE METHOD FOR SOLVING TWO-DIMENSIONAL FREDHOLM INTEGRAL EQUATION OF SECOND KIND WITH THE HYPERSINGULAR KERNEL

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Journal of Computational Mathematics 2001年第3期19卷 225-230页

作者： Wang, rh Lu, Y Dalian Univ Technol Inst Math Sci Dalian 116024 Peoples R China

Provides information on a study which proposed a spline method for solving two-dimensional Fredholm Integral Equations of second kind space with hypersingular kernels. Details on the quasi-interpolating operators; Inf... 详细信息

关键词： hypersingular integral finite-part integral quasi-interpolating operator nonuniform type-2 triangulation

PIECEWISE SEMIALGEBRAIC SETS

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Journal of Computational Mathematics 2005年第5期23卷 503-512页

作者： Zhu, CG Wang, rh Dalian Univ Technol Inst Math Sci Dalian 116024 Peoples R China

Semialgebraic sets are objects which are truly a special feature of real algebraic geometry. This paper presents the piecewise semialgebraic set, which is the subset of Rn satisfying a boolean combination of multivariate spline equations and inequalities with real coefficients. Moreover, the stability under projection and the dimension of C^μ piecewise semialgebraic sets are also discussed.

关键词： Algebraic geometry Semialgebraic geometry Tarski-Seidenberg Principle Multivariate splines Piecewise semialgebraic sets

肝脏类器官在肝脏疾病模型与移植治疗中的应用潜力

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中国组织工程研究 2025年第8期29卷 1684-1692页

作者：袁维勃刘婵余丽梅遵义医科大学附属医院贵州省细胞工程重点实验室贵州省遵义市563003 遵义医科大学教育部省部共建组织损伤修复与再生医学协同创新中心贵州省遵义市563000 遵义医科大学附属医院贵州省干细胞临床应用与新药研发工程研究中心贵州省遵义市563003 遵义医科大学附属医院贵州省生物治疗人才基地贵州省遵义市563003 遵义医科大学附属医院遵义市干细胞与再生医学工程研究中心贵州省遵义市563003

背景:肝脏类器官对阐明肝脏疾病的确切病理机制及对肝脏疾病的治疗具有重要的意义。目的:总结目前国内外该领域的基础研究,回顾以往肝脏类器官的构建、疾病建模和移植治疗的重要研究进展,探讨肝脏类器官联合组织工程技术的应用前景。方... 详细信息

背景:肝脏类器官对阐明肝脏疾病的确切病理机制及对肝脏疾病的治疗具有重要的意义。目的:总结目前国内外该领域的基础研究,回顾以往肝脏类器官的构建、疾病建模和移植治疗的重要研究进展,探讨肝脏类器官联合组织工程技术的应用前景。方法:检索PubMed数据库及中国知网数据库收录的相关文献,英文检索词为“liver,organoids,liver diseases”,中文检索词为“肝,类器官,肝脏疾病”,主要检索时限为2018年4月至2024年4月,通过人工阅读排除重复文献等,最终纳入94篇文献进行归纳分析。结果与结论:①肝脏类器官构建的种子细胞主要集中于成体细胞和多能干细胞,通过辅助各种细胞因子参与信号引导作用和细胞外基质提供3D微环境,促进类器官的产生,但是整体成熟度不高,有望通过结合组织工程技术改善这一问题;②体外疾病建模方面主要在简单疾病和单基因遗传病领域研究较多,类器官高度保留患者遗传特性,有望通过结合CRISPR-Cas9基因矫正和其他新兴技术模拟更复杂的肝脏疾病并阐明更深层次的病理机制;③体内移植治疗方面,肝脏类器官能够安全有效的植入,表现出惊人的肝功能替代潜力及组织再生能力,并且还可能通过与其他组织工程材料结合达到治疗目的。

关键词：肝脏类器官干细胞种子细胞肝脏疾病疾病建模体内移植综述

NON-QUASI-NEWTON UPDATES FOR UNCONSTRAINED OPTIMIZATION

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Journal of Computational Mathematics 1995年第2期13卷 95-107页

作者： YUAN, YX BYRD, rh ACAD SINICA CTR COMPBEIJING 100080PEOPLES R CHINA UNIV COLORADO DEPT COMP SCIBOULDERCO 80309

In this report we present some new numerical methods for unconstrained optimization. These methods apply update formulae that do not satisfy the quasi-Newton equation. We derive these new formulae by considering different techniques of approximating the objective function. Theoretical analyses are given to show the advantages of using non-quasi-Newton updates. Under mild conditions we prove that our new update formulae preserve global convergence properties. Numerical results are also presented.

关键词： NON-QUASI-NEWTON UPDATES FOR UNCONSTRAINED OPTIMIZATION Th

CONTROLLING　OVERGRINDING　OF　VALUABLE　MATERIALS　USING　MODIFIED　AIRSPARGED　HYDROCYCLONE

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中国有色金属学会会刊：英文版 1996年第3期6卷 16-21页

作者： Chu, LY Luo, Q Yu, rh SICHUAN UNION UNIV DEPT CHEM PROC MACHINERYCHENGDU 610065PEOPLES R CHINA NORTHEASTERN UNIV DEPT MINERAL ENGNSHENYANG 110006PEOPLES R CHINA

ＣＯＮＴＲＯＬＬＩＮＧＯＶＥＲＧＲＩＮＤＩＮＧＯＦＶＡＬＵＡＢＬＥＭＡＴＥＲＩＡＬＳＵＳＩＮＧＭＯＤＩＦＩＥＤＡＩＲＳＰＡＲＧＥＤＨＹＤＲＯＣＹＣＬＯＮＥ￥ＣｈｕＬｉａｎｇｙｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｃ... 详细信息

ＣＯＮＴＲＯＬＬＩＮＧＯＶＥＲＧＲＩＮＤＩＮＧＯＦＶＡＬＵＡＢＬＥＭＡＴＥＲＩＡＬＳＵＳＩＮＧＭＯＤＩＦＩＥＤＡＩＲＳＰＡＲＧＥＤＨＹＤＲＯＣＹＣＬＯＮＥ￥ＣｈｕＬｉａｎｇｙｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｃａｌＰｒｏｃｅｓｓｉｎｇＭａｃｈｉ...

关键词： modified air-sparged hydrocyclone grinding-classification overgrinding flotation

On the validity of microscopic calculations of double-quantum-dot spin qubits based on Fock-Darwin states

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Science China(Physics,Mechanics & Astronomy) 2018年第4期61卷 36-43页

作者： GuoXuan chan Xin Wang Department of Physics City University of Hong KongHong Kong SARChina City University of Hong Kong Shenzhen Research Institute Shenzhen 51805Z China

We consider two typical approximations that are used in the microscopic calculations of double-quantum dot spin qubits, namely,the Heitler-London(HL) and the Hund-Mulliken(HM) approximations, which use linear combinations of Fock-Darwin states to approximate the two-electron states under the double-well confinement potential. We compared these results to a case in which the solution to a one-dimensional Schr ¨odinger equation was exactly known and found that typical microscopic calculations based on Fock-Darwin states substantially underestimate the value of the exchange interaction, which is the key parameter that controls the quantum dot spin qubits. This underestimation originates from the lack of tunneling of Fock-Darwin states, which is accurate only in the case with a single potential well. Our results suggest that the accuracies of the current two-dimensional molecularorbit-theoretical calculations based on Fock-Darwin states should be revisited since underestimation could only deteriorate in dimensions that are higher than one.

关键词： spin qubits double quantum dots exchange interaction

E-cadherin in gastric cancer

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World Journal of Gastroenterology 2006年第2期12卷 199-203页

作者： Annie On On chan Division of Gastroenterology and Hepatology Department of MedicineThe University of Hong KongQueen Mary HospitalHong KongChina

Cadherin is an adhesion molecule and a superfamily of calcium-mediated membrane glycoproteins. E-cadherin is the prototype of the class E-cadherin that links to catenins to form the cytoskeleton. Recent evidence has shown that E-cadherin not only acts as an adhesive, but also plays important roles in growth development and carcinogenesis. It has been recently viewed as an invasion as well as a growth suppressor gene. This review summarizes the recent discoveries on E-cadherin and its role in gastric cancer. In particular, our work on E-cadherin in gastric cancer, including its relation with Helicobacter pylori and clinical applications, are described in detail.

关键词： E-cadherin Gastric cancer