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Ptip safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis

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Science Bulletin 2024年第13期69卷 2099-2113页

作者： Jianfei Liang Jing Wang Bingdong Sui yibo Tong Jihua chai Qin Zhou Chenxi Zheng Hao Wang Liang Kong Haojian Zhang yi Bai State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyTaikang Center for Life and Medical SciencesWuhan UniversityWuhan 430079China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710004China Department of Implant Dentistry College of StomatologyXi’an Jiaotong UniversityXi’an 710004China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyShaanxi International Joint Research Center for Oral DiseasesCenter for Tissue EngineeringSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDepartment of Oral and Maxillofacial SurgerySchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China Department of Hematology Zhongnan HospitalWuhan UniversityWuhan 430079China Frontier Science Center for Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan 430079China Taikang Center for Life and Medical Sciences Wuhan UniversityWuhan 430079China

Stem cells remain in a quiescent state for long-term maintenance and preservation of potency;this process requires fine-tuning regulatory *** this study,we identified the epigenetic landscape along the developmental trajectory of skeletal stem cells(SSCs)in skeletogenesis governed by a key regulator,Ptip(also known as Paxip1,Pax interaction with transcription-activation domain protein-1).Our results showed that Ptip is required for maintaining the quiescence and potency of SSCs,and loss of Ptip in type II collagen(Col2)^(+)progenitors causes abnormal activation and differentiation of SSCs,impaired growth plate morphogenesis,and long bone *** also found that Ptip suppressed the glycolysis of SSCs through downregulation of phosphoglycerate kinase 1(Pgk1)by repressing histone H3 lysine 27 acetylation(H3K27ac)at the promoter ***,inhibition of glycolysis improved the function of SSCs despite Ptip *** the best of our knowledge,this is the first study to establish an epigenetic framework based on Ptip,which safeguards skeletal stem cell quiescence and potency through metabolic *** framework is expected to improve SSC-based treatments of bone developmental disorders.

关键词： Skeletal stem cells Bone development Epigenetics Ptip Glycolysis

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浅议网上政府的房地产业管理

重庆建筑大学学报 2000年第4期22卷 65-70页

作者：柴毅吴德夫重庆建筑大学管理学院重庆400045

政府是现代经济生活的主体 ,在世界各国积极倡导的“信息高速公路”的五个应用领域中 ,“电子政府”被列为第一位。本文对我国“电子政府”的房地产业管理的现状进行了分析 ,指出了存在的不足 ,提出了构建网上政府房地产业管理初步框架... 详细信息

政府是现代经济生活的主体 ,在世界各国积极倡导的“信息高速公路”的五个应用领域中 ,“电子政府”被列为第一位。本文对我国“电子政府”的房地产业管理的现状进行了分析 ,指出了存在的不足 ,提出了构建网上政府房地产业管理初步框架的建议 ,有助于促进房地产业管理的规范化和现代化建设。

关键词：政府互联网房地产管理

The existence verification of barrier function with application to synchronous safety and stability

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The existence verification of barrier function with applicat...

第32届中国过程控制会议(CPCC2021)

作者： Zheren Zhu yi chai Zhihuan Song Xinmin Zhang IEEE State Key Laboratory of Industrial Control Technology College of Control Science and EngineeringZhejiang University State Key Laboratory of Power Transmission Equipment and System Security and New Technology and School of AutomationChongqing University

This paper mainly discusses the existence of barrier function which can guarantee a dynamic system synchronously safe and ***,scholars will use the terms "if there exists a barrier function" for most related *** this paper,we use a particular case to verify the existence of barrier function and whether it can realize stabilization with guaranteed safety,such as synchronously realizing safety and asymptotic stability,safety and uniform asymptotic stability,safety and exponential stability,and safety and finite-time *** think this paper can help to know the safety under the definitions of barrier functions and realize the safety-and-stability control.

关键词： Existence of barrier function synchronous safety and stability pre-compact forward invariant set and dynamic nonlinear system

Research on Detection Method of UAV Based on micro-Doppler Effect

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Research on Detection Method of UAV Based on micro-Doppler E...

第三十九届中国控制会议

作者： Shuo Li yi chai Maoyun Guo Yunling Liu Key Laboratory of complex system safety and control Ministry of Education

With the wide application of small UAV, its negative effects begin to appear gradually. Therefore, it is of great significance to detect UAV. Because the micro Doppler effect of objects is different under the radar, the UAV can be detected by the time-frequency characteristics of the target micro Doppler signal. In this paper, the radar echo of the UAV rotor is simulated and analyzed by using the scattering point integral model. The results show that the UAV can be detected according to the time-frequency characteristics of the micro Doppler signal generated by the UAV rotor rotation. In this paper, Discrete Wavelet Transform is used to remove the environment clutter in radar signal, Singular Value Decomposition is used to extract the timefrequency characteristics of signal, and finally Support Vector Machine is used as classifier to detect UAV. The experiment shows that the detection accuracy can reach 85%.

关键词： UAV micro Doppler detection

Identification of Early Esophageal Cancer Based on Data Augmentation

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Identification of Early Esophageal Cancer Based on Data Augm...

第三十九届中国控制会议

作者： Xinyi Li yi chai Weiqing Chen Fei Ao Complex system safety and control Key Laboratory of Ministry of EducationSchool of AutomationChongqing University Chongqing University Cancer Hospital

With the improvement of technology, computer-aided technology is playing an increasingly important role in medical diagnosis. Early detection of esophageal cancer has a high probability of cure, so reducing the rate of missed diagnosis is very important for patients. Due to the particularity of medical images, the image data of early esophageal cancer is very ***, we propose a new noise-filtered image augmentation method. After processing the original dataset using this method, a new image is generated to form the augmented the new dataset. The new dataset and the simple dataset are used in the early esophageal cancer recognition algorithm based on YOLOv3-Tiny for transfer learning to obtain training models. The experimental results show that the sensitivity of early esophageal cancer is improved after using the noise-filtered augmentation method. Therefore, the proposed noise-filtered image augmentation method can be applied in the recognition of early esophageal cancer.

关键词： Early esophageal cancer Data augmentation Noise-filtered augmentation method YOLOv3-Tiny

Non-negative Barrier functions to the Multiple Sets of safe state for a Class of Dynamic Systems

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Non-negative Barrier functions to the Multiple Sets of safe ...

第31届中国过程控制会议（CPCC2020）

作者： Zheren Zhu yi chai Zhimin Yang Chenghong Huang State Key Laboratory of Power Transmission Equipment and System Security and New Technology School of Automation Chongqing University

For a class of general systems described by dynamic equations, this article described the two different scenarios about the safe state set consisting of multiple independent subsets, which can be called Archipelago safe sets and Archipelago-bridge safe sets. The former hopes to solve the safety judgment and control problems under multiple working conditions or multiple independent safety state sets. The latter is hoped that it can solve the safety judgment and control problems under the non-convex, complex connectivity and other characteristics of the safety state sets which make state sets difficult to describe with smooth functions. We used the barrier function to establish related system operation safety definitions and safety criteria, and proposed the design idea of safety controller based on control barrier function.

关键词： Non-negative Barrier Function Multiple independent subsets Archipelago Safe Set Archipelago-bridge Safe set and Control Barrier Function

Safety Analysis of Cryogenic Loading System Based on Knowledge Graph

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Safety Analysis of Cryogenic Loading System Based on Knowled...

第40届中国控制会议

作者： Yunling Liu yi chai Wenyi Lin Xinyi Li Key Laboratory of complex system safety and control Ministry of Education College of AutomationChongqing University

Aiming at the problem that it is difficult to realize the traditional way of establishing mechanism model and then analyzing the safety of cryogenic loading system,this paper proposes to build a "system-subsystem-equipment" functional hierarchy model to simplify the difficulty of safety *** order to solve the problems of scattered research results of system safety analysis and difficult knowledge sharing,this paper uses knowledge graph to integrate knowledge related to filling accidents,establishes ontology model of cryogenic loading system based on OWL,realizes the association among accident,evaluation index,monitoring data and other ontologies,and uses SWRL to establish the corresponding relationship among class,instance and *** safety knowledge ontology and SWRL rules are put into the rule engine for reasoning and mining the hidden ***,an example of the actuator subsystem in cryogenic loading system is *** results show that the method can solve the problems of knowledge representation difficulty,lack of automatic semantic reasoning,poor reusability and sharing in cryogenic loading system.

关键词： knowledge graph SWRL rules safety analysis filling accidents

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基于多传感器信息融合的目标跟踪与防撞决策

控制理论与应用 2005年第1期22卷 127-133页

作者：廖传锦黄席樾柴毅重庆大学自动化学院导航制导实验室重庆400044

为了实现汽车主动安全系统中的目标跟踪与防撞,提出了混合式汽车防撞系统信息融合结构模型,采用分级信息融合实现目标跟踪,推导出了基于跟踪残留误差和预测残留误差共同校正的融合算法,并给出了算法的实现结构.在此基础之上,利用模糊积... 详细信息

为了实现汽车主动安全系统中的目标跟踪与防撞,提出了混合式汽车防撞系统信息融合结构模型,采用分级信息融合实现目标跟踪,推导出了基于跟踪残留误差和预测残留误差共同校正的融合算法,并给出了算法的实现结构.在此基础之上,利用模糊积分方法融合多种相关信息,确定了汽车应采用的安全运行模式,实现了主动安全防撞决策.大量实验表明,该算法具有很好的稳定性和准确率.

关键词：汽车防撞信息融合目标跟踪

基于征兆邻搜索优化聚类和自组织映射神经网络的多病害诊断

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农业工程学报 2011年第1期27卷 215-222页

作者：张可柴毅匡金骏输配电装备及系统安全与新技术国家重点实验室自动化学院重庆大学重庆400030

复杂过程具有多样性的特点,常出现多种异常同时发生的情况。针对该问题,对异常过程中征兆的表现及其描述进行了分析,在已有自组织特征映射神经网络(SOM NN,Self-organizing Map Neural Networks)单一故障(病害)诊断的方法的基础上,提出... 详细信息

复杂过程具有多样性的特点,常出现多种异常同时发生的情况。针对该问题,对异常过程中征兆的表现及其描述进行了分析,在已有自组织特征映射神经网络(SOM NN,Self-organizing Map Neural Networks)单一故障(病害)诊断的方法的基础上,提出了具有3级分析结构的SOM NN的多诊断模型。该模型以欧几里德距离作为主要判别条件对邻搜索方法进行优化和改进,在诊断过程中不用学习多病害样本。并在此基础上以农作物中具有代表性的番茄病害为例,提取病害征兆,建立病害与病害征兆之间的映射关系,完成了对病害征兆组合的分类,通过对实例的仿真,证明了该方法在多病害诊断上能获得良好的效果。

关键词：多病害诊断人工神经网络自组织映射邻搜索优化聚类分析番茄病害