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Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients

World Journal of Gastroenterology 2015年第5期21卷 1457-1467页

作者： Jeong Mo Bae Tae Hun lee Nam-Yun Cho Tae-You Kim Gyeong Hoon Kang Laboratory of Epigenetics Cancer Research InstituteSeoul National University College of MedicineSeoul 110-799South Korea Department of Pathology Seoul National University College of MedicineSeoul 110-799South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 110-799South Korea

AIM:To investigate the clinicopathologic characteristics and prognostic implications associated with loss of CDX2 expression in colorectal cancers(CRCs).METHODS:We immunohistochemically evaluated CDX2 expression in 713 CRCs and paired our findings to clinicopathologic and molecular characteristics of each *** included cytokeratin 7 and CK20 expression,microsatellite instability,Cp G island methylator phenotype,and KRAS and BRAF mutation *** and multivariate survival analysis was performed to reveal the prognostic value of CDX2 ***:CDX2 expression was lost in 42(5.9%) ***,loss of CDX2 expression was associated with proximal location,infiltrative growth,advanced T,N,M and overall *** microscopic examination,loss of CDX2 expression was associated with poor differentiation,increased number of tumor-infiltrating lymphocytes,luminal serration and mucin *** of CDX2 expression was also associated with increased CK7 expression,decreased CK20 expression,Cp G island methylator phenotype,microsatellite instability and BRAF *** a univariate survival analysis,patients with loss of CDX2 expression showed worse overall survival(P < 0.001) and progression-free survival(P < 0.001).In a multivariate survival analysis,loss of CDX2 expression was an independent poor prognostic factor of overall survival [hazard ratio(HR) = 1.72,95%CI:1.04-2.85,P = 0.034] and progression-free survival(HR = 1.94,95%CI:1.22-3.07,P = 0.005).CONCLUSION:Loss of CDX2 expression is associated with aggressive clinical behavior and can be used as a prognostic marker in CRCs.

关键词： CDX2 CpG island methylator phenotype Microsatellit

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TFE3-expressing malignant perivascular epithelioid cell tumor of the mesentery:A case report and review of literature

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World Journal of Clinical Cases 2020年第18期8卷 4207-4214页

作者： Nah Ihm Kim Ji Shin lee Yoo Duk Choi U Chul Ju Jong Hee Nam Department of Pathology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Pathology Chonnam National University Hwasun Hospital and Medical SchoolHwasun 58128South Korea Department of Obstetrics and Gynecology Chonnam National University Hwasun Hospital and Medical SchoolHwasun 58128South Korea

BACKGROUND Perivascular epithelioid cell tumor(PEComa)is a rare mesenchymal tumor that exhibits an epithelioid and spindle cell *** tumor is characterized by immunoreactivity for melanocytic and myogenic markers but can be misdiagnosed as more common tumors with similar characteristics,including gastrointestinal stroma tumors or ***,a subset of PEComas has been reported to harbor a transcription factor binding to TFE3 ***,we report a rare case of TFE3-expressing malignant PEComa arising from the *** SUMMARY A 50-year-old woman presented with abdominal discomfort for 3 *** of laboratory tests were all within the normal ranges,and the patient had no notable medical *** resonance imaging revealed a large tumor on the right side of the pelvic floor,which was originally suspected to be a primary ovarian ***,during surgery,the tumor was revealed to have originated from the ***,the tumor was composed of bundles of spindle cells and sheets of epithelioid *** coagulative necrosis and numerous mitotic figures were *** revealed that the tumor cells were positive for smooth muscle actin,HMB-45,and TFE3 *** involvement of the rectal serosa was identified,leading to a final diagnosis of malignant PEComa of the *** resection was followed by adjuvant *** recurrence or metastasis was observed over a 6-month follow-up *** Malignant PEComa of the mesentery is extremely rare and should be distinguished from morphological mimics through differential diagnosis and immunohistochemistry.

关键词： Perivascular epithelioid cell tumor TFE3 Differential diagnosis Mesentery Histology Case report

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Conodonts from the Upper Cambrian Sesong and Hwajeol Formations in the Sabuk Area, South Korea

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Acta Geologica Sinica(English Edition) 2002年第2期76卷 155-165页

作者： lee Byung-SuDepartment of Earth Science Education, Chonbuk National University,Jeonju, 561-756, Korea Zhu Xiling Chonbuk Natl Univ Dept Earth Sci Educ Jeonju 561756 South Korea

This paper presents a conodont biostratigraphic study on the Upper CambrianSesong and Hwajeol Formations in the Sabuk area, Korea. Two samples near the base of the SesongSlate at the Pukil section contain lower Upper Cambrian conodonts, comprising Furnishina furnishi,F. kranzae, F. pernica?, F. triangulata, Hertzina elongata, Laiwugnathus doidyxus?, Phakeloduselongatus, Muellerodus? obliquus, Westergaardodina matsushitai and W. moessebergensis. This is thefirst conodont record of the Upper Cambrian formations recovered yet in the northern limb of thePaekunsan syncline. The faunal assemblage is correlatable with the lower Upper Cambrian *** Zone of North China. Four local biozones are recognized in the Hwajeol Formation, *** Proconodontus, Eoconodontus notchpeakensis, cambrooistodus minutus and Cordylodus proavus Zonesin ascending order. This zonal scheme is essentially equivalent to that of the southern limb of thePaekunsan syncline and they are correlatable with zones in other parts of the world, including NorthAmerica, Australia, Iran and China.

关键词： Upper Cambrian conodonts biostratigraphy Korea

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Role of adjuvant chemotherapy on recurrence and survival in patients with resected ampulla of Vater carcinoma

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World Journal of Gastrointestinal Oncology 2023年第4期15卷 677-688页

作者： Se Jun Park Kabsoo Shin In-Ho Kim Tae Ho Hong Younghoon Kim Myung-ah lee Division of Medical Oncology Department of Internal MedicineThe Catholic University of KoreaSeoul St.Mary’s HospitalSeoul 06591South Korea Department of General Surgery The Catholic University of KoreaSeoul St.Mary’s HospitalSeoul 06591South Korea Department of Pathology The Catholic University of KoreaSeoul St.Mary’s HospitalSeoul 06591South Korea

BACKGROUND Owing to rarity of disease and lack of prospective studies, data supporting the role of adjuvant chemotherapy in ampulla of Vater(AoV) carcinoma is *** To evaluate whether adjuvant chemotherapy cases for AoV carcinoma had better disease-free survival(DFS) rates than cases of observation following curative *** We retrospectively analyzed the association between adjuvant chemotherapy and DFS and overall survival(OS) in patients with stage IB-Ⅲ AoV carcinoma who underwent curative surgical resection. Fluorouracil-based adjuvant chemotherapy was administered after surgery at the discretion of the physician. Adjusted multivariate regression models were used to evaluate the association between adjuvant chemotherapy and survival *** Of the total 104 patients who underwent curative surgery, 52 received adjuvant chemotherapy. Multivariate analysis revealed that higher histologic grade [hazard ratio(HR) = 2.24, P = 0.046], advanced tumor stage(HR = 1.85, P = 0.030), and vascular invasion(HR = 2.14, P = 0.010) were associated with shorter DFS. Adjuvant chemotherapy improved DFS compared to the observation group(HR =0.50, P = 0.015) and tended to be associated with a longer OS, although the difference was not statistically significant(HR = 0.58, P = 0.098).CONCLUSION Among patients with resected AoV carcinoma, the adjuvant chemotherapy group was not associated with a significant survival benefit compared to the observation group. However, on multivariate analysis adjusting for prognostic factors, adjuvant chemotherapy following surgery was an independent prognostic factor for DFS in patients with resected AoV carcinoma. Further studies are needed to investigate the effectiveness of adjuvant chemotherapy according to histologic phenotype.

关键词： Ampulla of Vater carcinoma Adjuvant chemotherapy Prognosis Recurrence

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Detection of Breaking Waves Using X-Band Pulse Radar in the Nearshore Region

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China Ocean Engineering 2013年第4期27卷 549-556页

作者： Y.C.Lin C.C.Chang M.C.lee H.C.Chan J.M.Leu Department of Hydraulic and Ocean Engineering National Cheng-Kung University Department of Soil and Water Conservation National Chung Hsing University Department of Hospitality Management Taiwan Shoufu University

An X-band pulsed Doppler microwave radar has been used to determine the characteristics of breaking waves. Field experiments were conducted at the Shuang-Si estuary in the north of Taiwan in the winter of 2005. Analyses on maxima radar cross section and Doppler frequency shift are done to characterize wave breaking zones. Based on observations of breaking waves, the wave breaking zones are shown to be located at water depths of 1.8 to 2.2 m in the experimental site. In general, the results indicate that a radar system has the potential to delineate the spatial variation of breaking waves clearly and that this is sufficient to achieve a measurement operation for near-shore air-sea interaction events.

关键词： radar Doppler effect wave breaking coastal zone

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Interstitial lung disease induced by the roots of Achyranthes japonica Nakai:Three case reports

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World Journal of Clinical Cases 2021年第8期9卷 2015-2021页

作者： Do-Sik Moon Sung-Ho Yoon Seung-Il lee Sang-Gon Park Yong-Sub Na Department of Pulmonology and Critical Care Medicine Chosun University HospitalGwangju 61453South Korea Department of Internal Medicine Hemato-OncologyChosun University HospitalGwangju 61453South Korea

BACKGROUND The roots of Achyranthes japonica Nakai(AJN),called“Useul-puli,”has been traditionally used to control pain and improve dysfunction in osteoarthritis patients in South *** SUMMARY We described 3 patients diagnosed with herbal medicine induced interstitial lung disease after consuming boiled the roots of *** were referred to our hospital because of the modified Medical Research Council grade 4 *** computed tomography showed bilateral ground-glass opacities with patchy *** treatment with systemic glucocorticoid therapy and discontinuation of the roots of AJN,their symptoms improved,and almost all ground-glass opacities and patchy consolidations on chest radiography and chest computed tomography *** We present three cases of interstitial lung disease induced by the roots of AJN.

关键词： Herb Interstitial lung disease Achyranthes japonica Nakai Case report

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A Layer-IntegratedModel of Solute Transport in HeterogeneousMedia

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Advances in Applied Mathematics and Mechanics 2014年第6期6卷 699-717页

作者： Hung-En Chen Hui-Ping lee Shih-Wei Chiang Tung-Lin Tsai Jinn-Chuang Yang Department of Civil Engineering National Chiao Tung University1001 Ta Hsueh RoadHsinchu 30010Taiwan Agricultural Engineering Research Center 196-1 Chung Yuan RoadChungli 32061Taiwan Department of Civil and Water Resources Engineering National Chiayi University 300 Syuefu RoadChiayi 60004Taiwan Department of Civil Engineering and Disaster Prevention and Water Environment Research Center National Chiao Tung University1001 Ta Hsueh RoadHsinchu 30010Taiwan

This study presents a numerical solution to the three-dimensional solute transport in heterogeneous media by using a layer-integrated *** vertical spatial variation of soil and hydraulic properties within each layer,a threedimensional solute transport can be simplified as a quasi-three-dimensional solute transport which couples a horizontal two-dimensional simulation and a vertical onedimensional *** finite analytic numericalmethod was used to discretize the derived two-dimensional governing equation.A quadratic function was used to approximate the vertical one-dimensional concentration distribution in the layer to ensure the continuity of concentration and flux at the interface between the adjacent *** integration over each layer,a set of system of equations can be generated for a single column of vertical cells and solved numerically to give the vertical solute concentration *** solute concentration field was then obtained by solving all columns of vertical cells to achieve convergence with the iterative solution *** proposed model was verified through examples from the published literatures including four verifications in terms of analytical and experimental *** of simulation results indicates that the proposed model satisfies the solute concentration profiles obtained from experiments in time and space.

关键词： Layer-integrated model groundwater solute transport finite analytic method heterogeneous media

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国际性酒店管理人才的培养战略

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中小企业管理与科技 2020年第13期4卷 114-115页

作者：王宁李贞远韩国信韩大学京畿道议政府11644

我国在开展现代化教育教学工作和培养人才的过程中,需要根据当前我国社会发展的实际情况,设计教育教学内容,合理制定人才培养战略。国际性酒店管理人才的培养是现阶段比较受重视的一项人才培养内容。为了解决国际性酒店管理人才不足的问... 详细信息

我国在开展现代化教育教学工作和培养人才的过程中,需要根据当前我国社会发展的实际情况,设计教育教学内容,合理制定人才培养战略。国际性酒店管理人才的培养是现阶段比较受重视的一项人才培养内容。为了解决国际性酒店管理人才不足的问题,必须通过科学的、合理的人才培养战略,加强对人才的培养。论文针对国际性酒店管理人才的培养现状进行了探究与分析,并提出了国际性酒店管理人才的培养战略,以期有助于国际性酒店管理人才的培养。

关键词：国际性酒店管理人才培养战略

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Expression of micro RNAs in fibroblast of pterygium

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International Journal of Ophthalmology(English edition) 2016年第7期9卷 967-972页

作者： Joon H.lee Sun-Ah Jung Young-A Kwon Jea-Lim Chung Ungsoo Samuel Kim Myung-Gok Eye Research Institute Konyang University College of Medicine Seoul 07301 Korea Department of Ophthalmology Kim's Eye Hospital Seoul 07301 Korea Department of Ophthalmology Konyang University College of Medicine Daejeon 35356 Korea

AIM：To screen microRNAs（miRNAs） and set up target miRNAs in ***：Primary fibroblasts were isolated from pterygium and Tenon＇s capsule and *** analysis and Western blotting were performed to confirm the culture of *** all,1733 miRNAs were screened in the first step by using GeneChip miRNA3.0 *** miRNAs involved in the pathogenesis of pterygium were subsequently determined using the following criteria：1） high reproducibility in a repetitive test;2） base log value of 〉7.0 for both control and pterygial fibroblasts;and 3） log ratio of 〉1.0 between pterygial fibroblasts and control ***：Primary screening showed that 887/1733 miRNAs were up-regulated and 846/1733 miRNAs were down-regulated in pterygial fibroblasts compared with those in control *** the 1733 miRNAs screened,4 miRNAs,namely,miRNA-143a-3p,miRNA-181a-2-3p,miRNA-377-5p and miRNA-411a-5p,met the above-mentioned *** screening showed that these 4 miRNAs were up-regulated in pterygial fibroblasts compared with control fibroblasts and that miRNA-143a-3p had the highest mean ratio compared with the miRNAs in control ***：miRNA-143a-3p,miRNA-181a-2-3p,miRNA-377-5p and miRNA-411a-5p are up-regulated in pterygial fibroblasts compared with control fibroblasts,suggesting their involvement in the pathogenesis of pterygium.

关键词： microRNA pterygium fibroblast

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Proinflammatory cytokine TNFα promotes HPV-associated oral carcinogenesis by increasing cancer stemness

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International Journal of Oral Science 2020年第1期12卷 40-49页

作者： Hannah SHong Jonathan Akhavan Sung Hee lee Reuben HKim Mo KKang No-Hee Park Ki-Hyuk Shin The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of DentistryLos AngelesCAUSA UCLA Jonsson Comprehensive Cancer Center Los AngelesCAUSA Department of Medicine David Geffen School of Medicine at UCLALos AngelesCAUSA

High-risk human papillomaviruses(HPVs) are involved in the development of several human cancers, including oropharyngeal squamous cell carcinomas. However, many studies have demonstrated that HPV alone is not sufficient for the oncogenic transformation of normal human epithelial cells, indicating that additional cofactors are required for the oncogenic conversion of HPV-infected cells. Inasmuch as chronic inflammation is also closely associated with carcinogenesis, we investigated the effect of chronic exposure to tumor necrosis factor α(TNFα), the major proinflammatory cytokine, on oncogenesis in two immortalized oral keratinocyte cell lines, namely, HPV16-immortalized and human telomerase reverse transcriptase(h TERT)-immortalized cells. TNFαtreatment led to the acquisition of malignant growth properties in HPV16-immortalized cells, such as(1) calcium resistance,(2)anchorage independence, and(3) increased cell proliferation in vivo. Moreover, TNFα increased the cancer stem cell-like population and stemness phenotype in HPV16-immortalized cells. However, such transforming effects were not observed in h TERTimmortalized cells, suggesting an HPV-specific role in TNFα-promoted oncogenesis. We also generated h TERT-immortalized cells that express HPV16 E6 and E7. Chronic TNFα exposure successfully induced the malignant growth and stemness phenotype in the E6-expressing cells but not in the control and E7-expressing cells. We further demonstrated that HPV16 E6 played a key role in TNFα-induced cancer stemness via suppression of the stemness-inhibiting micro RNAs mi R-203 and mi R-200 c. Overexpression of mi R-203 and mi R-200 c suppressed cancer stemness in TNFα-treated HPV16-immortalized cells. Overall, our study suggests that chronic inflammation promotes cancer stemness in HPV-infected cells, thereby promoting HPV-associated oral carcinogenesis.

关键词： carcinogenesis cytokine cancer

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