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Hepatobiliary & Pancreatic Diseases International 2002年第2期1卷 232-237页

作者： Yang D.H. Liang W.-F. Xie Y.-j. Zhao N.-F. Fan j. Department of Infectious Diseases First Affiliated Hospital Zhejiang University School of Med. Hangzhou 310003 China

Objective: To analyse the emergence of YMDD motif(tyrosine-methionine-aspartate-aspartate) variants inpatients with hepatitis b treated with ***: The amino acid substitution from methio-nine or isoleucine at the YMDD motif at the HbVpolymerase gene is a main mutation resistant to lami-vudine treatment. Generated from a fragment of do-main C of the polymerase gene, patients HbV DNA,which had been positive previously became positive a-gain ever since it had been negative during lamivudi-ne therapy. Variants were detected by cleavage of theproducts of the three PCRs with following enzymes:FokI, SspI, Alw441. The results of PCR-RELP wereanalysed by 8. 4% polypropylene acidemide gel elec-trophoresis. PCR-RFLP assay was compared to di-rect ***: HbV DNA was positive again in 33 patientsand positive for one year in 2 patients. YMDD vari-ants were detected in serum 14 of 35 patients, YIDDvariants in 4, YVDD variants in 6, and YI/MDD va-riants in 1; all were in concordance with the resultsof direct sequencing. The samples of other 3 patientsshowed YI/VDD mutations, as shown by direct se-quencing. The results of PCR-RFLP assay of themixed sera of YIDD and YVDD variants were similarto those sera of YI/VDD ***: PCR-RFLP is suitable for rapid detec-tion of YMDD variants of viral polymerase in hepati-tis b virus patients treated with lamivudine.

关键词： YMDD variants PCR-RFLR hepatitis b virus lamivudine polymerase gene

Polarized proton beams from laser-induced plasmas

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High Power Laser Science and Engineering 2019年第1期7卷 114-119页

作者： Anna Hützen johannes Thomas jürgen b?ker Ralf Engels Ralf Gebel Andreas Lehrach Alexander Pukhov T.Peter Rakitzis Dimitris Sofikitis Markus büscher Peter Grünberg Institut (PGI-6) Forschungszentrum Jülich Institut für Laser-und Plasmaphysik Heinrich-Heine-Universit?t Düsseldorf Institut für Theoretische Physik I Heinrich-Heine-Universit?t Düsseldorf Institut für Kernphysik (IKP-4) Forschungszentrum Jülich Institut für Kernphysik (IKP-2) Forschungszentrum Jülich jARA-FAME und III.Physikalisches Institut b RWTH Aachen Department of Physics University of Crete Institute of Electronic Structure and Laser Foundation for Research and Technology-Hellas

We report on the concept of an innovative source to produce polarized proton/deuteron beams of a kinetic energy up to several GeV from a laser-driven plasma accelerator. Spin effects have been implemented into the particle-in-cell(PIC) simulation code VLPL(Virtual Laser Plasma Lab) to make theoretical predictions about the behavior of proton spins in laser-induced plasmas. Simulations of spin-polarized targets show that the polarization is conserved during the acceleration process. For the experimental realization, a polarized HCl gas-jet target is under construction using the fundamental wavelength of a Nd:YAG laser system to align the HCl bonds and simultaneously circularly polarized light of the fifth harmonic to photo-dissociate, yielding nuclear polarized H atoms. Subsequently, their degree of polarization is measured with a Lamb-shift polarimeter. The final experiments, aiming at the first observation of a polarized particle beam from laser-generated plasmas, will be carried out at the 10 PW laser system SULF at SIOM, Shanghai.

关键词： laser-driven plasma accelerator particle-in-cell simulations polarized gas-jet target polarized proton beams

Resistant Starch Yield Do Not based on the Acetyl Group Content:A Study on Preparation of High RS4 Content Rice by Acetic Acid Esterification Reaction

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Resistant Starch Yield Do Not Based on the Acetyl Group Cont...

中国食品科学技术学会第五届年会暨第四届东西方食品业高层...

作者： b.Li~* j.X.Zhang L.P.,Zhu T.G.Liu~a College of Food Science and Technology,HuaZhong Agricultural University,WuHan,430070 China

Resistant starch(RS)had drawn broad interest for both potential health benefits and functional *** this study,lndica rice was reacted with Vinyl acetate at different temperatures(20-50℃),pH(8-12),ratio of liquor to material(0.5:10-3.0:10)for different reaction times(1-8 h),and the penetrate and reaction efficiency were enhanced by using physical and chemical *** effect of reaction conditions on RS and acetyl group content was *** sample with the highest RS content(78.74%)could be obtained when conducting the reaction at 30℃,pH10,ratio of liquor to material 2.0:10 for 7 ***,no statistically significant correlation existed between RS yield and acetyl group content,the modified rice with the relatively low acetyl group content(0.59%)could aslo hold rather high RS content(62.34%).In other words,the high RS content rice could be produced only in a milder acetylation reaction conditions with low cost.

关键词： Rice Resistant starch Acetylation Correlation

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食品和农业的战略计划工作

世界农业 1980年第1期 43-45页

作者： j.C.鲍曼,R.b.韦恩,宋濂教授夫人

二、三十年来在世界粮食问题上人们愈来愈关心的问题是世界粮食有没有充分的供应量,能不能继续供应得上来,会不会分配到最需要粮食的地方去。人们也关心农业发展对提高生活水平直接间接起到多大作用。增加食品供应是直接作用,提供就业机... 详细信息

二、三十年来在世界粮食问题上人们愈来愈关心的问题是世界粮食有没有充分的供应量,能不能继续供应得上来,会不会分配到最需要粮食的地方去。人们也关心农业发展对提高生活水平直接间接起到多大作用。增加食品供应是直接作用,提供就业机会,创造出购买其他商品和服务的财力是间接作用。即使形势有利,促进世界农业增产粮食也是一个艰巨的任务。联合国成立粮农组织标志着世界各国认识到了全球范围内解决这个问题的必要性。粮农组织定期向

关键词：农业形势食品战略计划

Development of Polycaprolactone/Poly(Vinyl Alcohol)/Clay Microparticles by Spray Drying

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Materials Sciences and Applications 2016年第10期7卷 575-592页

作者： Mariana Sato de S. de b. Monteiro Claudia Lopes Rodrigues Eduardo Miguez Maria Inês b. Tavares Instituto de Macromoléculas Professora Eloisa Universidade Federal do Rio de Janeiro Centro de Tecnologia Bloco J Cidade Universitária Ilha do Fundao Rio de Janeiro Brazil Faculdade de Farmácia Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde Bloco L Cidade Universitária Ilha do Fundao Rio de Janeiro Brazil

In this study, nanostructured microparticles was developed with polycaprolactone (PCL), poly(vinyl alcohol) (PVAL) and nanoparticles of the commercial sodium clay NT-25®by using the spray drying technique. The systems obtained were characterized by Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Dynamic Laser Light Scattering (DLS) and Differential Scanning Calorimetry (DSC). The NMR 13C and FTIR techniques showed that both polymers were present in the microparticles and the DSC analysis revealed a small variation in the glass transition temperature of the PCL. The XRD and SEM analyses showed that the microparticles produced were amorphous and had a concave morphology. The NT-25 nanoload reduced the microparticles’ size due to the multiple interactions formed in the hybrid nanocomposite material. Therefore, it was possible to develop microparticles by using biodegradable and biocompatible polymers, with different polarities, allowing the incorporation of hydrophilic and hydrophobic materials and enabling the inclusion of otherwise incompatible materials in the same system.

关键词： Microparticles Spray Drying Polycaprolactone Poly(Vinyl Alcohol) Sodium Clay NT-25

血氧水平依赖性MRI可检测急性卒中患者高危组织的代谢性状

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 42-43页

作者： Geisler b.S. brandhoff F. Fiehler j. 郭俊 Dr.Department of Neuroradiology University Medical Center Hamburg-EppendorfMartinistrasse 5220246 HamburgGermany

bACKGROUND AND PURPOSE-The delineation of the “penumbra”is of particular interest in acute stroke *** “mismatch concept”applying perfusion-weighted imaging(PWI)and diffusion-weighted imaging(DWI)appears to be an oversimplification of the underlying electrophysiological tissue *** additional parameter reflecting the metabolic state of the threatened brain tissue would improve our ability to describe the *** candidate is deoxyhemoglobin(deoxy-Hb)as an indicator of the oxygen extraction fraction that can be visualized by T2*-based blood oxygen level-dependent(bOLD)***-We analyzed data from 32 patients with acute stroke in the territory of the middle cerebral *** included fluid-attenuated inversion recovery,DWI,PWI,time-of-flight angiography,and quantitative T2 and T2*.(qT2,qT2*)***-up was performed on day 1 and days 5 to *** calculated 1/T2'=1/qT2*-1/*** of T2',representing the deoxy-Hb effect,were analyzed by 3D regions of interest(ROIs):apparent diffusion coefficient lesion day 0(L0),time-to-peak-lesion day 0(T0),final infarct size days 5 to 8(F5-8),lesion growth(LG;F5-8-L0),and surviving tissue(ST;T0-F5-8).RESULTS-We observed a clear decrease of T2'in the infarcted hemisphere compared with the unaffected control *** mean value showed the most pronounced loss of T2'signal intensity in L0(-15.7%),followed by LG(-10.5%)and ST(-8.0%).CONCLUSIONS-The implementation of bOLD imaging in acute stroke MRI offers a noninvasive estimation of the O2 utilization and is able to add additional information concerning the present metabolic state of the threatened brain *** changes in T2'intensity are visually noticeable in the reconstructed T2'images and provide a better estimation of the real penumbra.

关键词：急性卒中 MRI 半影区患者血氧

CoH（bH3CN）〔P（C6H5）3〕3的晶体与分子的结构

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厦门大学学报(自然科学版) 1982年第2期 218-221页

作者：胡盛志,R.j.巴顿,b.E.罗伯逊厦门大学化学系加拿大里贾纳大学物理系加拿大里贾纳大学物理系

本文介绍了新的Co（Ⅱ）络合物CoH（bH3CH）[P（C6H5）3]3的晶体和分子的结构,并与相似的某些络合物如CoH（N2）[ P（C6H5）3]3和CoH（CO）[P（C6H5）3]3等的结构对比。结果证明,在CoH（bH3CN）[P（C6H5）3]3中配位体bH3CN-呈端基络合,... 详细信息

本文介绍了新的Co（Ⅱ）络合物CoH（bH3CH）[P（C6H5）3]3的晶体和分子的结构,并与相似的某些络合物如CoH（N2）[ P（C6H5）3]3和CoH（CO）[P（C6H5）3]3等的结构对比。结果证明,在CoH（bH3CN）[P（C6H5）3]3中配位体bH3CN-呈端基络合,与N2和CO作为配位体的情况相同。CO（Ⅱ）的配位体介于三方双锥和四方锥之间,并显

关键词：晶体三方双锥 C6H5 配位多面体氢原子键长化学键四方锥分子

SSRI和他汀类药物可增加蛛网膜下腔出血后血管痉挛的风险

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 47-48页

作者： Singhal A.b. Topcuoglu M.A. Dorer D.j. 周永 Stroke Service VBK-802 Massachusetts General Hospital Boston MA 02114 United States Dr.

background: Use of medications with vasoconstrictive or vasodilatory effects can potentially affect the risk for vasospasm after aneurysmal subarachnoid hemorrhage (SAH). Methods: Using International Classification of Diseases-9 diagnostic codes followed by medical record review, the authors identified 514 patients with SAH admitted between 1995 and 2003 who were evaluated for vasospasm between days 4 and 14. The authors determined risks for vasospasm, symptomatic vasospas m, and poor clinical outcomes in patients with documented pre-hemorrhagic use o f calcium channel blockers, beta-receptor blockers, ACE inhibitors, aspirin, se lective serotonin reuptake inhibitors (SSRIs), non-SSRI vasoactive antidepressa nts, or statins. Results: Vasospasm developed in 62%, and symptomatic vasospasm in 29%of the cohort. On univariate analysis, the risk for all vasospasm tended to increase in patients taking SSRIs (p=0.09) and statins (p=0.05); SSRI use in creased the risk for symptomatic vasospasm (p=0.028). The Cochran-Armitage tren d test showed that the proportion of patients taking SSRIs and statins increased significantly across three wors ening categories (none, asymptomatic, symptomatic) of vasospasm. Logistic regres sion analysis showed that SSRI use tended to predict all vasospasm (O.R. 2.01 [0 .91 to 4.45]), and predicted symptomatic vasospasm (O.R. 1.42 [1.06 to 4.33]) . Statin exposure increased the risk for vasospasm (O.R. 2.75 [1.16 to 6.50]), perh aps from abrupt statin withdrawal (O.R. 2.54 [0.78 to 8.28]). Age bitor and statin users have a higher risk for su barachnoid hemorrhagerelated vasospasm. Whether the underlying disease indicatio n, direct actions, or rebound effects from abrupt drug withdrawal account for th e associated risk warrants further investiga

关键词：蛛网膜下腔出血血管痉挛他汀类药物 SSRI 钙通道阻滞剂血管收缩抗抑郁药 β受体阻滞剂国际疾病分类天对

遗传性大疱性表皮松解症的眼部表现:美国本土大疱性表皮松解症登记处的结果

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 13-14页

作者：赵炜 Fine j.-D johnson L.b Weiner M Natl.Epidermolysis bullosa R eg -istry Lexing tonKYUnited States.Dr.

Purpose To determine the frequency o f ocular manifesta-tions in inherited epidermolysis bullosa(Eb)within the continental United States and to define the estimated cu-mulative risks of developing nonscarring(blisters or ero-sions)and scarring corneal manifestation s within each major Eb subtype over *** Observational(cross-sectional and longitudinal).Methods Up to 16years of longitudinal follow-up was conducted on 3,280consec-utively enrolled patients in the National Eb Registry,an epidemiologic study funded by the Na tional Institutes of *** were stratified by majo r Eb type and *** of occurrence were dete rmined for eight vari-ables(corneal erosions or blistering;corneal scarring;symblepharons;blepharitis;ectro pions;lacrimal duct ob-struction;impaired vision;blindn ess)by contingency ta-bles,and cumulative risks were generated by life table analysis *** The most common ocular manifestations were corneal erosio ns and ***-quencies mirrored relative severity of skin disease,with74.10%of all patients with recessiv e dystrophic Eb,Hallopeau-Siemens(RDEb-HS )and 47.50%of all pa-tients with junctional Eb,Herlitz(jEb-H)experiencing at least one *** frequencie s were noted for corneal *** and ectrop ions were most com-monly seen in inversa RDEb and jEb-H,*** was reported in 6.47%of RD Eb-HS *** cumulative risks of nonscarring and scarring corneal lesions in jEb-H at age 5are 83.18%an d 27.08%and at age 25are 83.18%and 72.22%.With tim e,the cumu-lative risk of each in RDEb-HS approached that reported in jEb-H *** Ocular d isease activity,par-ticularly corneal,is common in some Eb *** ophthalmologic examination should become an integral part of the management of all patients wit h inherited Eb.

关键词：瘢痕化睑球粘连睑外翻角膜糜烂角膜病变泪小管累积危险度角膜瘢痕眼部病变瘢痕性

一种用井下传感数据在生产井的环空中进行通讯的新颖方法

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石油石化节能与计量 1996年第5期 37-40页

作者： j．V．LeggettⅢ,b．R．Green,赵晓林长庆油田钻采工艺研究所

一种传递和控制井下机理的大数据量（10～40波特）无线电通讯方法在油气井生产技术中具有多种用途。本文详述样机的研制、设计及在深度7500ft充满粘性液体的生产并环空里为证实声波通讯的性能进行试验的方法。完成的试验是要确定声波完... 详细信息

一种传递和控制井下机理的大数据量（10～40波特）无线电通讯方法在油气井生产技术中具有多种用途。本文详述样机的研制、设计及在深度7500ft充满粘性液体的生产并环空里为证实声波通讯的性能进行试验的方法。完成的试验是要确定声波完成、液体粘度、压力、声噪水平对于波特率的影响。通过评价时间与频度域信号，确定其对上行传递和下行传送信号的影响。还测量了在不同深度反射信号和其它类型干挠，以进一步调查信号通路。主要目标是要确定在不同粘度井液中，各种频谱情况下，声波的db／kft衰减情况。

关键词：生产井鼓波通讯换能器收发机