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Fractional flow reserve and non-hyperemic indices:Essential tools for percutaneous coronary interventions

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World Journal of Clinical Cases 2023年第10期11卷 2123-2139页

作者： Amine Mamoun Boutaleb chadi ghafari Claudiu Ungureanu Stéphane Carlier Department of Cardiology Ibn Rochd University HospitalCasablanca 20230CasablancaMorocco Department of Cardiology Centre Hospitalier Universitaire Ambroise ParéMons 7000Belgium Department of Cardiology University of MonsMons 7000Belgium Catheterization Unit Jolimont HospitalLa Louvière 7100BelgiumBelgium

Hemodynamical evaluation of a coronary artery lesion is an important diagnostic step to assess its functional *** flow reserve(FFR)received a class IA recommendation from the European Society of Cardiology for the assessment of angiographically moderate *** evaluation of coronary artery disease offers improvement of the therapeutic strategy,deferring unnecessary procedures for lesions with a FFR>0.8,improving patients'management and clinical *** intervention,an optimal FFR>0.9 post stenting should be reached and>0.8 post drug eluting ***-hyperemic pressure ratio measurements have been validated in previous studies with a common threshold of *** might overestimate the hemodynamic significance of some lesions but remain useful whenever hyperemic agents are *** remains the gold standard reference for invasive assessment of *** illustrate this review with two cases introducing the possibility to estimate also non-invasively FFR from reconstructed 3-D angiograms by quantitative flow *** conclude introducing a hybrid approach to intermediate lesions(DFR 0.85-0.95)potentially maximizing clinical decision from all measurements.

关键词： Fractional flow measurements Coronary artery physiology Quantitative flow reserve Non-hyperemic pressure ratios

Exercise-induced torsades de pointes as an unusual presentation of cardiac sarcoidosis: A case report and review of literature

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World Journal of Cardiology 2020年第6期12卷 291-302页

作者： chadi ghafari Frédéric Vandergheynst Emmanuel Parent Kaoru Tanaka Stéphane Carlier Department of Cardiology Centre Hospitalier Universitaire Ambroise ParéMons 7000Belgium Department of Cardiology Universitéde MonsMons 7000Belgium Department of Internal Medicine Cliniques Universitaires de Bruxelles-ErasmeBruxelles 1070Belgium Department of Cardiology Universitair Ziekenhuis BrusselsJette 1090Belgium

BACKGROUND Sarcoidosis is a rare multisystem disease characterized histologically by noncaseating granuloma formation in the affected *** cardiac sarcoidosis is found on autopsy in up to 25%of sarcoidosis cases,it is still underdiagnosed and is associated with a poor *** the etiology of sarcoidosis remains unclear,an antigen triggered exaggerated immune response has been *** detection and prompt management of cardiac sarcoidosis remains *** SUMMARY A 60-year-old female,with pulmonary sarcoidosis in remission,presented to the cardiology outpatient clinic for evaluation of weeks-long dyspnea on moderate exertion(New York Heart Association class II)that was relieved by *** exercise stress test showed multifocal ventricular extrasystoles,followed by a self-limiting torsades de *** magnetic resonance imaging showed nondilated and normotrophic left ventricle with basoseptal and mid-septal *** magnetic resonance imaging-derived left ventricular ejection fraction was 45%.Delayed enhancement showed patchy transmural fibrosis of the septum and hyperenhancement of the papillary muscles,all in favor of extensive cardiac involvement of sarcoidosis.A double-chamber implantable cardiac defibrillator was implanted,and methylprednisolone(12 mg/d)and methotrexate(12.5 mg/wk)treatment was ***-up and implantable cardiac defibrillator interrogation showed episodes of asymptomatic nonsustained ventricular tachycardia and an asymptomatic episode of nonsustained ventricular tachycardia ending by the first antitachycardia pacing *** Along an extensive review of the literature,this unusual case report highlights the importance of early detection of cardiac involvement of sarcoidosis,in order to avoid potential complications and increase survival.

关键词： Sarcoidosis Cardiac sarcoidosis Torsades de pointes Ventricular tachycardia Immunotherapy Case report

Flexible Traceable Generic Genetic Algorithm

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Open Journal of Applied Sciences 2022年第6期12卷 877-891页

作者： chadi Kallab Samir Haddad Jinane Sayah Department of Computer Science and Mathematics Faculty of Arts and Sciences University of Balamand Koura Lebanon Department of Telecom and Networks Issam Fares Faculty of Technology University of Balamand Koura Lebanon

This document elaborates on the generic implementation one of the main heuristics algorithms verified through its quick application to a biology problem requiring to find out an optimal sequences tree topology. In order to solve this problem, categorized as Non-Polynomial Hard (NP-Hard), “to minimize differences between given (leaf) and/or derived (parent) sequences”, many popular methods are used. “The higher the number of given sequences is, the more advisable and efficient it would be to go towards heuristics as they would provide a close-enough solution faster, as for instance genetic algorithms amongst others do. Thus, as part of a larger research in Heuristics and phylogenies, this paper aims to suggest a generic advanced flexible implementation of the Genetic Algorithm verified by a “general way to encode the problem into instances of different heuristic algorithms” as mentioned in our first reference below. The proposed algorithm will also present a chronology traceability feature for further analysis and potential improvements.

关键词： Generic Heuristics Phylogenies Bio-Informatics NP-Hard Genetic Algorithm

Takotsubo Cardiomyopathy with a Dramatically Rapid Resolution

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International Journal of Clinical Medicine 2011年第2期2卷 139-142页

作者： Muhammad Alichaudhry chadi Dib Ralph Lazzara 不详

Takotsubo cardiomyopathy is a relatively rare disease entity with a rapid reversible ventricular dysfunction, which usually occurs in post–menopausal women, and is frequently associated with a stressful event. Diagnosing Takotsubo cardiomyopathy can sometimes be challenging. The absence of coronary artery obstructive disease, and the dramatic presentation of the patient mimicking acute coronary syndrome, make this disease unique. We discuss here a case of Takotsubo cardiomyopathy with extremely rapid resolution in just two days, which we believe is being reported for the first time and touch briefly on the salient features, pathogenesis, diagnosis, treatment, prognosis, and clinical significance of this unique entity.

关键词： Takotsubo Cardiomyopathy Rapid Resolution

Generic Simulated Annealing

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Open Journal of Applied Sciences 2022年第6期12卷 1011-1025页

作者： chadi Kallab Samir Haddad Jinane Sayah Mohamad Chakroun Department of Computer Science and Mathematics Faculty of Arts and Sciences University of Balamand Koura Lebanon Department of Telecom and Networks Issam Fares Faculty of Technology University of Balamand Koura Lebanon Faculty of Computer Science and Electrical Engineering Universit&auml t Rostock Rostock Germany

One of the many problems that are considered to be NP-Hard is the Multiple Sequence Alignment one that initially requires, as for any other of its siblings, a specific encoding schema and design of the main functionalities of the heuristics algorithm being implemented and executed. This paper intends to discuss our proposed generic implementation of the Simulated Annealing, inspired for the procedure of cooling and shaping methods of metals. In our algorithm, we attempted to add some executions tracing functionalities in order to help later analysis for initial parameters tuning. On another hand, we also tried to get closer in our attempt to mimic the cooling of metals, but giving it an option to run under different cooling schedules. We proposed a few schedules that seemed to be studied and/or used in many algorithm implementations.

关键词： Generic Heuristics Phylogenies Bio-Informatics NP-Hard Simulated Annealing

Internet of Things: Towards a Solid Ecosystem of Interconnected Things

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Advances in Internet of Things 2022年第3期12卷 35-64页

作者： Mohamad Chakroun Jinane Sayah chadi Kallab Samir Haddad Faculty of Computer Science and Electrical Engineering Universit&#228 t Rostock Rostock Germany Issam Fares Faculty of Technology Department of Telecom and Network University of Balamand Koura Lebanon Faculty of Arts and Sciences Department of Computer Science University of Balamand Koura Lebanon

The Internet of Things (IoT) is a technological revolution that has changed everything we do and given us a new perspective on our daily lives, but despite the fact that numerous publications have focused on characterizing the many edges and technologies that make up an IoT system, the IoT ecosystem is still seen as too complex to be recognized as a stand-alone environment due to its significant diversity;hence, the objective of this research is to address such a complex environment in a way that highlights its components and distinguishes them both individually and in relation to their broader context. Therefore, the definition of IoT and its emergence were discussed and organized around the timeline of Internet development phases demonstrating that IoT has been a need that has accompanied the presence of the Internet since its early stages, and then its growth and impact were discussed and highlighted with estimates and numbers. On the technical side, each of the following groups, IoT components, protocols, and architectures, was defined, discussed, and grouped in such a way that their intergroup organization, as well as their placement and contribution to the overall ecosystem, was highlighted. This, in addition to the various examples mentioned throughout the discussion, will provide the reader with a better understanding of the Internet of Things and how deeply it has become entwined in our daily lives and routines as a result of its numerous applications.

关键词： Internet of Things IoT Components IoT Architectures IoT Economic Impact IoT Growth Networking Protocols TCP/IP IoT Protocols IoT Challenges IoT Attacks

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美食外交研究：突尼斯的案例与实践

美食外交研究：突尼斯的案例与实践

作者： Mohamed chadi Blout 吉林大学

学位级别：硕士

美食经常会出现在外交活动之中,法国著名政治家塔列朗曾经宣称:“外交官的最好助手就是他的厨师。”美食在外交中的运用正在成倍增加,从而催生了一个充满细微差别的新的概念领域。学术文献已经根据受众群体将美食外交的贡献进行了分类... 详细信息

美食经常会出现在外交活动之中,法国著名政治家塔列朗曾经宣称:“外交官的最好助手就是他的厨师。”美食在外交中的运用正在成倍增加,从而催生了一个充满细微差别的新的概念领域。学术文献已经根据受众群体将美食外交的贡献进行了分类。而在国际关系的这个分类中,研究方向的是烹饪外交,其是美食外交在外交活动中的具体应用。烹饪外交不仅寻求通过官方外交职能改善正式外交关系,并且希望可以通过美食来加强双边关系。所以在谈到美食在国家或公共领域之间的关系时,我们就称其为美食外交。美食外交或者说在公共外交背景下使用美食来分享一国文化是文化外交的最重要表现之一。因为少有哪个方面像美食一样,与文化、历史和地理有如此深刻的联系。罗维西将美食外交定义为“一种公共关系形式”。一些国家决定将自己的国家作为一种品牌来宣传,并利建设专门机构以及专项预算来制定战略,以出口他们的烹饪资产,以此提升国家知名度并且间接性的鼓励投资、促进贸易以及旅游业。从泡菜外交到世界烹饪资产,美食外交已经成为许多国家在世界舞台上提升自己、发展知名度以及吸引力的一种创新方式。如今,美食已经成为推广国家品牌和文化外交的战略工具,其在国际关系中的作用也得到了肯定。在这种背景下,突尼斯作为一个拥有丰富烹饪资产的国家,此种动员有助于恢复国家形象,使自己成为一个值得驻足的文化和旅行的目的地。事实上,尽管突尼斯已经为民主过渡采取了一定措施,但在刺激经济发展和吸引投资者方面收效不多。原因之一,近年来突尼斯在国际舞台上的形象有所动摇,主要体现在政治局势、社会需求、经济表现几个方面。基于此种情况,对于突尼斯来说恢复其受损的形象是刻不容缓的。另一方面,全球化刺激了国家间的激烈竞争,使得身处于国际市场的国家行为体必须变得比以前更富于竞争力和吸引力。各个国家竞相争取投资者、游客、消费者、捐助者、移民媒体以及外国政府的关注、尊重以及信任。这更加迫使突尼斯需要尽快弥合、发展自己的国家形象。而提升国家竞争力不仅仅是在经济一个方面,而是更依赖于文化和人的发展。在这种背景下,提升国家品牌形象必须与积极的文化外交齐头并进。突尼斯应该通过展示自己烹饪资产中的最好的一面来进行外交,某种意义上可以使其成为最好的“大使”。因此,突尼斯如何利用美食来进行文化外交和提升民族品牌就是一个值得研究的问题。本文旨在通过讨论突尼斯在美食外交领域采取过的措施及其可能产生的影响,填补美食外交研究领域的空白,以及通过探讨一个较新的概念的可实施程度以及描述已经采取的行动,评估美食外交在突尼斯外交政策中所起到的推动作用。这项研究可以通过发现需求以做出正确的选择,通过提出建议来指导未来的决策。为了达到以上这些目标,笔者进行了定性研究分析。定性研究着重分析研究对象所经历的现实情况,可以增加我们对当前问题的深入理解,激发与问题相关的想法、假说以及更多的选择。定性研究分析同时也为我们提供了一些方法和技术用来分组和分析数据。本研究选择了对政府机构的关键人事进行采访。为了使得受访者的回答更加多维度,我们进行了一次由预先制定的访谈指南支持的版指导性访谈。本指南由文献综述中确定的与美食外交的建议和实施相关的主题组成。本研究发现,现在还很难将突尼斯的美食外交当作真正意义上的美食外交。因为尽管突尼斯已经在海外美食推广方面展开行动,但突尼斯并不存在相关的用来推广烹饪与美食文化的相关机构和预算。并且之前的推广行动并不是以美食外交的方式进行的,即没能通过美食方面的文化让大家了解突尼斯,为文化交流和建设国家形象做出贡献。对于突尼斯美食的海外推广,无论是促进出口还是吸引游客方面,更多的还是作为其文化资产推广的一部分存在,或仍然局限在商业目标上。但这仅仅是推广烹饪战略的起点。许多国家都已经意识到利用美食外交的前景大有所为,但突尼斯似乎仍处于起始意识阶段,没有真正的采取行动。因此,突尼斯如果能意识到真正的问题并且抓住机会,其前景充满希望,其拥有使烹饪资产成为文化杠杆所需的相关资源。此外,本项研究还强调了以外交部为代表的统一机构,在其国际战略中的重要性。

关键词： heritage 文化交流国家品牌国际关系文化资产战略工具 diplomatic tourism 国际战略海外推广

Complete Modeling for Systems of a Marine Diesel Engine

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Journal of Marine Science and Application 2015年第1期14卷 93-104页

作者： Hassan Moussa Nahim Rafic Younes chadi Nohra Mustapha Ouladsine Faculty of Engineering Lebanese University Beirut Lebanon LSIS Aix Marseille University Marseille 13397 France Faculty of Engineering Beirut Arab University (BA U) Tripoli Lebanon

This paper presents a simulator model of a marine diesel engine based on physical, semi-physical, mathematical and thermodynamic equations, which allows fast predictive simulations The whole engine system is divided into several functional blocks： cooling, lubrication, air, injection, combustion and emissions. The sub-models and dynamic characteristics of individual blocks are established according to engine working principles equations and experimental data collected from a marine diesel engine test bench for SIMB Company under the reference 6M26SRP1. The overall engine system dynamics is expressed as a set of simultaneous algebraic and differential equations using sub-blocks and S-Functions of Matlab/Simulink. The simulation of this model, implemented on Matlab/Simulink has been validated and can be used to obtain engine performance, pressure, temperature, efficiency, heat release, crank angle, fuel rate, emissions at different sub-blocks. The simulator will be used, in future work, to study the engine performance in faulty conditions, and can be used to assist marine engineers in fault diagnosis and estimation （FDI） as well as designers to predict the behavior of the cooling system, lubrication system, injection system, combustion, emissions, in order to optimize the dimensions of different components. This program is a platform for fault simulator, to investigate the impact on sub-blocks engine＇s output of changing values for faults parameters such as： faulty fuel injector, leaky cylinder, worn fuel pump, broken piston rings, a dirty turbocharger, dirty air filter, dirty air cooler, air leakage, water leakage, oil leakage and contamination, fouling of heat exchanger, pumps wear, failure of injectors （and many others）.

关键词： marine diesel engine engine system cooling system lubrication system air system injection system combustion system emissions system fault diagnosis and estimation (FDI)

Diagnosis and management challenges of in-stent restenosis in coronary arteries

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World Journal of Cardiology 2017年第8期9卷 640-651页

作者： M chadi Alraies Fahed Darmoch Ramyashree Tummala Ron Waksman Heart and Vascular Institute Department of Interventional CardiologyGeorgetown University/Med Star Washington Hospital Center Internal Medicine Department St Vincent Charity Medical Center/Case Western Reserve University

Over the course of the 3 decades, percutaneous coronary intervention(PCI) with stent implantation transformed the practice of cardiology. PCI with stenting is currently the most widely performed procedure for the treatment of symptomatic coronary disease. In large trials, drugeluting stents(DES) have led to a significant reduction in in-stent restenosis(ISR) rates, one of the major limitations of bare-metal stents. Due to these favorable findings, DES was rapidly and widely adopted enabling more complex coronary interventions. Nevertheless, ISR remains a serious concern as late stent complications. ISR mainly results from aggressive neointimal proliferation and neoatherosclerosis. DES-ISR treatment continues to be challenging complications for interventional cardiologists.

关键词： Stent In-stent Restenosis Percutaneous coronary intervention