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Assessing the academic achievement of United States orthopaedic departments

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World j.urnal of Orthopedics 2022年第2期13卷 201-211页

作者： Rishi Trikha Thomas E Olson Ameen Chaudry chad R Ishmael Cristina Villalpando Clark j.Chen Kellyn R Hori Nicholas M Bernthal Department of Orthopaedic Surgery University of CaliforniaLos AngelesCA 90404United States Department of Orthopaedic Surgery David Geffen School of Medicine at UCLALos AngelesCA 90095United States

BACKGROUND Assessing academic productivity allows academic departments to identify the strengths of their scholarly contribution and provides an opportunity to evaluate areas for *** To provide obj.ctive benchmarks for departments seeking to enhance academic productivity and identify those with significant improvement in recent *** Our study retrospectively analyzed a cohort of orthopaedic faculty at United States-based academic orthopaedic programs.5502 full-time orthopaedic faculty representing 178 programs were included in *** included for analysis were National Institutes of Health funding(2014-2018),leadership positions in orthopaedic societies(2018),editorial board positions of top orthopaedic j.urnals(2018),total number of publications and Hirsch-index.A weighted algorithm was used to calculate a cumulative score for each academic *** study was performed at a large,United States medical *** All 178 programs included in analysis were evaluated using the comprehensive weighted *** five institutions with the highest cumulative score,in decreasing order,were:Washington University in ***,the Hospital for Special Surgery,Sidney Kimmel Medical College(SKMC)at Thomas j.fferson University,the University of California,San Francisco(UCSF)and Massachusetts General Hospital(MGH)/Brigham and Women’s/*** five institutions with the highest score per capita,in decreasing order,were:Mayo Clinic(Rochester),Washington University in ***,Rush University,Virginia Commonwealth University(VCU)and MGH/Brigham and Women’s/*** five academic programs that had the largest improvement in cumulative score from 2013 to 2018,in decreasing order,were:VCU,SKMC at Thomas j.fferson University,UCSF,MGH/Brigham and Women’s/Harvard,and Brown *** This algorithm can provide orthopaedic departments a means to assess academic productivity,monitor progress,and identify areas for improvement as th

关键词： Bibliometrics Academic achievement Number of publications National Institutes of Health funding Hirsch-index

Contribution to the Full 3D Finite Element Modelling of a Hybrid Stepping Motor with and without Current in the Coils

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j.urnal of Electromagnetic Analysis and Applications 2024年第2期16卷 11-23页

作者： Belemdara Dingamadj. Hilaire Mbaïnaïbeye j.rôme Guidkaya Golam Department of Physics and Engineering Sciences University of N&#8217Djamena N&#8217Djamena Chad Department of Physics University of Moundou Moundou Chad Department of Physics University of Ngaoundere Ngaoundere Cameroon

The paper presents our contribution to the full 3D finite element modelling of a hybrid stepping motor using COMSOL Multiphysics software. This type of four-phase motor has a permanent magnet interposed between the two identical and coaxial half stators. The calculation of the field with or without current in the windings (respectively with or without permanent magnet) is done using a mixed formulation with strong coupling. In addition, the local high saturation of the ferromagnetic material and the radial and axial components of the magnetic flux are taken into account. The results obtained make it possible to clearly observe, as a function of the intensity of the bus current or the remanent induction, the saturation zones, the lines, the orientations and the magnetic flux densities. 3D finite element modelling provide more accurate numerical data on the magnetic field through multiphysics analysis. This analysis considers the actual operating conditions and leads to the design of an optimized machine structure, with or without current in the windings and/or permanent magnet.

关键词： Modelling 3D Finite Elements Magnetic Flux Hybrid Stepping Motor

Students＇ Perception and Experiences of A Programme with Cultural and Adventure Initiatives Towards Group Cohesion

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j.urnal of Tourism and Hospitality Management 2016年第5期4卷 198-206页

作者： chad j. Roux Natasha j.nse van Rensburg Universityofj.hannesburg JohannesburgSouthAfrica VaalUniversityofTechnology VanderbijlparkSouthAfrica

SARS-CoV-2 Epitopes following Infection and Vaccination Overlap Known Neutralizing Antibody Sites

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Research 2022年第2期2022卷 71-84页

作者： Li Yang Te Liang Lane M.Pierson Hongye Wang j.sse K.Fletcher Shu Wang Duran Bao Lii Zhang Zhen Huang Wenshu Zheng Xiaomei Zhang Heewon Park Yuwen Li j.mes E.Robinson Amy K.Fechan Christopher j.Lyon j.ng Cao Lisa A.Morici Chenzhong Li chad j.Roy Xiaobo Yu Tony Hu Center for Cllular and Molecular Diagnostics Tulane University Schoo of Medicine1430 Tulane AveNew OrleansLA 70112USA Department of Biochemisty and Molecular Biology Tulane University School of Medicine1430 Tulane AveNew OrleansLA 70112USA Beij.ng Key Laboratory for Forest Pest Control Bejjing Foresiry UniersilyBeijing 10083.China State Key Laboratory of Proteommics Beijing Protcome Resarch CenterNattional Center for Protein Sciences-Beiing(PHOENIX Center)Beijing Institute of LijfeomicsBeijing 102206China Hayward Genetis Cener Department of PediatricsTulane Universily School of Medicine1430 Tulane AveNew OrleansLA 70112USA Department of Pediatrics Tulane Uhriversity School of Medicine1430 Ttulane AveNew OrleansLA 70112USA Infectious Disease Depariment Ochsner Clinic FoundationNew OrleansLA 70121USA Universty of Texas Souhwestern Medical Cener 5323 Harry Himes BlvdDallasTX 75390USA Department of Microbiology Imruolog Tulane Untiversity School of Medicine 1430 Tulane AveNew OrleansLA 70112USA Division of Microbiology Tulane National Primate Research Center18703 Three Rivers RoadCovingtonLA 70433USA

Identification of epitopes targeted following virus infection or vaccination can guide vaccine design and development of therapeutic interventions targeting functional sites,but can be ***,we employed peptide microarrays to map linear peptide epitopes(LPEs)recognized following SARS-CoV-2 infetion and *** detected by nonhuman primate(NHP)and patient IgMs after SARS-CoV-2 infection extensively overlapped,localized to functionally important virus regions,and aligned with reported neutralizing antibody binding *** LPE overlap occurred atfter infection and vaccination,with LPE clusters specifc to each stimulus,where strong and conserved LPEs mapping to sites known or likely to inhibit spike protein ***-specifc LPEs tended to map to sites known or likely to be afected by structural changes induced by the proline substitutions in the mRNA vaccine's S *** LPEs to regions of known functional importance in this manner may acelerate vaccine evaluation and discovery of targets for sile secific therapeutic interventions.

关键词： vaccine Antibody likely

A Comparative Study of the Economic Feasibility of Employing CHP Systems in Different Industrial Manufacturing Applications

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Energy and Power Engineering 2011年第5期3卷 630-640页

作者： chad A. Wheeley Pedro j. Mago Rogelio Luck 不详

Extensive research work including multiple methodologies and numerous simulations have been completed in order to determine the economic effectiveness of employing CHP at commercial and residential sites. In contrast to the above, very few attempts have been made to develop methodologies to study the feasibility of CHP systems at industrial manufacturing facilities. As a result, practical opportunities for CHP at industrial sites are often not realized or even investigated. It follows that there is a need in the CHP related literature for an analysis that is explicit and yet general enough to determine the economic viability and potential for success of CHP systems at industrial manufacturing facilities. Therefore, the purpose of this paper is to clearly outline a methodology to determine the economic effectiveness of installation and operation of a CHP system at industrial facilities that have a need for space or process heating in the form of steam. The effect on the CHP system economic performance of several parameters, such as the proj.ct payback, internal rate of return, net present value, etc., are considered in the proposed methodology. The applicability and generality of the methodology is illustrated by examples including four different manufacturing facilities. The effects of the variability of factors such as annual facility operational hours during which both process heat and electricity are needed, facility average hourly thermal load, cost of utility supplied electricity, and CHP fuel type and associated fuel cost, on the outcome of the economic analysis are also examined.

关键词： CHP Systems CHP For Industrial Manufacturing Facilities Economic Feasibility Study

Genetic Diversity in the Environmental Conditioning of Two Sorghum (<i>Sorghum bicolor</i>L.) Hybrids

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American j.urnal of Plant Sciences 2018年第4期9卷 817-831页

作者： j.hn j. Burke Yves Emendack chad Hayes j.nping Chen USDA-ARS PA Cropping Systems Research Laboratory Lubbock TX USA

Sorghum metabolism continually adapts to environmental temperature as thermal patterns modulate diurnally and seasonally. The degree of adaptation to any given temperature may be difficult to determine from phenotypic responses of the plants. The present study was designed to see if the efficiency of quantum yield of photosystem II could be used as a measure of how well leaf tissue metabolism was able to withstand a prolonged respiratory demand caused by elevated temperatures. The efficiency of quantum yield values of Pioneer 84G62 and Northrup King KS585 commercial sorghum hybrids showed that when the hybrids were grown in a 28°C/20°C day/night cycle in the greenhouse or the field, Pioneer hybrid 84G62 withstood subsequent elevated thermal challenges better than Northrup King KS585. The same hybrids grown in a 39°C/32°C day/night cycle showed similar efficiency of quantum yield values when thermally challenged. Water-deficit stress increased the heat resistance of the tissue raising the efficiency of quantum yield of both lines to the same level. Upon recovery from the water deficit stress the differential efficiency of quantum yield values between the two lines re-appeared. The data provided in this study suggest a metabolic advantage of Pioneer 84G62 to environmental thermal challenges compared with the Northrup King KS585.

关键词： Sorghum Sorghum bicolor L. Thermal Sensitivity Adaptation

SAR of tricyclic sulfones as γ-secretase inhibitors

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Science China Chemistry 2011年第11期54卷 1688-1701页

作者： COLE David ASBEROM Ted BARA Tom BENNETT chad BURNETT Duane A. CLADER j.hn DOMALSKI Martin GREENLEE William j. HYDE Lynn j.SIEN Hubert McBRIAR Mark McKITTRICK Brian PISSARNITSKI Dmitri RAj.GOPALAN Murali SASIKUMAR Thavalakulamgara Merck Research Laboratories 2015 Galloping Hill RoadKenilworth New Jersey 07033 USA

Novel tricyclic sulfones as γ-secretase inhibitors have been reported by this laboratory for the treatment of Alzheimer's disease. Compounds in this series have comparable or better in vitro activities and in vivo efficacies than sulfonamide analogues re- ported previously by this laboratory. Based on the previously reported tricyclic sulfone scaffold, additional SAR studies of C ring were carried out. Various C-ring structures including cyclohexane, pyran, and piperidine were tolerated. Additionally, the 7- and 8- positions of the C-ring were identified as the best sites to introduce substituent for modulating the pharmacokinetic properties of compounds from this series.

关键词：酶抑制剂三环特区分泌阿尔茨海默氏症砜磺胺类药物动力学性质

Changing the paradigm：the potential for targeted therapy in laryngeal squamous cell carcinoma

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Cancer Biology & Medicine 2016年第1期13卷 87-100页

作者： Megan L.Ludwig Andrew C.Birkeland Rebecca Hoesli Paul Swiecicki Matthew E.Spector j.chad Brenner Department of Otolaryngology Head and Neck SurgeryUniversity of Michigan Medical SchoolAnn ArborMI 48109USA Cellular and Molecular Biology Program University of MichiqanAnn ArborMI 48109USA Department of Hematology Oncology University of Michigan Medical SchoolAnn ArborMI 48109USA Comprehensive Cancer Center University of Michigan Medical SchoolAnn ArborMI 48109USA

Laryngeal squamous cell carcinoma(LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods for bringing stratified, personalized treatment strategies to the 21^(st) century.

关键词：鳞状细胞癌靶向治疗个性化癌症治疗模型系统疾病历史保存

Rapid Lab-Scale Microwave-Assisted Extraction and Analysis of Anthropogenic Organic Chemicals in River Sediments

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International j.urnal of Geosciences 2011年第3期2卷 267-273页

作者： Thomas j.Brown chad A Kinney 不详

An Ethos EZ Microwave Lab Station is employed in the development of a robust and efficient microwave extraction method for organic contaminants of anthropogenic origin in river sediments. The extraction method is designed for a small, representative set of target compounds encompassing a range of physicochemical properties. Listed in order of gas chromatography elution they are para-cresol, indole, 4-tert-octylphenol, phenanthrene, triclosan, bisphenol-A, carbamazepine, and benzo [a] pyrene. The sediments samples are extracted wet, which reduces preparation time, and allows the ambient moisture of the sediments to aid in microwave energy absorption and the extraction process. The microwave can hold up to 12 samples that can be simultaneously extracted allowing for rapid sample preparation. Utilizing the pressurized vessels, microwave energy, and a unique mixture of three organic solvents allows for multiple samples to be extracted rapidly with minimal solvent consumption. The final extracts are quantified by gas chromatography/mass spectrometry. Recoveries of the 8 target compounds in sediment range from 49% to 113%, and method detection limits range between 14 and 114 μg kg–1, which are comparable with other more time consuming methods.

关键词： Microwave Assisted Extraction Para-Cresol Phenanthrene Bisphenol-A Triclosan Ben-zo[a]pyrene