检索结果-南通市图书馆

Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2005年第32期11卷 5015-5018页

作者： Dénes grg János Regly-Mérei Sándor Paku László Kopper Péter Nagy Department of Transplantation and SurgerySemmelweis University BudapestHungary Third Department of SurgerySemmelweis University BudapestHungary Joint Research Organization of the Hungarian Academy of Sciences and Semmelweis UniversityBudapest Hungary First Department of Pathology and Experimental Cancer ResearchSemmelweis University BudapestHungary

AIM： To characterize the alpha-fetoprotein （AFP） positive and negative hepatocellular carcinoma （HCC） samples. METHODS： Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens： AFP,β-catenin, p53, CD44, MSH-2, MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups. RESULTS： Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nudear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples. CONCLUSION： AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data on in vivo human tumors.

关键词： Hepatocellular carcinoma Alpha-fetoprotein p53 β-catenin CD44

Restimate:Recovery Estimation Tool for Resilience Planning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Safety Science and Resilience 2024年第1期5卷 47-63页

作者： Scott Miles Megan ly Nick Terry Youngjun Choe Department of Human Centered Design&Engineering Campus Box 352315University of WashingtonSeattleWA 98195United States of America Department of Industrial&Systems Engineering Box 352650University of WashingtonSeattleWA 98195United States of America

The *** Institute of Standards and Technology(NIST)published the Community Resilience Planning guide in *** NIST guide advocates for a participatory process for developing a performance measurement framework for the jurisdiction’s resilience against a scenario *** framework centers around tables of expected and desired recovery times for selected community assets,such as electricity,water,and natural gas *** NIST guide does not provide a method for estimating the expected recovery ***,building high-fidelity computer models for such estimations requires substantial resources that even larger ju-risdictions cannot *** most promising approach to recovery time estimation is to systematically use data elicited from people to tap into the wisdom of the(knowledgeable)*** paper describes a novel research-through-design project to enable the computer-supported elicitation of recovery time series *** work is the first in the literature to examine people’s ability to estimate recovery curves and how design in-fluences such *** main contribution to resilience planning is three-fold:development of a new elicitation tool called Restimate,understanding its potential user base,and providing insights into how it can facilitate resilience *** is the first tool to enable evidence-based expert elicitation in any community with limited resources for resilience *** resilience planning,those who facilitate high-stakes planning activities under large uncertainties(e.g.,mission-critical system design and planning)will benefit from a similar research-through-design process.

关键词： expert elicitation disaster natural hazard infrastructure community resilience restoration user-centered design computer-supported cooperative work

Stochastic ordering by g-expectations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Probability, Uncertainty and Quantitative Risk 2021年第1期6卷 61-98页

作者： Sel ly Nicolas Privault School of Physical and Mathematical Sciences Division of Mathematical SciencesNanyang Technological UniversitySingapore 637371

We derive sufficient conditions for the convex and monotonic g-stochastic ordering of diffusion processes under nonlinear g-expectations and *** approach relies on comparison results for forward-backward stochastic differential equations and on several extensions of convexity,monotonicity,and continuous dependence properties for the solutions of associated semilinear parabolic partial differential *** to contingent claim price comparison under different hedging portfolio constraints are provided.

关键词： Stochastic ordering g-expectation g-evaluation g-risk measures Forward-backward stochastic differential equations Parabolic PDEs Propagation of convexity

Influence of Fe on electronic density of defects in NiAl alloys

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1997年第21期42卷 1783-1787页

作者： Deng, W Xiong, ly Wang, SH guo, JT Long, QW guangxi Univ Dept Phys Nanning 530004 Peoples R China

NiAl alloy is considered to be a good candidate material for high performance, high-tempera-ture structural applications since this material offers a wide range of attractive mechanical andphysical properties, such as low density (5. 86 g/cm^3), high melting point (1 640℃), goodthermal conductivity (4--8 times compared with Ni-based superalloys) and oxidation resis-tance. However, the use of NiAl is limited by its room-temperature brittleness. georgeand Liu have investigated the effects of microalloying elements B, C and Be on the fractureproperties and grain boundaries of NiAl alloy. Their results showed that the improvement

关键词： NiAl alloy positron lifetime microdefects electronic density.

Application of extreme gradient boosting in predicting the viscoelastic characteristics of graphene oxide modified asphalt at medium and high temperatures

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2024年第6期18卷 899-917页

作者： Huong-giang Thi HOANg Hai-Van Thi MAI Hoang Long NgUYEN Hai-Bang ly University of Transport Technology Hanoi 100000Vietnam

Complex modulus(g^(*))is one of the important criteria for asphalt classification according to AASHTO M320-10,and is often used to predict the linear viscoelastic behavior of asphalt *** addition,phase angle(φ)characterizes the deformation resilience of asphalt and is used to assess the ratio between the viscous and elastic *** is thus important to quickly and accurately estimate these two *** purpose of this investigation is to construct an extreme gradient boosting(XgB)model to predict g^(*)andφof graphene oxide(gO)modified asphaltat medium and high *** data sets are gathered from previously published experiments,consisting of 357 samples for g^(*)and 339 samples forφ,and the se are used to develop the XgB model using nine inputs representing theasphalt binder *** findings show that XgB is an excellent predictor of g^(*)andφof gO-modified asphalt,evaluated by the coefficient of determination R^(2)(R^(2)=0.990 and 0.9903 for g^(*)andφ,respectively)and root mean square error(RMSE=31.499 and 1.08 for g^(*)andφ,respectively).In addition,the model’s performance is compared with experimental results and five other machine learning(ML)models to highlight its *** the final step,the Shapley additive explanations(SHAP)value analysis is conducted to assess the impact of each input and the correlation between pairs of important features on asphalt’s two physical properties.

关键词： complex modulus phase angle graphene oxide asphalt extreme gradient boosting machine learning

Highly flexible conductive fabrics with hierarchically nanostructured amorphous nickel tungsten tetraoxide for enhanced electrochemical energy storage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2015年第12期8卷 3749-3763页

作者： goli Nagaraju Ramesh Kakarla Sung Min cha Jae Su Yu Department of Electronics and Radio Engineering Institute for Wearable Convergence Electronics Kyung Hee University 1 Seocheon-dong Giheung-gu Yongin-si Gyeonggi-do 446-701 Republic of Korea Department of Environmental Science and Engineering Kyung Hee University 1Seocheon-dong Giheung-gu Yongin-si Gyeonggido 446-701 Republic of Korea

Amorphous nickel tungsten tetraoxide （NiWO4） nanostructures （NSs） were successfully synthesized on a flexible conductive fabric （CF） using a facile one- step electrochemical deposition （ED） method. With an applied external cathodic voltage （-1.8 V for 15 min）, the amorphous NiWO4 NSs with burl-like morphologies adhered well on the seed-coated CF substrate. The burMike amorphous NiWO4 NSs on CF （NiWO4 NSs/CF） are employed as a flexible and binder-free electrode for pseudocapacitors, which exhibit remarkable electrochemical properties with high specific capacitance （1,190.2 F/g at 2 A/g）, excellent cyclic stability （92% at 10 A/g）, and good rate capability （765.7 F/g at 20 A/g） in 1 M KOH electrolyte solution. The superior electrochemical properties can be ascribed to the hierarchical structure and large specific surface area of the burl-like amorphous NiWO4 NSs/CF. This cost-effective facile method for the synthesis of metal tungsten tetraoxide nanomaterials on a flexible CF could be promising for advanced electronic and energy storage device applications.

关键词： amorphous NiWO4 nanostructures conductive fabrics electrochemical deposition electrochemical energystorage properties

Very-high-frequency probes for atomic force microscopy with silicon optomechanics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2022年第2期8卷 35-48页

作者： L.Schwab P.E.Allain N.Mauran X.Dollat L.Mazenq D.Lagrange M.gély S.Hentz g.Jourdan I.Favero B.Legrand Laboratoire d'Analyse et d'Architecture des Systemes Universite de ToulouseCNRS UPR 800131031 ToulouseFrance Laboratoire Materiaux et Phenomenes Quantiques Universite de ParisCNRS UMR 716275013 ParisFrance Universite grenoble Alpes CEALETIMinatec Campus38000 GrenobleFrance

Atomic force microscopy(AFM)has been consistently supporting nanosciences and nanotechnologies for over 30 years and is used in many fields from condensed matter physics to *** enables the measurement of very weak forces at the nanoscale,thus elucidating the interactions at play in fundamental ***,we leverage the combined benefits of micro/nanoelectromechanical systems and cavity optomechanics to fabricate a sensor for dynamic mode AFM at a frequency above 100 *** frequency is two decades above the fastest commercial AFM probes,suggesting an opportunity for measuring forces at timescales unexplored thus *** fabrication is achieved using very-large-scale integration technologies derived from photonic silicon *** probe's optomechanical ring cavity is coupled to a 1.55 pm laser light and features a 130 MHz mechanical resonance mode with a quality factor of 900 in air.A limit of detection in the displacement of 3×10^(-16)m/VHz is obtained,enabling the detection of the Brownian motion of the probe and paving the way for force sensing experiments in the dynamic mode with a working vibration amplitude in the picometer *** inserted in a custom AFM instrument embodiment,this optomechanical sensor demonstrates the capacity to perform force-distance measurements and to maintain a constant interaction strength between the tip and sample,an essential requirement for AFM *** indeed show a stable closed-loop operation with a setpoint of 4 nN/nm for an unprecedented subpicometer vibration amplitude,where the tip-sample interaction is mediated by a stretched water meniscus.

关键词： cavity maintain instrument

Preliminary analysis on roles of metal–organic compounds in the formation of invisible gold

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta geochimica 2021年第6期40卷 1050-1072页

作者： Medet Junussov Mádai Ferenc Kristály Ferenc Tòth Tivadar Fintor Krisztián Muránszky gábor Prekob Ádám Hámor-VidóMária Department of Mineralogy and Petrography Institute of Mineralogy and GeologyFaculty of Earth Sciences and EngineeringUniversity of MiskolcMiskolc-Egyetemváros 3515Hungary Institute of Mineralogy and geology Faculty of Earth Sciences and EngineeringUniversity of MiskolcMiskolc-Egyetemváros 3515Hungary Department of Mineralogy and geochemistry Faculty of Science and InformaticsUniversity of SzegedAradi vértank tere 1Szeged 6720Hungary Institute of Chemistry Faculty of Material Sciences and EngineeringUniversity of MiskolcMiskolc-Egyetemváros 3515Hungary Department of geology and Meteorology Institute of Geography and Earth SciencesFaculty of SciencesUniversity of PécsVasvári pál utcaPecs 7622Hungary

The paper comprises new analytical data on the nature and occurrence of gold in solid pyrobitumen,closely associated with the main gold-bearing sulfide arsenic ores of the Bakyrchik gold deposit(Kazakhstan),related to post-collisional magmatic-hydrothermal *** mineralization of the deposit occurs mainly in the form of an“invisible”type of gold in the structures of arsenian pyrite and arsenopyrite,and the form of gold-organic compounds of pyrobitumen in carbonaceous-terrigenous sequences of Carboniferous *** and electron microscopic analysis,Raman and FT-Infrared analysis,mineralogical and three-step sequential extraction analysis(NH2OHHCl,H2O2,HNO3?HCl)has been carried out using 9 ore samples(from 3 different types of ores)for a comprehensive study of pyrobitumen and sulfide arsenic ores focusing mainly on organic *** sequentially extracted precious metal content of pyrobitumen reaches up to 7 ppm gold and other metals like Ag 4 ppm,Pt 31 ppb,and Pd 26 ppb,forming metal–organic compounds,while arsenic sulfide minerals incorporate 11 ppm gold,39 ppm Ag,0.49 ppm *** enrichment of gold associating with organic matter and sulfide ore minerals was confirmed in this *** matter was active in the migration of gold and the capture of gold by ***,the reductive organic matter agent released gold,most likely for the sulfide arsenic ore *** was a decisive factor in the concentration,transportation,and preservation of gold in the deposit.

关键词： gold Pyrobitumen Bakyrchik Vitrinite Metal-organic compounds

Tumor-infiltrating B cells:their role and application in antitumor immunity in lung cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第1期16卷 6-18页

作者： Si-si Wang Wei Liu Dalam ly Hao Xu Limei Qu Li Zhang Department of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061China Department of Thoracic surgery The First Hospital of Jilin UniversityChangchun 130021China Toronto general Hospital Research Institute University Health NetworkTorontoON M5G 1L7 Canada Departments of Laboratory Medicine and Pathobiology ImmunologyUniversity of TorontoToronto ON M5G 1L7Canada Department of Pathology The First Hospital of Jilin UniversityChangchun 130021China

Evidence indicates that lung cancer development is a complex process that involves interactions between tumor cells,stromal fibroblasts,and immune ***-infiltrating immune cells play a significant role in the promotion or inhibition of tumor *** an integral component of the tumor microenvironment,tumor-infiltrating B lymphocytes(TIBs)exist in all stages of cancer and play important roles in shaping tumor ***,we review recent clinical and preclinical studies that outline the role of TIBs in lung cancer development,assess their prognostic significance,and explore the potential benefit of B cell-based immunotherapy for lung cancer treatment.

关键词： lung cancer B cells tumor-infiltrating B cells Bregs immunotherapy