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Effects of Initia. a.d Bounda.y Conditions on Hea.y Ra.nfa.l Simula.ion over the Yellow Sea.a.d the Korea. Peninsula.Compa.ison of ECMWF a.d NCEP a.a.ysis Da.a.Effects a.d Verifica.ion with Dropsonde Observa.ion

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a.va.ces in a.mospheric Sciences 2024年第9期41卷 1787-1803页

作者： Jiwon HWa.G Dong-Hyun cha Donghyuck YOON Ta.-Young GOO Sueng-Pil JUNG Depa.tment of Civil Urba. Ea.th a.d Environmenta. Engineering Ulsan National Institute of Science and TechnologyUlsan 44919South Korea Progra. in a.mospheric a.d Ocea.ic Sciences Princeton UniversityPrincetonNew Jersey 08544USA Na.iona. Institute of Meteorologica. Sciences NIMSJeju 63568South Korea

This study eva.ua.ed the simula.ion performa.ce of mesosca.e convective system(MCS)-induced precipita.ion,focusing on three selected ca.es tha. origina.ed from the Yellow Sea.a.d propa.a.ed towa.d the Korea. *** eva.ua.ion wa. conducted for the Europea. Centre for Medium-Ra.ge Wea.her Foreca.ts(ECMWF)a.d Na.iona. Centers for Environmenta. Prediction(NCEP)a.a.ysis da.a.a. well a. the simula.ion result using them a. initia. a.d la.era. bounda.y conditions for the Wea.her Resea.ch a.d Foreca.ting ***,tempera.ure a.d humidity profiles from 3D dropsonde observa.ions from the Na.iona. Center for Meteorologica. Science of the Korea.Meteorologica. a.ministra.ion served a. va.ida.ion *** showed tha. the ECMWF a.a.ysis consistently ha. sma.ler errors compa.ed to the NCEP a.a.ysis,which exhibited a.cold a.d dry bia. in the lower levels below 850 *** model,in terms of the precipita.ion simula.ions,pa.ticula.ly for high-intensity precipita.ion over the Yellow Sea.demonstra.ed higher a.cura.y when a.plying ECMWF a.a.ysis da.a.a. the initia. *** a.va.ta.e a.so positively influenced the simula.ion of ra.nfa.l events on the Korea. Peninsula.by rea.ona.ly inducing convective-fa.ora.le thermodyna.ic fea.ures(i.e.,wa.m a.d humid lower-level a.mosphere)over the Yellow *** conclusion,this study provides specific informa.ion a.out two globa. a.a.ysis da.a.ets a.d their impa.ts on MCS-induced hea.y ra.nfa.l simula.ion by employing dropsonde observa.ion ***,it suggests the need to enha.ce the initia. field for MCS-induced hea.y ra.nfa.l simula.ion a.d the a.plica.ility of a.simila.ing dropsonde da.a.for this purpose in the future.

关键词： initia. conditions dropsonde hea.y ra.nfa.l foreca.t globa. model a.a.ysis eva.ua.ion

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a.a.ysis of Differences in Electrochemica. Performa.ce Between Coin a.d Pouch Cells for Lithium-Ion Ba.tery a.plica.ions

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Energy & Environmenta. Ma.eria.s 2024年第3期7卷 59-63页

作者： Yeonguk Son Hyungyeon cha Ta.yong Lee Yujin Kim a.a. Boies Ja.phil Cho Michael De Volder Depa.tment of Engineering University of Cambridge17 Charles Babbage RoadCB30FSCambridge UK Depa.tment of Chemica. Engineering Changwon National UniversityChangwon Gyeongsangnam-do 51140Korea Depa.tment of Energy Engineering School of Energy a.d Chemica. Engineering Ulsa. Na.iona. Institute of Science a.d Technology(UNIST) Ulsan 44919Korea

Sma.l coin cell ba.teries a.e predomina.tly used for testing lithium-ion ba.teries(LIBs)in a.a.emia.beca.se they require sma.l a.ounts of ma.eria. a.d a.e ea.y to ***,insufficient a.tention is given to difference in cell performa.ce tha. a.ises from the differences in forma. between coin cells used by a.a.emic resea.chers a.d pouch or cylindrica. cells which a.e used in *** this a.ticle,we compa.e coin cells a.d pouch cells of different size with exa.tly the sa.e electrode ma.eria.s,electrolyte,a.d electrochemica. *** show the ba.tery impeda.ce changes substa.tia.ly depending on the cell forma. using techniques including Electrochemica. Impeda.ce Spectroscopy(EIS)a.d Ga.va.osta.ic Intermittent Titra.ion Technique(GITT).Using full cell NCa.gra.hite LIBs,we demonstra.e tha. this difference in impeda.ce ha. importa.t knock-on effects on the ba.tery ra.e performa.ce due to ohmic pola.iza.ion a.d the ba.tery life time due to Li meta. pla.ing on the *** hope this work will help resea.chers getting a.better idea.of how sma.l coin cell forma.s impa.t the cell performa.ce a.d help predicting improvements tha. ca. be a.hieved by implementing la.ger cell forma.s.

关键词： coin cell full cell lithium-ion ba.teries pouch cell

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Intra.ellula. zinc signa.ing via.Kruppel-like tra.scription fa.tor 6 promotes HuD expression in pa.crea.ic β cell

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Genes & Disea.es 2024年第4期11卷 24-27页

作者： Seongho cha Chongta. Kim Myeongwoo Jung Seungyeon Ryu Sukyoung Ha. Wook Kim Eun Kyung Lee Depa.tment of Biochemistry Department of Biomedicine&Health SciencesCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Ca.holic Institute for Visua. Science College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Depa.tment of Molecula. Science&Technology Ajou UniversitySuwon 16499South Korea

Dysfunction of pa.crea.icβcells ca.sed by zinc deficiency is rela.ed to the pa.hogenesis of dia.etes.1 Impa.red zinc homeosta.is in dia.etes is a.socia.ed with reduced zinc tra.sporters.2 Down-regula.ion of HuD,a. es... 详细信息

关键词： βcell homeosta.is zinc

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Do brood pa.a.itic Common Cuckoos develop brood pa.ches during the breeding sea.on?

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a.ia. Resea.ch 2024年第3期15卷 363-368页

作者： Jun-Seo Go Ha.-Ni Kim Sue-Jeong Jin Myeong-chan cha Heesoo Lee Jin-Won Lee Korea.Institute of Ornithology&Depa.tment of Biology Kyung Hee University02447SeoulRepublic of Korea Bird Resea.ch Sa.ZiP 12504YangpyeongRepublic of Korea

Ma.y birds develop brood pa.ches on their ventra. a.terium under hormona. regula.ion to effectively tra.smit body hea. to eggs during *** developed pa.ch ha. severa. chara.teristics,including de-fea.hering,va.cula.iza.ion,a.d ***,little is known a.out whether a.ia. brood pa.a.ites tha. do not incuba.e their eggs exhibit brood pa.ch development during the breeding *** this study,we mea.ured the size of the ventra. a.terium in 114 Common Cuckoos(Cuculus ca.orus)ca.tured in the field throughout the breeding sea.on a.d exa.ined the a.pea.a.ce of the ventra. a.terium to confirm the development of brood *** a.so exa.ined whether morphologica. tra.ts a.d va.ious fa.tors correla.ed with the size of the ventra. a.terium(sterna. a.terium a.d a.domina. a.terium)a.d how it changed during the breeding *** found no clea. signs of brood pa.ch development in Common Cuckoos ca.tured throughout the breeding sea.on,indica.ing tha. they likely did not develop brood pa.ches on the ventra. a.terium during this *** a.so found tha. ventra. a.terium size wa. positively correla.ed with wing length a.d body *** a.dition,Common Cuckoos with newly growing fea.hers on the bounda.y of the ventra. a.terium with pteryla.were frequently observed a. sea.ons progressed to the *** conclusion,Common Cuckoos exhibit neither brood pa.ch development nor the vestigia. chara.teristics of a.cestra. brood pa.ches,except for the growth of fea.hers on bounda.y the ventra. *** studies exa.ining brood pa.ches a.ross different groups of a.ia. brood pa.a.ites a.e va.ua.le for enha.cing our understa.ding of the developmenta. a.d physiologica. a.a.ta.ions of a.ia. brood pa.a.ites.

关键词： Brood pa.a.itism Brood pa.ch Common Cuckoo Pterylosis Re-fea.hering Ventra. a.terium

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Huma. Ga.t Recognition for Biometrics a.plica.ion Ba.ed on Deep Lea.ning Fusion a.sisted Fra.ework

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Computers, Ma.eria.s & Continua 2024年第1期78卷 357-374页

作者： Ch a.a.s Ha.if Muha.ma. a.i Mugha. Muha.ma. a.tique Kha. Nouf a.dulla. a.muja.ly Ta.ra.g Kim Ja.-Hyuk cha Depa.tment of Electrica. Engineering HITEC UniversityTaxila47080Pakistan Depa.tment of Computer Science a.d Ma.hema.ics Lebanese American UniversityBeirutLebanon Depa.tment of Computer Science HITEC UniversityTaxila47080Pakistan Depa.tment of Informa.ion Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Depa.tment of Computer Science Hanyang UniversitySeoul04763Korea

The dema.d for a.non-conta.t biometric a.proa.h for ca.dida.e identifica.ion ha. grown over the pa.t ten *** on the most importa.t biometric a.plica.ion,huma. ga.t a.a.ysis is a.significa.t resea.ch topic in computer *** ha.e pa.d a.lot of a.tention to ga.t recognition,specifica.ly the identifica.ion of people ba.ed on their wa.king pa.terns,due to its potentia. to correctly identify people fa. *** recognition systems ha.e been used in a.va.iety of a.plica.ions,including security,medica. exa.ina.ions,identity ma.a.ement,a.d a.cess *** systems require a.complex combina.ion of technica.,opera.iona.,a.d definitiona. *** employment of ga.t recognition techniques a.d technologies ha. produced a.number of beneficia. a.d well-liked *** proposes a.novel deep lea.ning-ba.ed fra.ework for huma. ga.t cla.sifica.ion in video *** fra.ework’sma.n challenge is improving the a.cura.y of a.cura.y ga.t cla.sifica.ion under va.ying conditions,such a. ca.rying a.ba. a.d changing *** proposed method’s first step is selecting two pre-tra.ned deep lea.ningmodels a.d tra.ning fromscra.ch using deep tra.sfer ***,deepmodels ha.e been tra.ned using sta.ic hyperpa.a.eters;however,the lea.ning ra.e is ca.cula.ed using the pa.ticle swa.moptimiza.ion(PSO)***,the best fea.ures a.e selected from both tra.ned models using the Ha.ris Ha.ks controlled Sine-Cosine optimiza.ion *** a.gorithm chooses the best fea.ures,combined in a.novel correla.ion-ba.ed fusion ***,the fused best fea.ures a.e ca.egorized using medium,bi-la.er,a.d tri-la.ered neura. *** the publicly a.cessible da.a.et known a. the Ca.Ia.B da.a.et,the experimenta. process of the suggested technique wa. ca.ried out,a.d a. improved a.cura.y of 94.14% wa. *** a.hieved a.cura.y of the proposed method is improved by the recent sta.e-of-the-a.t techniques tha. show the significa.ce of this wor

关键词： Ga.t recognition cova.ia.t fa.tors biometric deep lea.ning fusion fea.ure selection

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Deep Convolutiona. Neura. Networks for a.cura.e Cla.sifica.ion of Ga.trointestina. Tra.t Syndromes

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Computers, Ma.eria.s & Continua 2024年第1期78卷 1207-1225页

作者： Za.id Fa.ooq Kha. Muha.ma. Ra.za. Muda.sa. Ra.a.Muha.ma. a.tique Kha. Kha.id Iqba. Ta.ra.g Kim Ja.-Hyuk cha Depa.tment of Computer Science COMSATS University IslamabadWah CampusWah47040Pakistan Depa.tment of Computer Science a.d Ma.hema.ics Lebanese American UniversityBeirut13-5053Lebanon Depa.tment of Computer Science HITEC UniversityTaxila47080Pakistan Depa.tment of Computer Science COMSATS University IslamabadAttock CampusAttock43600Pakistan Depa.tment of Computer Science Hanyang UniversitySeoul04763Korea

a.cura.e detection a.d cla.sifica.ion of a.tifa.ts within the ga.trointestina.(GI)tra.t fra.es rema.n a.significa.t challenge in medica. ima.e *** science combined with a.tificia. intelligence is a.va.cing to a.toma.e the dia.nosis a.d trea.ment of numerous *** to this is the development of robust a.gorithms for ima.e cla.sifica.ion a.d detection,crucia. in designing sophistica.ed systems for dia.nosis a.d *** study ma.es a.sma.l contribution to endoscopic ima.e *** proposed a.proa.h involves multiple opera.ions,including extra.ting deep fea.ures from endoscopy ima.es using pre-tra.ned neura. networks such a. Da.knet-53 a.d ***,fea.ure optimiza.ion utilizes the bina.y dra.onfly a.gorithm(BDa.,with the fusion of the obta.ned fea.ure *** fused fea.ure set is input into the ensemble subspa.e k nea.est neighbors(ESKNN)*** Kva.ir-V2 benchma.k da.a.et,a.d the COMSa.S University Isla.a.a.(CUI)Wa. priva.e da.a.et,fea.uring three cla.ses of endoscopic stoma.h ima.es were *** a.sessments considered va.ious fea.ure selection techniques,including genetic a.gorithm(Ga.,pa.ticle swa.m optimiza.ion(PSO),sa.p swa.m a.gorithm(SSa.,sine cosine a.gorithm(SCa.,a.d grey wolf optimizer(GWO).The proposed model excels,a.hieving a. overa.l cla.sifica.ion a.cura.y of 98.25% on the Kva.ir-V2 benchma.k a.d 99.90% on the CUI Wa. priva.e *** a.proa.h holds promise for developing a. a.toma.ed computer-a.ded system for cla.sifying GI tra.t syndromes through endoscopy ima.es.

关键词： Fea.ure fusion Da.knet-53 Xception bina.y dra.onfly a.gorithm ensemble

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Enha.cement of vertica. pha.e sepa.a.ion in sequentia.ly deposited orga.ic photovolta.cs through the independent processing of a.ditives

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Journa. of Energy Chemistry 2024年第7期94卷 768-777页

作者： Da.in Lee changwoo Pa.k Ga.oung Ha. Young Yong Kim Sung-Na. Kwon Junyeong Lee Sungjin Jo Seok-In Na.Hyojung cha Depa.tment of Hydrogen a.d Renewa.le Energy Kyungpook National UniversityDaegu 41566Republic of Korea Depa.tment of Energy Convergence a.d Clima.e change Kyungpook National UniversityDaegu 41566Republic of Korea Poha.g a.celera.or La.ora.ory(Pa.) Pohang University of Science and Technology(POSTECH)PohangGyeongbuk 37673Republic of Korea Depa.tment of Flexible a.d Printa.le Electronics Jeonbuk National UniversityJeonju-siJeollabuk-do 54896Republic of Korea School of Energy Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

Herein,the impa.t of the independent control of processing a.ditives on vertica. pha.e sepa.a.ion in sequentia.ly deposited (SD) orga.ic photovolta.cs (OPVs) a.d its subsequent effects on charge ca.rier kinetics a. the electron donor-a.ceptor interfa.e a.e *** film morphology exhibits nota.le va.ia.ions,significa.tly depending on the la.er to which 1,8-diiodoocta.e (DIO) wa. *** incidence wide-a.gle X-ra. sca.tering a.a.ysis revea.s distinctly sepa.a.ed donor/a.ceptor pha.es a.d vertica. crysta.linity deta.ls in SD ***-of-flight seconda.y ion ma.s spectrometry a.a.ysis is employed to obta.n component distributions in diverse vertica. pha.e structures of SD films depending on a.ditive *** a.dition,na.osecond tra.sient a.sorption spectroscopy shows tha. DIO control significa.tly a.fects the dyna.ics of sepa.a.ed charges in SD *** SD OPVs,DIO a.pea.s to a.t through distinct mechanisms with minima. restriction,depending on the a.plied *** study empha.izes the significa.ce of morphologica. optimiza.ion in improving device performa.ce a.d underscores the importa.ce of independent a.ditive control in the a.va.cement of OPV technology.

关键词： Sequentia. deposition Vertica. pha.e sepa.a.ion charge dyna.ics Orga.ic photovolta.cs Nonfullerene a.ceptors

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a. a.tificia. Intelligence-Ba.ed Fra.ework for Fruits Disea.e Recognition Using Deep Lea.ning

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Computer Systems Science & Engineering 2024年第2期48卷 529-554页

作者： Irfa. Ha.der Muha.ma. a.tique Kha. Muha.ma. Na.ir Ta.ra.g Kim Ja.-Hyuk cha Depa.tment of Computer Science HITEC UniversityTaxila47080Pakistan Depa.tment of Computer Science Hanyang UniversitySeoulKorea

Fruit infections ha.e a. impa.t on both the yield a.d the qua.ity of the *** a.result,a. a.toma.ed recognition system for fruit lea. disea.es is *** a.tificia. intelligence(a.)a.plica.ions,especia.ly in a.riculture,deep lea.ning shows promising disea.e detection a.d cla.sifica.ion *** recent a.-ba.ed techniques ha.e a.few challenges for fruit disea.e recognition,such a. low-resolution ima.es,sma.l da.a.ets for lea.ning models,a.d irreleva.t fea.ure *** work proposed a.new fruit lea. lea. lea. disea.e recognition fra.ework using deep lea.ning fea.ures a.d improved pa.hfinder *** fruit types ha.e been employed in this work for the va.ida.ion process,such a. a.ple,gra.e,a.d *** the first step,a.noisy da.a.et is prepa.ed by employing the origina. ima.es to lea.n the designed fra.ework *** EfficientNet-B0 deep model is fine-tuned on the next step a.d tra.ned sepa.a.ely on the origina. a.d noisy *** tha.,fea.ures a.e fused using a.seria. conca.ena.ion a.proa.h tha. is la.er optimized in the next step using a. improved Pa.h Finder a.gorithm(PFa..This a.gorithm a.ms to select the best fea.ures ba.ed on the fitness score a.d ignore redunda.t *** selected fea.ures a.e fina.ly cla.sified using ma.hine lea.ning cla.sifiers such a. Medium Neura. Network,Wide Neura. Network,a.d Support Vector *** experimenta. process wa. conducted on ea.h fruit da.a.et sepa.a.ely a.d obta.ned a. a.cura.y of 100%,99.7%,99.7%,a.d 93.4%for a.ple,gra.e,Citrus fruit,a.d citrus pla.t lea.es,respectively.a.deta.led a.a.ysis is conducted a.d a.so compa.ed with the recent techniques,a.d the proposed fra.ework shows improved a.cura.y.

关键词： Fruit disea.e contra.t enha.cement a.gmenta.ion deep lea.ning fusion fea.ure selection cla.sifica.ion

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TRa.L a.d Cela.trol Combina.iona. Trea.ment Suppresses Prolifera.ion, Migra.ion, a.d Inva.ion of Huma. Gliobla.toma.Cells via.Ta.geting Wnt/β-ca.enin Signa.ing Pa.hwa.

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Chinese Journa. of Integra.ive Medicine 2024年第4期30卷 322-329页

作者： QIN Jing-jing NIU Meng-da.cha Zhe GENG Qing-hua.LI Yu-lin REN Chun-gua.g Da.id P.Molloy YU Hua.rong Resea.ch Center of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China La.ora.ory of Developmenta. Biology Department of Cell Biology and GeneticsSchool of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Depa.tment of Biochemistry a.d Molecula. Biology School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China

Objective To investiga.e the mechanistic ba.is for the a.ti-prolifera.ion a.d a.ti-inva.ion effect of tumor necrosis fa.tor-rela.ed a.optosis-induced liga.d(TRa.L)a.d cela.trol combina.ion trea.ment(TCCT)in gliobla.toma.*** Cell counting kit-8 wa. used to detect the effects of different concentra.ions of cela.trol(0-16µmol/L)a.d TRa.L(0-500 ng/mL)on the cell via.ility of gliobla.toma.cells.U87 cells were ra.domly divided into 4 groups,na.ely control,TRa.L(TRa.L 100 ng/mL),Cel(cela.trol 0.5µmol/L)a.d TCCT(TRa.L 100 ng/mL+cela.trol 0.5µmol/L).Cell prolifera.ion,migra.ion,a.d inva.ion were detected by colony forma.ion,wound hea.ing,a.d Tra.swell a.sa.s,*** reverse tra.scription polymera.e chain rea.tion a.d Western blotting were performed to a.sess the levels of epithelia.-mesenchyma. tra.sition(EMT)ma.kers(zona.occludens,N-ca.herin,vimentin,zinc finger E-box-binding homeobox,Slug,a.d β-ca.enin).Wnt pa.hwa. wa. a.tiva.ed by lithium chloride(LiCl,20 mol/L)a.d the mechanism for a.tion of TCCT wa. *** Cela.trol a.d TRa.L synergistica.ly inhibited the prolifera.ion,migra.ion,inva.ion,a.d EMT of U87 cells(Pa.ed the expression of GSK-3β a.d down-regula.ed the expression of β-ca.enin a.d its a.socia.ed proteins(Pa.d ma.rix meta.loproteina.e(MMP)-*** a.dition,LiCl,a. a.tiva.or of the Wnt signa.ing pa.hwa.,restored the inhibitory effects of TCCT on the expression of β-ca.enin a.d its downstrea. genes,a. well a. the migra.ion a.d inva.ion of gliobla.toma.cells(Pa.trol a.d TRa.L ca. synergistica.ly suppress gliobla.toma.cell migra.ion,inva.ion,a.d EMT,potentia.ly through inhibition of Wnt/β-ca.enin *** underlies a.novel mechanism of a.tion for TCCT a. a. effective thera.y for gliobla.toma.

关键词： cela.trol Chinese medicine tumor necrosis fa.tor-rela.ed a.optosis-induced liga.d gliobla.toma β-ca.enin Tripterygium wilfordii

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Des-a.g(9)bra.ykinin a. a.ca.sa. meta.olite for a.tism spectrum disorder

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World Journa. of Psychia.ry 2024年第1期14卷 88-101页

作者： Zhong-Yu Hua.g Zi-Pa. Lyu Hong-Gui Li Hua.Zhi You Xia.g-Na.Ya.g Ca.-Hui cha Center for Medica. Resea.ch on Innova.ion a.d Tra.sla.ion Institute of Clinical MedicineGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510000Guangdong ProvinceChina School of Biologica. Sciences Nanyang Technological UniversityNanyang Ave 639798Singapore Depa.tment of Pedia.rics First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Depa.tment of Nutrition First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Depa.tment of Pedia.ric Tra.itiona. Chinese Medicine Clinic Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina Depa.tment of Psychology Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina

Ba.KGROUND Ea.ly dia.nosis a.d thera.eutic interventions ca. grea.ly enha.ce the developmenta. tra.ectory of children with a.tism spectrum disorder(a.D).However,the etiology of a.D is not completely *** presence of confounding fa.tors from environment a.d genetics ha. increa.ed the difficulty of the identifica.ion of dia.nostic bioma.kers for *** To estima.e a.d interpret the ca.sa. rela.ionship between a.D a.d meta.olite profile,ta.ing into considera.ion both genetic a.d environmenta. *** a.two-sa.ple Mendelia. ra.domiza.ion(MR)a.a.ysis wa. conducted using summa.ized da.a.from la.ge-sca.e genome-wide a.socia.ion studies(GWa.)including a.meta.olite GWa. da.a.et covering 453 meta.olites from 7824 Europea. a.d a. a.D GWa. da.a.et comprising 18381 a.D ca.es a.d 27969 hea.thy *** in pla.ma.were set a. exposures with a.D a. the ma.n *** ca.sa. rela.ionships were estima.ed using the inverse va.ia.t weight(IVW)*** a.so performed lea.e-one-out sensitivity tests to va.ida.e the robustness of the *** on the dra.ted meta.olites,enrichment a.a.ysis wa. conducted to interpret the a.socia.ion via.constructing a.protein-protein intera.tion network with multi-sca.e evidence from da.a.a.es including Infinome,SwissTa.getPrediction,STRING,a.d *** Des-a.g(9)-bra.ykinin wa. identified a. a.ca.sa. meta.olite tha. increa.es the risk of a.D(β=0.262,SE=0.064,P_(IVW)=4.64×10^(-5)).The a.socia.ion wa. robust,with no significa.t heterogeneity a.ong instrument va.ia.les(P_(MR Egger)=0.663,P_(IVW)=0.906)a.d no evidence of pleiotropy(P=0.949).Neuroinfla.ma.ion a.d the response to stimulus were suggested a. potentia. biologica. processes media.ing the a.socia.ion between Des-a.g(9)bra.ykinin a.d *** Through the a.plica.ion of MR,this study provides pra.tica. insights into the potentia. ca.sa. a.socia.ion between pla.ma.meta.olites a.d *** findings offer perspectives for the discovery of dia.nos

关键词： Des-a.g(9)bra.ykinin a.tism spectrum disorder Mendelia. ra.domiza.ion Meta.olite Enrichment a.a.ysis

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