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Deep Convolutional Neural Networks for Accurate Classification of Gastrointestinal Tract Syndromes

Computers, Materials & Continua 2024年第1期78卷 1207-1225页

作者： Zahid Farooq Khan Muhammad Ramzan Mudassar Raza Muhammad Attique Khan Khalid Iqbal Taerang Kim Jae-Hyuk cha Department of Computer Science COMSATS University IslamabadWah CampusWah47040Pakistan Department of Computer Science and Mathematics Lebanese American UniversityBeirut13-5053Lebanon Department of Computer Science HITEC UniversityTaxila47080Pakistan Department of Computer Science COMSATS University IslamabadAttock CampusAttock43600Pakistan Department of Computer Science Hanyang UniversitySeoul04763Korea

Accurate detection and classification of artifacts within the gastrointestinal(GI)tract frames remain a significant challenge in medical image *** science combined with artificial intelligence is advancing to automate the diagnosis and treatment of numerous *** to this is the development of robust algorithms for image classification and detection,crucial in designing sophisticated systems for diagnosis and *** study makes a small contribution to endoscopic image *** proposed approach involves multiple operations,including extracting deep features from endoscopy images using pre-trained neural networks such as Darknet-53 and ***,feature optimization utilizes the binary dragonfly algorithm(BDA),with the fusion of the obtained feature *** fused feature set is input into the ensemble subspace k nearest neighbors(eSKNN)*** Kvasir-V2 benchmark dataset,and the COMSATS University Islamabad(CUI)Wah private dataset,featuring three classes of endoscopic stomach images were *** assessments considered various feature selection techniques,including genetic algorithm(GA),particle swarm optimization(PSO),salp swarm algorithm(SSA),sine cosine algorithm(SCA),and grey wolf optimizer(GWO).The proposed model excels,achieving an overall classification accuracy of 98.25% on the Kvasir-V2 benchmark and 99.90% on the CUI Wah private *** approach holds promise for developing an automated computer-aided system for classifying GI tract syndromes through endoscopy images.

关键词： Feature fusion Darknet-53 Xception binary dragonfly algorithm ensemble

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estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy

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Bone Research 2024年第1期12卷 95-106页

作者： Tian Nie Varun S.Venkatesh Suzanne Golub Kathryn S.Stok Haniyeh Hemmatian Reena Desai David J.Handelsman jeffrey D.Zajac Mathis Grossmann Rachel A.Davey Department of Medicine Austin HealthUniversity of MelbourneHeidelbergVIC 3084Australia Department of Biomedical engineering University of MelbourneParkvilleVIC 3010Australia ANZAC Research Institute University of Sydney and AndrologyConcord Repatriation General HospitalConcordNSW 2137Australia

The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent trans girls are *** address this knowledge gap,we developed a mouse model to simulate male-to-female transition in human adolescents in whom puberty is first arrested by using gonadotrophin-releasing hormone analogs with subsequent estradiol *** was suppressed by orchidectomy in male mice at 5 weeks of *** 3 weeks post-surgery,male-to-female mice were treated with a high dose of estradiol(~0.85 mg)by intraperitoneal silastic implantation for 12 *** included intact and orchidectomized males at 3 weeks post-surgery,vehicle-treated intact males,intact females and orchidectomized males at 12 weeks *** to male controls,orchidectomized males exhibited decreased peak bone mass accrual and a decreased maximal force the bone could withstand prior to *** treatment in orchidectomized male-to-female mice compared to mice in all control groups was associated with an increased cortical thickness in the mid-diaphysis,while the periosteal circumference increased to a level that was intermediate between intact male and female controls,resulting in increased maximal force and *** trabecular bone,estradiol treatment increased newly formed trabeculae arising from the growth plate as well as mineralizing surface/bone surface and bone formation rate,consistent with the anabolic action of estradiol on osteoblast *** data support the concept that skeletal integrity can be preserved and that long-term fractures may be prevented in trans girls treated with GnRHa and a sufficiently high dose of *** study is needed to identify an optimal dose of estradiol that protects the bone without adverse side effects.

关键词： treatment treatment strength

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evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant *** infection with osseointegration in murine models of implant-associated osteomyelitis

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Bone Research 2023年第4期11卷 751-763页

作者： Youliang Ren Jason Weeks Thomas Xue Joshua Rainbolt Karen L.de Mesy Bentley Ye Shu Yuting Liu elysia Masters Philip Cherian cha.les e.mckenna.jeffrey neighbors Frank H.ebetino edward M.Schwarz Shuting Sun chao Xie Center for Musculoskeletal Research University of Rochester Medical CenterRochesterNY 14642USA Department of Orthopaedics University of Rochester Medical CenterRochesterNY 14642USA Department of Pathology and Center for Advanced Research Technologies University of Rochester Medical CenterRochesterNY 14642USA BioVinc LLCPasadenaCA 91107USA Department of Chemistry University of Southern CaliforniaLos AngelesCA 90089USA Department of Pharmacology Pennsylvania State UniversityHersheyPA 17033USA Department of Chemistry University of RochesterRoche

eradication of MRSA osteomyelitis requires elimination of distinct *** overcome this,we developed bisphosphonateconjugated sitafloxacin(BCS,BV600072)and hydroxybisphosphonate-conjugate sitafloxacin(HBCS,BV63072),which achieve“target-and-release”drug delivery proximal to the bone infection and have prophylactic efficacy against MRSA static biofilm in vitro and in *** we evaluated their therapeutic efficacy in a murine 1-stage exchange femoral plate model with bioluminescent MRSA(USA300LAC::lux).Osteomyelitis was confirmed by CFU on the explants and longitudinal bioluminescent imaging(BLI)after debridement and implant exchange surgery on day 7,and mice were randomized into seven groups:1)Baseline(harvested at day7,no treatment);2)HPBP(bisphosphonate control for BCS)+vancomycin;3)HPHBP(hydroxybisphosphonate control for HBCS)+vancomycin;4)vancomycin;5)sitafloxacin;6)BCS+vancomycin;and 7)HBCS+*** confirmed infection persisted in all groups except for mice treated with BCS or HBCS+*** revealed catastrophic femur fractures in all groups except mice treated with BCS or HBCS+vancomycin,which also displayed decreases in peri-implant bone loss,osteoclast numbers,and *** confirm this,we assessed the efficacy of vancomycin,sitafloxacin,and HBCS monotherapy in a transtibial implant *** results showed complete lack of vancomycin efficacy while all mice treated with HBCS had evidence of infection control,and some had evidence of osseous integrated septic implants,suggestive of biofilm *** together these studies demonstrate that HBCS adjuvant with standard of care debridement and vancomycin therapy has the potential to eradicate MRSA osteomyelitis.

关键词： implant infection overcome

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expression of androgen receptor target genes in skeletal muscle

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Asian Journal of Andrology 2014年第5期16卷 675-683,I0006页

作者： Kesha Rana Nicole KL Lee jeffrey D Zajac Helen e MacLean Department of Medicine Austin Health University of Melbourne Heidelberg Victoria Australia

We aimed to determine the mechanisms of the anabolic actions of androgens in skeletal muscle by investigating potential androgen receptor （AR）-regulated genes in in vitro and in vivo models. The expression of the myogenic regulatory factor myogenin was significantly decreased in skeletal muscle from testosterone-treated orchidectomized male mice compared to control orchidectomized males, and was increased in muscle from male AR knockout mice that lacked DNA binding activity （AR△ZF2） versus wildtype mice, demonstrating that myogenin is repressed by the androgen/AR pathway. The ubiquitin ligase Fbxo32 was repressed by 12 h dihydrotestosterone treatment in human skeletal muscle cell myoblasts, and c-Myc expression was decreased in testosterone-treated orchidectomized male muscle compared to control orchidectomized male muscle, and increased in AR△ZF2 muscle. The expression of a group of genes that regulate the transition from myoblast proliferation to differentiation, Tceal7, p57Kip2, Ief2 and calcineurin Aa, was increased in AR△ZF2 muscle, and the expression of all but p57kip2 was also decreased in testosterone-treated orchidectomized male muscle compared to control orchidectomized male muscle. We conclude that in males, androgens act via the AR in part to promote peak muscle mass by maintaining myoblasts in the proliferative state and delaying the transition to differentiation during muscle growth and development, and by suppressing ubiquitin ligase-mediated atrophy pathways to preserve muscle mass in adult muscle.

关键词： androgen receptor anabolic atrophy gene expression skeletal muscle

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Today’s protected areas:supporting a more sustainable future for humanity

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Integrative Zoology 2020年第6期15卷 603-616页

作者： jeffrey A.MCNeeLY Society for Conservation Biology Asia Section Cha-AmPetchburiThailand

Nature provides significant benefits to people,especially those living in and around protected *** services from protected areas include producing wild food,supporting biodiversity and water cycles,regulating climate,and providing cultural services like better health,tourism,and legacy for future *** economic terms,the flows of ecosystem services provided by protected areas are worth hundreds of billions of dollars each year,well justifying the costs of managing these sites,but protected areas are suffering from environmental problems such as impacts from human population growth,rural poverty,growing demands for natural resources,land use change that degrades ecosystem productivity,invasive non-native species that harm natural ecosystems,and climate change that is affecting all *** these linked challenges will require mobilizing all parts of the economy,including the protected area *** example,protected areas can take a leadership role in rural development,expand the conservation estate to half of the planet through connectivity and improved management of more of the non-agricultural land,enhance the prominent role of protected areas in contributing to climate change mitigation and adaptation,encourage productive research on applying modern technology to protected areas management,seek broader private sector participation in conserving biodiversity and ecosystem services,and include protected areas as relevant parties in relevant trade and other international *** protected area managers embrace this broader role,they will find enthusiastic public support for this contribution to a sustainable human society.

关键词： Aichi target climate change economic benefit ecosystem service landscape conservation protected area

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Injectable bioorthogonal hydrogel (BIOGeL) accelerates tissue regeneration in degenerated intervertebral discs

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Bioactive Materials 2023年第5期23卷 551-562页

作者： jeffrey Luo Anjani Darai Thanapat Pongkulapa Brian Conley Letao Yang Inbo Han Ki-Bum Lee Department of Chemistry and Chemical Biology RutgersThe State University of New JerseyPiscatawayNJ08854USA Department of Neurosurgery CHA University School of MedicineCHA Bundang Medical Center59 Yaptap-roBundang-guSeongnam-siGyeonggi-do13496Republic of Korea

Intervertebral disc(IVD)degeneration is a leading cause of back pain and precursor to more severe conditions,including disc herniation and spinal *** traditional growth factor therapies(e.g.,TGFβ)are effective at transiently reversing degenerated disc by stimulation of matrix synthesis,it is increasingly accepted that bioscaffolds are required for sustained,complete IVD *** scaffolds(e.g.,metal/polymer composites,non-mammalian biopolymers)can be improved in one or more IVD regeneration demands:biodegradability,noninvasive injection,recapitulated healthy IVD biomechanics,predictable crosslinking,and matrix repair *** meet these demands,tetrazine-norbornene bioorthogonal ligation was combined with gelatin to create an injectable bioorthogonal hydrogel(BIOGeL).The liquid hydrogel precursors remain free-flowing across a wide range of temperatures and crosslink into a robust hydrogel after 5-10 min,allowing a human operator to easily inject the therapeutic constructs into degenerated ***,BIOGeL encapsulation of TGFβpotentiated histological repair(e.g.,tissue architecture and matrix synthesis)and functional recovery(e.g.,high water retention by promoting the matrix synthesis and reduced pain)in an in vivo rat IVD degeneration/nucleotomy *** BIOGeL procedure readily integrates into existing nucleotomy procedures,indicating that clinical adoption should proceed with minimal *** bioorthogonal crosslinking is essentially non-reactive towards biomolecules,our developed material platform can be extended to other payloads and degenerative injuries.

关键词： Bioorthogonal chemistry Growth factor Injectable hydrogel Intervertebral disc degeneration Tissue engineering

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美国麻醉患者安全发展史是否对中国麻醉有借鉴作用？

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中华麻醉学杂志 2017年第8期37卷 897-901页

作者： jeffrey B. Cooper 麻省总医院麻醉-危重症-疼痛科美国波士顿02129

麻醉学主要关注患者安全问题，无论在美国还是中国，麻醉医生都将“无一例患者受到麻醉伤害”作为奋力追求的终极目标。本文简要介绍了美国患者麻醉安全发展史及经验和思路，通过抛砖引玉，引发中国麻醉医生进一步思考和关注麻醉患者安... 详细信息

麻醉学主要关注患者安全问题，无论在美国还是中国，麻醉医生都将“无一例患者受到麻醉伤害”作为奋力追求的终极目标。本文简要介绍了美国患者麻醉安全发展史及经验和思路，通过抛砖引玉，引发中国麻醉医生进一步思考和关注麻醉患者安全问题，从而有益于患者围术期转归和麻醉学科发展。本文主要围绕5个方面展开述评：阐述美国麻醉学界如何深刻认识患者安全的重要性；介绍有利于麻醉患者安全的措施；介绍近期美国及其他地区有关麻醉患者安全的提议；列举加强围术期护理文化理念的其他措施；特别就每位麻醉医生如何直接提高患者安全给出了一些建议。

关键词：麻醉学安全管理

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Gender and tachycardia： independent modulation of platelet reactivity in patients with atrial fibrillation

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Journal of Geriatric Cardiology 2016年第3期13卷 202-208页

作者： Nathan eK Procter Jocasta Ball Doan TM Ngo jeffrey S Isenberg elaine M Hylek Yuliy Y Chirkov Simon Stewart John D Horowitz Basil Hetzel Institute for Translational Research Queen Elizabeth Hospital University of Adelaide Adelaide Australia National Health and Medical Research Council(HMRC) Centre of Research Excellence to Reduce Inequality in Heart Disease Mary MacKillop Institutefor Health Research Australian Catholic University Melbourne Australia Heart Lung Blood and Vascular Medicine Institute Division of Pulmonary Allergy and Critical Care Medicine Department University of Pittsburgh Pitts-burgh Pennsylvania USA Department of Medicine Boston University School of Medicine Boston Massachusetts USA

Background Female patients with atrial fibrillation （AF） experience increased risk of thromboembolism compared to males, an observation that is reflected by its inclusion in the cha2DS2VASc score. New onset AF （often associated with tachycardia） also confers upon patients increased thromboembolic risk. The mechanisms underlying this risk are uncertain, but new onset AF is associated with profound impairment of platelet nitric oxide （NO） signalling. Given that cardiovascular responses to catecholamines are gender-dependent, and that the presence of tachycardia in new onset AF may represent a response to catecholaminergic stimulation, we explored the potential impact of gender and tachycardia on platelet aggregation and NO signalling. Methods Interactions were sought in 87 AF patients between the extent of adenosine diphosphate （ADP）-induced platelet aggregation, the anti-aggregatory effects of the NO donor, sodium nitroprusside, gender, and admission heart rate. The potential impact of platelet expression of thioredoxin-interacting protein （Txnip） was also evaluated. Results Analysis ofcovariance confLrmed the presence of physiological antagonism between platelet ADP and NO responses [F （1, 74） = 12.212, P 〈 0.01 ], while female sex correlated with impaired NO responses independent of platelet aggregability [F （2, 74） = 8.313, P 〈 0.01]. Admission heart rate correlated directly with platelet aggregation （r = 0.235, P 〈 0.05）, and inversely with NO response （r = -0.331, P 〈 0.01）. Txnip expression varied neither with gender nor with heart rate. Conclusions These results indicate, that gender and heart rate are independent determinants of platelet fimction. Prospective studies of the putative benefit of reversal of tachycardia on restoration of normal platelet function are therefore a priority.

关键词： Atrial fibrillation Gender Heart rate Nitric oxide Platelet aggregation

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登陆病综合征诊断标准:Bárány协会前庭疾病分类委员会共识

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神经损伤与功能重建 2021年第12期16卷 683-687页

作者：宋宁(译) 李响(译) 张梦露(译) 隋汝波(审校) 杨旭(审校) Yoon-Hee cha Robert W.Baloh Catherine Cho Måns Magnusson Jae-Jin Song Michael Strupp Floris Wuyts jeffrey P.Staab 航天中心医院(北京大学航天临床医学院)神经内科锦州医科大学附属第一医院神经内科美国明尼苏达大学神经病学系美国加州大学洛杉矶分校神经病学系美国纽约大学格罗斯曼医学院神经内科和耳鼻喉-头颈外科瑞典隆德大学耳鼻喉科韩国首尔大学盆唐医院耳鼻喉-头颈外科德国慕尼黑大学神经内科德国眩晕与平衡疾病中心比利时安特卫普平衡研究与航空航天实验室(LeIA) 美国明尼苏达州罗彻斯特市梅奥诊所精神心理学系和耳鼻喉-头颈外科

我们提出了登陆病综合征(mal de débarquement syndrome,MdDS)的诊断标准,并将其纳入国际前庭疾病分类。这些诊断标准包括:(1)非旋转性眩晕,其特征是持续性或1天中大部分时间都存在振荡感("摇摆"、"摆动"或"晃动");(2)被动运动结束后4... 详细信息

我们提出了登陆病综合征(mal de débarquement syndrome,MdDS)的诊断标准,并将其纳入国际前庭疾病分类。这些诊断标准包括:(1)非旋转性眩晕,其特征是持续性或1天中大部分时间都存在振荡感("摇摆"、"摆动"或"晃动");(2)被动运动结束后48小时内发作;(3)症状在被动运动时(例如驾驶)可暂时减轻;(4)症状持续>48小时。病程不足1月且症状仍持续者,定义为"进展型";如果症状在1个月或1个月内得以缓解,观察期至少延长到缓解点,则为"短暂型";如果症状持续超过1个月不缓解,则为"持续型"。事实上,MdDS患者亦可伴发空间定向障碍、视觉运动不耐受、疲劳以及头痛或焦虑加剧的症状。本文也回顾总结了MdDS与前庭性偏头痛、运动病及持续性姿势-感知性头晕(persistent postural perceptual dizziness,PPPD)的临床鉴别要点。此外,非运动触发、可通过运动缓解的振荡性眩晕在其他前庭疾病、内科疾病、精神紧张加剧或代谢紊乱之后出现,由于其具有MdDS和PPPD这2种疾病的特点,在非运动诱发的表现描述方面多样,因此,进一步研究其现象及生物学与MdDS、PPPD及其他前庭疾病的相关性是非常有必要的。

关键词：登陆病综合征 MdDS 被动运动非运动触发的持续性振荡性眩晕持续性姿势-感知性头晕

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运动不耐受诊断标准:Bárány协会分类委员会共识文件

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神经损伤与功能重建 2022年第12期17卷 687-695页

作者：宋宁(译) 邢玥(译) 李康之(译) 金占国(审校) 杨旭(审校) Yoon-Hee cha John F.Golding Behrang Keshavarz Joseph Furman Ji-Soo Kim Jose A.Lopez-escamez Måns Magnusson Bill J.Yates Ben D.Lawson jeffrey P.Staab(顾问) Alexandre Bisdorff(顾问) 航天中心医院(北京大学航天临床医学院)神经内科北京大学首钢医院神经内科中国人民解放军空军特色医学中心眩晕中心明尼苏达大学神经病学系美国明尼苏达州明尼阿波里斯市威斯敏斯特大学社会科学学院心理学英国伦敦多伦多康复研究所-多伦多综合医院加拿大安大略省多伦多市瑞尔森大学心理学系加拿大安大略省多伦多市匹兹堡大学耳鼻咽喉科美国宾夕法尼亚州匹兹堡首尔大学神经病学系韩国首尔格拉纳达大学耳鼻咽喉科外科西班牙格拉纳达辉瑞公司/格拉纳达大学/安达卢西亚(GeNyO)基因组与肿瘤研究中心基因组医学系耳科和神经科小组CTS495 PTS西班牙格拉纳达涅维斯圣女医院生物卫生研究所耳鼻喉科西班牙格拉纳达隆德大学耳鼻喉科瑞典隆德匹兹堡大学耳鼻喉科美国宾夕法尼亚州匹兹堡新伦敦海军潜艇基地海军潜艇医学研究实验室美国康涅狄格州格罗顿梅奥诊所精神心理学系美国明尼苏达州罗彻斯特 emileMayrisch医疗中心神经内科卢森堡阿尔泽特河畔埃施

我们提出了运动不耐受(motion sickness,MS),视觉诱发运动不耐受(visually induced motion sickness,VIMS),运动病(motion sickness disorder,MSD)和视觉诱发运动病(visually induced motion sickness disorder,VIMSD)的诊断标准,这些标准将被纳入国际前庭疾病分类。MS和VIMS是一种正常生理反应,几乎所有人都可能出现,但在某些情况下,个体对这种反应的易感性和严重性过高则被认为是一种疾病。本文提供了对由躯体运动或视觉运动引起的症状和体征的评价标准及个体反应严重程度是否可构成疾病诊断的指南。MS和VIMS的诊断标准包括由于暴露于躯体运动或视觉运动所引发的不良反应,通常导致在以下方面出现严重程度大于最低限度的症状或体征:恶心和/或胃肠道功能紊乱、体温调节功能紊乱、觉醒水平改变、头晕和/或眩晕、头痛和/或眼疲劳。这些症状/体征在暴露于运动状态时出现,随着暴露时间延长而加重,最终随运动结束而消失。当相同或相似的刺激反复诱发MS或VIMS发作,其严重程度在反复暴露后没有明显减轻,且因症状/体征而调整活动状态、避免参与诱发不耐受的运动刺激或负性情绪反应时,即可诊断为MSD和VIMSD。MS/MSD和VIMS/VIMSD可以单独出现,也可同时出现。由躯体运动或视觉运动刺激诱发的症状严重程度个体差异较大,并且同一个体也会因年龄、适应能力及合并疾病的变化而发生改变。本文探讨了评估MS症状的主要方法,易出现MS和VIMS相关情境以及导致易感性增加相关的个体特征。对上述环境和个人因素特征的准确评估及理解,将有助于MSD和VIMSD的诊断优化。

关键词：躯体运动诊断标准胃肠道功能紊乱活动状态运动病眼疲劳疾病诊断 MS/MS

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