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Ca2+ cation-mediated microenvironment for electrochemical hydrodimerization of furfural

Science China Chemistry 2025年

作者： Wei Du Shuangshuang cha Can Lei Mengxin Qu Zhongqiang Deng Ming Gong Xinhe Bao Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University State Key Laboratory of Catalysis National Laboratory for Clean Energy Collaborative Innovation Center of Chemistry for Energy Materials Dalian Institute of Chemical Physics Chinese Academy of Sciences

Furfural is one of the most important biomass-based platform molecules as sustainable precursors for chemicals and fuels. The electrochemical hydrodimerization of furfural can generate hydrofuroin, which is a promising precursor for gasoline or jet ***, steering the selectivity toward hydrodimerization under near-neutral conditions that suppress polymerization and disproportionation of furfural remains challenging. Herein, we discovered that tuning the electrolyte cations could be an effective and alternative strategy for modulating furfural reduction to the traditional electrocatalyst design. Under the optimal Ca2+cations,hydrofuroin yield could be much improved from other cations with hydrofuroin selectivity of 95.5%. The systematic characterization of the ion-centered double layer reflected the suitable sizes and charges of hydrated Ca2+for suppressing the hydrogen evolution reaction from activation of surrounding water molecules as well as encouraging furfural accumulation via non-covalent interaction for directing the electron transfer to furfurals. Ions with smaller or larger sizes can either activate local water molecules or form a crowded ionic interface that casts an adverse effect on furfural enrichment. This work not only presents an effective strategy for facilitating biomass valorization via hydrodimerization but also emphasizes the essential role of the ion-centered microenvironment for steering the electrocatalytic pathways.

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Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural regeneration research 2025年第3期20卷 725-739页

作者： Benjamin r.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

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A theoretical and 1-D numerical investigation on a valve/valveless air-breathing pulse detonation engine

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Chinese Journal of Aeronautics 2021年第1期34卷 68-78页

作者： Hua QIU cha XIONG Jianling LI School of Power and Energy Northwestern Polytechnical UniversityXi'an 710072China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

The important operating characteristics of pulsed Pressure Gain Combustion(PGC)propulsion are the pressure gain of the combustor component and the propulsive performance gain of the engine.A ramjet-type valve/valveless air-breathing pulsed detonation engine with a supersonic internal compression inlet is *** on an ideal thermal cycle,the ideal equivalent pressure ratios(pcb)of the Pulsed Detonation Combustor(PDC)are obtained theoretically which are directly related with the propulsive performance of the *** introducing an orifice loss model into the cycles,the critical pressure drop ratios through the orifice for the PDC achieving pressure gain and the engine achieving thrust gain are *** influencing factors are investigated by the use of a one-dimensional(1-D)numerical simulation *** operating characteristics of the pulse detonation engine are investigated with changes of the valve type,the inlet/outlet area ratio of the PDC,the nozzle area ratio,and flight *** these factors can affect pcbof the PDC,and pcbcan be optimized by changing the geometry of the *** most important influence parameter is the valve *** using an orifice-type aerodynamic valve,simulation results show that the PDC cannot achieve the pressure gain *** a supersonic internal compression inlet is introduced to the engine,whether the Pulse Detonation Engine(PDE)can achieve thrust gain comparable with that of an ideal Brayton cycle engine not only is related to the pressure gain of the combustor,but also needs to optimize the engine structure to reduce the total pressure loss.

关键词： Detonation Pressure gain characteristics Propulsive performance Supersonic internal compression inlet Valve/valveless Thermal cycle

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Updates on esophageal and gastric cancers

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World Journal of Gastroenterology 2006年第20期12卷 3237-3242页

作者： Amy Gallo cha.les cha resident Department of Surgery Yale University School of Medicine333 Cedar St.FMB 121New HavenCT 06520United States Department of Surgery Yale University of School of Medicine 333 Cedar St.FMB 121New HavenCT 06520United States

Esophageal and gastric cancers are both common and deadly. Patients present most often after disease progression and survival is therefore poor. Due to demographic variability and recent changes in disease incidence, much emphasis has been placed on studying risk factors for both esophageal and gastric cancers. However, with increasing understanding of these diseases, low survival rates persist and continued intensive studies are necessary to optimize treatment plans. This review article discusses updates in the evolving epidemiology, clinical presentation, risk factors, and diagnostic and treatment modalities of esophageal and gastric cancers.

关键词： Gastric cancer Esophageal cancer Surgery Treatment

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What determines irrigation efficiency when farmers face extreme weather events? A field survey of the major wheat producing regions in China

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Journal of Integrative Agriculture 2018年第8期17卷 1888-1899页

作者： SONG Chun-xiao les Oxley MA Heng-yun College of Economics and Management Henan Agricultural University Department of Economics and Finance University of Waikato

Water availability is a major constraint on grain production in China, therefore, improving irrigation efficiency is particularly important when agriculture faces extreme weather events. This paper first calculates irrigation efficiency with a translog stochastic frontier production function and then investigates what happens when extreme weather events occur via a Tobit model. The estimated results reveal several important features of irrigation practices: i) irrigation efficiency is lower when extreme weather events occur; ii) large variations in irrigation efficiency occur across irrigation facilities; iii) the farm plots exhibit an extreme distribution across efficiency levels; and iv) water-saving techniques, technology adoption, and the maintenance of farmers’ economic resilience are major determinants of irrigation efficiency. Based on these results we propose the following recommendations: i) farmers should balance crop yield and water use; undertake relevant training programs and adopt water-saving techniques; ii) local governments and researchers should help farmers to find the optimal level of irrigation water use based on their own circumstances and provide better water-saving techniques and training programs rather than simply encouraging farmers to invest in irrigation facilities in the most extreme weather years; and iii) the income level of farm households should be increased so as to improve their resilience to natural disasters.

关键词： irrigation efficiency determinants irrigation facilities water-saving techniques extreme weather events

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Effects of excluding bottom-disturbing mobile fishing gear on abundance and biomass of groundfishes in the Stellwagen Bank National Marine Sanctuary,USA

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Current Zoology 2010年第1期56卷 134-143页

作者： Briana K.BrOWN Elizabeth SOULE les KAUFMAN Biology Department Boston University

The Stellwagen Bank National Marine Sanctuary （southern Gulf of Maine, northwest Atlantic） is partially overlapped by the Western Gulf of Maine Closure Area （WGMCA）. This is a region in which mobile, bottom-disturbing fishing gear has been banned by the New England Fishery Management Council to facilitate the rebuilding of depleted gronndfish populations. We assessed the effects and effectiveness of the WGMCA on groundfish assemblages using habitat-stratified （gravel, sand, mixed benthic habitats） sampling by means of a commercial trawler, inside and outside of the WGMCA. Sampling occurred over three mouth-long sampling periods in 2004-2005, two during the spring seasons and one during the fall season. A total of 18 species were analyzed for protection effects. After controlling for substratum, location and sampling season, eight groundfish species exhibited higher mean proportional abundance inside than outside the WGMCA while two were proportionally more abundant on average outside of the closure. Four species had higher mean proportional biomasses on average inside the closure and three outside. We conclude that the WGMCA may be achieving its goal of rebuilding abundance and biomass for some commercially targeted groundfishes but not all. This study, six to seven years post-closure establishment, reveals fine-scale spatial and taxonomic complexity which will require a very different monitoring protocol than the one currently in place if adaptive management is to be successful in the region [Current Zoology 56 （1）： 134-143, 2010].

关键词： Effects of fishing Groundfish Gulf of Maine Stellwagen Bank National Marine Sanctuary trawl closure

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Conception and Design of Active Balancer for Planar Mechanisms

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Chinese Journal of Mechanical Engineering 2009年第6期22卷 822-832页

作者： ZHANG Ying YAO Yan-An cha Jianzhong School of Mechanical and Electronic Control Engineering Beijing Jiaotong University Beijing 100044 China

The dynamic balancing is an important issue in mechanism design. For the existing balancing methods, both passive and active ones, there is still room for improvement in adaplability and independency. In view of this, a concept of active balancer is developed as a new solution for the dynamic balancing with more flexibility. The proposed balancer is an independent additional device with a control system inside, which consists of a two-degree-of-freedom （DOF） linkage and a controllable motor, and can be attached to a machine expediently with little change to its original structure and motion. One of the two inputs of the two-DOF linkage shares the same shaft with its output, which is connected to the input shaft of a machine to be balanced and driven by the original actuator. The other input is driven by the control motor. By properly selecting the speed trajectories of the control motor and link parameters of the two-DOF linkage, one or more dynamic effects of the mechanisms can be minimized or eliminated adaptively. The design procedure of the active balancer is put forward and a two-step optimization is developed to find out optimal design parameters of the balancer for various design requirements and constraints. Taking a force-balanced crank-rocker mechanism as the reference mechanism, numerical examples are given to illustrate the design procedure. The balancing effects of the proposed balancer are compared with those of the existing adding dyads （DYAD） method. The results show that the introduction of the control system provides the active balancer with better balancing effect and more flexibility than the DYAD method. A considerable reduction in the dynamic effects （input torque, shaking moment and shaking force） can be achieved for different balancing object by designing the structural and control parameters of the balancer, and the deterioration of dynamic performance caused by alterative working conditions can be compensated effectively by redesigning the

关键词： active balancing shaking moment input torque shaking force optimum balancing two-degree-of-freedom linkage

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Assessment of densified fuel quality parameters:A case study for wheat straw pellet

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Journal of Bioresources and Bioproducts 2023年第1期8卷 45-58页

作者： Bidhan Nath Guangnan Chen les Bowtell raid Ahmed Mahmood School of Agriculture and Environmental Science University of Southern QueenslandToowoombaQLD 4350Australia School of Engineering University of Southern QueenslandToowoombaQLD 4350Australia Department of Mechanical Engineering College of EngineeringUniversity of ZakhoZakho 44001Iraq

An investigation was conducted to examine the impact of additive mixing with wheat straw(WS)for pellet *** study manufactured seven types of pellets with different additive combina-tions to evaluate pellet quality characteristics and their relationships.A laboratory-type hammer mill and a pellet mill were used for feedstock preparation and pellet *** investigations showed that the lignin content increased from 7.0%to 13.1%,which was a primary need for ***,the heating value rose from 17.02 to 20.36 MJ/***,the ash content also increased from 7.09%to 16.2%.results showed that dimension(length and diame-ter),durability,and tensile strength increased significantly with additives while the fines content *** fines content had an inverse relationship with durability and *** straw(60%),together with 10%sawdust(SD),10%corn starch(CS),10%bentonite clay(BC),and 10%biochar(BiC),was optimal with good pellet performance(T7).In addition,both the T5 pellets(70%WS,10%SD,10%BiC,and 10%BC)and the T6 pellets(70%WS,10%SD,10%BiC,and 10%CS)provide suitable quality according to EN plus 2015 standard *** ash content of produced pellet was higher than the recommended value,which suggests that further research onto the alternative additive use for ash reduction is needed.

关键词： Biomass Wheat straw Pellet quality Properties relationship Additive/binding material

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Variations in dynamic recrystallization behavior and mechanical properties of AZ31 alloy with extrusion temperature

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Journal of Magnesium and Alloys 2023年第7期11卷 2351-2365页

作者： Jae Won cha Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

This study investigates the effects of extrusion temperature on the dynamic recrystallization(DrX)behavior of a Mg-3Al-1Zn-0.3Mn(AZ31,wt%)alloy during hot extrusion and on the microstructural characteristics and mechanical properties of materials extruded at 350 and 450℃.An increase in the extrusion temperature causes a decrease in the amount of strain energy accumulated in the material during extrusion,because of promoted activation of pyramidalslip and dynamic *** reduced strain energy weakens the DrX behavior during extrusion,which eventually results in a decrease in the area fraction of recrystallized grains of the extruded *** material extruded at 450℃has coarser grains and a stronger basal fiber texture than that extruded at 350℃.As the extrusion temperature increases from 350 to 450℃,the tensile yield strength(TYS)of the extruded material increases from 191.8 to 201.5 MPa,whereas its compressive yield strength(CYS)decreases from 122.5 to 111.0 MPa;consequently,its tension-compression yield stress ratio(CYS/TYS)decreases from 0.64 to *** increase in the TYS is attributed mainly to the stronger texture hardening and strain hardening effects of the extruded material,and the decrease in the CYS is attributed to the reduced twinning stress resulting from grain coarsening and texture *** microstructural and textural evolutions of the materials during extrusion and the deformation and hardening mechanisms of the extruded materials are discussed in detail.

关键词： Mg-Al-Zn alloy Extrusion Dynamic recrystallization Microstructure Yield asymmetry

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Posterior propriety in nonparametric mixed efects model

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Applied Mathematics(A Journal of Chinese Universities) 2013年第3期28卷 369-378页

作者： XU An-cha TANG Yin-cai College of Mathematics and Information Science Wenzhou University School of Finance and Statistics East China Normal University

It is well known that spline smoothing estimator relates to the Bayesian estimate under partially informative normal prior. In this paper, we derive the conditions for the pro- priety of the posterior in the nonparametric mixed effects model under this class of partially informative normal prior for fixed effect with inverse gamma priors on the variance compo- nents and hierarchical priors for covariance matrix of random effect, then we explore the Gibbs sampling procedure.

关键词： nonparametric mixed effect model Bayesian spline smoothing Gibbs sampling.

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