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A cost-effective gain-locked Erbium doped fiber amplifier

作者： Bae,I.A. Oh,h.S. kim,h.Y. choi,S.h. Lee,k.P. Department of Chemistry Bk 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry Bk 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry Bk 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry Bk 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry Graduate School kyungpook National University Daegu 702-701Republic of Korea

＜正＞Polysaccharides are the most abundant optically active polymers on the earth and can be easily modified to carbamate group through the reaction with isocyanate *** carbamate group-modified polysaccharide can be used the CSP for enantioseparation of chiral *** this study,we firstly prepared the CSP based on cellulose with crown ether group by reaction of cellulose and 4-isocyanatebenzo-15-crown-5,which is prepared by reaction of 4-aminobenzo-15-crown-5 and *** obtained CSP with crown ether group was characterized by FT-IR,13C-NMR and element *** order to compare enantioseparation efficiency of the CSP with crown ether group and that of commercial ChIRALCEL OD with phenyl group,cellulose tris（3,5-dimethylphenyl carbamate）was also prepared according to Okamoto *** enantioseparation of chiral compounds including chiral drugs and amino acid is in progress.

关键词： Polysaccharides Enantioseparation Chiral compounds CSP Crown ether Cellulose

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A cost-effective gain-locked Erbium doped fiber amplifier

Epidural electrical stimulation for spinal cord injury

亚太地区通信会议暨光电子通信会议

作者： k.W.Na J.T.choi W.J.Lee S.h.Park W.W.Yoon k.k.Lee Y.I.choi Optical Communication Laboratory LGIC R&D Center 533 hogye-dong Dongan-gu Anyang-shi kyongki-do 431-080 korea Optical Communication Laboratory LGIC R&D Center 533 hogye-dong Dongan-gu Anyang-shi kyongki-do 431-080 korea Optical Communication Laboratory LGIC R&D Center 533 hogye-dong Dongan-gu Anyang-shi kyongki-do 431-080 korea Optical Communication Laboratory LGIC R&D Center 533 hogye-dong Dongan-gu Anyang-shi kyongki-do 431-080 korea Optical Communication Laboratory LGIC R&D Center 533 hogye-dong Dongan-gu Anyang-shi kyongki-do 431-080 korea Optical Communication Laboratory LGIC R&D Center 533 hogye-dong Dongan-gu Anyang-shi kyongki-do 431-080 korea Optical Communication Laboratory LGIC R&D Center 533 hogye-dong Dongan-gu Anyang-shi kyongki-do 431-080 korea

A cost-effective gain controlscheme for erbium-doped fiber amplifiers ispresented. By sinusoidally modulating thepump laser and monitoring its light at the endof active medium, gain control is obtained,resulting in ve...

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Neural Regeneration Research 2021年第12期16卷 2367-2375页

作者： Elliot h.choi Sandra Gattas Nolan J.Brown John D.hong Joshua N.Limbo Alvin Y.Chan Michael Y.Oh Department of Pharmacology School of MedicineCase Western Reserve UniversityClevelandOHUSA Department of Ophthalmology Gavin Herbert Eye InstituteSchool of MedicineUniversity of CaliforniaIrvineCAUSA Department of Neurosurgery University of CaliforniaIrvineCAUSA

A long-standing goal of spinal cord injury research is to develop effective repair strategies,which can restore motor and sensory functions to near-normal *** advances in clinical management of spinal cord injury have significantly improved the prognosis,survival rate and quality of life in patients with spinal cord *** addition,a significant progress in basic science research has unraveled the underlying cellular and molecular events of spinal cord *** efforts enabled the development of pharmacologic agents,biomaterials and stem-cell based *** these efforts,there is still no standard care to regenerate axons or restore function of silent axons in the injured spinal *** challenges led to an increased focus on another therapeutic approach,namely *** multiple animal models of spinal cord injury,epidural electrical stimulation of the spinal cord has demonstrated a recovery of motor *** evidence regarding the efficacy of epidural electrical stimulation has further expanded the potential of epidural electrical stimulation for treating patients with spinal cord ***,most clinical studies were conducted on a very small number of patients with a wide range of spinal cord ***,subsequent studies are essential to evaluate the therapeutic potential of epidural electrical stimulation for spinal cord injury and to optimize stimulation ***,we discuss cellular and molecular events that continue to damage the injured spinal cord and impede neurological recovery following spinal cord *** also discuss and summarize the animal and human studies that evaluated epidural electrical stimulation in spinal cord injury.

关键词： central nervous system chondroitin sulfate proteoglycans epidural electrical stimulation glial scar gliosis neural activity neuromodulation oligodendrocyte spinal cord injury

Effect of Black Sea bream extracts on cytokine production inlipopolysaccharide-induced inflammation

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BIOCELL 2020年第2期44卷 193-199页

作者： EUN NA MYOUNGWON choi INDAL PARk SUNYOUNG LIM Ocean Science and Technology School Korea Maritime&Ocean UniversityBusanKorea Department of Microbiology Kosin University College of MedicineBusanKorea Division of Marine Bioscience Korea Maritime&Ocean UniversityBusanKorea

We investigated the effect of black sea bream extracts on changes in pro-inflammatory and anti-inflammatory cytokines induced by lipopolysaccharide(LPS)in murine *** levels of pro-inflammatory cytokines[interleukin(IL)-6,tumor necrosis factor-α(TNF-α),IL-12/IL-23(p40)and IL-17A]and anti-inflammatory cytokines[IL-4,IL-10 and interferon-γ(IFN-γ)]were *** of murine splenocytes with acetone+methylene chloride(A+M)and methanol(MeOh)extracts significantly decreased LPS-induced IL-6,IL-12/IL-23(p40)and IL-17A productions after 6 h incubation(phe A+M and MeOh extracts significantly increased LPS-induced IL-4 and IFN-γproductions at 48 and 72 h incubation(ph A+M extract resulted in significantly higher IL-10 production in splenocytes after 72 h(pk sea bream extracts were shown to be efficient in falling several pro-inflammatory cytokines while rising anti-inflammatory *** our results suggest that black sea bream extracts selectivity modulate immune events.

关键词： Black Sea bream Cytokines Interleukin-4 Interleukin-6 Interleukin-17A

Identification of Aristolactam Derivatives That Act as Inhibitors of human Immunodeficiency Virus Type 1 Infection and Replication by Targeting Tat-Mediated Viral Transcription

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Virologica Sinica 2021年第2期36卷 254-263页

作者： Young hyun Shin Chul Min Park hong Gi kim Dong-Eun kim Min Suk choi Jeong-ah kim Byeong-Sun choi Cheol-hee Yoon Division of Viral Disease Research Center for Infectious Disease ResearchKorea National Institute of HealthHeungdeok-guCheongju-siShungbuk 28159Republic of Korea Center for Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea

Despite the success of antiretroviral therapy(ART),efforts to develop new classes of antiviral agents have been hampered by the emergence of drug ***-indole-bearing aristolactams are compounds that have been isolated from various plants species and which show several clinically relevant effects,including anti-inflammatory,antiplatelet,and antimycobacterial ***,the effect of these compounds on human immunodeficiency virus type 1(hIV-1)infection has not yet been *** this study,we discovered an aristolactam derivative bearing dibenzo[cd,f]indol-4(5 h)-one that had a potent anti-hIV-1 effect.A structure-activity relationship(SAR)study using nine synthetic derivatives of aristolactam identified the differing effects of residue substitutions on the inhibition of hIV-1 infection and cell *** the compounds tested,1,2,8,9-tetramethoxy-5-(2-(piperidin-1-yl)ethyl)-dibenzo[cd,f]indol-4(5 h)-one(Compound 2)exhibited the most potent activity by inhibiting hIV-1 infection with a half-maximal inhibitory concentration(IC50)of 1.03 lmol/L and a half-maximal cytotoxic concentration(CC50)of 16.91 lmol/L(selectivity index,16.45).The inhibitory effect of the compounds on hIV-1 infection was linked to inhibition of the viral replication ***-of-action studies showed that the aristolactam derivatives did not affect reverse transcription or integration;instead,they specifically inhibited Tat-mediated viral *** together,these findings show that several aristolactam derivatives impaired hIV-1 infection by inhibiting the activity of Tat-mediated viral transcription,and suggest that these derivatives could be antiviral drug candidates.

关键词： human immunodeficiency virus type 1(hIV-1) Aristolactam Antiviral activity hIV-1 transcription

Neo-adjuvant therapy for hepatocellular carcinoma before liver transplantation:Where do we stand?

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World Journal of Gastroenterology 2014年第18期20卷 5308-5319页

作者： Masato Fujiki Federico Aucejo Minsig choi Richard kim Transplant Center Cleveland ClinicClevelandOH 44195United States Department of Gastrointestinal Oncology Wayne State University/Karmonos Cancer Center DetroitMI 48202United States Department of Gastrointestinal Oncology H Lee Moffitt Cancer CenterTampaFL 33612United States

Liver transplantation (LT) for hepatocellular carcinoma (hCC) within Milan criteria is a widely accepted optimal therapy. Neo-adjuvant therapy before transplantation has been used as a bridging therapy to prevent dropout during the waiting period and as a down-staging method for the patient with intermediate hCC to qualify for liver transplantation. Transarterial chemoembolization and radiofrequency ablation are the most commonly used method for locoregional therapy. The data associated with newer modalities including drug-eluting beads, radioembolization with Y90, stereotactic radiation therapy and sorafenib will be discussed as a tool for converting advanced hCC to LT candidates. The concept “ablate and wait” has gained the popularity where mandated observation period after neo-adjuvant therapy allows for tumor biology to become apparent, thus has been recommended after down-staging. The role of neo-adjuvant therapy with conjunction of “ablate and wait” in living donor liver transplantation for intermediate stage hCC is also discussed in the paper.

关键词： Bridging therapy Neo-adjuvant therapy Locoregional therapy Intermediate stage Living donor liver transplantation Ablation Transarterial chemotherapy Transarterial radioembolization External beam radiotherapy

Spectral Properties and Photochromic Characteristics of Spiropyran Dyes

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Chemical Research in Chinese Universities 2006年第4期22卷 505-509页

作者： ShEN kai-hua hAN Jian-guo ZhANG Gang choi Dong-hoon The State key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 P. R. China The key Laboratory of Cellulose and Lignocellulosics Chemistry Guangzhou Institute of Chemistry Chinese Academy of Sciences Guangzhou 510650 P. R. China Polymer and Fiber Material Engineering Kyunghee University Kyong Kido 449-701 Korea

A bis-benzospiropyran（BBSP） and nitro-substituted indoline spirobenzopyrans（SBP） were prepared by following a simple procedure. The reaction mechanism of synthesizing bis-benzospiropyran is discussed. A comparative analysis of the spectral and photochromic properties between SBP and BBSP was carried out with the aid of a PMMA film. The results indicate that chemical structures and UV irradiation played an important role in the spectral and photochromic properties of SBP and BBSP, which would readily affect λmax of the colored forms and the reversibility. The IR spectra and ^1h NMR spectra of these compounds are used to interpret the photochromic phenomena under different UV irradiation and determine the configurations of SBP and BBSP.

关键词： Photochromism Spiropyran UV radiation Protonation

Partial Oxidation of Methane with Sol-Gel Fe/hf/YSZ Catalyst in Dielectric Barrier Discharge: Catalyst Activation by Plasma

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Journal of Rare Earths 2006年第5期24卷 513-518页

作者： Antonius Indarto Jae-Wook choi hwaung Lee hyung keun Song Jelliarko Palgunadi Clean Technology Research Center Korea Institute of Science and Technology KoreaDepartment of Chemical and Biological Engineering Korea University Korea Clean Technology Research Center Korea Institute of Science and Technology Korea hydrogen Energy Research Center Korea Institute of Science and Technology Korea

A 1% Fe-30% hf over yttria-stabilized zirconia catalyst in combination with novel plasma-assisted activation techniques for a direct partial oxidation of methane to methanol was tested using dielectric barrier discharge plasma at ambient temperature and atmospheric pressure. however, instead of methanol, the reaction products were dominated by hE, CO, CO2, C2, and h2O. A catalytically activated plasma process increased the production of methanol compared with a noncatalytic plasma process. The maximum selectivity of methanol production was achieved using a catalyst that was treated at higher applied power.

关键词： methane oxidation dielectric barrier discharge catalyst plasma activation rare earths

Synergistic Effect of Core/Shell‑Structured Composite Fibers:Efficient Recovery of Rare‑Earth Elements from Spent NdFeB Permanent Magnets

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Advanced Fiber Materials 2024年第6期6卷 1729-1745页

作者： Youngkyun Jung Yun Lee Su‑Jin Yoon Jae‑Woo choi Center for Water Cycle Research Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Chemical and Biological Engineering Korea UniversitySeoul 02841Republic of Korea Department of Energy and Environment Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea

NdFeB magnets are third-generation permanent magnets that are employed as indispensable components in various ***,rare-earth elements(REEs)such as Dy and Nd must be efficiently recovered from end-of-life magnets to enable resource circulation and reinforce unstable supply *** that end,this paper reports synergistically performing core/shell-structured composite fibers(CSCFs)containing sodium polyacrylate and nanoporous zeolitic imidazolate framework-8(NPZIF-8)nanocrystals as a readily recoverable adsorbent with an exceptional REE-adsorbing *** CSCF core forms an NPZIF-8 nanocrystal shell on the fiber surface as well as draws REEs using its dense sodium carboxylate groups into the NPZIF-8 nanocrystal lattice with high specific surface *** CSCFs exhibit significantly higher maximum adsorption capacities(468.60 and 435.13 mg·g-1)and kinetic rate constants(2.02 and 1.92 min-1)for the Nd3+and Dy3+REEs than those of previously reported REE ***,the simple application of the CSCFs to an adsorption reactor considerably mitigates the adsorbent-shape-induced pressure drop,thereby directly influencing the energy efficiency of the ***,the high REE-recovery ability,tractability,and recyclability of the CSCFs offers a pragmatic pathway to achieving cost-effective REE ***,this study provides new insights into designing synergistically performing core/shell architectures for feasible REE recovery.

关键词： Core/shell structures Fibrous adsorbents Synergistic adsorption Metal resource recovery Pressure drop Rare-earth elements