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Risk assessment of corroded casing based on analytic hierarchy process and fuzzy comprehensive evaluation

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Petroleum Science 2021年第2期18卷 591-602页

作者： Sheng-Shan chen Han-Xiang Wang Hao Jiang Ya-Nan Liu yan-xin Liu Xiao-Xiao Lv College of Mechanical and Electronic Engineering China University of Petroleum(East China)Qingdao266580China

Casing corrosion during CO2 injection or storage results in significant economic loss and increased production ***,in this paper,a corroded casing risk assessment model based on analytic hierarchy process and fuzzy comprehensive evaluation is established to identify potential risks in ***,the corrosion rate and residual strength characteristics are analyzed through corrosion tests and numerical simulations,respectively,to determine the risk factors that may lead to an ***,an index system for corroded casing risk evaluation is established based on six important factors:temperature,CO2 partial pressure,flow velocity,corrosion radius,corrosion depth and wellhead ***,the index weights are calculated via the analytic hierarchy ***,the risk level of corroded casing is obtained via the fuzzy comprehensive *** corroded casing risk assessment model has been verified by a case well,which shows that the model is valuable and *** provides an effective decision-making method for the risk evaluation of corroded casing in CO2 injection well,which is conductive to improve the wellbore operation efficiency.

关键词： Corrosion rate Residual strength Analytic hierarchy process Fuzzy comprehensive evaluation

半胱氨酸蛋白酶CfAtg4在油茶果生刺盘孢中的功能分析

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林业科学 2024年第7期60卷 65-72页

作者：郭树峰郭源陈妍李河张盛培经济林培育与保护省部共建教育部重点实验室中南林业科技大学长沙410004

[目的]揭示半胱氨酸蛋白酶CfAtg4在油茶果生刺盘孢中的生物学功能,为油茶炭疽病新型防控药剂的开发提供候选靶标位点。[方法]通过Overlap PCR构建CfATG4基因敲除片段,利用同源重组原理和PEG介导的原生质体转化法获得敲除突变体和回补菌... 详细信息

[目的]揭示半胱氨酸蛋白酶CfAtg4在油茶果生刺盘孢中的生物学功能,为油茶炭疽病新型防控药剂的开发提供候选靶标位点。[方法]通过Overlap PCR构建CfATG4基因敲除片段,利用同源重组原理和PEG介导的原生质体转化法获得敲除突变体和回补菌株;测定野生型、突变体、回补菌株对自噬诱导剂雷帕霉素的敏感性,通过倒置荧光显微镜观察饥饿诱导前后自噬小体数量评价自噬发生程度,采用蛋白免疫印迹试验验证显微观察结果;测定野生型、突变体、回补菌株的生长速率、分生孢子产量、致病力、孢子萌发、附着胞形成以及对外界胁迫敏感性。[结果]1)果生刺盘孢CfATG4基因敲除突变体ΔCfatg4对雷帕霉素更敏感,自噬小体数量显著少于野生型,ΔCfatg4突变体饥饿诱导前后均不能降解自噬标记蛋白GFP-CfAtg8,自噬作用丧失。2)通过生物学表型分析发现,突变体ΔCfatg4在不同营养条件培养基上生长速率减缓,气生菌丝减少;ΔCfatg4突变体产孢量显著减少,在油茶叶片上致病性丧失,且无法穿透玻璃纸。3)突变体ΔCfatg4孢子萌发率和附着胞形成率显著降低。4)突变体ΔCfatg4对盐胁迫(NaCl、KCl)更耐受,对细胞壁完整性胁迫剂SDS更敏感,对CR更耐受;突变体ΔCfatg4在氧化环境(H_(2)O_(2))下更敏感,在还原环境(DTT)下更耐受。[结论]半胱氨酸蛋白酶CfAtg4介导的自噬参与调控油茶果生刺盘孢生长发育、产孢、附着胞形成、外界胁迫应答和致病过程。

关键词：油茶果生刺盘孢半胱氨酸蛋白酶Atg4 致病力

维得利珠单克隆抗体治疗中重度溃疡性结肠炎的长期疗效及安全性的单中心回顾性观察研究

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中华炎性肠病杂志(中英文) 2024年第4期8卷 274-277页

作者：史海涛沙素梅李嫱范清王燕刘欣西安交通大学第二附属医院消化内科西安

目的评估维得利珠单克隆抗体(VDZ)治疗中重度溃疡性结肠炎(UC)患者的长期疗效及安全性。方法回顾性收集2021年2月至2023年4月于西安交通大学第二附属医院消化内科就诊并使用VDZ治疗超过52周的中重度活动期UC患者的临床资料。观察指标为... 详细信息

目的评估维得利珠单克隆抗体(VDZ)治疗中重度溃疡性结肠炎(UC)患者的长期疗效及安全性。方法回顾性收集2021年2月至2023年4月于西安交通大学第二附属医院消化内科就诊并使用VDZ治疗超过52周的中重度活动期UC患者的临床资料。观察指标为治疗52周后的临床应答率、临床缓解率、内镜黏膜愈合率和不良反应事件。结果纳入中重度UC患者21例, 其中中度17例, 重度4例, 男性17例, 女性4例, 年龄为(44.2±14.3)岁, 病程为60(36, 103)个月。治疗52周时的临床应答率为85.7%(18/21), 临床缓解率为76.2%(16/21), 内镜黏膜愈合率为71.4%(15/21)。21例患者中, 2例(9.5%)出现转氨酶增高, 5例(23.8%)出现艰难梭菌感染, 1例(4.8%)出现肠道EB病毒感染, 无其他不良反应。结论 VDZ对中重度活动期UC患者具有较好的长期疗效, 且安全性好。

关键词：溃疡性结肠炎维得利珠单克隆抗体长期疗效安全性

Relaxing effect on radial arterial spasm in coronary artery bypass graft： A comparison among nitroglycenn, verapamil and paraverine

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中国组织工程研究与临床康复 2007年第34期11卷 6888-6892页

作者： Zhu yan Wang Xiao-chen Li xin＇min Depmtment of Science Researchand Training GeneratHospital of ShenyangMilitary AreaCommand of ChinesepLA Shenyang110016 LiaoningProvince China Department ofScience Researchand Training GeneratHospital of ShenyangMilitary AreaCommand of ChinesepLA Shenyang110016 LiaoningProvince China Department ofCardiosurgery FirstClinical College ChinaMedical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND; As the bridge vessel, radial artery is easy to occur spasm and injury of endometrium, and the abnormal proliferation of endometrium, re-vasospasm, etc. appear at early period postoperatively, which can affect the operative ***: To compare the effects of nitroglycenn (NTG), verapamil (VP), paraverine (PA), and the mixture of NTG and VP on relaxing spasm of radial artery in human ***: A randomized controlled ***: Department of Cardiosurgery, General Hospital of Shenyang Military Area Command of Chinese ***: Thirty patients who underwent coronary artery bypass graft (CABG) with autologous radial artery, were selected from the Department of Cardiosurgery, General Hospital of Shenyang Military Area Command of Chinese PLA from September to November in 2006, including 18 males and 12 females, 48-74 years of age. Informed consents were obtained from all the patients or their relatives ***:① The samples of human radial artery in CABG were collected, and totally 95 vascular rings were used in this study. The rings were divided into five groups: NTG group, VP group, PA group, VP+NTG group and control *** two parts of the experiment, vasospasm relaxation test and vasospasm prevention test. The vascular rings in the control group were only immersed in the Krebs- Ringer solution without any drug. ② Drugs: NTG was purchased from Solo Pak Laboratories (Franklin Park, IL), PA from Eli Lilly & Co., (Indianapolis, IN), VP and others from Sigma (***, MO). ③ Thirty vascular rings were used in the vasospasm relaxation test, and the method of bath chamber was applied. Deoxyepinephrine (terminal concentration of 1 ×10~(-3) mol/L) was added to stimulate the contraction and spasm of the vascular rings, then four vasodilatators were added, the concentrations of VP and NTG were 30 μmol/L, and that of PA was 0.1%. Relaxation rate=(resting tension after stimulation-initial resting tension)/initial resting

关键词：动脉痉挛硝酸甘油维拉帕米罂栗碱作用比较缓解症状动脉旁路移植手术

Theoretical study of ullage washing with mixed inert gas in a non-equilibrium state

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Chinese Journal of Aeronautics 2020年第12期33卷 3167-3175页

作者： Shiyu FENG Xiaotian PENG Lei SHAO yan yan chen chen Weihua LIU Key Laboratory of Aircraft Environment Control and Life Support of MIIT College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China College of Aeronautics Chongqing Jiaotong UniversityChongqing 400074China College of Mechanical and Electrical Engineering Xi'an Polytechnic UniversityXi'an 710000China

The Mixed Inert Gas(MIG)produced by the novel Green On Board Inerting Gas Generation System(GOBIGGS)mainly consists of carbon dioxide,nitrogen and *** of the large solubility of carbon dioxide in jet fuel compared with nitrogen,the no gas release or equilibrium model could not be employed any *** this paper,first,a mathematical model of the ullage washing was set up to predict the variation of the oxygen concentration on ullage and in the fuel,and the gas evolution and dissolution rate were calculated by Fick's second ***,an experimental apparatus was constructed to verify the accuracy of the ***,the numerical comparisons of ullage washing using Nitrogen Enriched Air(NEA)and MIG are presented under various flow rates and fuel loads,and the result reveals that the variation of the oxygen concentration on ullage is nearly identical whatever the inert gas is NEA or ***,the variation of the oxygen concentration in the fuel is disparate,and the oxygen concentration decreases rapidly if the inert gas is MIG,especially when the fuel load is low or the flow rate of the inert gas is ***,MIG could suppress the rising trend of the oxygen concentration on ullage when the aircraft ascends if the fuel tank is fully washed into an equilibrium state on ground.

关键词： Inert gas Mixed inert gas Nitrogen enriched air Non-equilibrium Washing

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高原含氧柴油燃料研究现状

现代化工 2024年第2期44卷 62-66页

作者：杨修政夏鑫蔺建民杨鹤赵杰李妍中石化石油化工科学研究院有限公司北京100083

高原的低压条件造成柴油燃烧性能下降,导致柴油机出现动力性不足等问题。在柴油中加入醇类燃料、醚类燃料、酯类燃料等含氧燃料,可以在不改变柴油机结构的情况下改善柴油机在高原环境下的使用性能。对上述含氧柴油燃料在柴油发动机中的... 详细信息

高原的低压条件造成柴油燃烧性能下降,导致柴油机出现动力性不足等问题。在柴油中加入醇类燃料、醚类燃料、酯类燃料等含氧燃料,可以在不改变柴油机结构的情况下改善柴油机在高原环境下的使用性能。对上述含氧柴油燃料在柴油发动机中的燃烧特性、动力性和经济性等方面进行对比,结果表明,在高原环境下,含醇柴油会导致发动机滞燃期延长,且脂肪醇的碳数越少影响越严重;含醚柴油缩短滞燃期,但热值较低;含酯柴油凝点较高,难以在高原的低温环境条件下应用;复合型含氧柴油燃料或许能够综合含氧燃料的优点。新型高原含氧柴油燃料应关注聚醚、短链酯以及少量长链醇复合组分。

关键词：高原环境柴油机含氧柴油燃烧性能动力性经济性

养血安胎方调节自噬治疗复发性自然流产小鼠的机制研究

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中国药物警戒 2024年第4期21卷 378-385页

作者：姚伟洁闫仕祺袁偲偲贡磊磊冯欣首都医科大学附属北京妇产医院北京妇幼保健院药事部北京100026 首都医科大学中医药学院中医络病研究北京市重点实验室北京100069

目的探讨养血安胎方调节自噬影响胎盘血管生成进而治疗复发性自然流产(RSA)的机制。方法对妊娠小鼠分别使用雷帕霉素、3-甲基腺嘌呤及养血安胎方进行干预,收集小鼠胎盘,苏木素伊红(HE)染色、马松(Masson)染色观察妊娠小鼠的病理改变,免... 详细信息

目的探讨养血安胎方调节自噬影响胎盘血管生成进而治疗复发性自然流产(RSA)的机制。方法对妊娠小鼠分别使用雷帕霉素、3-甲基腺嘌呤及养血安胎方进行干预,收集小鼠胎盘,苏木素伊红(HE)染色、马松(Masson)染色观察妊娠小鼠的病理改变,免疫组化法测定增殖细胞核抗原(PCNA)、Fibrinogen及CD34蛋白的表达,Western blot法测定血管内皮生长因子(VEGF)、血管内皮细胞生长因子受体2(p-VEGFR2)、p62、Beclin1、LC3Ⅰ和LC3Ⅱ蛋白的表达,透射电镜观察胎盘的超微结构。结果与正常妊娠组比较,雷帕霉素(Rapa)组小鼠取材时体重明显减轻,胚胎吸收率明显增加,HE染色、Masson染色及PCNA与Fibrinogen蛋白表达显示小鼠胎盘发育变差;透射电镜结果与p62、Beclin1和LC3Ⅱ/LC3Ⅰ蛋白表达显示小鼠胎盘自噬水平明显增加;CD34、VEGFA和p-VEGFR2蛋白表达显示胎盘血管生成异常;与Rapa组比较,Rapa+养血安胎组小鼠取材时体重明显增加,胚胎吸收率明显降低,HE染色、Masson染色及PCNA与Fibrinogen蛋白表达显示小鼠胎盘发育得到明显改善,透射电镜结果与p62、Beclin1和LC3Ⅱ/LC3Ⅰ蛋白表达显示小鼠胎盘自噬水平明显降低,CD34、VEGFA和p-VEGFR2蛋白表达显示胎盘血管生成增加。结论养血安胎方通过抑制自噬体和溶酶体的融合,从而抑制自噬,改善妊娠小鼠的胎盘发育状况,促进胎盘的血管生成,从而降低了流产率。

关键词：复发性自然流产自噬血管生成养血安胎方中药复方雷帕霉素 3-甲基腺嘌呤蛋白表达

混合型电子音乐信号重叠时频自动化分离系统设计

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电子设计工程 2024年第15期32卷 180-184页

作者：闫雪姣陈娟中北大学艺术学院山西太原030051

针对混合型电子音乐信号重叠时频自动化分离中存在的中心频率求取不准确、分离性能欠佳的问题,文中设计了一种新型分离系统。通过硬件部分的音乐信号采样传感器和混频器,结合音乐信号的字典表示,引入双曲正切函数降维滤波信号,并精确计... 详细信息

针对混合型电子音乐信号重叠时频自动化分离中存在的中心频率求取不准确、分离性能欠佳的问题,文中设计了一种新型分离系统。通过硬件部分的音乐信号采样传感器和混频器,结合音乐信号的字典表示,引入双曲正切函数降维滤波信号,并精确计算信号中心频率。基于特征信号库,系统计算时频幅度调制系数和状态参数,有效提取源信号中的有用信息,实现自动化分离。系统性能测试显示,所设计的系统可以有效分离混合信号,得到的PESQ分数较高,分离性能更好,为电子音乐信号处理提供了有效解决方案。

关键词：混合型电子音乐信号重叠时频自动化分离系统设计

Asteroseismology of the DBV star CBS 114

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Research in Astronomy and Astrophysics 2016年第8期16卷 17-24页

作者： yan-Hui chen Institute of Astrophysics Chuxiong Normal University School of Physics and Electronical Science Chuxiong Normal University Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences

Asteroseismology is a unique and powerful tool to investigate the internal structure of stars. CBS 114 is the sixth known pulsating DBV star. It was observed by Handler, Metcalfe, ＆ Wood at the South African Astronomical Observatory over three weeks in 2001. Then, it was observed by Metcalfe et al. for seven nights （2004 Feb. 19-25） on the 1.8 m telescope at the Bohyunsan Optical Astronomy Observatory and seven nights （2004 Feb. 21-27） on the 2.1 m telescope at the McDonald Observatory. Totally two triplets, four doublets, and five singlets were identified. The frequency splitting values are very different, from 5.2 *** to 11.9 ~tHz, which may reflect differential rotations. We evolve grids of white dwarf models by MESA. Cores, added with He/C envelopes, of those white dwarf models are inserted into WDEC to evolve grids of DBV star models. With those DBV star models, we calculate eigenperiods. Those calculated periods are used to fit observed periods. A best-fitting model is selected. The parameters are T^ff ----- 25 000 K, M, = 0.740 MG and log（MHe/M,） = -4.5. With the relatively large stellar mass, the effective temperature is close to the previous spectroscopic result. In addition, kinetic energy distributions are calculated for the best-fitting model. We find that the observed modes with large frequency splitting values are fitted by the calculated modes with a large amount of kinetic energy distributed in the C/O core. After preliminary analysis, we suggest that the C/O core may rotate at least two times faster than the helium layer for CBS 114.

关键词： stars: oscillations (including pulsations) -- stars: individual (CBS 114) -- white dwarfs