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应用腮腺炎、念珠菌及毛癣菌的皮试抗原进行疣的皮损内免疫治疗:一项单盲随机对照试验

世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 55-55页

作者： Hor. T.D. Johnson S.M. Helm r.M. roberson P.K. 潘敏 Dr. Depar.ment of Der.atology University of Arkansas for Medical Sciences Mail Box 576 4301 W Markham Little Rock AR 72205 United States

Backgr.und: War.s occur.commonly in humans. Destr.ctive modalities ar. gener.lly the fir.t physician- administer.d ther.py. Other.tr.atment options include immunother.py. Intr.lesionalimmunother.pyusingmumps,Candida,or.r.chophyton skin test antigens has pr.ved efficacy in the tr.atment of war.s. Objectives: To deter.ine r.tes of war. r.solution in r.sponse to injection of antigen alone, antigen plus inter.er.n alfa- 2b, inter.er.n alfa- 2b alone, and nor.al saline; and to compar. r.sponse accor.ing to vir.l type, major.histocompatibility complex antigens, and per.pher.l blood mononuclear.cell pr.lifer.tion to autologous human papillomavir.s antigen befor. and after.injection. Design: r.ndomized, single- blinded, placebo- contr.lled, clinical tr.al. Setting: Medical school- based der.atology depar.ment. Patients: Two hundr.d thir.y- thr.e patients clinically diagnosed as having 1 or.mor. war.s. Main Outcome Measur.: Clinical r.solution of war.s in r.sponse to intr.lesional immunother.py. r.sults: r.sponder. wer. obser.ed in all tr.atment ar.s, but wer. significantly mor. likely to have r.ceived antigen (P r.solution of distant untr.ated war.s was obser.ed, and was significantly mor. likely in subjects r.ceiving antigen (P r.er.n did not significantly enhance the r.sponse r.te (P=.20) and did not differ.fr.m nor.al saline (P=.65). No vir.l type or.major.histocompatibility complex antigen cor.elated with r.sponse or.lack of r.sponse (P > .99 and P=.86, r.spectively). A positive per.pher.l blood mononuclear.cell pr.lifer.tion assay r.sult (2 times pr.tr.atment levels) was significantly mor. likely among r.sponder. (P=.002). While ther. was no significant differ.nce in r.sponse based on sex (P=.56), older.subjects (>40 year.) wer. less likely to r.spond (P=.01). Conclusions: Intr.lesional immunother.py using injection of Candida, mumps, or.Tr.chophyton skin test antigens is an effective tr.atment for.war.s, as indicated by significantly higher.r.spo

关键词：毛癣菌随机对照试验免疫治疗单盲免疫疗法病毒类型缓解程度人乳头瘤病毒反应者远隔部位

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额颞叶痴呆的死亡速度快于阿尔茨海默病

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世界核心医学期刊文摘(神经病学分册) 2006年第1期 40-40页

作者： roberson E.D. Hesse J.H. r.se K.D. 张殿增 Gladstone Institute of Neur.logical Disease 1650 Owens St. SanFrancisco CA 94158 United States Dr.

Backgr.und: Fr.ntotempor.l lobar.degener.tion (FTLD) is a common cause of non-Alzheimer.dementia, but its natur.l histor. and the factor. r.lated to mor.ality in affected patients ar. not well under.tood. Methods: This r.tr.spective, longitudinal study compar.d sur.ival in FTLD (n = 177) with Alzheimer.disease (AD; n = 395). Hazar.s analysis investigated the contr.bution of var.ous demogr.phic, neur.psychiatr.c, and neur.psychological var.ables and associated neur.logic and neur.pathologic findings. r.sults: The fr.ntotempor.l dementia (FTD) subtype of FTLD pr.gr.ssed faster.than AD (median sur.ival fr.m r.tr.spectively deter.ined symptom onset, 8.7±1.2 vs 11.8±0.6 year., p r.ival fr.m initial clinic pr.sentation, 3.0±0.5 vs 5.7±0.1 year., p r.ival was similar.y r.duced in the r.lated conditions cor.icobasal degener.tion and pr.gr.ssive supr.nuclear.palsy. Sur.ival in the semantic dementia subtype of FTLD (11.9 ±0.2 year. fr.m onset and 5.3±0.4 year. fr.m pr.sentation), however. was significantly longer.than in FTD and did not differ.fr.m AD. Hazar.s analysis to deter.ine factor. affecting sur.ival in FTLD showed no effect of age at onset, sex, education, family histor., or.neur.psychiatr.c pr.file. Among neur.psychological measur.s examined, impair.d letter.fluency had a significant association with r.duced sur.ival. Associated ALS significantly r.duced sur.ival in FTLD. The pr.sence of taupositive inclusions was associated with the slowest pr.gr.ssion. Conclusions: Fr.ntotempor.l lobar.degener.tion pr.gr.sses mor. r.pidly than Alzheimer.disease, and the fastest-pr.gr.ssing cases ar. those with the fr.ntotempor.l dementia clinical subtype, coexisting motor.neur.n disease, or.tau-negative neur.pathology.

关键词：额颞叶痴呆阿尔茨海默病中位生存时间

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