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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong Fu Meina Wang chao Han Zhongyue Lv liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

Zircon U-Pb dating of Shuiquangou alkaline complex intrusives, northwestern Hebei Province

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chinese Science Bulletin 1997年第9期42卷 772-775页

作者： Mo, ch liang, HY Wang, XZ cheng, JP Li, HM Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou China Tianjin Institute of Geology and Mineral Resources Chinese Academy of Geological Sciences Tianjin China

SUPER large gold deposits related to alkaline intrusions have been found in America,Canada,Australia,Papua New Guinea and *** gold deposit with superlarge potentialhas also been found in Shuiquangou alkaline complex intrusions,northwestern Hebei Province,*** of the keys to resolving the possible genetic relationship between gold deposits andore-host alkaline intrusions is to determine their formation *** note dates the Shuiquan-gou intrusions with zircon U-Pb method.

关键词： alkaline intrusions Proterozoic Era zircon U-Pb dating gold deposit.

Facile synthesis of the dodecahydridododecaborate (B12H122-) from borane Lewis base adducts

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Science china chemistry 2025年

作者： Yi Jing Xin-Ran Liu Xing-Hua Wang Hui Han Sha-Sha liang Xi-Meng chen Dong-Hui Wei Lai-Sheng Wang Xue-Nian chen College of chemistry Zhengzhou University School of chemistry and chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced MaterialsHenan Normal University Department of chemistry Brown University

Polyhedral boranes are a class of well-known boron molecular clusters widely used in energy,chemistry,medicine,and materials science because of their unique physical and chemical *** efforts have been made in the past decades to find more effective synthetic methods for this important class of boron ***,existing synthetic methods suffer from low efficiency and low ***,we report a facile one-pot synthesis of[（ch3）3S]2B12H12with moderate yields at mild *** mechanisms for the multi-step chemoselective synthesis of B12H122-without other by-products are elucidated based on theoretical results and our previous *** Lewis base used in B–H bond condensation reaction,which acts as a hydrogen or to balance the newly generated polyhedral borane charges,is proposed and studied in *** current study has led to a more effective and selective synthetic method for B12H122-and has also implicated the syntheses of other new polyhedral boranes.

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Hyperhomocysteinemia independently causes and promotes atherosclerosis in LDL receptor-deficient mice

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Journal of Geriatric Cardiology 2014年第1期11卷 74-78页

作者： Hang-Yuan GUO Fu-Kang XU Hai-Tao LV Long-Bin LIU Zheng JI Xiao-Ya ZHAI Wei-liang TANG Ju-Fang ch Department of Cardiology Shaoxing Hospital of Zhejiang University Shaoxing 312000 Zhejiang Province China

Background Hyperhomocysteine is an independent risk factor of coronary heart disease （chD）. However, whether hyperhomocys teine affects the progression of atherosclerosis is unclear. In the present study, we examined the effect of hyperhomocysteine on the forma tion of atherosclerosis in low-density lipoprotein receptor-deficient （LDLr ） mice. Methods Forty-eight 7-week-old LDLr/ mice were assigned to the following groups： mice fed a standard rodent diet （control group）, mice fed a high-methionine diet （high-methionine group）, mice fed a high-fat diet （high-fat group）, and mice fed a diet high in both methionine and fat （high-methionine and high-fat group）. At the age of 19, 23, and 27 weeks, four mice at each interval in every group were sacrificed. Results At the end of the study, mice did not show atherosclerotic lesions in the aortic sinus and aortic surface until 27 weeks old in the control group. However, atherosclerotic lesions developed in the other three groups at 19 weeks. The amount of atherosclerotic lesions on the aortic surface was lower in the high-methionine group than in the high-fat group （P 〈 0.001）. Atherosclerotic lesions on the aortic surface in the high-methionine and high-fat group were the most severe. The mean area of atherosclerotic lesions in the aortic sinus compared with atherosclerotic lesions on the aortic surface was lower in the high-methionine group than in the high-fat group （P 〈 0.001）. Atherosclerotic lesions in the aortic sinus in the high-methionine and high-fat group were the most severe. Conclusions Homocysteinemia accelerates atherosclerotic lesions and induces early atherosclerosis independently in LDLrmice. Reducing the level of homocysteinemia may be beneficial for prevention and treatment of chD.

关键词： Atherosclerosis Homocysteine Low-density lipoprotein Hyperhomocysteinemia

Electro-derived Cu-Cu2O nanocluster from LDH for stable and selective C2 hydrocarbons production from CO2 electrochemical reduction

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Journal of Energy chemistry 2020年第9期29卷 169-180,I0005页

作者： Naveed Altaf Shuyu liang liang Huang Qiang Wang College of Environmental Science and Engineering Beijing Forestry UniversityBeijing 100083China

Recently,CO2 conversion by electrochemical tool into value-added chemicals has been considered as one of the most promising strategies to offer sustainable development in energy and *** this contribution,we investigated electro-derived composites from Cu-based layered double hydroxide(LDH)for CO2 electrochemical *** Cu-Cu2O based nanocomposite(HPR-LDH)were derived by using electro-strategy from LDH having the stability up to 20 h and selectivity toward C2H4 with faraday efficiency up to 36%by significantly suppressing ch4 and H2 with respect to bulk Cu foil.A highly negative reduction potential derived catalyst(HPR-LDH)maintained long-term stability for the selective production of ethylene over methane,and a small amount of Cu2O was still observed on the catalyst surface after CO2 reduction reaction(CO2RR).Moreover,such unique strategy for electro-derived composite from LDH having small nanoparticles stacked each other grown on layered structure,would provide new insight to improve durability of O-Cu combination catalysts for C-C coupling products during electrochemical CO2conversion by suppressing *** XRD,SEM,ESR,and XPS analyses confirmed that the long-term ethylene selectivity of HPR-LDH is due to the presence of subsurface *** designed composite catalyst significantly enhances the stability and selectivity,and also decreases the over potential for CO2 *** predict that the new designed LDH 2D-derived composites may attract new insight for transition metal and may open up a new direction for known structural properties of selective catalyst synthesis regarding effective CO2 reduction reaction.

关键词： Electrochemical Electro-derived strategy Layered double hydroxide Ethylene Cu2O nanocomposites

Probe manipulators for Wendelstein 7-X and their interaction with the magnetic topology

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Plasma Science and Technology 2018年第5期20卷 6-17页

作者： M RACK D HOSchEN D REITER B UNTERBERG J W COENEN S BREZINSEK O NEUBAUER S BOZHENKOV G CZYMEK Y liang M HUBENY ch LINSMEIER the Wendelstein 7-X Team Forschungszentrum Julich GmbH Institut für Energie- und Klimaforschung-Plasmaphysik Partner of the Trilateral Euregio Cluster (TEC) D-52425 Julich Germany JARA-HPC D-52425 Julich Germany Max-Planck-Institut für Plasmaphysik D-17491 Greifswald/D-85748 Garching Germany

Probe manipulators are a versatile addition to typical plasma edge *** with material samples they allow for detailed investigation of plasma–wall interaction processes,such as material erosion,deposition or impurity transport *** combined with electrical probes,a study of scrape-off layer and plasma edge density,temperature and flow profiles as well as magnetic topologies is possible.A mid-plane manipulator is already in operation on Wendelstein 7-X.A system in the divertor region is currently under *** the present paper we discuss the critical issue of heat and power loads,power redistribution and experimental access to the complex magnetic topology of Wendelstein *** the aforementioned aspects are of relevance for the design and operation of a probe manipulator in a device like Wendelstein？7-X.A focus is put on the topological region that is accessible for the different coil current configurations at Wendelstein 7-X and the power load on the manipulator with respect to the resulting different magnetic *** analysis of power loads on plasma-facing components is performed using a numerical tracer particle diffusion tool provided via the Wendelstein 7-X Webservices.

关键词： stellarators Wendelstein 7-X manipulator divertor power load

Reminiscences of Tsingtao(Excerpt)

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英语世界 2019年第10期 110-112页

作者： liang Shih-ch'iu 军厚

[1]Although I was born and bred in Peiping1,I have never regarded it as the best place to call my *** once prosperous and elegant city has gone through untold vicissitudes over the years,falling into decline and vulga... 详细信息

关键词： china Reminiscences of Tsingtao Excerpt

Research on a New Type of Diamond Saw Plate

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厦门大学学报（自然科学版） 2002年第S1期41卷 294-295页

作者： SHI Xiao-liang, DUAN Long-chen, TANG Feng-lin, YANG Kai- hua (Engineering Faculty, china University of Geosciences, Wuhan 430074, ch ina)

With the developing of stone material, diamond saw pl ate is used widely, and in order to increase cutting efficiency and life-span o f diamond saw plate, there are a lot of research jobs of segment for diamond saw plate. Layered segment for diamond saw plate is to divide single segment into s everal cutting tools by its structure, then increases rock-cutting faces. For i mpregnated man-made diamond saw plate, the bonding strength of diamonds with ma trix material has great effect on its life and service. Diamond is a kind of non metal and there is such high interface energy between diamond and common metals or alloys that diamond surface can’t be soaked by low melt-point metal or allo y. Diamonds are hold in metal matrix of working layer only mechanically, rather than bonded chemically, so the usage rate of diamonds in working layer is very l ow. Weakly impregnated method refers to covering diamonds with a thin layer of tu ngsten carbide mechanically by physical method, and chemical plating membrane re fers to coating a layer of carbide, which can react with the carbon atoms on the surface of diamond by chemical method and be soaked by matrix metal. In this pa per it analyses working mechanism and sintering process of layered segment of di amond saw plate by means of resistor hot-pressing sintering, it points out shor tages of layered structure, and raises using weakly impregnated layer instead of pure matrix layer, then overcomes the pure matrix layer slipping by pulling out diamonds earlier to improve cutting efficiency of saw plate, in the same time u ses diamond grains of chemical plating membrane proposed then preventing the hea t-hurting to diamond grains in working layer during the process of welding and sintering and improving the bonding strength of diamond with matrix, then improv ing life-span and aging of diamond saw. The theory of the design of mixed holding of diamonds by matrix of saw plate assures that chemical plating diamonds in working layer cut

关键词： diamond saw plate layered segment weakly impre gnated plating membrane slipping

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Efficient Pd-Catalyzed C-H Oxidative Bromination of Arenes with Dimethyl Sulfoxide and Hydrobromic Acid

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chinese Journal of chemistry 2020年第11期38卷 1245-1251页

作者： Yizhi Yuan Yujie liang Shihui Shi Yu-Feng liang Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityXue Yuan Rd.38Beijing 100191China State Key Laboratory of Organometallic chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200062China

of main observation and conclusion We have developed an efficient Pd-catalyzed directed C-H bromination protocol,in which dimethyl sulfoxide(DMSO)is employed as oxidant with hydrobromic add aqueous solution(HBr(aq))as bromide *** DMSO/HBr(aq)system,which is novelly and efficiently utilized in transition-metal catalyzed C-H activation,illustrates its practicability by the operational simplicity,inexpensive and readily available starting materials,and high bromide-atom economy.

关键词： catalyzed bromide simplicity