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Effects of salvianolic acid-A on NIH/3T3 fibroblast proliferation,collagen synthesis and gene expression

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World Journal of Gastroenterology 2000年第3期6卷 361-364页

作者： liu ch Hu YY Wang XL liu P Xu LM Shanghai Univ Tradit chinese Med Inst Liver Dis Shanghai 200032 Peoples R China

AIM To investigate the mechanisms ofsalvianolic acid A（SA-A）against liver fibrosisin *** NIH/3T3 fibroblasts were culturedroutinely,and incubated with 10-4mol/L-10-7mol/L SA-A for 22 *** cell viability wasassayed by[3H]proline incorporation,cellproliferation by[3H]TdR incorporation,cellcollagen synthetic rate was measured with[3H]proline impulse and collagenase *** total RNA was prepared from thecontrol cells and the drug treated cellsrespectively,and α（1）I pro-collagen mRNAexpression was semi-quantitatively analyzedwith *** 10-4mol/L SA-A decreased cellviability and exerted some cytotoxiciy,while10-5mol/L-10-7mol/L SA-A did not affect cellviability,but inhibited cell proliferationsignificantly,and 10-6mol/L SA-A had the besteffect on cell viability among theseconcentrations of drugs.10-5mol/L-10-6mol/LSA-A inhibited intracellular collagen syntheticrate,but no significant influence on extracellularcollagen *** 10-5mol/L and10-6mol/L SA-A could decrease α（1）I pro-collagen mRNA expression *** SA-A had potent action againstliver *** inhibited NIH/3T3 fibroblastproliferation,intracellular collagen syntheticrate and type I pro-collagen gene expression,which may be one of the main mechanisms of thedrug.

关键词： salvianolic acid-A NIH/3T3 fibroblast cell viability cell proliferation collagen gene expression

Protective actions of salvianolic acid A on hepatocyte injured by peroxidation in vitro

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World Journal of Gastroenterology 2000年第3期6卷 402-404页

作者： Hu YY liu ch Wang RP liu C liu P Zhu DY Shanghai Univ Tradit chinese Med Inst Liver Dis Shanghai 200032 Peoples R China

INTRODUCTION Salvianolic radix,one of the most commonly usedtraditional chinese herbs,was widely studied aboutits actions against liver injury and fibrosis,and wasone of the focuses of recent *** acid-A(SA-A)was an aq... 详细信息

关键词： Salvianolic acid A hepatocyte carbon tetrachloride liver injury lipid peroxidation water soluble vitamin E ALT AST superoxide dismutase malondiadehyde catalase lactase dehydrogenase glutathione peroxidase glutathione

Deep CLSTM for Predictive Beamforming in Integrated Sensing and Communication-Enabled Vehicular Networks

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Journal of Communications and Information Networks 2022年第3期7卷 269-277页

作者： ch.ng liu Xuemeng liu Shuangyang Li Weijie Yuan Derrick Wing Kwan ng School of Electrical Engineering and Telecommunications the University of New South WalesSydneyNSW 2052Australia School of Electrical and Information Engineering the University of SydneySydneyNSW 2006Australia Department of Electrical Electronic and Computer Engineeringthe University of Western AustraliaPerth WA 6009Australia Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055China

Predictive beamforming design is an essential task in realizing high-mobility integrated sensing and communication(ISAC),which highly depends on the accuracy of the channel prediction(CP),i.e.,predicting the angular parameters of ***,the performance of CP highly depends on the estimated historical channel stated information(CSI)with estimation errors,resulting in the performance degradation for most traditional CP *** further improve the prediction accuracy,in this paper,we focus on the ISAC in vehicle networks and propose a convolutional long-short term memory(CLSTM)recurrent neural network(CLRNet)to predict the angle of vehicles for the design of predictive *** the developed CLRNet,both the convolutional neural network(CNN)module and the LSTM module are adopted to exploit the spatial features and the temporal dependency from the estimated historical angles of vehicles to facilitate the angle ***,numerical results demonstrate that the developed CLRNet-based method is robust to the estimation error and can significantly outperform the state-of-the-art benchmarks,achieving an excellent sum-rate performance for ISAC systems.

关键词： integrated sensing and communication predictive beamforming deep learning convolutional longshort term neural network vehicular networks

Some Regularities of Continuous Solid Solutions of Alloy Systems

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Journal of Materials Science & Technology 1997年第5期13卷 431-434页

作者： Guo, JK Li, ch Qin, P liu, HL chen, NY chINESE ACAD SCI SHANGHAI INST METSHANGHAI 200050PEOPLES R CHINA

A modified Miedema model and pattern recognition technique are used to establish the criteria for the formation of continuous solid solutions in alloy systems, and to study the occurrence of the melting temperature mi... 详细信息

关键词： Binary alloys

Evaluation of strongly singular domain integrals for internal stresses in functionally graded materials analyses using RIBEM

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Acta Mechanica Sinica 2014年第6期30卷 917-926页

作者： Hai-Feng Peng Jian liu Qiang-Hua Zhu ch.Zhang School of Aeronautics and Astronautics Faculty of Vehicle Engineering and MechanicsDalian University of Technology Department of Civil Engineering University of Siegen D-57068 Siegen Germany

An accurate evaluation of strongly singular domain integral appearing in the stress representation formula is a crucial problem in the stress analysis of functionally graded materials using boundary element *** solve this problem,a singularity separation technique is presented in the paper to split the singular integral into regular and singular parts by subtracting and adding a singular *** singular domain integral is transformed into a boundary integral using the radial integration *** expressions of the radial integrals are obtained for two commonly used shear moduli varying with spatial *** regular domain integral,after expressing the displacements in terms of the radial basis functions,is also transformed to the boundary using the radial integration ***,a boundary element method without internal cells is established for computing the stresses at internal nodes of the functionally graded materials with varying shear modulus.

关键词： Stress integral equations Functionally graded materials Strongly singular domain integral Singularity separation technique Radial integration method

Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system

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Journal of Molecular Cell Biology 2020年第5期12卷 327-336页

作者： Ya-Jie Xu Pei-Pei liu Shyh-ch.ng ng Zhao-Qian Teng ch.ng-Mei liu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

High-throughput sequencing has facilitated the identification of many types of non-coding RNAs(ncRNAs)involved in diverse cellular *** as epigenetic mediators play key roles in neuronal development,maintenance,and dysfunction by controlling gene expression at multiple *** may not only target specific DNA or RNA for gene silence but may also directly interact with chromatin-modifying proteins like Polycomb group(PcG)proteins to drive orchestrated transcriptional *** significant progress has been made in characterizing ncRNAs and PcG proteins involved in transcriptional,post-transcriptional,and epigenetic *** importantly,dysregulation of ncRNAs,PcG proteins,and interplay among them is closely associated with the pathogenesis of central nervous system(CNS)*** this review,we focus on the interplay between ncRNAs and PcG proteins in the CNS and highlight the functional roles of the partnership during neural development and diseases.

关键词： epigenetics Polycomb complexes non-coding RNAs central nervous system neurological diseases

You shall never walk alone:burnout and depression amongst healthcare professionals

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 678-681页

作者： Kelvin Lin chieh ng chen liu Institute of Mental Health SingaporeSingapore United Family Hospital BeijingChina

There are two stages of tsunami,first is the earthquake in deep sea,followed by *** are three waves of pandemic,the death toll,economic and social disruption,and a psychological storm that is looming in the distance *** this time of worldwide COVID-19 pandemic,to date,we have seen over 200 million cases worldwide,and the death toll is in excess of 4 million,and there are various news reports coming in about devastating economic and social ***,numerous studies report that the public,as well as the healthcare professionals are at heightened risk mental health problems in the short and longer term from pandemic.

关键词： storm earthquake alone

Uniqueness and perturbation bounds for sparse non-negative tensor equations

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Frontiers of Mathematics in china 2018年第4期13卷 849-874页

作者： Dongdong liu Wen LI Michael K. ng Seak-Weng VOng School of Applied Mathematics Guangdong University of Technology Guangzhou 510006 China School of Mathematical Sciences South China Normal University Guangzhou 510631China Department of Mathematics Hong Kong Baptist University Hong Kong China Department of Mathematics University of Macao Macao China

We discuss the uniqueness and the perturbation analysis for sparse non-negative tensor equations arriving from data sciences. By two different techniques, we may get better ranges of parameters to guarantee the uniqueness of the solution of the tensor equation. On the other hand, we present some perturbation bounds for the tensor equation. Numerical examples are given to show the efficiency of the theoretical results.

关键词： Stochastic tensor tensor equation uniqueness perturbation

Incorporating geotechnical and geophysical investigations for underground obstruction detection:A case study

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Underground Space 2023年第4期11卷 116-129页

作者： Yaohui liu Yannick C.H.ng Yunhuo Zhang Ping Yang Taeseo Ku School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221000China Department of Civil and Environmental Engineering National University of Singapore117576Singapore Geotechnical&Tunnel Division Land Transport Authority Singapore219428Singapore Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Department of Civil and Environmental Engineering Konkuk UniversitySeoul 05029South Korea

Determining the location and boundary of underground obstructions and/or anomalies is a common problem and often a great chal-lenge for tunneling and underground *** this study,geotechnical investigations(penetration tests and borehole drilling/sam-pling)and geophysical investigations(surface wave method and cross-hole seismic method)were conducted with the aim of identifying the location and boundary of rock obstructions in ch.ngi East,*** surface wave method is frequently used in the sites with lateral homogeneity in previous studies,but its application in the sites with rock obstructions is *** experimental results of this study indicate that the surface wave method is also able to determine the upper surface of rock obstructions,but difficult to identify the lateral and bottom boundaries of rock *** improve the precision of detection,the full waveform inversion(FWI)method was used to process the data from the cross-hole seismic *** results indicate that the inversion precision of P-wave is higher than that of *** horizontal and vertical ranges of rock obstructions in the P-wave inversion results are 14–26 m and 7.5–11.0 m respectively,roughly consistent with the results of penetration tests(about 15–25 m)and borehole log(8.85–10.80 m).This result proves that the sequential application of first-arrival time analysis and FWI can effectively delineate the boundary of rock ***,the results of various detection methods were analyzed and compared in this *** the advantages of various methods,we propose a cost-effective and high-precision workflow containing both geotechnical and geophysical investigations.

关键词： FWI Geotechnical and geophysical investigations Cross-hole seismic method Surface wave method Obstruction detection