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Science in china,Ser.A 1953年第3期 201-215页

作者： chU chi-MIng Faccine and Serum Institute Peking

The influenza A strain, WS (England, 1933), is antigenically unique. Apart from a few other strains isolated between 1934-37, there is no authentic evidence of similar strains occurring in any of the epidemics in subsequent years. Between the years 1934, when PR8 virus was first described, and 1943, many strains were isolated from epidemics in different parts of the

关键词： FMI STUDIES ON THE VARIATION OF INFLUENZA A VIRUS IN NATURE-THE SIGNIFICANCE OF ISOLATION SINCE 1946 OF STRAINS ANTIGENICALLY RELATED TO WS OR PR8 PRS WS

儿科临床研究协调员职业培训现状的调查与需求分析

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中华医学教育探索杂志 2024年第3期23卷 327-332页

作者：樊文香李吉王瑞李春梅郑莞尔徐驰倪韶青浙江大学医学院附属儿童医院临床试验机构管理办公室国家儿童健康与疾病临床医学研究中心杭州1310052 杭州医学院药学院杭州310053 浙江中医药大学第三临床医学院浙江省针灸神经病学研究重点实验室杭州310053

目的了解儿科临床研究协调员(clinical research coordinator,CRC)职业培训现状,探讨儿科CRC基地化培训建设,以促进儿科CRC的能力提升。方法采用匿名问卷调研法,于2023年7月25日至10月16日期间,通过问卷星向调查对象发放自行设计的问卷... 详细信息

目的了解儿科临床研究协调员(clinical research coordinator,CRC)职业培训现状,探讨儿科CRC基地化培训建设,以促进儿科CRC的能力提升。方法采用匿名问卷调研法,于2023年7月25日至10月16日期间,通过问卷星向调查对象发放自行设计的问卷,以进行儿科CRC职业培训及基地化培训需求相关情况的调查分析。采用Excel对数据进行整理。计数资料以例数或者率表示。结果回收有效问卷328份。调查结果显示,认为当前CRC培训充分且可以满足实际工作需求的仅为7.62%(25人),另有4.88%(16人)的人认为没有CRC培训,46.34%(152人)的人认为培训不足以支撑实际工作的要求。87.50%(287人)的人认为CRC需要持续的培训。46.95%(154人)的人选择了有经验的CRC是较为合适的带教人员之一,但是需要3年及以上CRC工作经验。46.95%(154人)选择了CRC合适的培训时长为3个月。培训方式的选择从高到低为:有经验的CRC带教实习(90.85%,298人)、实操技能手把手带教(88.41%,290人)、案例分析讨论(87.20%,286人)、流程模拟(83.23%,273人)、授课(76.52%,251人)。培训后考核方式的选择从高到低为:案例分析(76.52%,251人)、操作模拟(74.09%,243人)、流程模拟(73.17%,240人)、笔试(66.16%,217人)、面试(63.72%,209人)。结论目前,儿科CRC的培训还不足以满足实际工作需求,急需制定一个符合工作需要的CRC培训体系并进行推广实践,从基础上促进中国儿科临床研究健康生态的构建。

关键词：儿科临床研究协调员培训需求基地化

潍坊青州M_(L)4.1地震震源区发震构造分析

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震灾防御技术 2024年第1期19卷 61-67页

作者：柴光斌张辉崔华伟李翠芹赵银刚池国民刘海林李世莹山东省地震局潍坊地震监测中心站山东潍坊261000 山东省地震局济南250102 河北省地震动力学重点实验室河北三河065201

2022年5月2日7时53分山东潍坊青州发生M_(L)4.1地震,基于中国地震台网中心的地震观测报告和山东数字化台网的波形资料,采用双差定位法对潍坊青州地震序列进行重新精定位,利用P波初动方法对其中11个M_(L)2.0以上的地震求震源机制解。利... 详细信息

2022年5月2日7时53分山东潍坊青州发生M_(L)4.1地震,基于中国地震台网中心的地震观测报告和山东数字化台网的波形资料,采用双差定位法对潍坊青州地震序列进行重新精定位,利用P波初动方法对其中11个M_(L)2.0以上的地震求震源机制解。利用阻尼时空应力反演方法和MSATSI软件包反演震源区局部应力场特征。经过分析得到以下结论:青州地震序列往SN向展布、倾向N。主震震源机制显示为正断,其节面Ⅰ走向263°、倾角31°、滑动角-109°,节面Ⅱ走向106°、倾角61°、滑动角-78°,局部应力场最佳主压应力轴呈NWW-SEE向(-92.19°)低倾角(16.09°)挤压,最优主张应力轴呈SSE-NNW向(0.26°)近水平(8.45°)拉张。本文推断发震断层为走向EW的隐伏断裂。

关键词：青州地震震源机制解双差重定位应力场

非口服抗凝药物应用于妊娠期和产褥期静脉血栓栓塞疾病的临床综合评价体系的建立

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中国临床药学杂志 2024年第7期33卷 493-501页

作者：魏丽雯陈青山于景娴张海池里群范洁同济大学附属妇产科医院药剂科上海201204 北京市海淀区妇幼保健院药剂科北京100080

目的对非口服抗凝药物在妊娠期和产褥期静脉血栓栓塞疾病中的应用进行临床综合评价,为临床合理使用非口服抗凝药物提供科学依据。方法采用德尔菲法和层次分析法对非口服抗凝药物的安全性、有效性、经济性、适宜性、创新性和可及性6个维... 详细信息

目的对非口服抗凝药物在妊娠期和产褥期静脉血栓栓塞疾病中的应用进行临床综合评价,为临床合理使用非口服抗凝药物提供科学依据。方法采用德尔菲法和层次分析法对非口服抗凝药物的安全性、有效性、经济性、适宜性、创新性和可及性6个维度进行评价指标筛选,以及循证证据收集和分析,构建非口服抗凝药物应用于妊娠期和产褥期静脉血栓栓塞疾病的临床综合评价体系,包括6个一级指标、22个二级指标,对低分子肝素钙/钠、依诺肝素、那屈肝素、贝米肝素、达肝素和磺达肝癸进行临床综合评价。结果6个一级指标和22个二级指标的循证证据来源于系统评价(Meta分析)、药品说明书、临床指南和专家共识等。根据建立的非口服抗凝药物应用于妊娠期和产褥期静脉血栓栓塞疾病的临床综合评价体系对非口服抗凝药物进行评价,结果显示,在6种药物中,总分最高为那屈肝素,最低为贝米肝素。其中安全性得分最高的是磺达肝癸,有效性得分最高的是低分子肝素钙/钠和依诺肝素,适宜性得分最高的是磺达肝癸,可及性得分最高的是依诺肝素,创新性得分最高的是磺达肝癸,经济性得分最高的是低分子肝素钙/钠。结论不同非口服抗凝药物在妊娠期和产褥期静脉血栓栓塞疾病的治疗中具有不同的优势,通过临床综合评价对药品进行量化评分可为临床合理用药提供参考。

关键词：非口服抗凝药物临床综合评价静脉血栓栓塞疾病层次分析法低分子肝素

Quantum-limited localization and resolution in three dimensions

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Photonics Research 2021年第8期9卷 1522-1530页

作者： BEN WAng LIAng XU JUN-chi LI LIJIAN ZHAng National Laboratory of Solid State Microstructures and College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093China

As a method to extract information from optical systems,imaging can be viewed as a parameter estimation *** fundamental precision in locating one emitter or estimating the separation between two incoherent emitters is bounded below by the multiparameter quantum Cramér-Rao bound(QCRB).Multiparameter QCRB gives an intrinsic bound in parameter *** determine the ultimate potential of quantum-limited imaging for improving the resolution of a far-field,diffraction-limited optical field within the paraxial *** show that the quantum Fisher information matrix(QFIm)in about one emitter’s position is independent on its true *** calculate the QFIm of two unequal-brightness emitters’relative positions and intensities;the results show that only when the relative intensity and centroids of two-point sources,including longitudinal and transverse directions,are known exactly,the separation in different directions can be estimated simultaneously with finite *** results give the upper bounds on certain far-field imaging technology and will find wide use in applications from microscopy to astrometry.

关键词： estimation quantum directions

Metasurfaces designed by a bidirectional deep neural network and iterative algorithm for generating quantitative field distributions

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Light(Advanced Manufacturing) 2023年第2期4卷 28-38页

作者： Yang Zhu Xiaofei Zang Haoxiang chi Yiwen Zhou Yiming Zhu Songlin Zhuang Terahertz Technology Innovation Research Institute and Shanghai Key Lab of Modern Optical SystemUniversity of Shanghai for Science and TechnologyNo.516 JunGong RoadShanghai200093China

Metasurfaces,which are the two-dimensional counterparts of metamaterials,have demonstrated unprecedented capabilities to manipulate the wavefront of electromagnetic waves in a single flat *** various advances in this field,the unique functionalities achieved by metasurfaces have come at the cost of the structural complexity,resulting in a time-consuming parameter sweep for the conventional metasurface *** artificial neural networks provide a flexible platform for significantly improving the design process,the current metasurface designs are restricted to generating qualitative field *** this study,we demonstrate that by combining a tandem neural network and an iterative algorithm,the previous restriction of the design of metasurfaces can be overcome with quantitative field *** proof-of-principle examples,metalenses predicted via the designed network architecture that possess multiple focal points with identical/orthogonal polarisation states,as well as accurate intensity ratios(quantitative field distributions),were numerically calculated and experimentally *** unique and robust approach for the metasurface design will enable the acceleration of the development of devices with high-accuracy functionalities,which can be applied in imaging,detecting,and sensing.

关键词： Metasurfaces Bidirectional deep neural network Iterative algorithm Focal points Vortex

Sarcaglarols A-D, Lindenane-Monoterpene Heterodimers from Sarcandra glabra Based on Molecular Networks

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chinese Journal of chemistry 2021年第1期39卷 129-136页

作者： Yongyue Wang Zhirong Cui Jun chi Pengfei Tang Meihui Zhang Jixin Li Yongyi Li Hao Zhang Jun Luo Lingyi Kong Jingsu Key laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines School of Taditional Chinese PharmacyChina Pharmaceutical UniversityNanjingJiangsu 210009China

Sarcaglarols A-D(1-4),two pairs of lindenane-monoterpene heterodimers fused by a 1,2-dioxane moiety,were discovered and isolated from the leaves of Sarcandra glabra guided by MS/MS molecular networking-based *** planar structures,absolute configurations of basic skeleton and flexible polyhydric side chain were established by analysis of HRESIMS,NMR spectroscopic data,ECD spectrum,and the X-ray diffraction study of isopropylidene *** intermolecular[2+2+2]cycloaddition may play a key role in the biosynthesis pathway of the 1,2-dioxane moiety fused lindenane-monoterpene heterodimer skeleton,which can be recognized as the biogenetic precursors of our previous reported lindenane-normonoterpene *** addition,compounds 1,3 and 4 exhibited moderate inhibitory effects of lipid accumulation in free fatty acid-exposed L02 cells.

关键词： Sarcandra glabra Molecular networks Natural products Structural elucidation Peroxides

微RNA-509-3p/干扰素刺激基因15轴对喉癌细胞血管生成及血管内皮生长因子蛋白表达的影响

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安徽医药 2024年第8期28卷 1593-1598,I0002页

作者：鞠叶秦世成孙月石小红迟文韬董金叶海军第九七一医院耳鼻咽喉科山东青岛266071 青岛大学青岛市中心医院耳鼻喉科山东青岛266000 青岛大学附属妇女儿童医院耳鼻喉科山东青岛266000

目的探究微RNA(miR)-509-3p/干扰素刺激基因15(ISG15)轴对喉癌细胞血管生成及血管内皮生长因子(VEGF)蛋白表达的影响。方法2022年1―9月,将喉癌M4E细胞分为Con组、miR-NC组、miR-509-3p组、pcDNA-ISG15组。逆转录聚合酶链式反应(RT-PCR... 详细信息

目的探究微RNA(miR)-509-3p/干扰素刺激基因15(ISG15)轴对喉癌细胞血管生成及血管内皮生长因子(VEGF)蛋白表达的影响。方法2022年1―9月,将喉癌M4E细胞分为Con组、miR-NC组、miR-509-3p组、pcDNA-ISG15组。逆转录聚合酶链式反应(RT-PCR)检测细胞中miR-509-3p表达;细胞计数试剂盒(CCK8)检测细胞增殖能力;Transwell检测细胞侵袭能力;划痕实验检测细胞迁移能力;流式细胞仪检测细胞凋亡率;Matrigel体外成管实验检测血管生成能力;蛋白质印迹法检测细胞中ISG15、VEGF蛋白表达;萤光素酶活性报告检测miR-509-3p和ISG15的靶向关系。结果与喉上皮细胞NP69中miR-509-3p表达(1.01±0.13)μg/L相比,喉癌细胞SCC-40、SCC-2、M4E中miR-509-3p表达[(0.61±0.08)、(0.45±0.07)、(0.18±0.07)μg/L]均降低,且M4E细胞中miR-509-3p表达低于SCC-40、SCC-2细胞(P0.05)。与Con组相比,miR-509-3p组细胞增殖(1.71±0.02比3.09±0.07)、侵袭(55.33±2.52比150.67±2.52)、迁移(30.58±2.08比98.33±1.53)、形成小管数量(61.28±2.15比135.62±2.54)及细胞中ISG15(0.24±0.03比1.11±0.13)、VEGF(0.35±0.02比0.99±0.04)蛋白表达均降低,细胞凋亡率[(18.76±0.18)%比(5.61±0.08)%]增加(P0.05);与miR-509-3p组相比,pcDNA-ISG15组细胞增殖(3.25±0.06)、侵袭(144.00±2.65)、迁移(89.34±5.13)、形成小管数量(131.56±2.08)及细胞中ISG15(0.83±0.05)、VEGF蛋白(0.89±0.03)表达增加,细胞凋亡率降低(6.85±0.06)%(P<0.05)。结论过表达miR-509-3p可抑制喉癌细胞血管生成及VEGF蛋白表达。

关键词：喉肿瘤微RNA-509-3p 干扰素刺激基因15 血管生成血管内皮生长因子

Highly stable capacitive tactile sensors with tunable sensitivity facilitated by electrostatic interaction of layered double hydroxide,MXene,and Ag NWs

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Science china(Technological Sciences) 2023年第11期66卷 3287-3297页

作者： SHEN GengZhe HUAng WeiQing LI HaiFeng WAng FengMing SU DaoJian LI BaiJun ZHAng BoLun LIAng Ping ZHAng chi XIN Yue HE Xin School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006China

A capacitive tactile sensor(CTS)has been developed by assembling a double-sided patterned dielectric layer and novel *** patterned aluminium foil-supported electrode comprises zinc-aluminium layered double hydroxides(Zn AlLDH),MXene,and Ag NWs via electrostatic *** flexible device enables greater structural deformation,thereby enhancing sensitivity to a wide range of *** sensitivity of the CTS can be customized to meet specific requirements by match.ng the microstructured electrodes with the patterned dielectric *** optimized sensor exhibits a sensitivity of 2.752 kPa^(–1)within 30 kPa,a response time of approximately 100 ms,and a wide detection range of 0–300 *** strong physical interaction among the electrode materials ensures a reliable conductive network,ensuring the long-term stability of the sensor,even after 7500 loading and unloading ***,the fabricated CTS device presents a promising prospect for the integration into wearable electronics,with the ability to effectively respond to both human activities and external physical stimuli.

关键词： capacitive tactile sensor adjustable sensitivity long-term durability human activity monitoring

Extensive retroperitoneal and right thigh abscess in a patient with ruptured retrocecal appendicitis:An extremely fulminant form of a common disease

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World Journal of Gastroenterology 2006年第3期12卷 496-499页

作者： chi-Hsun Hsieh Yu-chun Wang Horng-Ren Yang Ping-Kuei ch.ng Long-Bin Jeng Ray-Jade chen Department of Traumaand Emergency Surgery China Medical University HospitalTaichung Taiwan China

As a disease commonly encountered in daily practice, acute appendicitis is usually diagnosed and managed easily with a low mortality and morbidity rate. However, acute appendicitis may occasionally become extraordinarily complicated and life threatening. A 56-year-old man, healthy prior to this admission, was brought to the hospital due to spiking high fever, poor appetite, dysuria, progressive right flank and painful swelling of the thigh for 3 d. Significant inflammatory ch.nge of soft tissue was noted, involving the entire right trunk from the subcostal margin to the knee joint. Painful disability of the right lower extremity and apparent signs of peritonitis at the right lower abdomen were disclosed. Laboratory results revealed leukocytosis and an elevated C-reactive protein level. Abdominal CT revealed several communicated gas-containing abscesses at the right retroperitoneal region with mass effect, pushing the duodenum and the pancreatic head upward, compressing and encasing inferior vena cava, destroying psoas muscle and dissecting downward into the right thigh. Laparotomy and right thigh exploration were performed immediately and about 500 mL of frank pus was drained. A ruptured retrocecal appendix was the cause of the abscess. The patient fully recovered at the end of the third post-operation week. This case reminds us that acute appendicitis should be treated carefully on an emergency basis to avoid serious complications. CT scan is the diagnostic tool of choice, with rapid evaluation followed by adequate drainage as the key to the survival of the patient.

关键词： Acute appendicitis Retrocecal appendicitis Complication Retroperitoneal abscess Thigh abscess