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noncoding RnAs：＇our turn＇ to join the p53 networ

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Journal of Molecular Cell Biology 2014年第3期8卷 179-180页

作者： Yong li Hua l.u Department of Bioch.mistry and Molecular Biology School of Medicine University of Louisville 319 Abraham Flexner Way Louisville KY40202 USA E-mail: yong.ti@louisviUe.edu Department of Bioch.mistry& Molecular Biology andTulane Cancer Center TulaneUniversity School ofMedicine New Orleans LA70112 USA

The p53 tumor suppressor is the guardian of the rrr- o human genome. Since ,ts discovery in pS3 has been the most studied molecule in the field of cancer. Recently, its role has also been extended to other biological and pathological processes, p53 functions primarily as a transcription factor to regulate target genes that encode proteins crucial for promot- ing apoptotic cell death, cell cycle arrest, senescence, and so on in response to diverse upstream stressors. Interestingly, some of the p53 targets are noncoding RnAs. noncoding RnAs can be functional without being translated into proteins and are often independent RnA molecules or noncoding parts of messenger RnAs. The past decade has witnessed bur- geoning intensive investigation on the interplay of noncoding RnAs with p53, its regulators, and effectors during the development of cancer and/or other dis- eases. This issue of Journal of Molecular Cell Biology presents five essays to review the rapid progress in this area from five different angles and to offer new insight into the role of noncoding RnAs in the p53 signaling web with updated information.

关键词：非编码RnA BP网络分子细胞生物学 P53 编码蛋白质细胞周期阻滞 p53 人类基因组

ch.ldhood malaria in the niger delta area of nigeria:mothers/care givers'perception,definition and treatment practices

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 52-58页

作者： Idogun E.Sylvester Airauhi l.u Department of ch.mical Pathology University of Benin Teaching HospitalBenin City Department of Medical Microbiology Biology University of Benin Teaching HospitalBenin City

Objective:The objective of the study was to evaluate mothers/care givers perception of malaria,their treatment practices and the effects on the outcome of ***:Four hundred and sixty ch.ldren were enrolled and their mothers/care givers *** ch.ldren were screened for malaria parasitaemia and there after,blood specimens were obtained for bioch.mical and haematological evaluation from those ch.ldren who met the criteria and tested positive to *** *** cell volume,electrolytes,urea, creatinine,plasma glucose,and serum bilirubin were ***:A total of 460 ch.ldren were studied, 233(50.7%) males and 227(49.3%) *** malaria cases were 112(24.3%) and severe malaria 348(75.7%).Those who presented early 106(23.0%) and those who presented late 354(77.0%).Perception and definition of malaria as well as the treatment seeking behaviors vary significantly with the level of education of the mothers and care *** without formal education 68(51.9%) wrongly perceived that the etiology of malaria can only be diagnosed by native doctors compared to those with primary six education 61 (26.5%) and junior secondary education 10(10.1%).Only 43(9.3%) gave the correct dose of ch.oroquine syrup to their sick ch.ldren,while 32(7.0%) gave at sub optimal ***:Wrong perception of malaria especially the complicated malaria and wrong treatment practices are major contributory factors to the high mortality and morbidity of malaria in *** is therefore a need for health education to correct the wrong ideas about the cause and treatment practices of malaria as part of malaria control programme.

关键词： ch.ldhood malaria Mothers/Caregivers Perception and treatment practices nigeria

Experimental evaluation of a“u”type earth-to-air heat exch.nger planned for narrow installation space in warm climatic conditions

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Energy and Built Environment 2024年第5期5卷 772-786页

作者： Ricardo Molina-Rodea Jorge Alejandro Wong-loya Hugo Pocasangre-ch.vez Jennifer Reyna-Guillén Institute of Renewable Energies National Autonomous University of MexicoTemixcoMorelosMexico

The thermal performance of a“u”type earth-to-air heat exch.nger is presented in this experimental *** device has a serial-connected vertical *** wells where tubes were installed have a depth of fewer than 3 m and are separated every 1.5 m,using an installation area of *** experimentation was carried out in March.in Morelos,Mexico when the environmental temperature reach.s 35℃ during the *** performance of the device was measured and compared to the requirements of an office for cooling purposes within a university campus to reproduce the space restrictions found in urbanized *** using a small land surface,it is feasible for urbanized *** air temperature inside the“u”type earth-to-air heat exch.nger,the surrounding soil temperature,the airspeed,and the power consumed by the fan were *** air temperature and the fan’s power consumption data were obtained by modifying the airspeed in four constant values,from 1.3 m/s to 6.6 m/*** show that the device evaluated in this work has adequate thermal performance for cooling purposes compared to the requirements of an office.A decrease in air temperature was recorded in a range of 5.1℃ to 9.4℃.Over 70%of the total temperature difference was reach.d in the first well,where the average soil thermal disturbance at 5 cm was 2.8℃.The device ach.eved a maximum COP of 12.8 and a maximum effectiveness of 88.4%.With these results,it is concluded that the system is suitable for cooling purposes in areas with space *** work is novel since the dimensions available for installation in urbanized areas are considered and compared with the thermal requirements of an *** addition to the fact that there are no published works with vertical heat exch.ngers connected in series.

关键词： low temperature geothermal energy Thermal performance Vertical heat exch.ngers Space restrictions in urbanized areas Geothermal direct uses

Zircon u-Pb dating of Shuiquangou alkaline complex intrusives, northwestern Hebei Province

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ch.nese Science Bulletin 1997年第9期42卷 772-775页

作者： Mo, ch.liang, HY Wang, XZ ch.ng, JP li, HM Guangzhou Institute of Geoch.mistry Chinese Academy of Sciences Guangzhou China Tianjin Institute of Geology and Mineral Resources Chinese Academy of Geological Sciences Tianjin China

SuPER large gold deposits related to alkaline intrusions have been found in America,Canada,Australia,Papua new Guinea and *** gold deposit with superlarge potentialhas also been found in Shuiquangou alkaline complex intrusions,northwestern Hebei Province,*** of the keys to resolving the possible genetic relationship between gold deposits andore-host alkaline intrusions is to determine their formation *** note dates the Shuiquan-gou intrusions with zircon u-Pb method.

关键词： alkaline intrusions Proterozoic Era zircon u-Pb dating gold deposit.

Polygeneration Study of low-to-Medium Enthalpy Geothermal Reservoirs in Mexico

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Journal of Thermal Science 2021年第3期30卷 1077-1087页

作者： ch.VEZ Oscar GODÍnEZ Francisco Tecnológico nacional de México/I.T.ch.huahua.Av.Tecnológico 2909 C.P.31310ChihuahuaChihuahuaMéxico Instituto de Ingeniería Universidad Nacional Autónoma de MéxicoUNAMC.U.Ciudad de MéxicoC.P.04510México Polo universitario de Tecnología Avanzada Universidad Nacional Autónoma de MéxicoVía de la Innovación No.410Autopista Monterrey-Aeropuertokm.10 PIITC.P.66629Apodaca Nuevo LeónMéxico

This study combines the thermodynamic analysis of a polygeneration system along with the numerical modelling of the thermal behavior of geothermal reservoirs in Mexico to exploit their *** reservoir was modeled as a porous medium assuming a five-spot well configuration and local thermal *** heat conduction-convection along with the laplace equations were solved to compute temperature distributions,the useful life and the optimum distance between injection-extraction *** predicted temperature and pressure of the geothermal fluid at the outlet of the reservoir were exploited in the polygeneration system consisting of:(1)a Rankine cycle,(2)an absorption refrigeration cycle,and(3)a heat *** developed approach.allows cal.ulating both the optimal distance between injection-extraction wells and the global.utilization)efficiency of six arrangements(each.composed by a reservoir connected to a polygeneration system)by assuming that reservoirs have a lifespan of 30 *** also show that:(a)due to the low efficiency of the Rankine cycle,very little thermal energy is converted into electrical one;(b)not only the temperature and the size are important when evaluating the power production performance of reservoirs,but also the permeability plays a fundamental role;(c)the first law efficiency of the polygeneration system ranges from 41.9%to 43.7%;(d)the utilization efficiency of the six arrangements lies in the range between 25.8%and 31%.

关键词： polygeneration system geothermal reservoir local thermal equilibrium low-to-medium enthalpy

Electronic Absorption Spectroscopy of H2X （X=O, Te, Po）： Theoretical Treatment of Spin-Orbit Effects

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ch.nese Journal of ch.mical Physics 2009年第2期22卷 171-177页

作者： ch.rif A. A. ndoye ch.ntal Daniel laboratoire de ch.mie Quantique Institut de Chimie UMR 7177 CNRS-Université de Strasbourg 4 Rue Blaise Pascal 67000 Strasbourg France

The electronic spectroscopy of H2X （X=O, Te, Po） was investigated by means of spinorbit configuration interaction （EPCISO） and restricted active space state interaction （SORASSI）. The transition energies to the low-lying singlet and triplet states of H2O, in which.the SO interaction is zero, compare rather well with the experimental data as well as to other theoretical values. The theoretical electronic absorption spectrum is ch.racterized by three allowed transitions A^1B1 （2px（O）→σ^＊g/3s（O））, B^1A1（σg→σ^＊g/3s（O）） and A^1S2（σg→σ^＊u） cal.ulated at 7.68, 9.94, and 11.72 eV, respectively. The theoretical absorption spectra of H2X （X=Te, Po） are shifted to the red with the A^1B1 （npx（X）→σ^＊g） states cal.ulated at 5.06 eV （H2Te） and 4.40 eV （H2Po） and the A^1B2 （σg→σ^＊u） states cal.ulated at 7.89 eV （H2Te） and 7.77 eV （H2Po）. The largest SO splitting amounts to 0.34 eV and is found for the lowest a^3A1 of H2Po. In H2Te the SO effects are still negligible with a maximum splitting of 0.04 eV for the lowest a^3B2. The two methods lead to comparable results but the EPCISO approach.depends strongly on the reference wavefunction.

关键词： Spin-orbit Excited state Group Ⅵ dihydride

Bounded type Siegel disks of finite type maps with few singular values Dedicated to the Memory of Professor lei Tan

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Science ch.na Mathematics 2018年第12期61卷 2139-2156页

作者： Arnaud ch.ritat Adam lawrence Epstein CnRS Institut de Mathematiques de ToulouseUniversite Paul SabatierToulouse F-31062France Mathematics Institute University of WarwickCoventry CV47ALUK

let u be an open subset of the Riemann sphere C. We give sufficient conditions for which.a finite type map f : u →C with at most three singular values has a Siegel disk compactly contained in u and whose boundary is a quasicircle containing a unique critical point. The main tool is quasiconformal surgery à la Douady-Ghys-Herman-(S′)wia tek. We also give sufficient conditions for which. instead, ? has not compact closure in u. The main tool is the Sch.arzian derivative and area inequalities à la Graczyk-(S′)wia tek.

关键词： Siegel disks quasicircles quasiconformal surgery Sch.arzian derivative

Evaluation of ligninolytic activity in spent mushroom substrate from four cultivated mushrooms

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Journal of Bioresources and Bioproducts 2022年第4期7卷 288-294页

作者： Ana Marión Pérez-ch.vez María Melisa Alberti Edgardo Albertó laboratory of Mycology and Mushroom Cultivation.Instituto Tecnológico de ch.scomús(InTEch. Universidad Nacional de San Martín(UNSAM)-Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Intendente Marino AveCC 164.7130ChascomúsBuenos AiresArgentina

Spent mushroom substrate(SMS)is an abundant residue generated by the mushroom industry,which.is mostly *** this study,the SMS of four cultivated mushrooms were evaluated as potential sources of ligninolytic *** ostreatus,***,*** and Ganoderma lucidum were cultivated in two different substrates to determine growth,mushroom yields and ligninolytic activity of laccase(lac)and manganese peroxidase(MnP).Maximum activities in the SMS were 3.731 u/g lac and 0.191 u/g MnP,both for *** mushroom substrates were also analyzed,and higher activities were found in almost all samples.A correlation test between mushroom yields and ligninolytic activities of each.cul.ure was made,and we found that high enzymatic activity in the substrate did not result in high mushroom productivity or vice *** SMS was a good source of ligninolytic *** activity depended on the mushroom species and its affinity to the substrate,and it was not influenced by the mushroom *** of mushrooms in diverse lignocel.ulosic substrates is gaining interest,and ob-taining ligninolytic enzymes from residual SMS is an excellent alternative in the circular economy concept.

关键词： laccase Manganese peroxidase Biological efficiency Pl.urotus spp Ganoderma lucidum Circular economy

Kinetic Instability of Anisotropic Drift Wave Accompanied by Field Aligned Currents in Solar Coronal loop

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Communications in Theoretical Physics 2018年第10期70卷 470-476页

作者： Hafsa naim ch.uzma G.Murtaza Salam ch.ir Department of Physics GC University

Solar coronal loops are frequently accompanied by the field-aligned currents, which.drive instabilities if the drift velocity u0 > v A the Alfv′en velocity. For our ch.ice of parameters, the critical threshold value of u0/v A is ～ 3.0 for growth and the corresponding current filling factor ～ 10-3-10-4. Below this value we are no longer in the kinetic *** coronal loops also have short-scale density gradients within each.loop. The electron resonance in the presence of density gradient causes the drift mode to grow. We study the effect of these two free energy sources, the electron drift and the density gradient, in the presence of temperature anisotropy T⊥_α > T∥_α. These effects simultaneously exist in the coronae. using gyrokinetic theory, we investigate the influence of these effects, examine how they interplay with each.other and study the consequent growth of the magnetosonic wave. We observe that kinetic instability driven by density gradient can be suppressed by field-aligned currents. The temperature anisotropy with ch.sen signatures causes further stabilizing effect. The results may prove useful to study the heating mech.nism of solar coronal loops, acceleration of particles and confinement of particles in the thermonuclear reactors.

关键词： solar corona coronal loops temperature anisotropy density inhomogeneity field-aligned currents gyrokinetic