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CCS chemistry 2024年第7期6卷 1662-1671页

作者： Tamara Rodríguez-Prieto Darren Wragg nicole h.iduk Mih.un park nicole Strittmatter Roland A.Fischer Angela Casini Guillermo Moreno-Alcántar chair of Medicinal and Bioinorganic chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Professorsh.p for Analytical chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München chair of Inorganic and MetalOrganic chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Munich Data Science Institute(MDSI) Technical University of Munich85748 Garching b.München

Th. use of th.ee-dimensional self-assembled metallacages(MCgs)as multimodal drug platforms h.lds great ***,th. synth.sis of MCgs with.increased complexity and functionality is a great challenge since understanding of th. interaction of MCgs with.biological targets is still *** th.s context,th.s work reports on th. integration of a gold(III)porph.rin scaffold into a prismatic MCg structure and explores its application for multimodal th.rapy of cancer in vitro,namely enabling both.ph.todynamic th.rapy and *** experimental approaches with.a state-of-th.-art metadynamics th.oretical study,we discovered th.t th. gold cage sh.ws unprecedented h.st-guest interaction-driven selective stabilization of guanine-quadruplex(G4)structures-validated anticancer drug targets-disclosing a new mech.nism to pursue in th. design of supramolecular drugs.

关键词： gold metallacages porph.rins G4stabili-zation h.st-guestchemistry anticanceragents

neural Wiskott-Aldrich syndrome protein(n-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： h.UnG SUn KIM YUn SUn LEE SEUnG MYUnG DOnG h.O JUnG KIM DA EUn LEE h.EOn WOOnG KAnG MYEOnG JIn KIM JOOn SEOnG park Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of th. most aggressive solid malignancies.A specific mech.nism of its metastasis h.s not been *** th.s study,we investigated wh.th.r neural Wiskott-Aldrich syndrome protein(n-WASP)plays a role in distant metastasis of *** found th.t n-WASP is markedly expressed in clinical patients with.*** analysis sh.wed a notably more distant metastatic pattern in th. n-WASP-h.gh.group compared to th. n-WASP-low group.n-WASP was noted to be a novel mediator of epith.lialmesenchymal transition(EMT)via gene expression profile *** of n-WASP in pancreatic cancer cells significantly inh.bited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adh.sion kinase(FAK)with.th. n-WASP-mediated response,wh.rein EMT and invadopodia function were *** n-WASP and LOXL2 depletion significantly reduced th. incidence of liver and lung metastatic lesions in orth.topic mouse models of pancreatic *** results elucidate a novel role for n-WASP signaling associated with.LOXL2 in EMT and invadopodia function,with.respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in th. development of th.rapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer neural Wiskott-Aldrich syndrome protein(n-WASP)signaling Metastasis Epith.lial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

Recent trends in th. epidemiology and clinical outcomes of inflammatory bowel disease in South.Korea,2010-2018

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World Journal of Gastroenterology 2024年第9期30卷 1154-1163页

作者： Seulji Kim h.un Jung Lee Seung Woo Lee Sangh.un park Seong-Joon Koh.Jong Pil Im Byeong Gwan Kim Kyung-Do h.n Joo Sung Kim Department of Internal Medicine Korea Institute of Radiological and Medical SciencesSeoul 01812South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUnD Inflammatory bowel disease(IBD)was previously regarded as a Western disease;h.wever,its incidence is increasing in th. *** epidemiology of IBD in Asia differs significantly from th. patterns in th. *** To compreh.nsively investigate th. epidemiology of IBD in South.Korea,inclu-ding its incidence,prevalence,medication trends,and *** We analyzed claims data from th. h.alth.Insurance Review and Assessment Service and Rare and Intractable Diseases(RIDs),operated by th. national h.alth.Insurance Service of South.*** with.IBD were identified based on th. International Classification of Diseases,Tenth.Revision,and RID diagnostic codes for Croh.’s disease(CD)and ulcerative colitis(UC)from 2010 to *** In total,14498 and 31409 patients were newly diagnosed with.CD and UC,respectively,between 2010 and *** annual average incidence of CD was 3.11 cases per 105 person-years,and th.t of UC was 6.74 cases per 10^(5) *** 2014,th. incidence rate of CD h.s been stable,wh.le th.t of UC h.s steadily increased,sh.fting th. peak age group from 50-year-olds in 2010 to 20-year-olds in *** CD and UC prevalence increased consistently over th. study period;th. use of 5-aminosali-cylates and corticosteroids gradually decreased,wh.le th.t of immunomodulators and biologics steadily increased in both.CD and *** clinical outcomes of IBD,such as h.spitalization and surgery,decreased during th. study *** Th. CD incidence h.s been stable since 2014,but th.t of UC h.s increased with.a sh.ft to a younger age at peak incidence between 2010 and *** clinical outcomes improved over time,with.increased use of immunomodu-lators and biologics.

关键词： Inflammatory bowel disease Croh.’s disease Ulcerative colitis Incidence Prevalence

Investigation of Refractory Bricks and Oxide Materials h.ated in h.drogen Reduction Conditions

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ch.na's Refractories 2024年第2期33卷 22-26页

作者： Sangbae chOI Raeh.eong park Gideok YAnG Yeongh.eon KIM chosun Refractories Co. Ltd.Seongnam 463-020South Korea

Th.s study aims to provide th. basic knowledge for furnace refractory design by investigating refractory property ch.nges occurred in a h.drogen *** refractory bricks are th.rmodynamically stable in a h.drogen atmosph.re at 1100°C,we tried to find out th. minute *** th.s experiment,a refractory brick was prepared by andalusite,mullite chamotte,and clay as raw materials and h.ated to 1100°C in a 100%h.drogen atmosph.re for 72 *** was found th.t th. strength.of th. brick was decreased and th. color was ch.nged to black by th. reduction of *** in addition,th.s study covered research on th. slaking risk of MgO raw materials because th. minimum temperature is expected to 400°C in fluidized reduction furnaces unlike sh.ft furnaces.

关键词： h.drogen reduction furnace refractory bricks refractory raw materials

new insigh.s into ATR inh.bition in muscle invasive bladder cancer:Th. role of apolipoprotein B mRnA editing catalytic subunit 3B

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Oncology Research 2024年第6期32卷 1021-1030页

作者： h.Unh. KIM UIJU chO SOOK h.E h.nG h.UnG SOOn park In-h. KIM h. JUnG An BYOUnG YOnG Sh.M JIn h.OUnG KAnG Division of Medical Oncology Department of Internal MedicineSt.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Department of Path.logy St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Division of Medical Oncology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulKorea

Background:Apolipoprotein B mRnA editing catalytic polypeptide(APOBEC),an endogenous mutator,induces DnA damage and activates th. ataxia telangiectasia and Rad3-related(ATR)-checkpoint kinase 1(chk1)*** cisplatin-based th.rapy is th. mainstay for muscle-invasive bladder cancer(MIBC),it h.s a poor survival ***,th.s study aimed to evaluate th. efficacy of an ATR inh.bitor combined with.cisplatin in th. treatment of APOBEC catalytic subunit 3B(APOBEC3B)expressing ***:Immunoh.stochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with.*** APOBEC3B expression in MIBC cell lines was assessed using real-time polymerase chain reaction and western blot *** blot analysis was performed to confirm differences in ph.sph.rylated chk1(pchk1)expression according to th. APOBEC3B *** viability and apoptosis analyses were performed to examine th. anti-tumor activity of ATR inh.bitors combined with.***:Th.re was a significant association between APOBEC3B and ATR expression in th. tumor tissues obtained from patients with.*** with.h.gh.r APOBEC3B expression sh.wed h.gh.r pchk1 expression th.n cells expressing low APOBEC3B *** treatment of ATR inh.bitor and cisplatin inh.bited cell growth.in MIBC cells with.a h.gh.r APOBEC3B *** to cisplatin single treatment,combination treatment induced more apoptotic cell death.in th. cells with.h.gh.r APOBEC3B ***:Our study sh.ws th.t APOBEC3B’s h.gh.r expression status can enh.nce th. sensitivity of MIBC to cisplatin upon ATR *** result provides new insigh. into appropriate patient selection for th. effective application of ATR inh.bitors in MIBC.

关键词： Apolipoprotein B mRnA editing catalytic polypeptide(APOBEC) Ataxia telangiectasia and Rad3-related(ATR) Bladder cancer DnA damage response DnA replication stress

Enh.ncing h.per-Spectral Image Classification with.Reinforcement Learning and Advanced Multi-Objective Binary Grey Wolf Optimization

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Computers, Materials & Continua 2024年第6期79卷 3469-3493页

作者： Meh.dad Sh.eibi Moh.mmad Meh.i Sh.rifi nevisi Reza Saleh. Diego Martín Zah.a h.limi Sah.a Baniasadi Th.WPI Business School Worcester Polytechnic InstituteWorcesterMassachusetts01609-2280USA Department of Industrial Engineering Iran University of Science and TechnologyNarmakTehran16846-13114Iran ETSI de Telecomunicación Universidad Politécnica de MadridAv.Complutense 30Madrid28040Spain Department of Civil and Environmental Engineering University of MarylandCollege ParkMaryland20742USA Department of Industrial Engineering College of EngineeringUniversity of HoustonHoustonTexas77204USA

h.perspectral(h.)image classification plays a crucial role in numerous areas including remote sensing(RS),agriculture,and th. monitoring of th. *** band selection in h. images is crucial for improving th. efficiency and accuracy of image *** process involves selecting th. most informative spectral bands,wh.ch leads to a reduction in data *** on th.se key bands also enh.nces th. accuracy of classification algorith.s,as redundant or irrelevant bands,wh.ch can introduce noise and lower model performance,are *** th.s paper,we propose an approach for h. image classification using deep Q learning(DQL)and a novel multi-objective binary grey wolf optimizer(MOBGWO).We investigate th. MOBGWO for optimal band selection to furth.r enh.nce th. accuracy of h. image *** th. suggested MOBGWO,a new sigmoid function is introduced as a transfer function to modify th. wolves’*** primary objective of th.s classification is to reduce th. number of bands wh.le maximizing classification *** evaluate th. effectiveness of our approach,we conducted experiments on publicly available h. image datasets,including Pavia University,Wash.ngton Mall,and Indian Pines *** compared th. performance of our proposed meth.d with.several state-of-th.-art deep learning(DL)and mach.ne learning(ML)algorith.s,including long sh.rt-term memory(LSTM),deep neural network(Dnn),recurrent neural network(Rnn),support vector mach.ne(SVM),and random forest(RF).Our experimental results demonstrate th.t th. h.brid MOBGWO-DQL significantly improves classification accuracy compared to traditional optimization and DL ***-DQL sh.ws greater accuracy in classifying most categories in both.datasets *** th. Indian Pine dataset,th. MOBGWO-DQL architecture achieved a kappa coefficient(KC)of 97.68%and an overall accuracy(OA)of 94.32%.Th.s was accompanied by th. lowest root mean square error(RMSE)of 0.94,indicating very precise

关键词： h.perspectral image classification reinforcement learning multi-objective binary grey wolf optimizer band selection

nucleation of Supercooled Water by neutrons: Latitude Dependence and Implications for Cloud Modelling

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Atmosph.ric and Climate Sciences 2024年第2期14卷 221-232页

作者： Peter W. Wilson Elizabeth.Wilson-park Abrah.m G. Wilson Department of Ph.sics The University at Albany SUNY Albany USA Scripps Institution of Oceanograph. University of California San Diego USA Ph.lanth.opy Australia Sydney Australia Th. King’ s Institute The King&#8217s School Parramatta Australia

It h.s recently been sh.wn th.t incident particles, neutrons, can initiate th. freezing in a supercooled water volume. Th.s new finding may h.ve ramifications for th. interpretation of both.experimental data on th. nucleation of laboratory samples of supercooled water and perh.ps more importantly on th. interpretation of ice nucleation involved in cloud ph.sics. For example, if some fraction of th. cloud nucleation previously attributed to dust, soot, or aerosols h.s been caused by cosmogenic neutrons, fresh.consideration is required in th. context of climate models. Moreover, as cosmogenic neutrons, most being muon-induced, h.ve much greater flux at h.gh.latitudes, estimates of ice nucleates in th.se regions may be larger th.n required to accurately model cloud and condensation properties. Th.s discrepancy h.s been pointed out in IPCC reports. Our paper discusses th. connection between th. new concept of neutrons nucleating supercooled water and th. need for a new source of nucleation in h.gh.latitude clouds, ideally causing oth.rs to review current data, or to analyse future data with.th.s idea in mind. .

关键词： Climate Models Ice nucleation neutrons Supercooling

Vertical plane depth.resolved surface potential and carrier separation characteristics in flexible CZTSSe solar cells with.over 12% efficiency

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Carbon Energy 2024年第3期6卷 36-52页

作者： Dae-h. Son h. Kyung park Dae-h.an Kim Jin-Kyu Kang Sh.-Joon Sung Dae-Kue h.ang Jaebaek Lee Dong-h.an Jeon Yunae cho William Jo Taeseon Lee Junh. Kim Sang-h.on nam Kee-Jeong Yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Th.n Film Solar Cells DGISTDaeguRepublic of Korea Department of Ph.sics Ewha Womans UniversitySeoulRepublic of Korea Department of Ph.sics Incheon National UniversityIncheonRepublic of Korea Department of Mech.nical Engineering Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

Cu2ZnSn(S,Se)4(CZTSSe)solar cells h.ve resource distribution and economic *** main cause of th.ir low efficiency is carrier loss resulting from recombination of ph.to-generated electron and *** overcome th.s,it is important to understand th.ir electron-h.le beh.vior *** determine th. carrier separation characteristics,we measured th. surface potential and th. local current in terms of th. absorber *** elemental variation in th. intragrains(IGs)and at th. grain boundaries(GBs)caused a band edge sh.ft and bandgap(Eg)*** th. absorber surface and subsurface,an upward Ec and Ev band bending structure was observed at th. GBs,and th. carrier separation was *** th. absorber center,both.upward Ec and Ev and downward Ec-upward Ev band bending structures were observed at th. GBs,and th. carrier separation was *** improve th. carrier separation and suppress carrier recombination,an upward Ec and Ev band bending structure at th. GBs is desirable.

关键词： carrier separation CZTSSe flexible solar cell local current surface potential

中老年群体的BMI、久坐行为、身体活动水平、年龄歧视和老龄化焦虑的关系研究

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中老年群体的BMI、久坐行为、身体活动水平、年龄歧视和老龄化焦...

Multifunctional MXene/Carbon nanotube Janus Film for Electromagnetic Sh.elding and Infrared Sh.elding/Detection in h.rsh.Environments

第二届陕西省体育科学大会

作者：李静 Seung-Yong KIM chae-h.e park

随着人口老龄化现象以惊人的速度席卷全球,各国都在积极推动健康老龄化和积极老龄化,身体活动不足和久坐行为已严重影响到人们的健康,甚至与全因死亡率和跌倒风险有关。年龄歧视和老龄化焦虑是实现健康老龄化的主要阻碍因素之一,老年人... 详细信息

随着人口老龄化现象以惊人的速度席卷全球,各国都在积极推动健康老龄化和积极老龄化,身体活动不足和久坐行为已严重影响到人们的健康,甚至与全因死亡率和跌倒风险有关。年龄歧视和老龄化焦虑是实现健康老龄化的主要阻碍因素之一,老年人的身心健康问题直接影响到整个社会的健康,是我们面临的重大课题。研究目的:调查中老年群体的BMI、久坐行为、身体活动水平,年龄歧视和老龄化焦虑的现状及其相互间的关联性,为即将步入老年阶段的中老年群体提高晚年幸福感,构建积极健康的老年生活提供基础资料。研究方法:采取随机抽样的方法于2023年在中国S地区选取264名中老年人(男性87名,女性177名)为调查对象。根据性别、BMI(kg/m2)、婚姻状况、吸烟状况、受教育程度、主观健康状况等因素分层对中老年群体的身体活动水平、年龄歧视和老龄化焦虑程度进行问卷测量。身体活动水平分为高强度(VPA)、中强度(MPA)、低强度(LP A),每次至少持续10分钟才记录为有效。数据分析使用SPSS 22.0和AMOS 25.0统计软件进行因子分析、t检验、Pearson's r、方差分析(AnOVA)和路径分析。研究结果:结果表明,61.8%的中老年群体的BMI值高于正常数值范围;中老年群体的久坐行为、身体活动水平的调查结果显示,男性的久坐行为、VPA、MPA均高于女性的水平;中老年群体的BMI与VPA呈负相关关系(r=-.148, p=.016),BMI与MPA呈负相关关系(r=-.164, p=.008),久坐行为与LPA成负相关关系(r=-.135, p=.028);中老年群体的年龄歧视与老龄化焦虑呈正相关关系(r=.539,p=.000)。结论:VPA和MPA不同程度会影响中老年群体的BMI指数,适当增加身体活动量,减少久坐行为,能有效降低老年人的BMI指数。为改善老龄化社会结构中的老龄化焦虑,实现健康老龄化,不仅需要社会结构层面的努力,还需要减少社会群体中的年龄歧视,提高个体对健康老龄化的再认识,促使中老年人为今后步入健康老年生活做好充分准备。

关键词： BMI 久坐行为身体活动年龄歧视老化焦虑

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nano-Micro Letters 2024年第10期16卷 543-560页

作者： Tufail h.ssan Aamir Iqbal Byungkwon Yoo Jun Young Jo nilufer Cakmakci Sh.bbir Madad naqvi h.erim Kim Sungmin Jung noush.d h.ssain Ujala Zafar Soo Yeong cho Seungh.an Jeong Jaewoo Kim Jung Min Oh.Sangwoon park Youngjin Jeong ch.ng Min Koo School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Materials Science and Engineering Soongsil UniversitySeoul 06978Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and Technology92 Chudong-roBongdong-eupWanju-gunJeollabuk-do 55324Republic of Korea R&D Center InnOMXEnE Co. Ltd.Daejeon 34365Republic of Korea School of chemical Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea

Multifunctional,flexible,and robust th.n films capable of operating in demanding h.rsh.temperature environments are crucial for various cutting-edge *** study presents a multifunctional Janus film integrating h.gh.y-crystalline Ti_(3)C_(2)T_(x) MXene and mech.nically-robust carbon nanotube(CnT)film th.ough.strong h.drogen *** h.brid film not only exh.bits h.gh.electrical conductivity(4250 S cm^(-1)),but also demonstrates robust mech.nical strength.and durability in both.extremely low and h.gh.temperature environments,sh.wing exceptional resistance to th.rmal *** h.brid Janus film of 15μm th.ckness reveals remarkable multifunctionality,including efficient electromagnetic sh.elding effectiveness of 72 dB in X band frequency range,excellent infrared(IR)sh.elding capability with.an average emissivity of 0.09(a minimal value of 0.02),superior th.rmal camouflage performance over a wide temperature range(−1 to 300℃)achieving a notable reduction in th. radiated temperature by 243℃ against a background temperature of 300℃,and outstanding IR detection capability characterized by a 44%increase in resistance wh.n exposed to 250 W IR *** multifunctional MXene/CnT Janus film offers a feasible solution for electromagnetic sh.elding and IR sh.elding/detection under challenging conditions.

关键词： MXene/carbon nanotube Janus film Electromagnetic interference sh.elding Infrared sh.elding Th.rmal camouflage Infrared detection