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Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5

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骨研究:英文版 2023年第3期11卷 595-606页

作者： Cassandra R.Diegel ina Kramer charles Moes Gabrielle E.Foxa Mitchell J.McDonald Zachary B.Madaj Sabine Guth Jun Liu Jennifer L.harris Michaela Kneissel Bart O.Williams Department of Cell Biology Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Diseases of Aging and Regenerative Medicine Novartis Institutes for Biomedical ResearchCH-4002 BaselSwitzerland Bioinformatics and Biostatistics Core Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Oncology Novartis Institutes for Biomedical ResearchSan DiegoCA 92121USA

Proper regulation of Wnt signaling is critical for normal bone development and *** in several Wnt signaling components,which increase the activity of the pathway in the skeleton,cause high bone mass in human subjects and mouse *** bone mass is often accompanied by severe headaches from increased intracranial pressure,which can lead to fatality and loss of vision or hearing due to the entrapment of cranial *** addition,progressive forehead bossing and mandibular overgrowth occur in almost all *** that would provide symptomatic relief in these subjects are ***-mediated palmitoylation is necessary for Wnt secretion and binding to the frizzled *** inhibition of porcupine is a highly selective method of Wnt signaling *** treated three different mouse models of high bone mass caused by aberrant Wnt signaling,including homozygosity for loss-of-function in Sost,which models sclerosteosis,and two strains of mice carrying different point mutations in Lrp5(equivalent to human G171V and A214V),at 3 months of age with porcupine inhibitors for 5–6 *** significantly reduced both trabecular and cortical bone mass in all three *** demonstrates that porcupine inhibition is potentially therapeutic for symptomatic relief in subjects who suffer from these disorders and further establishes that the continued production of Wnts is necessary for sustaining high bone mass in these models.

关键词： homeostasis function mass

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固体边壁上点面脉动压力转换的数学推导

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数学的实践与认识 2003年第10期33卷 78-84页

作者：张力霆齐清兰河北工程技术高等专科学校河北沧州061001

利用相关分析方法 ,详细讨论了作用于水工建筑物的平面、柱面和球面上的边壁脉动压力的点面转换关系 ,推导出面脉动荷载的解析表达式 .

关键词：水工建筑物边壁脉动压力转换面脉动荷载传感器工程设计

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早产儿脑室周围白质软化与低碳酸血症的关系

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中华围产医学杂志 2003年第6期6卷 329-332页

作者：吴本清 young-You ch oi chang-Yee cho 暨南大学第二附属医院(深圳市人民医院)新生儿科深圳518020 Department of neonatology Chonnam University Hospital

目的　探讨早产儿脑室周围白质软化 (PVL)与机械通气下低碳酸血症的关系。　方法　对合并PVL和未合并PVL的胎龄 2 6～ 3 2周早产儿各 2 5例 ,进行对照研究。对生后前 3d机械通气参数和血气指标进行比较。　结果　两组生后前 3d机械通气... 详细信息

目的　探讨早产儿脑室周围白质软化 (PVL)与机械通气下低碳酸血症的关系。　方法　对合并PVL和未合并PVL的胎龄 2 6～ 3 2周早产儿各 2 5例 ,进行对照研究。对生后前 3d机械通气参数和血气指标进行比较。　结果　两组生后前 3d机械通气参数吸气峰压、呼气末正压、平均气道压、呼吸频率差异均无显著性。PVL组和对照组低氧血症的持续时间分别为 (3 .7± 1.1)和(4.1± 1.3 )h ,两组差异无显著性 (P >0 .0 5)。PVL组和对照组生后 72h最低PaCO2 分别为 (2 3 0±1.2 )mmhg (1mmhg =0 .13 3kPa)和 (3 1 0± 7.6)mmhg ;低碳酸血症的持续时间分别为 (2 6.3±7.8)和 (1.7± 0 .4)h ;两组差异有非常显著性 (P hg时 ,病例对照研究的比值比 (OR)为 16.6(95% ,可信限为 4.1～ 67.4,P h内PaCO2 低于 2 5mmhg 。

关键词：早产儿脑室周围白质软化低碳酸血症机械通气合并症

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4-1BB-4-1BBL cis-interaction contributes to the survival of selfreactive CD8^(+)T cell

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Cellular & Molecular Immunology 2023年第9期20卷 1077-1080页

作者： Eunjung cho Rohit Singh chungyong han Seon-hee Kim Kwang h.Kim Bo-Mi Park Dong hoon Shin Seongeun han young h.Kim Byoung S.Kwon Ki Taek Nam Beom K.choi Immuno-oncology Branch Division of Rare and Refractory CancerNational Cancer CenterGoyang 10408Republic of Korea Severance Biomedical Science Institute Brain Korea 21 Project for Medical ScienceYonsei University College of MedicineSeoulRepublic of Korea Department of Cancer Biomedical Science Graduate School of Cancer Science and PolicyNational Cancer CenterGoyang 10408Republic of Korea Department of Biomedical Laboratory Science Catholic Kwandong UniversityGangneung 25601Republic of Korea Biomedicine Production Branch Research InstituteNational Cancer CenterGoyang 10408Republic of Korea Anticancer Resistance Branch Division of Rare and Refractory CancerResearch InstituteNational Cancer CenterGoyang 10408Republic of Korea Eutilex Co. Ltd.Geumcheon-guSeoul 08594Republic of Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA 70112USA Innobationbio Co. Ltd.Mapo-guSeoul 03929Republic of Korea

4-1BB is an inducible receptor expressed on activated T cells,while its ligand,4-1BBL,is mainly expressed in antigen-presenting cells and macrophages[1,2].To the best of our knowledge,ligandmediated transactivation of... 详细信息

关键词： interaction activation knowledge

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利用集成计算方法迈向虚拟产品开发的道路

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工程设计学报 2001年第4期8卷 176-178页

作者： ch.Lffel h.Golbach 毛谦德 ina轴承制造无限公司北京理工大学机械工程与自动化学院教授100081

满足功效需求的计算机辅助产品开发过程使得提供新的集成软件产品成为必需 .然而 ,由于对产品开发来说不可少的 CAE工具缺乏兼容性和集成度 ,因此出现了很大的问题 .利用虚拟产品开发的概念启发了新的思路 ,可以消除现今 CAE应用中普遍... 详细信息

满足功效需求的计算机辅助产品开发过程使得提供新的集成软件产品成为必需 .然而 ,由于对产品开发来说不可少的 CAE工具缺乏兼容性和集成度 ,因此出现了很大的问题 .利用虚拟产品开发的概念启发了新的思路 ,可以消除现今 CAE应用中普遍存在的缺陷 .以一个汽车制造和机械制造配件供应公司里“技术计算”参与部门的开发过程为例 ,描述了用以优化开发过程且改善与用户之间数字通信的一种方式 .

关键词：虚拟产品开发集成计算方法 CAD CAE 计算机辅助产品开发

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The dichotomy of p53 regulation by noncoding RNAs

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Journal of Molecular Cell Biology 2014年第3期8卷 198-205页

作者： Qipan Deng Lindsey Becker Xiaodong Ma Xiaoming Zhong Ken young Kenneth Ramos and Yong Li Department of Biochemistry and Molecular Biology School of Medicine University of Louisville 319 Abraham Flexner Way Louisville KY 40202 USA Department of Cardiology Huaihe Hospital of Henan University Kaifeng 475000 China Department of hematopathology The University of Texas MD AndersonCancer Center Houston TX 77030 USA School of Life Science and Technology ShanghaiTech University Shanghai 200031 Cl~ina

The p53 tumor suppressor gene is the most frequently mutated gene in cancer. Significant progress has been made to discern the im- portance of p53 in coordinating cellular responses to DNA damage, oncogene activation, and other stresses. Noncoding RNAs are RNA molecules functioning without being translated into proteins. In this work, we discuss the dichotomy of p53 regulation by noncoding RNAs with four unconventional questions. First, is overexpression of microRNAs responsible for p53 inactivation in the absence of p53 mutation？ Second, are there somatic mutations in the noncoding regions of the p53 gene？ Third, is there a germline mutant in the non- coding regions of the p53 gene that predisposes carriers to cancer？ Fourth, can p53 activation mediated by a noncoding RNA mutation cause cancer？ This work highUghts the prominence of noncoding RNAs in p53 dysregutation and tumorigenesis.

关键词： noncoding RNA p53 activation mutation 3'UTR poiymorphism ribosomopathies

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Differences between young architects'and non-architects'aesthetic evaluation of buildings

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Frontiers of Architectural Research 2019年第2期8卷 229-237页

作者： Katarína Safárová Martin Pírko Vojtěch Jurík Tomás Pavlica Ondrej Németh Institute of Social Sciences Brno University of TechnologyZizkova 17Brno 602 00Czech Republic Department of Psychology Masaryk UniversityArne Nováka 1Brno 602 00Czech Republic Institute of Architecture Brno University of TechnologyVeverí 331/95Brno 602 00Czech Republic

Previous studies showed significant differences between expert architects and laypeople in aesthetic evaluations of ***,studies exploring the aesthetic preferences of architecture students are *** present study focused on a population of students and young architects to explore the aesthetic opinion shift within architectural *** study was intended to be a conceptual replication of the study of Brown and Gifford(2001)in a Central European context.A total of 109 participants(21-28 years old)evaluated 40 randomized pictures of houses to detect whether non-architecture undergraduates and fresh graduates of architecture would express different aesthetic preferences compared with their peers from the general *** study also examined whether laypersons can predict the preferences of architects,and vice *** show a trend that is contrary to the original research,that is,young architects and laypeople did not significantly differ in their aesthetic evaluations of the given *** revealed high prediction ability in young architects and their non-architect ***,the existing professional experience of young architects had no influence on the accuracy of their *** suggest that the professional shift in architects'expertise is obscured at an early career stage,as revealed in their aesthetic preferences.

关键词： Environmental aesthetics Aesthetic preferences Building aesthetics Environmental apperception Professional opinion shift

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Association between cytochrome CYP17A1, CYP3A4, and CYP3A43 polymorphisms and prostate cancer risk and aggressiveness in a Korean study population

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Asian Journal of Andrology 2015年第2期17卷 285-291,I0010页

作者： Jun hyun han Yong Seong Lee hae Jong Kim Shin young Lee Soon chul Myung Department of Urology Hallym University Dongtan Sacred Heart Hospital Hwaseong-si 445-170 Korea Department of Urology Hallym University Kangnam Sacred Heart Hospital Seoul 150-950 Korea Advanced Urogenital Disease Research Center Chung-Ang University College of Medicine Seoul 156-756 Korea Research Institute for Translational System Biomics Chung-Ang University College of Medicine Seoul 156-756 Korea Department of Urology Seoul Medical Center Seoul 131-865 Korea Department of Urology Chung-Ang University Hospital Seou1156-756 Korea.

In this study, we evaluated genetic variants of the androgen metabolism genes CYP17A1, CYP3A4, and CYP3A43 to determine whether they play a role in the development of prostate cancer （PCa） in Korean men. The study population included 240 pathologically diagnosed cases of PCa and 223 age-matched controls. Among the 789 singie-nucleotide polymorphism （SNP） database variants detected, 129 were reported in two Asian groups （han chinese and Japanese） in the hapMap database. Only 21 polymorphisms of CYP17A1, CYP3A4, and CYP3A43 were selected based on linkage disequilibrium in Asians （d = 1）, locations （SNPs in exons were preferred）, and amino acid changes and were assessed. In addition, we performed haplotype analysis for the 21 SNPs in CYP17A1, CYP3A4, and CYP3A43 genes. To determine the association between genotype and haplotype distributions of patients and controls, logistic analyses were carried out, controlling for age. Twelve sequence variants and five major haplotypes were identified in CYP17A1. Five sequence variants and two major haplotypes were identified in CYP3A4. Four sequence variants and four major haplotypes were observed in CYP3A43. CYP17A1 haplotype-2 （ht-2）（odds ratio [OR], 1.51; 95% confidence interval [Cl], 1.04-2,18） was associated with PCa susceptibility. CYP3A4 ht-2 （OR. 1.87; 95% CI. 1.02-3.43） was associated with PCa metastatic potential according to tumor stage, rs17115149 （OR： 1.96; 95% ch 1.04-3.68） and CYP17A1 ht-4 （OR： 2.01; 95% ch 1.07-4.11） showed a significant association with histologic aggressiveness according to Gleason score. Genetic variants of CYP17A1 and CYP3A4 may play a role in the development of PCa in Korean men.

关键词： androgens CYP17A1 CYP3A4 CYP3A43 genetics prostatic neoplasms

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Estimation of Non-CO_2 GhGs Emissions by Analyzing Burn Severity in the Samcheok Fire,South Korea

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Journal of Mountain Science 2012年第6期9卷 731-741页

作者： WON Myoung Soo KOO Kyo Sang LEE Myung Bo LEE Woo Kyun KANG Kyu-young Division of Forest Disaster Management Korea Forest Research Institute130712 SeoulRepublic of Korea Faculty of Environmental Science and Ecological Engineering Korea University-Seoul136701 SeoulRepublic of Korea Department of Biological and Environmental Science Dongguk University-Seoul100715 SeoulRepublic of Korea

This study was performed to estimate the emission of non-CO 2 greenhouse gases(GhGs) from biomass burning at a large fire *** extended methodology adopted the IPCC Guidelines(2003) equation for use on data from the Samcheok forest fire gathered using 30 m resolution Landsat TM satellite imagery,digital forest type maps,and growing stock information per hectare by forest type in *** burn ratio(NBR) technique was employed to analyze the area and severity of the Samcheok forest fire that occurred in *** differences between NBR from pre-and post-fire datasets are examined to determine the extent and degree of change detected from *** results of burn severity analysis by dNBR of the Samcheok forest fire area revealed that a total of 16,200 ha of forest were *** proportion of the area characterized by a 'Low' burn severity(dNBR below 152) was 35%,with 'Moderate'(dNBR 153-190) and 'high'(dNBR 191-255) areas were at 33% and 32%,*** combustion efficiency for burn severity was calculated as 0.43 for crown fire where burn severity was 'high',as 0.40 for 'Moderate' severity,and 0.15 for 'Low' severity surface *** emission factors for estimating non-CO 2 GhGs were separately applied to CO 130,ch 4 9,NO x 0.7 and N 2 O ***-CO 2 GhGs emissions from biomass burning in the Samcheok forest fire area were estimated to be CO 44.100,ch 4 3.053,NO x 0.238 and N 2 O 0.038 Gg.

关键词： Biomass burning Non-CO 2 GhGs Normalized burn ratio Combustion efficiency Emission factor Landsat TM

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“围合的”幸福时光

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现代装饰（家居） 2012年第12期 30-40页

作者： Greg Truen ina Fourie Mark Rielly Ashleigh Gilmour Sarika Jacobs Adam Letch Elsa young 肖俊南非SAOTA 南非ANTONI ASSOCIATES

本案位于南非约翰内斯堡,业主是当地的一个大家庭。在设计之初,业主希望能根据他们的家庭生活方式打造一个充满现代感的家居空间。建筑的地形从东向西形成平缓坡度,在南面有一个入口。建筑被各种人工种植的树木包围,从上面的楼层还可观... 详细信息

本案位于南非约翰内斯堡,业主是当地的一个大家庭。在设计之初,业主希望能根据他们的家庭生活方式打造一个充满现代感的家居空间。建筑的地形从东向西形成平缓坡度,在南面有一个入口。建筑被各种人工种植的树木包围,从上面的楼层还可观赏到秀丽的风景。"整个建筑场地被分成两个独立的方块,它们拥有共同的入口和位于南面的车道。建筑的两个部分形成一个‘U’型结构,中间围绕着一个朝北的内部庭院,可通往室内的其他区域和泳池。"建筑师Greq Truen说道。

关键词：家居空间家庭生活方式儿童房现代感主卧空间氛围生活空间人工照明 garden 士一

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