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3D printing for ultra-precision mach.ning:current status,opportunities,and future perspectives

Frontiers of Mech.nical Engineering 2024年第4期19卷 1-28页

作者： Tao HE wai Sze yip Edward Hengzhou YAN Jiuxing TANG Muhammad REHAN Long TENG ch. Ho WONG Linhe SUN Baolong ZHANG Feng GUO Shaohe ZHANG Suet TO State Key Laboratory of Ultra-precision Mach.ning Tech.ology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Physics The Hong Kong University of Science and TechnologyHong KongChina Sch.ol of Geosciences and Info-Physics Central South UniversityChangsha 410083China

Additive manufacturing,particularly 3D printing,has revolutionized the manufacturing industry by allowing the production of complex and intricate parts at a lower cost and with greater ***,3D-printed parts frequently require post-processing or integration with other mach.ning tech.ologies to ach.eve the desired surface finish,accuracy,and mech.nical ***-precision mach.ning(UPM)is a potential mach.ning tech.ology that addresses these ch.llenges by enabling high surface quality,accuracy,and repeatability in 3D-printed *** study provides an overview of the current state of UPM for 3D printing,including the current UPM and 3D printing stages,and the application of UPM to 3D *** the presentation of current stage perspectives,this study presents a detailed discussion of the benefits of combining UPM with 3D printing and the opportunities for leveraging UPM on 3D printing or supporting each.*** particular,future opportunities focus on cutting tools manufactured via 3D printing for UPM,UPM of 3D-printed components for real-world applications,and post-mach.ning of 3D-printed ***,future prospects for integrating the two advanced manufacturing tech.ologies into potential industries are *** study concludes that UPM is a promising tech.ology for 3D-printed components,exhibiting the potential to improve the functionality and performance of 3D-printed products in various *** also discusses how UPM and 3D printing can complement each.other.

关键词： ultra-precision mach.ning 3D printing additive manufacturing future perspectives start-of-the-art-review

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Microcurvature landscapes induce neural stem cell polarity and enhance neural differentiation

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生物设计与制造(英文) 2023年第5期6卷 522-535页

作者： Ho-Yin Yuen wai-Sze yip Suet To Xin Zhao Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina State Key Laboratory of Ultra-Precision Mach.ning Tech.ology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina

Tissue curvature has long been recognized as an important anatomical parameter that affects intracellular behaviors,and there is emerging interest in applying cell-scale curvature as a designer property to drive cell fates for tissue engineering *** neural cells are known to undergo dramatic and terminal morphological ch.nges during development and curvature-limiting behaviors have been demonstrated in neurite outgrowth studies,there are still crucial gaps in understanding neural cell behaviors,particularly in the context of a three-dimensional(3D)curvature landscape similar to an actual tissue engineering *** this study,we fabricated two substrates of microcurvature(curvature-substrates)that present a smooth and repeating landscape with focuses of either a concave or a convex *** these curvature-substrates,we studied the properties of morphological differentiation in N2a neuroblastoma *** contrast to other studies where two-dimensional(2D)curvature was demonstrated to limit neurite outgrowth,we found that both the concave and convex substrates acted as continuous and uniform mech.nical protrusions that significantly enhanced neural polarity and differentiation with few morphological ch.nges in the main cell *** enhanced differentiation was manifested in various properties,including increased neurite length,increased nuclear displacement,and upregulation of various neural *** demonstrating how the micron-scale curvature landscape induces neuronal polarity,we provide further insights into the design of biomaterials utilizing the influence of surface curvature in neural tissue engineering.

关键词： Curvature Neural differentiation Neurite outgrowth Mech.notransduction

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Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells

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ch.nese Journal of Cancer 2014年第11期33卷 549-555页

作者： ch. Man Tsang Wen Deng Yim Ling yip Mu-Sheng Zeng Kwok wai Lo Sai Wah Tsao Department of Anatomy Li Ka Shing Faculty of MedicineThe University of Hong Kong Sch.ol of Nursing Li Ka Shing Faculty of MedicineThe University of Hong Kong State Key Laboratory of Oncology in South ch.na Sun Yat-sen University Cancer Center Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong

Epstein-Barr virus(EBV) infection is closely associated with undifferentiated nasopharyngeal carcinoma(NPC), strongly implicating a role for EBV in NPC pathogenesis; conversely, EBV infection is rarely detected in normal nasopharyngeal epithelial tissues. In general, EBV does not show a strong tropism for infecting human epithelial cells, and EBV infection in oropharyngeal epithelial cells is believed to be lytic in nature. To establish life-long infection in humans, EBV has evolved efficient strategies to infect B cells and hijack their cellular mach.nery for latent infection. Lytic EBV infection in oropharyngeal epithelial cells, though an infrequent event, is believed to be a major source of infectious EBV particles for salivary transmission. The biological events associated with nasopharyngeal epithelial cells are only beginning to be understood with the advancement of EBV infection methods and the availability of nasopharyngeal epithelial cell models for EBV infection studies. EBV infection in human epithelial cells is a highly inefficient process compared to that in B cells, which.express the complement receptor type 2(CR2) to mediate EBV infection. Although receptor(s) on the epithelial cell surface for EBV infection remain(s) to be identified, EBV infection in epithelial cells could be ach.eved via the interaction of glycoproteins on the viral envelope with surface integrins on epithelial cells, which.might trigger membrane fusion to internalize EBV in cells. Normal nasopharyngeal epithelial cells are not permissive for latent EBV infection, and EBV infection in normal nasopharyngeal epithelial cells usually results in growth arrest. However, genetic alterations in premalignant nasopharyngeal epithelial cells, including p16 deletion and cyclin D1 overexpression, could override the growth inhibitory effect of EBV infection to support stable and latent EBV infection in nasopharyngeal epithelial cells. The EBV episome in NPC is clonal in nature, suggesting that

关键词：病毒感染上皮细胞鼻咽癌持久性细胞周期蛋白D1 全国人民代表大会生长抑制作用 EB病毒

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APAch. system is better than Ranson system in the prediction of severity of acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 294-299页

作者： Yuk Pang Yeung Billy Yeung Kit Lam Andrew wai ch.n yip Department ot Surgery Kwong Wah Hospital 25 Waterloo Road Kowloon Hong Kong China

BACKGROUND: It has been suggested that addition of obesity score to the APAch.-Ⅱ system can lead to more accurate prediction of severity of acute pancreatitis. However there is scanty information on the usefulness of the combined APAch.-O scoring system in Asian patients. This study aimed to compare the accuracy of Ranson, APAch.-Ⅱ and APAch.-O systems in assessing severity of acute pancreatitis in a local ch.nese population. METHODS: One hundred and one consecutive patients with acute pancreatitis were prospectively studied. Body mass index (BMI) was measured on admission. Ranson score, APAch.-Ⅱ and APAch.-O scores were recorded on admission and at 48 hours. By adopting the cut-off levels and definitions advocated in the Atlanta consensus for severe disease, the diagnostic accuracy of the three scoring systems was compared by the area under the curve (AUC) under the receiver operator ch.racteristic curve. RESULTS: Of the 101 patients, 12 (11.9%) patients suffered from severe pancreatitis. Obesity was uncommon and only two patients (2.0%) had BMI >30. Eighty-two (81.2%) patients were normal weight (BMI≤25) whereas 17 (16.8%) were overweight ( BMI 25-30 ). Overweight or obesity (BMI >25) was not associated with severe pancreatitis (P= 0.40). The AUC for admission scores of Ranson, APAch.-Ⅱ, and APAch.-O systems was 0. 549, 0. 904 and 0. 904, respectively. The AUC for 48-hour scores of Ranson, APAch.-Ⅱ and APAch.-O systems was 0.808, 0.955 and 0.951, respectively. CONCLUSIONS: The APAch.-Ⅱ scoring system is more accurate than the Ranson scoring system of the prediction of severity in acute pancreatitis. Addition of obesity score does not significantly improve the predictive accuracy of the APAch.-Ⅱ system in our local population with a low prevalence of obesity.

关键词： acute pancreatitis APAch.-Ⅱ score APAch.-O score disease severity Ranson score

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Why Daoism Today?

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Comparative Literature:East & West 2003年第1期 1-26页

作者： wai-lim yip University of California San Diego

1"Today"in the title of my talk is not"today"in the calendar sense."Today"refers to the cultural ecology,the radical ch.nges and displacements, brought about in ch.na since the Opium War first by attendant colonizing ...

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Fulminant ulcerative colitis associated with steroid-resistant minimal ch.nge disease and psoriasis: A case report

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World Journal of Gastroenterology 2007年第29期13卷 4022-4024页

作者： Ka-Ho Lok Hiu-Gong Hung wai-Man yip Kin-Kong Li Kam-Fu Li Ming-Leung Szeto Division of Gastroenterology and Hepatology Department of Medicine and Geriatrics Tuen Mun Hospital Tsing Chung Koon Road Tuen Mun Hong Kong China

A 43-year-old ch.nese patient with a history of psoriasis developed fulminant ulcerative colitis after immunosuppressive therapy for steroid-resistant minimal ch.nge disease was stopped. Minimal ch.nge disease in association with inflammatory bowel disease is a rare condition. We here report a case showing an association between ulcerative colitis, minimal ch.nge disease, and psoriasis. The possible pathological link between 3 diseases is discussed.

关键词： Ulcerative colitis Inflammatory bowel disease Minimal ch.nge disease

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Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men： results of an integrated analysis

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Asian Journal of Andrology 2009年第4期11卷 423-433页

作者： Ying-Lu Guo Vijay P Viswanathan Han-Sun ch.ang Hyung Ki ch.i Andrew wai ch.n yip Wei Shen Vladimir Kopernicky Andrology Center Peking University First Hospital Peking University Beo＇ing 100009 China M. V. Hospital for Diabetes and Diabetes Research.Centre Chennai 600013 India Sch.ol of Medicine Fu Jen Catholic University Taipei 24205 Taiwan China Department of Urology Yongdong Severance Hospital Seoul 135720 Korea Department of Surgery Kwong Wah Hospital Hong Kong China Lilly USA LLC Indianapolis IN 46285 USA

We evaluated the efficacy and safety of as-needed tadalafil in a diverse clinical population （with varying patient demographics, disease severity, and comorbid medical conditions） of Asian men with erectile dysfunction （ED）. An integrated analysis of five double-blind, placebo-controlled trials （N = 1 046） was performed. Patients were randomly assigned to receive 10 mg tadalafil （N = 185）, 20 mg tadalafil （N = 510）, or placebo （N = 351）. Efficacy assessments included the International Index of Erectile Function （IIEF）, Sexual Encounter Profile （SEP） diary and Global Assessment Question （GAQ）. Patients receiving 10 mg or 20 mg tadalafil showed significant improvement from baseline-to-end point on the Erectile Function domain of the International Index of Erectile Function （IIEF-EF） domain score in all clinical sub-populations analyzed, compared with patients receiving placebo （P 〈 0.001）. The 10-mg and 20-mg tadalafil groups showed a mean success rate of 64.1% and 70.5% for sexual intercourse attempts （SEP3, successful intercourse）, respectively, compared with 33.4% in the placebo group （P 〈 0.001）, and 85.5% and 85.4% reported improved erections at end point GAQ, respectively, versus 43.5% in the placebo group （P 〈 0.001）. Tadalafil was well tolerated across all groups studied. Headach. and back pain were the most frequently reported adverse events. Overall, tadalafil was effective and well tolerated across a diverse clinical spectrum of Asian men with ED.

关键词： Asia comorbidity erectile dysfunction phosphodiesterase inhibitors tadalafil

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Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)

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Genomics, Proteomics & Bioinformatics 2003年第4期1卷 247-262页

作者： Raymond Kin Hi Hui Raymond Tsz Yeung Wong ch. wai yip Frederick ch. ch.ng Leung Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.

The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identifi-

关键词： severe acute respiratory syndrome SARS-CoV genome phylogenetics human leukocyte antigen (HLA) system molecular epidemiology

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Traditional ch.nese medicine poisoning in the emergency departments in Hong Kong: Trend, clinical presentation and predictors for poor outcome

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World Journal of Emergency Medicine 2021年第2期12卷 143-150页

作者： Rex Pui Kin Lam Eric Ho Yin Lau wai Lam yip Joe Kai Shing Leung Matthew Sik Hon Tsui Emergency Medicine Unit Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina Accident and Emergency Department Pamela Youde Nethersole Eastern HospitalHong KongChina Sch.ol of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Dear editor,Traditional ch.nese medicine (TCM) is popular in many countries,especially in the ch.nese population.^([1,2]) In Hong Kong,it has been estimated that around 15%of the population consumed ch.nese medicine products/herbs in the preceding *** reasons for consumption include regulating bodily functions,curing disease,and building up health.

关键词： has editor curing

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Surgical outcomes for unilateral superior oblique palsy in ch.nese population: a retrospective study

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 107-112页

作者： Gordon Shing Kin Yau Victor Tak Yau Tam Jacky wai yip Lee Theo Tak Kwong ch.n Can Yin Fun Yuen Department of Ophthalmology Caritas Medical Centre Department of Anatomy Faculty of MedicineUniversity of Hong Kong

AIM: To evaluate the outcome after surgery for unilateral superior oblique(SO) palsy in ***: The medical records of 39 patients that underwent surgery for unilateral SO palsy between January 2003 and December 2012 at Caritas Medical Centre, Hong Kong, were retrospectively reviewed. All surgeries were performed by a single surgeon. Pre-operative assessments for vertical deviation, cyclo-deviation, and Knapp’s classification were obtained to determine the nature and degree of surgical *** deviation was measured at 1wk; 1, 6mo and on last follow-up day post-operatively. Cyclo-deviation was measured on last follow-up day ***: During the 10 y period, 39 subjects were recruited. The most common etiology was congenital(94.9%). Knapp’s Type III(66.7%) and Type I(12.8%)classifications were the most common subtypes. To treat SO palsy, the most common surgical procedures were:isolated inferior oblique(IO) anteriorization(41.0%),isolated IO myectomy(10.3%), and isolated IO recession(10.3%). At 3.5 ±2.1y post-operatively, the vertical deviation was significantly reduced(15.1 ±6.2 PD versus0.5±1.4 PD, P ch.eved a vertical deviation within ±3 PD.· CONCLUSION: The majority of subjects ach.eved corrected vertical deviation after a single surgery although there was no improvement in *** with over-correction of primary position deviation had greater preoperative vertical deviation and it may be related to simultaneous multiple muscle surgery.

关键词： superior oblique palsy vertical deviation surgery diplopia

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