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Fractal nature of human gastrointestinal system:Exploring a new era

World Journal of Gastroenterology 2023年第25期29卷 4036-4052页

作者： Fabio Grizzi Marco Spadaccini Maurizio Chiriva-Internati Mohamed A A A Hegazi Robert S Bresalier cesare Hassan Alessandro Repici Silvia Carrara Department of Immunology and Inflammation IRCCS Humanitas Research HospitalRozzano 20089MilanItaly Department of Biomedical Sciences Humanitas UniversityPieve Emanuele 20072MilanItaly Division of Gastroenterology and Digestive Endoscopy Department of GastroenterologyIRCCS Humanitas Research HospitalRozzano 20089MilanItaly Departments of Gastroenterology Hepatology&NutritionDivision of Internal MedicineThe University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

The morphological complexity of cells and tissues,whether normal or pathological,is characterized by two primary attributes:Irregularity and self-similarity across different *** an object exhibits self-similarity,its shape remains unchanged as the scales of measurement vary because any part of it resembles the *** the other hand,the size and geometric characteristics of an irregular object vary as the resolution increases,revealing more intricate *** numerous attempts,a reliable and accurate method for quantifying the morphological features of gastrointestinal organs,tissues,cells,their dynamic changes,and pathological disorders has not yet been ***,fractal geometry,which studies shapes and patterns that exhibit self-similarity,holds promise in providing a quantitative measure of the irregularly shaped morphologies and their underlying self-similar temporal *** this context,we explore the fractal nature of the gastrointestinal system and the potential of fractal geometry as a robust descriptor of its complex forms and ***,we examine the practical applications of fractal geometry in clinical gastroenterology and hepatology practice.

关键词： Fractals Geometry Gastroenterology Esophagus Stomach Colon Pancreas Liver Time-series Shape Behavior

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Use of proton pump inhibitors in general practice

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第3期8卷 180-185页

作者： cesare Tosetti Ilaria Nanni Health Agency of Bologna 40046 Alto Reno TermeItaly

To evaluate the characteristics of the prescription of the proton pump inhibitor drugs (PPI) and the adherence to the indications of the guidelines regulating the reimbursement limitations set forth by the Italian Drug Agency. METHODSThirty general practitioners (GP) participated in the study, providing data on more than 40000 patients in total. The population was divided into non occasional users of PPI drugs (PPI users) and non-users (PPI non-users) based on evidence of a prescription of at least 3 packs of PPIs in the last 90 d before analysis. The data provided allowed an assessment of compliance with the requirements of eligibility for PPI reimbursement according to the Italian Drug Agency rules, in order to obtain subpopulations which complied or not with the rules. RESULTSSix thousand three hundred and twenty-two patients were found to be PPI users, accounting for 14.9% of the patient population. PPI users were more frequently female, older and more frequently diagnosed with gastroesophageal reflux disease, gastric or duodenal ulcers, arthropathy, heart disease and cancer than the rest of the population. PPI users had more frequently received prescriptions for non-steroidal ant-inflammatory drugs (NSAIDS), acetylsalicylic acid (ASA), oral anticoagulant therapy (OAT) and systemic steroids. PPI reimbursement resulted applicable to 69.3% of the PPI users, but a potential for reimbursement of PPI prescriptions was identified in the non PPI users for the treatment of peptic or reflux disease (8.5%) and for the protection of gastric damage caused by NSAIDS (6.1%). Patients who are potentially eligible for reimbursement are older, diagnosed with arthropathy and heart disease more frequently and most commonly receive NSAID and ASA prescriptions compared with PPI users who do not satisfy eligibility requirements. Patients in whom it was not possible to identify conditions related to prescription suitability were more frequently associated with use of OAT. CONCLUSIONA

关键词： Proton pump inhibitors Appropriateness General practice Gastroprotection Peptic disease

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Thrombosis of celiacomesenteric trunk:Report of a case

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World Journal of Gastroenterology 2012年第29期18卷 3917-3920页

作者： Federico Lovisetto Gianbattista Finocchiaro De Lorenzi Piera Stancampiano Carmen Corradini Fabio De cesare Orazio Geraci Mario Manzi Francesco Arceci Division of General and Vascular Surgery San Biagio Hospital28845 DomodossolaItaly Division of General and Vascular Surgery Castelli Hospital28921 VerbaniaItaly

Here we present the case of a 79-year-old woman who complained of acute abdominal pain,vomiting and *** exams demonstrated a severe metabolic *** X-rays showed bowel overdistension and pneumatosis of the stomach *** tomography revealed infarction of the stomach,duodenum and small bowel due to thrombosis of the celiacomesenteric *** laparotomy revealed ischemia of the liver,spleen infarction and necrosis of the gastro-intestinal tube(from the stomach up to the first third of the transverse colon).No further surgical procedures were *** patient died the following *** our knowledge,this is the first reported case about severe gastro-intestinal ischemia due to thrombosis of the celiacomesenteric trunk,a rare anatomic variation of the gastrointestinal vascularisation.

关键词： Celiacomesenteric trunk Celiac trunk Thrombosis Anomalies Gastrointestinal vascularisation

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Role of dynamic perfusion magnetic resonance imaging in patients with local advanced rectal cancer

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World Journal of Gastroenterology 2020年第20期26卷 2657-2668页

作者： Davide Ippolito Silvia Girolama Drago Anna Pecorelli cesare Maino Giulia Querques Ilaria Mariani Cammillo Talei Franzesi Sandro Sironi Department of Diagnostic Radiology H.S.Gerardo MonzaSan Gerardo HospitalUniversity of Milano-BicoccaMonza 20900Italy Department of Diagnostic Radiology Papa Giovanni XXIII HospitalUniversity of Milano-BicoccaBergamo 20110Italy

BACKGROUND The management of rectal cancer patients is mainly based on the use of the magnetic resonance imaging(MRI)technique as a diagnostic tool for both staging and *** treatment,to date,the evaluation of complete response is based on the histopathology assessment by using different tumor regression grade(TRG)features(e.g.,Dworak or Mandard classifications).While from the radiological point of view,the main attention for the prediction of a complete response after chemotherapy treatment focuses on MRI and the potential role of diffusion-weighted images and perfusion imaging represented by dynamiccontrast enhanced *** main aim is to find a reliable tool to predict tumor response in comparison to histopathologic *** To investigate the value of dynamic contrast-enhanced perfusion-MRI parameters in the evaluation of the healthy rectal wall and tumor response to chemo-radiation therapy in patients with local advanced rectal cancer with histopathologic *** Twenty-eight patients with biopsy-proven rectal adenocarcinoma who underwent a dynamic contrast-enhanced MR study performed on a 1.5 T MRI system(Achieva,Philips),before(MR1)and after chemoradiation therapy(MR2),were enrolled in this *** protocol included T1 gadolinium enhanced THRIVE sequences acquired on axial planes.A dedicated workstation was used to generate color permeability *** of interest was manually drawn on tumor tissue and normal rectal wall,hence the following parameters were calculated and statistically analyzed:Relative arterial enhancement(RAE),relative venous enhancement(RVE),relative late enhancement(RLE),maximum enhancement(ME),time to peak and area under the curve(AUC).Perfusion parameters were related to pathologic TRG(Mandard’s criteria;TRG1=complete regression,TRG5=no regression).RESULTS Ten tumors(36%)showed complete or subtotal regression(TRG1-2)at histology and classified as responders;18 tumors(64%)were classified as non-responders(TR

关键词： Rectal neoplasm Chemotherapy Radiotherapy Tumor staging Treatment response Magnetic resonance imaging

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Preoperative trans-jugular porto-systemic shunt for oncological gastric surgery in a cirrhotic patient

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World Journal of Gastroenterology 2015年第3期21卷 997-100页

作者： Andrea Liverani Luigi Solinas Tatiana Di cesare Luca Velari Tiziano Neri Francesco Cilurso Francesco Favi Giancarlo Bizzarri Department of General Surgery Regina Apostolorum Hospital00100 RomeItaly Department of Radiology Regina Apostolorum Hospital00100 RomeItaly

Abdominal surgery in cirrhotic patients with portal hypertension is associated with high incidence ofdisease and *** these patients,oncological gastric procedures with lymph-nodes dissection show much higher complication rates than in normotensive portal vein ***,normalization of portal vein pressure may be a favorable determinant factor to reduce *** report a case of a patient with hepatitis C virus-related hepatic cirrhosis,esophageal varices,portal hypertension and gastric *** demonstrated the efficacy of a preoperative trans-jugular porto-systemic shunt to perform oncological radical resection more *** retained preoperative the trans-jugular porto-systemic shunt in the patients with elevated portal pressure and gastric cancer to perform a gastrectomy more safely and to decrease morbidity and mortality of these cases.

关键词： Gastric cancer Cirrhotic patients Esophageal varic

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意大利歌剧院的体形、体量及材料对声场的影响(英文)

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华南理工大学学报（自然科学版） 2007年第B10期35卷 21-24页

作者： Alessandro Cocchi Marco cesare-Consumi Ryota Shimokura Franz Policardi Energy Management Nuclear and Environmental Control Engineering Department DIENCA Bologna University Viale Risorgimento 2 40136 Bologna Italy

针对意大利歌剧院进行研究,着重研究建筑设计对厅堂音质的影响.对两个剧院的常规音质参量进行了测量.这两座剧院是由同一建筑师Antonio Galli Bibiena设计的,分别是波仑亚的市立剧院和曼图亚的科学剧院.二者具有相当近似的形式,但尺寸不... 详细信息

针对意大利歌剧院进行研究,着重研究建筑设计对厅堂音质的影响.对两个剧院的常规音质参量进行了测量.这两座剧院是由同一建筑师Antonio Galli Bibiena设计的,分别是波仑亚的市立剧院和曼图亚的科学剧院.二者具有相当近似的形式,但尺寸不同,所用的材料也各异,前者是用砖石建成,后者是用木料建成,因此在整修前采用了许多预应力钢筋混凝土结构.文中提供了不少数据并给出了对这些数据加以比较和分析的结果,特别是关于某些特征尺寸与扫频信号各可闻频率产生的空间听觉感受之间相关性的分析,以及若干有关材料和体型对IACC和EDT等音质参量的影响的思考.

关键词：建筑设计建筑声学意大利歌剧院客观声学参量

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Molecular regulations of circadian rhythm and implications for physiology and diseases

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Signal Transduction and Targeted Therapy 2022年第3期7卷 666-685页

作者： Francesca Fagiani Daniele Di Marino Alice Romagnoli Cristina Travelli Davide Voltan Lorenzo Di cesare Mannelli Marco Racchi Stefano Govoni Cristina Lanni Department of Drug Sciences(Pharmacology Section) University of PaviaV.le Taramelli 1427100 PaviaItaly Department of Life and Environmental Sciences Polytechnic University of Marchevia Brecce Blanche60131 AnconaItaly New York-Marche Structural Biology Center(NY-MaSBiC) Polytechnic University of Marchevia Brecce Bianche60131 AnconaItaly NEUROFARBA Department University of FlorenceFlorenceItaly

The term"circadian rhythms"describes endogenous oscillations with ca.24-h period associated with the earth’s daily rotation and light/dark *** rhythms reflect the existence of an intrinsic circadian clock that tempor... 详细信息

关键词： rotation earth Molecular

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Treatment of type III middle phalangeal neck fractures through a palmar approach： a case report

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Chinese Journal of Traumatology 2013年第2期16卷 107-109页

作者： Stefano Lucchina cesare Fusetti Hand Surgery Unit EOC Surgical DepartmentLocarno's Regional HospitalLocarnoSwitzerland

Phalangeal neck fractures occur almost exclusively in children. We present the case of a 49 years old man with a dislocated fracture of the neck of the middle phalanx with the distal fragment rotated at 180~, due to a traumatic circular saw injury to the left index, which was solved by anatomical reduction and bone fixation with two 1.5 mm Synthes screws and a temporary transarticular K- wire at the distal interphalangeal joint. Zone I flexor digitorum profundus repair was performed using a modification of the Kessler 4-strands core suture and a full-thickness skin graft from the hypothenar eminence was taken to cover the skin gap. At 6-month follow-up the patient was pain-free and with a total active movement equivalent to 190~. No radio-logical signs of avascular necrosis of the head of the middle phalanx or nonunion of the distal fragment was detectable with recovery to the previous manual work. Owing to the position of the phalangeal head maintained in position by the collateral ligaments an anatomic reduction from dorsal approach is difficult to be performed and a longitudinal trac- tion can render the reduction harder too. The volar approach permits an easier reduction of the fracture through a derotation of the distal fragment facing palmar.

关键词： Finger phalanges Fractures, bone Finger joint

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Relationship between p-catenin expression and epithelial cell proliferation in gastric mucosa with intestinal metaplasia

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World Journal of Gastroenterology 2005年第28期11卷 4400-4403页

作者： Adriana Romiti Angelo Zullo Francesco Borrini Ida Sarcina cesare Hassan Simon Winn Silverio Tomao Aldo Vecchione Sergio Morini Pietro Mingazzini Medical Oncology "Sant'Andrea" Hospital RomeItaly Gastroenterology and Digestive Endoscopy "Nuovo Regina Margherita" Hospital RomeItaly Department of Experimental Medicine and Pathology "La Sapienza" University RomeItaly Medical Oncology "Sant" Andrea" Hospital RomeItaly Oncology IRCCS "Regina Elena" RomeItaly Co-first-authors: Adriana Romiti and Angelo Zullo

AIM： To investigate β-catenin expression in patients with intestinal metaplasia, and to look for a possible relationship between β-catenin expression and either epithelial proliferation values or Helicobacter pylori （ H pylori） infection.METHODS： Twenty patients with complete type intestinal metaplasia were studied. β-Catenin expression and epithelial cell proliferation in antral mucosa were assessed using an immunohistochemical analysis. H pylori infection was detected by histology and a rapid urease test.RESULTS： Reduced β-catenin expression on the surface of metaplastic cells was detected in 13 （65%） out of 20 patients. Moreover, in eight （40%） patients intranuclear expression of β-catenin was found. When patients were analyzed according to H pylori infection, the prevalence of both β-catenin reduction at the cell surface and its intranuclear localization did not significantly differ between infected and uninfected patients. Cell proliferation was higher in patients with intranuclear β-catenin expression as compared to the remaining patients, although the difference failed to reach the statistical significance （36±8.9 vs 27.2±11.4, P= 0.06）. On the contrary, a similar cell proliferation value was observed between patients with reduced expression of β-catenin on cell surface and those with a normal expression （28.1±11.8 vs 26.1±8.8, P= 0.7）.H pylori infection significantly increased cell proliferation （33.3±10.2% vs 24.6±7.4% , respectively, P= 0.04）.CONCLUSION： Both cell surface reduction and intranuclear accumulation of β-catenin were detected in intestinal metaplasia. The intranuclear localization of β-catenin increases cell proliferation. H pylori infection does not seem to play a direct role in β-catenin alterations, whilst it significantly increases cell proliferation.

关键词： β-Catenin Intestinal metaplasia Proliferation Helicobacter pylori

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华南理工大学学报（自然科学版） 2007年第B10期35卷 88-91页

作者： Ryota Shimokura Alessandro Cocchi Lamberto Tronchin Marco cesare Consumi Energy Management Nuclear and Environmental Control Engineering Department DIENCABologna UniversityViale Risorgimento 240136 BolognaItaly

双耳脉冲响应(BIRs)是用以表征音乐厅和歌剧院声场特征的参量.由于BIRs是表征声场的转移函数,因此,在消声室中录制的声源信号与BIRs卷积,就代表在实际声场中听到的信号.为了探究原信号的声学特征,一种有效的方法是计算其自相关函数(ACF)... 详细信息

双耳脉冲响应(BIRs)是用以表征音乐厅和歌剧院声场特征的参量.由于BIRs是表征声场的转移函数,因此,在消声室中录制的声源信号与BIRs卷积,就代表在实际声场中听到的信号.为了探究原信号的声学特征,一种有效的方法是计算其自相关函数(ACF),因为从ACF中导出的参量能与听者的主观优选良好相关.因此可以说,卷积与相关是室内声学中最重要的计算方法.文中通过将BIRs导出的双耳互相关函数(IACF)和将干信号与BIRs卷积后的IACF作比较,探讨了声源信号与声场之间的关系.在特定条件下,卷积与相关是等同的,此时,干信号与BIRs卷积后的IACC可直接由BIRs导出的IACC与干信号的ACF的有效时间τ_e来表示.

关键词：双耳互相关系数自相关函数有效时间卷积

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