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Perianal Crohn's disease: Is there something new?

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World Journal of Gastroenterology 2011年第15期17卷 1939-1946页

作者： cesare ruffolo Marilisa Citton Marco Scarpa Imerio Angriman Marco Massani Ezio Caratozzolo Nicolò Bassi Ⅱ Department of Surgery (IV unit) Regional Hospital Ca' Foncello 31100 Treviso Italy Department of Surgicaland Gastroenterological Sciences University of Padova 35122 Padua Padova Italy Department of Oncological Surgery VenetoOncological Institute 35100 Padova Italy Department of Surgicaland Gastroenterological Sciences University of Padova 35122Padua Padova Italy

Perianal lesions are common in patients with Crohn's disease, and display aggressive behavior in some cases. An accurate diagnosis is necessary for the optimal management of perianal lesions. Treatment of perianal Crohn's disease includes medical and/or surgical options. Recent discoveries in the pathogenesis of this disease have led to advances in medical and surgical therapy with good results. Perianal lesions in Crohn's disease remain a challenging aspect for both gastroenterologists and surgeons and lead to a greatly impaired quality of life for all patients affected by this disease. A multidisciplinary approach is mandatory to obtain the best results.

关键词：手术治疗攻击行为病变化管理胃肠病挑战性强制性多学科

Management of ruptured hepatocellular carcinoma:Implications for therapy

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World Journal of Gastroenterology 2010年第10期16卷 1221-1225页

作者： Nicolò Bassi Ezio Caratozzolo Luca Bonariol cesare ruffolo Alessio Bridda Luigi Padoan Michele Antoniutti Marco Massani IV Unit of Surgery Regional Reference Center of Hepato-Biliary-Pancreatic Surgery

AIM:To assess the treatment and tumor-related variables associated with outcome after treatment of spontaneously ruptured hepatocellular carcinoma (HCC).METHODS: Patients with ruptured HCC were identif ied. The complications, mortality and survival were assessed. The relationship between tumor size and the severity of hemoperitoneum and between tumor size and grade were ***: From January 1993 to January 2008, 556 patients with HCC with or without cirrhosis were evaluated; of which, 16 (2.87%) presented with spontaneous rupture. All but 1 patient had cirrhosis. Twelve patients underwent surgical resection while 4 underwent trans-cutaneous arterial catheter embolization (TAE) (trans-cutaneous arterial embolization). Early mortality (<30 d) was 25% (4 of 16) and was inversely relatedto Child-Pugh score; 3 of the 4 early deaths occurred in patients treated with TAE with 1 of 12 occurring in the resected group. There was no correlation between tumor size and grade or between size and severity of ***: Tumor size did not correlate with severity of the hemoperitoneum. There was an inverse relationship between G1-G3 (grade of cellular differentiation) HCC and dimensions.

关键词： Bleeding hepatocellular carcinoma Management of ruptured hepatocellular carcinoma Ruptured hepatocellular carcinoma

Antioxidative potential of a combined therapy of anti TNFα and Zn acetate in experimental colitis

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World Journal of Gastroenterology 2011年第36期17卷 4099-4103页

作者： Michela Barollo Valentina Medici Renata DIncà Antara Banerjee Giuseppe Ingravallo Marco Scarpa Surajit Patak cesare ruffolo Romilda Cardin Giacomo Carlo Sturniolo Department of Surgical and Gastroenterological Sciences University of PadovaPadova 35128Italy Department of Internal Medicine Division of Gastroenterology and HepatologyUniversity of CaliforniaDavisCA 95616United States Department of Pathology University of BariBari 70121Italy Department of Oncological Surgery Veneto Oncological InstitutePadova 35128Italy

AIM:To evaluate whether combination therapy with antitumour necrosis factor α (TNFα) antibody and Zn acetate is beneficial in dextran sodium sulphate (DSS) ***:Colitis was induced in CD1-Swiss mice with 5% DSS for 7 *** experimental mice were then randomised into the following subgroups:standard diet + DSS treated (induced colitis group);standard diet + DSS + subcutaneous 25 μg anti-TNFα treated group;Zn acetate treated group + DSS + subcutaneous 25 μg anti-TNFα;standard diet + DSS + subcutaneous 6.25 μg anti-TNFα treated group and Zn acetate treated group + DSS + subcutaneous 6.25 μg anti-TNFα.Each group of mice was matched with a similar group of sham control *** and histological features were scored *** of the colonic mucosa were assessed for myeloperoxidase activity as a biochemical marker of inflammation and DNA adducts (8OH-dG) as a measure of oxidative ***:DSS produced submucosal erosions,ulcers,inflammatory cell infiltration and cryptic abscesses which were reduced in both groups of mice receiving either anti-TNFα alone or combined with *** effect was more pronounced in the latter group (vs Zn diet,P < 0.02).Myeloperoxidase activity (vs controls,P < 0.02) and DNA adducts,greatly elevated in the DSS fed colitis group (vs controls,P < 0.05),were significantly reduced in the treated groups,with a more remarkable effect in the group receiving combined therapy (vs standard diet,P < 0.04).CONCLUSION:DSS induces colonic inflammation which is modulated by the administration of anti-TNFα.Combining anti-TNFα with Zn acetate offers marginal benefit in colitis severity.

关键词：肿瘤坏死因子综合治疗醋酸锌结肠炎抗氧化实验性 DNA加合物过氧化物酶活性

Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis

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World Journal of Gastroenterology 2005年第34期11卷 5303-5308页

作者： Lino Polese Imerio Angriman Giuseppe De Franchis Attilio Cecchetto Giacomo C.Sturniolo Renata D'Incà Marco Scarpa cesare ruffolo Lorenzo Norberto Mauro Frego Davide F D'Amico Department of Gastroenterological and Surgical Sciences. Surgical Unit University of Padova Italy Department of Laboratory Medicine University of Padova Italy Department of Pathology University of Padova Italy Department of Gastroenterological and Surgical Sciences Gastroenterological Unit University of Padova Italy

AIM: To focus on the role of CD40 and CD40L in their ***: We analyzed by immunohistochemistry the CD40 and CD40L expression in the pouch mucosa of 28 patients who had undergone RPC for UC, in the terminal ileum of 6 patients with UC and 11 healthy subjects. We also examined by flow cytometry the expression of CD40 by B lymphocytes and monocytes in the peripheral blood of 20 pouch patients, 15 UC patients and 11 healthy ***: Ileal pouch mucosa leukocytes presented a significantly higher expression of CD40 and CD40L as compared to controls. This alteration correlated with pouchitis, but was also present in the healthy pouch and in the terminal ileum of UC patients. CD40 expression of peripheral B lymphocytes was significantly higher in patients with UC and pouch, respect to controls. Increased CD40 levels in blood B cells of pouch patients correlatedwith the presence of spondyloarthropathy, but not with pouchitis, or inflammatory ***: High CD40 expression in the ileal pouch mucosa could be implied in the pathogenesis of pouchitis following proctocolectomy for UC, whereas its increased levels on peripheral blood B lymphocytes are associated with the presence of extraintestinal manifestations.

关键词： CD40 CD40L 基因表达大肠炎滋补剂

Acute appendicitis: What is the gold standard of treatment?

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World Journal of Gastroenterology 2013年第47期19卷 8799-8807页

作者： cesare ruffolo Alain Fiorot Giulia Pagura Michele Antoniutti Marco Massani Ezio Caratozzolo Luca Bonariol Francesco Calia di Pinto Nicolò Bassi Ⅱ Deparment of Surgery (Ⅳ Unit) Regional Hospital "Ca’ Foncello"31100 TrevisoItaly

McBurney’s procedure represented the gold-standard for acute appendicitis until 1981,but nowadays the number of laparoscopic appendectomies has progressively increased since it has been demonstrated to be a safe procedure,with excellent cosmetic results and it also allows a shorter hospitalization,a quicker and less painful postoperative *** aim of this editorial was to perform a review of the literature in order to address controversial issues in the treatment of acute appendicitis.

关键词： Acute appendicitis Surgery Laparoscopy